Synaptic plasticity and memory storage in the hippocampal formation of monkeys

• Project/Area Number: 17500273
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: University of Toyama
• Principal Investigator: TAMURA Ryoi University of Toyama, Grad. Sch Med. Pharmaceu. Sci. Res, Professor (60227296)
• Co-Investigator(Kenkyū-buntansha): EIFUKU Satoshi Univ. Toyama, Grad. Sch. Med. Pharmaceu. Sci. Res, Associate Professor (70262508) ; UWANO Teruko Univ. Toyama, Grad. Sch. Med. Pharmaceu. Sci. Res, Assistant Professor (80242486)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,710,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000); Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: monkeys / primates / hippocampal formation / synaptic plasticity / evoked potentials / memory / lone-term potentiation / long-term depression

Research Abstract

Long-term potentiation (LTP) and long-term depression (LTD) are both forms of synaptic plasticity which are recognized as a neural substrate for memory. LTP and LTD have been studied extensively in the hippocampus using rodent models. However, there has been no information about synaptic plasticity in the primate hippocampus. Therefore, we addressed this issue in the present study. In the first fiscal year, we exploited a model for recording evoked potentials in the hippocampus of monkeys, precisely implanting stimulation and recording electrodes in the perforant pathway and dentate gyrus, respectively, based on the coordinates determined by MRI images. In the second fiscal year, using this animal model, we tested the effects of high-frequency or low-frequency repetitive stimulation (HFS or LFS) on evoked potentials, and found that only the HFS with the highest frequency (400 Hz) induced LTP, while all LFS conditions failed to induce LTD. In the third fiscal year, we compared the induction and maintenance of LTP between monkeys and rats, and found that LTP was stably maintained more than 1 month without decay in monkeys, while it decayed rapidly and returned to the baseline level within a week in rats. Furthermore, we induced LTP in senile and young monkeys, and tested the relations between LTP induction or maintenance and memory task performance. The senile monkey tended to show worse task performance than the younger monkey. However, no clear correlations between LTP induction or maintenance and task performance were observed. These data indicate that 1) LTP can be a ubiquitous model for long-term synaptic plasticity, and 2) the difference of LTP maintenance between the 2 species is involved in the difference of hippocampal-dependent duration necessary for memory consolidation between the species (i.e., longer in primates and shorter in rodents).

Research Products

• [Journal Article] Neural correlates of stimulus-reward association in the rat mediodorsal thalamus. (2007)
  • Author(s): Kawagoe, T., Tamura, R., Uwano, T., Asahi, T., Nishijo, H., Eifuku, S., Ono, T.
  • Journal Title: Neuro Report 18 Pages: 683-688
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Neural correlates of stimulus-reward association in the rat mediodorsal thalamus (2007)
  • Author(s): Kawagoe, T., Tamura, R., Uwano, T., Asahi, T., Nishijo, H., Eifuku, S., Ono, T
  • Journal Title: NeuroReport 18 Pages: 683-688
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neural correlates of stimulus-reward association in the rat mediodorsal thalamus (2007)
  • Author(s): Kawagoe, T., Tamura, R., Uwano, T., Asahi, T., Nishijo, H., Eifuku, S. & Ono, T.
  • Journal Title: NeuroReport 18 Pages: 683-688
  • Peer Reviewed
• [Journal Article] Neuronal responses to a delayed-response delayed-reward go/nogo task in the monkey posterior insular cortex. (2006)
  • Author(s): Asahi, T., Uwano, T., Eifuku, S., Tamara, R., Endo, S., Ono, T., Nishijo, H.
  • Journal Title: Neuroscience 143 Pages: 627-639
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Spatial firing properties of lateral septal neurons. (2006)
  • Author(s): Takamura, Y., Tamura, R., Zhou, T. L., Kobayashi, T., Tran, A. H., Eifuku, S., Ono, T.
  • Journal Title: Hippocampus 16 Pages: 635-644
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Spatial firing properties of lateral septal neurons (2006)
  • Author(s): Takamura, Y., Tamura, R., Thou, T.L., Kobayashi, T., Tran, A.H., Eifuku, S., Ono, T.
  • Journal Title: Hippocampus 16 Pages: 635-644
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neuronal responses to a delayed-response delayed-reward go/nogo task in the monkey posterior insular cortex (2006)
  • Author(s): Asahi, T., Uwano, T., Eifuku, S., Tamura, R., Endo, S., Ono, T., Nishijo, H
  • Journal Title: Neuroscience 143 Pages: 627-639
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Spatial firing properties of lateral septal neurons. (2006)
  • Author(s): Takamura, Y, Tamura, R., Zhou, T.L., Kobayashi, T., Tran, A.H., Eifuku, S., Ono,T.
  • Journal Title: Hippocampus 16 Pages: 635-644
• [Journal Article] Neuronal responses to a delayed-response delayed-reward go/nogo task in the monkey posterior insular cortex. (2006)
  • Author(s): Asahi, T., Uwano, T., Eifuku, S., Tamura, R., Endo, S., Ono, T., Nishijo,H.
  • Journal Title: Neuroscience 143 Pages: 627-639
• [Journal Article] Neural correlates of stimulus-reward association in the mediodorsal thalamus. (2006)
  • Author(s): Kawagoe, T., Tamura, R., Uwano, T., Asahi, T., Nishijo, H., Eifuku, S., Ono,T.
  • Journal Title: NeuroReport (in press)
• [Journal Article] Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place. (2005)
  • Author(s): Tran A. H. Tamura R., Uwano T., Kobayashi T, , Katsuki M., Ono T.
  • Journal Title: Proc. Natl. Acad. Sci. USA 102 Pages: 2117-2122
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Differential characteristics of face neuron responses within the anterior superior temporal sulcus of macaques. (2005)
  • Author(s): De Souza W. C., Eifuku S., Tamura R., Nishijo H., Ono T.
  • Journal Title: J. Physiol. 94 Pages: 1251-1566
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Auditory thalamus integrates visual inputs into behavioral gains. (2005)
  • Author(s): Komura Y., Tamara R., Uwano T., Nishijo H., Ono T.
  • Journal Title: Nat. Neurosci. 8 Pages: 1203-1209
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 情動と前部帯状回. (2005)
  • Author(s): 田村了以, 小野武年
  • Journal Title: Clin. Neurosci. 23 Pages: 1256-1260
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 情動行動とモノアミン系 (2005)
  • Author(s): 田村了以, 小野武年
  • Journal Title: 神経研究の進歩 50 Pages: 53-67
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place (2005)
  • Author(s): Tran, A. H., Tamura, R., Uwano, T., Kobayashi, T., Katsuki, M., Ono, T
  • Journal Title: Proc Natl Acad Sci USA 102 Pages: 2117-2122
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differential characteristics of face neuron responses within the anterior superior temporal sulcus of macaques (2005)
  • Author(s): De, Souza., W. C., Eifuku, S., Tamura, R., Nishijo, H., Ono, T
  • Journal Title: J Neurophysiol 94 Pages: 1251-1566
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Auditory thalamus integrates visual inputs into behavioral gains (2005)
  • Author(s): Komura, Y., Tamura, R., Uwano, T., Nishijo, H., Ono, T
  • Journal Title: Nature Neurosci 8 Pages: 1203-1209
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place. (2005)
  • Author(s): Tran A.H., Tamura R., Uwano T., Kobayashi T., Katsuki M., Ono T.
  • Journal Title: Proc.Natl.Acad.Sci.USA 102 Pages: 2117-2122
• [Journal Article] Differential characteristics of face neuron responses within the anterior superior temporal sulcus of macaques. (2005)
  • Author(s): De Souza W.C., Eifuku S., Tamura R., Nishijo H., Ono T.
  • Journal Title: J.Neurophysiol. 94 Pages: 1251-1566
• [Journal Article] Auditory thalamus integrates visual inputs into behavioral gains. (2005)
  • Author(s): Komura Y., Tamura R., Uwano T., Nishijo H., Ono T.
  • Journal Title: Nature Neurosci. 8 Pages: 1203-1209
• [Journal Article] 情動と前部帯状回 (2005)
  • Author(s): 田村了以, 小野武年
  • Journal Title: Clin.Neurosci. 23 Pages: 1256-1260
• [Presentation] Neuronal responses to a delayed-response delayed-reward go/nogo task in the monkey posterior insular cortex. (2007)
  • Author(s): Asahi T., Uwano T., Eifuku S., Tamura R., Endo S., Ono T., Nishijo H.
  • Organizer: 6th Cong. Asian Soc. Stereotact. Func. Comput. Assist. Neurosurg
  • Place of Presentation: Fujiyoshida
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] D1R in hippocampal responses to novel environment. (2007)
  • Author(s): Tran A. H., Uwano T., Kimura T., Hori E., Katsuki M., Tamura R., Nishijo H., Ono T.
  • Organizer: The 37th Ann. Meet. Soc. Neurosci
  • Place of Presentation: San Diego
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] サル海馬体における長期増強の誘導・維持. (2007)
  • Author(s): 田村了以, 永福智志, 上野照子, 北村貴志, Tran A. H., 小野武年
  • Organizer: 第84回日本生理学会大会
  • Place of Presentation: 大阪
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 海馬体における長期増強の誘導・維持に関する動物種差. (2007)
  • Author(s): 田村了以, 永福智志, 上野照子, 北村貴志, 小野武年
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] サルの海馬における長期増強の誘導と持続. (2007)
  • Author(s): 田村了以, 永福智志, 上野照子, 杉森道也, 小野武年
  • Organizer: 第54回中部日本生理学会
  • Place of Presentation: 津
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Neuronal responses to a delayed-response delayed-reward go/nogo task in the monkey posterior insular cortex (2007)
  • Author(s): Asahi, T., Uwano, T., Eifuku, S., Tamura, R., Endo, S., Ono, T., Nishijo, H
  • Organizer: 6th Cong. Asian Soc. Stereotact. Func. Comput. Assist. Neurosurg
  • Place of Presentation: Fujiyoshida
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] D1R in hippocampal responses to novel environment (2007)
  • Author(s): Tran, A.H., Uwano, T., Kimura, T., Hori, E., Katsuki, M., Tamura, R., Nishijo, H., Ono, T
  • Organizer: The 37th Ann. Meet. Soc. Neurosci
  • Place of Presentation: San Diego
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Induction and maintenance of long-term potentiation in the monkey hippocampal formation (2007)
  • Author(s): Tamura, R., Eifuku, S., Uwano, T., Kitamura, T., Ono, T
  • Organizer: The 84th Ann. Meet. Physiol. Soc. Jpn
  • Place of Presentation: Oosaka
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Specific difference in the induction and maintenance of long-term potentiation in the hippocampal formation (2007)
  • Author(s): Tamura, R., Eifuku, S., Uwano, T., Kitamura, T., Ono, T
  • Organizer: The 30t Ann. Meet. Jpn. Soc. Neurosci
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Induction and maintenance of long-term potentiation in the monkey hippocampus (2007)
  • Author(s): Tamura, R., Eifuku, S., Uwano, T., Sugimori, M., Ono, T
  • Organizer: The 54th Ann. Meet. Physiol. Soc. Chubu Jpn
  • Place of Presentation: Tsu
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Hippocampal neuronal activity in spatial navigation tasks in familiar and novel environments. (2006)
  • Author(s): Tran A. H., Tamura R., Uwano T., Kimura T., Hori E., Katsuki M., Nishijo H., Ono T.
  • Organizer: 36th Ann. Meet. Soc. Neurosci
  • Place of Presentation: Atlanta
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] サル海馬体における長期増強および長期抑圧. (2006)
  • Author(s): 田村了以, 北村貴志, 永福智志, 上野照子, 小野武年
  • Organizer: 第83回日本生理学会大会
  • Place of Presentation: 前橋
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Hippocampal neuronal activity in spatial navigation tasks in familiar and novel environments (2006)
  • Author(s): Tran, A.H., Tamura, R., Uwano, T., Kimura, T., Hori, E., Katsuki, M., Nishijo, H., Ono, T
  • Organizer: 36th Ann. Meet. Soc. Neurosci
  • Place of Presentation: Atlanta
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Long-term potentiation and depression in the monkey hippocampal formation (2006)
  • Author(s): Tamura, R., Kitamura, T., Eifuku, S., Uwano, T., Ono, T
  • Organizer: The 83rd Ann. Meet. Physiol. Soc. Jpn
  • Place of Presentation: Maebashi
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The effects of dopamine receptor subtype knockout on goal-directed behavior and reward-anticipatory neural responses in the nucleus accumbens of mice. (2005)
  • Author(s): Tamura, R.
  • Organizer: New Perspectives in Affective Science
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Long-term synaptic plasticity in the monkey hippocampus. (2005)
  • Author(s): Tamura, R., Kitamura, T., Eifuku, S., Uwano, T. Ono, T.:
  • Organizer: 35th Ann. Meet. Soc. Neurosci.,
  • Place of Presentation: Washington, D. C.
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Self-adaptive control of the sensory signal in the thalamus. (2005)
  • Author(s): Komura, Y., Tamura, R., Uwano, T., Nishijo, H., Ono, T.
  • Organizer: 35th Ann. Meet. Soc. Neurosci.,
  • Place of Presentation: Washington, D. C.
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Firing properties of amygdala neurons in spatial navigation tasks. (2005)
  • Author(s): Tran, A. H., Nishijo, H., Tamura, R., Uwano, T., Kimura, T., Katsuki, M., Ono, T
  • Organizer: 35th Ann. Meet. Soc. Neurosci.,
  • Place of Presentation: Washington, D. C.
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Neural response properties and plasticity in the monkey hippocampus. (2005)
  • Author(s): Tamura, R., Ono, T.
  • Organizer: The University of British Columbia-Toyama University Neuroscience Joint Meeting '05
  • Place of Presentation: Toyama
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Involvement of dopamine receptors in spatial learning and neural responses to rewards and spatial context in some limbic structures. (2005)
  • Author(s): Tran, A. H., Tamura, R., Uwano, T., Kimura, T., Nishijo, H., Katsuki, M., Ono, T.
  • Organizer: The University of British Columbia-Toyama University Neuroscience Joint Meeting '05
  • Place of Presentation: Toyama
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] サル海馬体における誘発電位記録. (2005)
  • Author(s): 田村了以, 北村貴志, 永福智志, 上野照子, 小野武年
  • Organizer: 第28回日本神経科学大会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] アイデンティティ認知課題におけるサル前部側頭皮質「顔」ニューロンの応答性. (2005)
  • Author(s): 永福智志, 田村了以, De Souza, W. C., 小野武年
  • Organizer: 視覚科学フォーラム
  • Place of Presentation: 青森
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The effects of dopamine receptor subtype knockout on goal-directed behavior and reward-anticipatory neural responses in the nucleus accumbens of mice (2005)
  • Author(s): Tamura, R
  • Organizer: New Perspectives in Affective Science
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Long-term synaptic plasticity in the monkey hippocampus (2005)
  • Author(s): Tamura, R., Kitamura, T., Eifuku, S., Uwano, T., Ono, T
  • Organizer: 35th Ann. Meet. Soc. Neurosci
  • Place of Presentation: Washington, D.C.
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Self-adaptive control of the sensory signal in the thalamus (2005)
  • Author(s): Komura, Y., Tamura, R., Uwano, T., Nishijo, H., Ono, T
  • Organizer: 35th Ann. Meet. Soc. Neurosci
  • Place of Presentation: Washington, D. C
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Firing properties of amygdala neurons in spatial navigation tasks (2005)
  • Author(s): Tran, A.H., Nishijo, H., Tamura, R., Uwano, T., Kimura, T., Katsuki, M., Ono, T
  • Organizer: 35th Ann. Meet. Soc. Neurosci
  • Place of Presentation: Washington, D. C
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Neural response properties and plasticity in the monkey hippocampus (2005)
  • Author(s): Tamura, R. and Ono, T
  • Organizer: The University of British Columbia - Toyama University Neuroscience Joint Meeting '05
  • Place of Presentation: Toyama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Involvement of dopamine receptors in spatial learning and neural responses to rewards and spatial context in some limbic structures (2005)
  • Author(s): Tran, A.H., Tamura, R., Uwano, T., Kimura, T., Nishijo, H., Katsuki, M., Ono, T
  • Organizer: The University of British Columbia - Toyama University Neuroscience Joint Meeting '05
  • Place of Presentation: Toyama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Recording of evoked potentials in the monkey hippocampus (2005)
  • Author(s): Tamura, R., Kitamura, T., Eifuku, S., Uwano, T., Ono, T
  • Organizer: The 28th Ann. Meet. Jpn. Soc. Neurosci
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Responses of face neurons in the anterior temporal cortex of monkeys during the performance of identity cognition task (2005)
  • Author(s): Eifuku, S., Tamura, R., De Souza, W. C., Ono, T
  • Organizer: The 9th Vison Forum
  • Place of Presentation: Aomori
  • Description: 「研究成果報告書概要(欧文)」より