| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Research Abstract |
Existence of cerebral microdysgenesis is pointed out as a qualitative alteration of the focal cerebral lesion of intractable epilepsy. Existence of three kinds of views (superficial hypermyelination, subpial large neuron, persistent granule cell) was scored, and the sum total in each group and frequency were computed. As a result, the example with which three views coexisted went up to the abbreviation half, and it was suggested strongly that it was appropriate to diagnose it as microdysgenesis in such a case. Neuronal cytoskeletons (neurofilament, microtubule, microtubule-associated protein), glial cytoskeletons (GFAP, vimentin), calcium-binding proteins (calbindin, parvalbumin, calretinin), a GABA index (GAD) and phosphoryalted tau, ubiquitin, synuclerin, NMDAR-1, muscarinic acetylcholine receptor, myelin-associated glycoprotein etc. was stained on the microdysgenesis region. Moreover, it was shown clearly that the stainability by an anti-beta-catenin antibody is useful as a marker of diagnosis of occult cortical dysplasia. In addition, publication of the case reports and the textbook was performed about pathology change of the focal part of the abnormalities in brain formation which received the surgical treatment of intractable epilepsy.
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