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Epidemiology of Myelodysplastic Syndromes in Atomic Bomb Survivors

Research Project

Project/Area Number 17590545
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionNagasaki University

Principal Investigator

IWANAGA Masako  Nagasaki Univ., Graduate School of Biomedical Sciences, Dent. Hematology., Assistant Professor, 大学院医歯薬学総合研究科, 助手 (00372772)

Co-Investigator(Kenkyū-buntansha) TOMONAGA Masao  Nagasaki Univ., Graduate School of Biomedical Sciences, Dent.Homatology., Professor, 大学院医歯薬学総合研究科, 教授 (40100854)
SODA Midori  Radiation Effects Research Foundation, Dept.Epidemiology, Assistant Chief (Researcher), 疫学部, 副部長(研究員) (00359457)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2005: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsMyelodysplastic Syndromes / Atomic Bomb Survivors / Radiation Exposure / Epidemiology / Pre-Leukemia / Cancer Registry / Database
Research Abstract

[Background] Myelodysplastic syndromes (MDS) are acquired clonal stem cell disorders characterized by ineffective hematopoiesis and a high risk of progression to leukemia. Etiologies of MDS are still unknown. So far, there is no large-scale epidemiological study for population exposed to radiation.
[Aim] To investigate the association between radiation exposure and a risk of MDS in Atomic bomb survivors.
[Methods] Overall MDS cases were retrospectively accumulated from five hospitals in Nagasaki City and then identified Atomic bomb survivors by linkage with the Database of Nagasaki Atomic Bomb Survivors in the Scientific Data Center at Nagasaki University. Disease confirmation was conducted with the microscopic examination of bone marrow smear and clinical data. In retrospective cohort analyses, we set a retrospective cohort of Atomic bomb survivors who were alive at 1980.1.1 but no MDS. In age-adjusted population analyses, we used official prefecture population statistics and then compared MDS incidence between Atomic bomb survivors and Non-Atomic bomb survivors.
[Results] Up to now, we accumulated approximately 600 MDS cases diagnosed during 1970' to 2004, and identified around 200 cases who were Atomic bomb survivors. In retrospective cohort analyses, 162 MDS were identified among a cohort of 87496 survivors during 1980 to 2004 (crude incidence rate: 10.7 per 103 PY). Risk of MDS was high in male than female (RR=1.7), in survivors exposed within 1.5km from hypocenter than those over 3.0km (RR=4.3). Risk of subtypes of RAEB & RAEB-t was high compared with subtypes of RA & RARS among survivors exposed within 1.5km. In age-adjusted population analyses, crude incidence rate of MDS was higher in Atomic bomb survivors than Non-Atomic bomb survivors (crude incidence rate: 10.0 vs. 6.49 per 106 PY, RR=1.5).
[Discussion] Results suggest a clear association between radiation exposure and a risk of MDS. Radiation dose analysis is needed to confirm this association.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (26 results)

All 2007 2006 2005

All Journal Article (24 results) Book (2 results)

  • [Journal Article] Improvement of criteria for refractory cytopenia with multilineage dysplasia according to the WHO classification based on prognostic significance of morphological features in patients with refractory anemia according to the FAB classification2007

    • Author(s)
      Matsuda A, et al.
    • Journal Title

      Leukemia 21(4)

      Pages: 678-86

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Late hematological effects in the atomic bomb survivors.2007

    • Author(s)
      Tsukasaki K, Iwanaga M, Tomonaga M.
    • Journal Title

      International Congress Series 1299, Radiation Risk Perspectives (Eds. Shibata S. Yamashit S. Tomonaga M)(Elsevier, Tokyo)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Imatinib provides durable molecular and cytogenetic responses in prectical setting for cases with chronic myelogenous leukemia of both newly diagnosed and previously treated; A study in Nagasaki Prefecture, Japan.2007

    • Author(s)
      Matsuo E, et al.
    • Journal Title

      Int Hematol 85・2

      Pages: 132-139

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 特集 骨髄異形成症候群(MDS) : 病態の解明と最新の診療 MDS-診断と分類・鑑別すべき病態2006

    • Author(s)
      朝長万左男
    • Journal Title

      血液・腫瘍科 53・2

      Pages: 115-119

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] 原子爆弾後障害研究の将来の展望 : これからの10年間に期待される成果-血液疾患のリスク-白血病・MDS・多発性骨髄腫-2006

    • Author(s)
      朝長万左男
    • Journal Title

      広島医学 59・4

      Pages: 302-306

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chemokine Expression In Human Erythroid Leukemia Cell Line AS-E2 : Macrophage Inflammatory Protein-3a/CCL20 Is Induced By Inflammatory Cytokines.2006

    • Author(s)
      Inoue Y, et al.
    • Journal Title

      Exp. Hematol. 34・1

      Pages: 19-26

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chemokine Expression In Human Erythroid Leukemia Cell Line AS-E2 : Macrophage Inflammatory Protein-3a/CCL20 Is Induced By Inflammatory Cytokines.2006

    • Author(s)
      Inoue Y, et al.
    • Journal Title

      Exp.Hematol. 34(1)

      Pages: 19-26

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Epidemiology of MDS in Nagasaki City and Nagasaki A-bomb Survivors.2006

    • Author(s)
      Iwanaga M, et al.
    • Journal Title

      Rinsho Ketsueki 47(9)

      Pages: 1019-1019

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Prevalence of Monoclonal Gammopathy of Undetermined Significance (MGUS) and Its Malignant Progression in Radiation-Exposed Population.2006

    • Author(s)
      Iwanaga M, et al.
    • Journal Title

      Blood (part2) 108(11)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] MDSの疫学研究 : 長崎市および長崎原爆被爆者集団における発生状況2006

    • Author(s)
      岩永正子 他
    • Journal Title

      臨床血液 47・9

      Pages: 1019-1019

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Prevalence of Monoclonal Gammopathy of Undetermined Significance (MGUS) and Its Malignant Progression in Radiation-Exposed Population.2006

    • Author(s)
      Iwanaga M, et al.
    • Journal Title

      Blood(part2) 108・11

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 原子爆弾後障害研究の将来の展望 : これからの10年間に期待される成果-血液疾患のリスク-白血病・MDS・多発性骨髄種-2006

    • Author(s)
      朝長万左男
    • Journal Title

      広島医学 59・4

      Pages: 302-306

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Chyemokine Expression In Human Erythroid Leukemia Cell Line AS-E2 : Macrophage Inflammatory Protein-3a/CCL20 Is Induced By Inflammatory Cytokines.2006

    • Author(s)
      Inoue Y, et al.
    • Journal Title

      Exp.Hematol. 34・1

      Pages: 19-26

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Myelodysplastic syndromes in Nagasaki atomic bomb survivors : a preliminary analysis.2005

    • Author(s)
      Iwanaga M, et al.
    • Journal Title

      Acta Medica Nagasakiensia 50・S2

      Pages: 97-100

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Late medical effects of Atomoc bombs still persisting after over sixty years.2005

    • Author(s)
      Tomonaga M.
    • Journal Title

      Acta Medica Nagasakiensia 50・S1

      Pages: 19-21

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Difference in clinical features between Japanese and German patients with refractory anemia in myelodysplastic syndromes.2005

    • Author(s)
      Matsuda A, et al.
    • Journal Title

      Blood 106・8

      Pages: 2633-2640

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Myelodysplastic syndromes in Nagasaki atomic bomb survivors : a preliminary analysis.2005

    • Author(s)
      Iwanaga M, et al.
    • Journal Title

      Acta Medica Nagasakiensia 50(S2)

      Pages: 97-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Late medical effects of Atomoc bombs still persisting after over sixty years.2005

    • Author(s)
      Tomonaga M.
    • Journal Title

      Acta Medica Nagasakiensia 50(S1)

      Pages: 19-21

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Difference in clinical features between Japanese and German patients with refractory anemia in myelodysplastic syndromes.2005

    • Author(s)
      Matsuda A, et al.
    • Journal Title

      Blood 106(8)

      Pages: 2633-40

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Myelodysplastic syndromes in Nagasaki atomic bomb survivors : a preliminary analysis.2005

    • Author(s)
      Masako Iwanaga, et al.
    • Journal Title

      Acta Medica Nagasakiensia 50・S2

      Pages: 97-100

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Late medical effects of Atomoc bombs still persisting after over sixty years.2005

    • Author(s)
      Masao Tomonaga
    • Journal Title

      Acta Medica Nagasakiensia 50・S1

      Pages: 19-21

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Epidemiology of MDS among Nagasaki Atomic Bomb Survivors.2005

    • Author(s)
      Masako Iwanaga, et al.
    • Journal Title

      Leukemia Research 29・S1

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Difference in clinical features between Japanese and German patient with refractory anemia in myelodysplastic syndromes.2005

    • Author(s)
      Akira Matsuda, et al.
    • Journal Title

      Blood 106・8

      Pages: 2633-2640

    • Related Report
      2005 Annual Research Report
  • [Journal Article] MGUSの疫学:長崎被爆者集団のM蛋白血症スクリーニングに基づく解析2005

    • Author(s)
      岩永正子, et al.
    • Journal Title

      臨床血液 46・8

      Pages: 869-869

    • Related Report
      2005 Annual Research Report
  • [Book] International Congress Series 1299. Radiation Risk Perspectives Page 67-72, Late hematological effects in the atomic bomb survivors.(Eds. Shibata S. Yamashit S. Tomonaga M)2007

    • Author(s)
      Tsukasaki K, Iwanaga M, Tomonag M
    • Total Pages
      298
    • Publisher
      Elsevier, Tokyo.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] International Congress Series 1299. Radiation Risk Perspectives (Eds. Shibata S. Yamashit S. Tomonaga M). pp 67-72, Late hematological effects in the atomic bomb survivors.2007

    • Author(s)
      Tsukasaki K, et al.
    • Publisher
      Elsevier, Tokyo.(In press)
    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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