Anti-stress effects of plants used in Japanese traditional festivals and development of the anti-stress aromatic agents of the taste of the Japanese
| Project/Area Number |
17500484
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kitasato University (2007)
Nigata University of Phermacy and Applied Life Sciences (2005-2006) |
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Principal Investigator |
KOBAYASHI Yoshinori Kitasato University, 薬学部, Professor (60367414)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,750,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | autonomic nervous system / stress / Japanese traditional seasonal ceremony / aromatic ingredients / essential oil / heart rate variability / electrocardiogram / リラックス / 心拍 / 脳波 |
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| Research Abstract |
Anti-stress effects of the aromatic plants used for Japanese traditional seasonal events were evaluated. Essential oils were obtained from Atractylodes rhizomes, pine leafs, white peach blossoms, peach kernels, mugwort leafs, calamus rhizomes, bamboo leafs, chrysanthemum flowers and Evodia fruits. The sedative effects of these essential oils were evaluated in a mice open field test. The exposure of a mouse to a novel environment induces exploratory behavior resulting in an increase in spontaneous motor activity. The reduction of the spontaneous motor activity was translated as the sedative effects, or anti-stress effects. The essential oils from Atractylodes rhizomes and Evodia fruits showed significant reduction in the spontaneous motor activity. The sedative effect of Evodia fruit's essential oil was comparable to that of lavender flower's essential oil. In addition, the sedative effects of these essential oils disappeared in the experimentally induced anosmic mice. Our data suggest that the fragrance of the Evodia fruits would be useful for relaxation and stress management. The analysis of heart rate variably might be useful to evaluate the anti-stress effects of the fragrance. The variation index of the heart rate R-R interval was the most suitable index to detect the load and liberation of mental stress in human studies. The effects of the intake of coffee and GABA were also observed. Anti-stress effects of the fragrance of Evodia Fruits in mice and human are going to be evaluated in future.
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Report
(4 results)
Research Products
(8 results)
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[Presentation] 呉茱萸精油の吸入による鎮静効果2008
Author(s)
菅田佳奈子, 竹元裕明, 浅田善久, 小林義典
Organizer
日本生薬学会第55年会
Place of Presentation
長崎
Year and Date
2008-09-20
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] 白朮精油の吸入による鎮静効果2008
Author(s)
矢部景子, 竹元弘明, 小林義典, 芳賀裕輔
Organizer
日本生薬学会第55年会
Place of Presentation
長崎
Year and Date
2008-09-20
Description
「研究成果報告書概要(和文)」より
Related Report
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