Cooperative Effects of Exercise and Food component on Bone Metabolism in Japanese Men.

• Project/Area Number: 17500494
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: National Institute of Health and Nutrition
• Principal Investigator: YAMADA Kazuhiko National Institute of Health and Nutrition, Food Function and Labeling Program, Leader, 食品保健機能プログラム, リーダー (60158178)
• Co-Investigator(Kenkyū-buntansha): ISHIMI Yosiko National Institute of Health and Nutrition, Nutritional Epidemiology Program, Project Leader, 栄養疫学ブログラム生体指標ブロジェクト, リーダー (50154159) ; TABATA Izumi National Institute of Health and Nutrition, Health Promotion Program, Leader, 健康増進ブログラム, リーダー (20188402) ; NISIMUTA Mamoru National Institute of Health and Nutrition, Nutritional Epidemiology program, Senior Researcher, 栄養疫学ブログラム生体指標ブロジェクト, 上級研究員 (50112850)
• Project Period (FY): 2005 – 2006
• Project Status: Completed (Fiscal Year 2006)
• Budget Amount: ¥3,500,000 (Direct Cost: ¥3,500,000); Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000); Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: Isoflavone / Walking Exercise / Bone mineral density / Mineral / Fat mass / Male / Osteoporosis / 男性 / 閉経h後 / 閉経後

Research Abstract

Introduction : We recently demonstrated that the favorable effects of isoflavones and exercise on bone and lipid metabolism in postmenopausal Japanese women. In this study, we determined the effects of isoflavone intake, walking exercise, and their interaction on bone, fat mass, and mineral metabolism over 1 year in aged Japanese men.
Methods : A total of 33 aged men (50〜75 years old) were randomly assigned to three groups: (1) placebo, (2) isoflavone intake (75 mg of isoflavone conjugates/day, 47mg/day of aglycone form), (3) combination of isoflavone plus walking (45 min/day, 3 days/week). Bone mineral density (BMD), fat mass, serum lipid, and serum and urinary isoflavone and mineral concentrations were assessed.
Results : A significant main effect of walking exercise on the prevention in trunk fat mass gain was obtained at 6 months. Walking prevented bone loss at the right leg to significant degrees. The effect of the combined intervention on BMD and fat mass was greater than that of isoflavone alone. No significant interaction was observed between isoflavone and walking in any measurements recorded during the study.
Conclusion : Our study suggest that combined intervention of 75 mg/day of isoflavone intake and walking exercise 3 times/week for 12 month showed a greater effect on BMD of Ward's triangle of hip than isoflavone alone. Further studies over longer treatment duration that include assessment of BMD at various regions are necessary to ascertain the clinical significance of the combined intervention of isoflavone plus walking in aged Japanese men.

Research Products

• [Journal Article] Effects of Isoflavone and Exercise on Bone Mineral Density and Fat Mass in Postmenopausal Japanese Women : A One year Randomized Placebo-controlled Trial (2006)
  • Author(s): Wu J, Oka J, Tabata I, Higuchi M, Toda T, Fuku N, Ezaki J, Sugiyama F, Uchiyama S, Yamada K, Ishimi Y
  • Journal Title: J Bone Mineral Res 21・5 Pages: 780-789
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cooperative Effects of Isoflavones and Exercise on Bone and Lipid Metabolisn Postmenopausal Japanese Women : A Randomized Placebo-Controlled Trial (2006)
  • Author(s): Wu J, Oka J, Higuchi M, Tabata I, Toda T, Fujioka M, Fuku N, Teramoto T, Okuhira T, Ueno T, Uchiyama S, Urata K, Yamada Y, Ishimi
  • Journal Title: Metabolism 55・4 Pages: 423-433
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Soybean isoflavones preserve bone mass in hindlimb-unloading mice. (2006)
  • Author(s): Sugiyama F, Wu J, Fujioka M, Ezaki J, Takeda K, Miyaura C, Ishida T, Yamada K, Ishimi Y
  • Journal Title: J Bone Miner Metab 24・6 Pages: 439-446
  • NAID: 10020335940
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of genistein, and isoflavone, on pregnancy outcome and organ weighs of pregnant and lactating rats and development of their suckling pups. (2006)
  • Author(s): Tousen Y, Umeki M, Nakashima Y, Ishimi Y, Ikegami S
  • Journal Title: J Nutr Sci Vitaminol 52・3 Pages: 174-182
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cooperative Effects of Isoflavones and Exercise on Bone and L Metabolism in Postmenopausal Japanese Women : A Randomized Placebo-Controlled Trial (2006)
  • Author(s): Wu J, Oka J, Higuchi M, Tabata I, Toda T, Fujioka M, Fuku N, Terar T, Okuhira T, Ueno T, Uchiyama S, Urata K, Yamada Y, Ishim
  • Journal Title: Metabolism 55・4 Pages: 423-433
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of Isoflavone and Exercise on Bone Mineral Density and Fat Mass in Postmenopausal Japanese Women : A One-year Randomized Placebo-controlled Trial (2006)
  • Author(s): Wu J, Oka J, Tabata I, Higuchi M, Toda T, Fuku N, Ezaki J, Sugiyama F, Uchiyama S, Yamada K, Ishimi Y.
  • Journal Title: J Bone Mineral Res 21・5 Pages: 780-789
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Soybean isoflavones preserve bone mass in hindlimb-unloading mice. (2006)
  • Author(s): Sugiyama F, Wu J, Fujioka M, Ezaki J, Takeda K, Miyaura C, Ishida T, Yamada K, Ishimi Y.
  • Journal Title: J Bone and Mineral Metabolism 24・6 Pages: 439-446
  • NAID: 10020335940
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of genistein, and isoflavone, on pregnancy outcome and organ weighs of pregnant and lactating rats and development of their suckling pups. (2006)
  • Author(s): Tousen Y, R Umeki M, R Nakashima Y, R Ishimi Y, R Ikegami S
  • Journal Title: J Nutr Sci Vitaminol 52・3 Pages: 174-182
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of Isoflavone and Exercise on Bone Mineral Density and Fat Mass in Portmenopausal Japanese Women : A One-year Randomized Placebo-controlled Trial (2006)
  • Author(s): Wu J, Oka J, Tabata I, Higuchi M, Toda T, Fuku N, Ezaki J, Sugiyama F, Uchiyama S, Yamada K, Ishimi Y
  • Journal Title: J Bone Mineral Res 21・5 Pages: 780-789
• [Journal Article] Cooperative Effects of Isoflavones and Exercise on Bone and Lipid Metabolism Postmenopausal Japanese Women : A Randomized Placebo-Controlled Trial (2006)
  • Author(s): Wu J, Oka J, Higuchi M, Tabata I, Toda T, Fujioka M, Fuku N, Teramoto T, Okuhira T, Ueno T, Uchiyama S, Urata K, Yamada Y, Ishimi
  • Journal Title: Metabolism 55・4 Pages: 423-433
• [Journal Article] Soybean isoflavones preserve bone mass in hindlimb-unloading mice. (2006)
  • Author(s): Sugiyama F, Wu J, Fujioka M, Ezaki J, Takeda K, Miyaura C, Ishida T, Yamada K, Ishimi Y
  • Journal Title: J Bone Niner Metab 24・6 Pages: 439-446
  • NAID: 10020335940