| Project/Area Number |
17591144
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
KAWADA Kou Kagawa university hospital, Faculty of medicine, Assistant, 医学部附属病院, 助手 (40284369)
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Susumu Kagawa university, Faculty of medicine, Professor, 医学部, 教授 (80145052)
ISOBE Kenichi Kagawa university, Faculty of medicine, Assitant Professor, 医学部, 助教授 (00159815)
KUSAKA Takashi Kagawa university hospital, Faculty of medicine, Lecturer, 医学部附属病院, 講師 (50274288)
OKUBO Kensuke Kagawa university, Faculty of medicine, Assistant, 医学部, 助手 (80335851)
YASUDA Saneyuki Kagawa university, Faculty of medicine, Assistant, 医学部, 助手 (00380155)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | caffeine / methylxanthine / Braselton / NBAS / drug metabolism / fetus / neonate / placenta / 方位反応 / 母体薬物 / 胎盤移行 / 高速液体クロマトグラフ / 消失半減期 / 臍帯血濃度 / クリアランス / 血中濃度測定 |
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| Research Abstract |
We investigated whether changes in neonatal neurodevelopment, as determined by the Brazelton neonatal behavioral assessment scale (NBAS), were associated with in utero exposure to caffeine.
Bloods of mothers (n=32) and her babies (n=33), who were born at Kagawa university hospital, were measured serum caffeine concentrations by HPLC. Samples were corrected from mothers and umbilical cords at birth and from babies at day2 and day5. NBAS scores at day2 and day 5 were made a comparison between high caffeine concentrations (>4mg/L) group (n=12) and low caffeine concentrations (<4mg/L) group (n=21).
Mean serum concentrations in mothers and umbilical cord bloods were 1.47 mg/L and 1.73 mg/L at birth, respectively (p=0.078; paired t test).
Half-lives of caffeine elimination over 14 days were 10 in neonates.
We demonstrated that umbilical caffeine concentration (caffeine exposure in utero) effect on Orientation (a cluster of NBAS) in early neonates.
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