| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Research Abstract |
We investigated the incidence of MS in 549 obese children, with a mean age of 9.4 years and an obesity degree of 42.7%, using the criteria for childhood metabolic syndrome (MS). On evaluation of the waist circumference, abnormal values were noted in 56.8% of the 549 children. They were more frequent in obese boys. The abnormal values of serum triglyceride level and diastolic blood pressure were second most frequent. The values of HDL-C, fasting blood sugar, and systolic blood pressure were less frequently evaluated as abnormal. Overall, 11.5% of the children were diagnosed as having MS. In 49.9% of them, including a preliminary group, MS was suspected. Based on these results, obesity may markedly increase the risk of MS even in children.
Subsequently, we performed diet and exercise therapies for 4 months in 39 moderately to severely obese children, with a mean age of 9.9 years and a mean percentage of overweight of 54.1%. Before our weight-loss program, 81.6% of the 39 children showed abnormal waist circumference values. Overall, 13.2% of them were diagnosed as having MS. After our program, the mean body weight decreased by 8.1 kg. The mean visceral fat area also significantly decreased from 53.3 cm^2 to 33.1 cm^2. The absolute value of maximum oxygen uptake, an index of aerobic capacity, significantly increased despite weight loss, improving physical strength. After our weight-loss program, 13.2% of the children showed abnormal waist circumference values. No child showed any abnormal values of serum triglyceride level, systolic blood pressure, nor fasting blood sugar. The incidence of MS decreased from 13.2% to 2.6%, suggesting the ameliorating effects of diet/exercise therapies on MS in obese children.
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