| Co-Investigator(Kenkyū-buntansha) |
KOHZUKI Masahiro Internal Medicine and Rehabilitation Science, Tohoku University, Graduate School of Medicine, professor (70234698)
KUROSAWA Hajime Tohoku University, Health Administration Center, Associate professor (60333788)
村上 新治 札幌医科大学, 保健医療学部, 教授 (30142756)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Research Abstract |
Weight loss in patients with chronic pulmonary failure (CPF) is a major complication, and is an important determinant of the survival prognosis. Adiponectin, one of adipocyte-secreted protein has a unique feature about fat metabolism and body weight. The aim of this study was to investigate whether adiponectin increased in patients with CPF.
We measured the following items.
・Lung functions: VC, %VC, FEV1, %FEV1, FEV1/VC
・Body composition: body mass index (BMI), % ideal body weight (%IBW), body fat mass (BFM), body fat percentage (BF%), skeletal muscle mass(SMM), protein mass (PM), fat free mass (FFM)
・Blood samples: plasma adiponectin, tumor necrosis factor (TNF)-a, plasma leptin, fasting glucose (FBG), insulin(LRI), free fatty acid (FFA), retinol binding protein (RBP), prealbumin (PA), hemoglobin Alc (Hb-Alc)
%FEV1 and %VC were negatively correlated with plasma adiponectin concentrations. BMI was significantly correlated with plasma adiponectin concentrations. FFM was significantly correlated with plasma adiponectin concentrations, but not BFM did not. Insulin resistance (HOMA-R) was negatively correlated with plasma adiponectin concentrations. Adiponectin is a candidate for one of major contributors of weight loss in patients with CPF.
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