Direct Assessment of the Left Atrial Myocardial Function Using Strain Imaging
| Project/Area Number |
17500331
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | FUJITA HEALTH UNIVERSITY |
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Principal Investigator |
TABATA Tomotugu FUJITA HEALTH UNIVERSITY, School of Medicine, Associate Professor, 医学部, 准教授 (80291491)
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| Co-Investigator(Kenkyū-buntansha) |
MUKAIDE Daisuke FUJITA HEALTH UNIVERSITY, School of Medicine, Assistant, 医学部, 助教 (80421262)
WATANABE Atsushi FUJITA HEALTH UNIVERSITY, School of Medicine, Assistant, 医学部, 助教 (90421263)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2005: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | cardiology / cardiac function / left atrium / ultrasound / strain |
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| Research Abstract |
We have evaluated the left atrial (LA) function in the normal subjects, patients with dilated cardiomyopathy, ischemic heart disease, hypertensive heart disease and hypertrophic cardiomyopathy using the LA volume measurements. At first, we analyzed the normal values of the LA volumes and works. Using the prototype LA volume tracking technique, we have found that we could create LA volume loop easily and precisely. In the normal subjects the LA emptying during atrial systole plays and important role in the LA forword stroke and the maximal LA volume regulates the following LA volumes and emptying. We found that the LA active emptying was deteriorated in patients with dilated cardiomyopathy and hypertrophic cardiomyopathy which has the pathologic change in the LA myocardium compared to ischemic cardiomyopathy and hypertensive heart disease without myocardial damage in the LA myocardium, because the LA active emptying volume was decreased and LA overloading was increased in the cardiomyopathies. The response to the preload increase by the lower body positive pressure stress in patients with cardiomyopathies was different from those with ischemic heart disease and hypertensive heart disease. The preload increase in patients with cardiomyopathies caused the LA pressure rise and pulmonary venous congestion. It was considered to be useful to evaluate the response of the LA volume increase to the preload increase when determining whether heart failure can be easily produced or not in the clinical setting. Those results have already presented at the meetings of the Japanese Collage of Cardiology, the Japanese Circulation Society and World Congress of Cardiac Ultrasound. Those are also going to be published in the journal of Circulation or Journal of the American Collage of Cardiology.
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Report
(3 results)
Research Products
(25 results)
