| Project/Area Number |
17590534
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Chiba University |
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Principal Investigator |
KOBAYASHI Etsuko (2006) Chiba University, Graduate School of Medicine, Lecturer, 大学院医学研究院, 講師 (80097427)
能川 浩二 (2005) 千葉大学, 大学院・医学研究院, 教授 (40019584)
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| Co-Investigator(Kenkyū-buntansha) |
SUWAZONO Yasushi Chiba University, Graduate School of Medicine, Associate Professor, 大学院医学研究院, 助教授 (90302546)
DOCHI Mirei Chiba University, Graduate School of Medicine, Research Associate, 大学院医学研究院, 助手 (30376371)
NOGAWA Koji Chiba University, Graduate School of Medicine, Professor, 大学院医学研究院, 教授 (40019584)
小林 悦子 千葉大学, 大学院・医学研究院, 講師 (80097427)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Genetic polymorphism / Hyperlipidemia / Diabetes mellitus / Hyperuricemia / Hypertension |
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| Research Abstract |
We examined the relationship between the C825T, C1429T and A-350G variants in the G-protein beta-3 subunit (GNB3) gene, and the risk of hypercholesterolemia in a prospective study in Japanese workers. This study included observations over a 5-year period from 1997 to 2002 on 936 males and 662 females who were not hypercholesterolemic on entry. Hypercholesterolemia was defined as a serum total cholesterol level ≧240 mg/dL. GNB3/C825T and GNB3/C1429T were significantly in complete linkage disequilibrium in both genders. Other linkage disequilibrium nor haplotype-disease relationship was not found in the present study. Pooled logistic regression analyses were performed using either of the gene variants with age, body mass index, smoking, alcohol consumption and habitual exercise as the covariates. The risk of the development of hypercholesterolemia was 2.27 times higher in males with the TT genotype of GNB3/C1429T than in males with the CC genotype (95% confidence interval: 1.04-4.94), after adjustment for the effects of other potential covariates. This study indicates the GNB3/C1429T is an independent risk factor for hypercholesterolemia in Japanese males and suggests that targeting this polymorphism may be beneficial when attempting to prevent hypercholesterolemia in the general Japanese male population.
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