• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Research of significance of AKT for the radioresistant mechanisms in normal and malignant tissue

Research Project

Project/Area Number 17591268
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKobe University

Principal Investigator

OKAMOTO Yoshiaki  Kobe University, University Hospital, Radiology, Lecturer, 医学部附属病院, 講師 (20362791)

Co-Investigator(Kenkyū-buntansha) SUGIMURA Kazuro  Kobe University Graduate School of Medicine, Radiology, Professor, 大学院・医学系研究科, 教授 (00136384)
NIBU Kenichi  Kobe University, Graduate School of Medicine, Head and Neck surgery, Professor, 大学院・医学系研究科, 教授 (20251283)
SASAKI Ryohei  Kobe University Graduate School of Medicine, Radiology, Associate Professor, 大学院・医学系研究科, 学術推進研究員 (30346267)
KAWASAKI Ryota  Kobe University Hospital, Radiology, Assistant Professor, 医学部附属病院, 助手 (00362781)
OTA Yosuke  Kobe University, University Hospital, Radiology, Fellow, 医学部附属病院, 医員 (90397810)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsAKT / NF-KappaB / Radiosensitivity / Radioresistance / p53
Research Abstract

Significance of AKT in the radioresistant mechanism has not been clarified. In this study, Free radical mediated AKT activation and NF-kappa B activation were closely related to the radioresistance in both normal and malignant cells. Especially, Pelicano and Sasaki have reported that mitochondrial respiratory function communicated with AKT activation through free radical, and the communication led to the invasiveness of the tumor or chemosensitivity.
Demizu and Okamoto have reported that effectiveness of cisplatin-based concurrent chemoradiotherapy in patients with nasopharyngeal carcinoma, and clinical outcomes of the treatment as a preliminary report. In the present study, we have found there are certain percentage of patients who experienced their poor outcomes. Moreover, we are now investigating that the relationships between resistance to the anticancer treatment and the AKT activation, as well as p53, NF-kappa B.
Ejima and Okamoto have reported that outcomes of MALT lymphoma of the orbita in the journal of Radiotherapy and Oncology. In the study, prognostic factors and adverse effects were clarified from the analysis, in the same time. For this disease, prognostic factors have not been determined. Therefore, candidates for molecular mechanisms of radioresistance, such as AKT, p53 BCL-10, were also assessed. Those results were now preparing for another submission.
Thus, the significance of AKT in the radioresistant mechanism were investigated in the multiple situation. In vitro study, and clinical investigation were performed, leading to the fact that AKT was one of the important candidate for molecular mechanisms of intracellular radioresistance.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (11 results)

All 2006 2005 Other

All Journal Article (11 results)

  • [Journal Article] Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism2006

    • Author(s)
      Pelicano H
    • Journal Title

      Journal of Cell Biology 175(6)

      Pages: 913-923

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Efficacy and feasibility of cisplatin-based concurrent chemoradiotherapy for nasopharyngeal carcinoma.2006

    • Author(s)
      Demizu Y
    • Journal Title

      Japanese Journal of Clinical Oncology 36(10)

      Pages: 620-625

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy.2006

    • Author(s)
      Ejima Y
    • Journal Title

      Radiotherapy and Oncology 78(1)

      Pages: 6-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Mitochondrial DNA determines androgen dependence in prostate cancer cell lines.2006

    • Author(s)
      Higuchi M
    • Journal Title

      Oncogene 25(10)

      Pages: 1437-1445

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 食道癌の診断から治療まで -化学放射線療法2005

    • Author(s)
      岡本 欣晃
    • Journal Title

      画像診断 25・5

      Pages: 611-623

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma.2005

    • Author(s)
      Achanta G, Sasaki R
    • Journal Title

      EMBO J. 24(19)

      Pages: 3482-3492

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] High mutagen sensitivity in peripheral blood lymphocytes predicts poor overall and disease-specific survival in patients with stage III non-small cell lung cancer treated with radiotherapy and chemotherapy.2005

    • Author(s)
      Chang JY
    • Journal Title

      Clin Cancer Res 11(8)

      Pages: 2894-2898

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chemoradiotherapy for Esophageal Carcinoma2005

    • Author(s)
      Okamoto Y
    • Journal Title

      Gazoshindan 25(5)

      Pages: 611-23

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma.2005

    • Author(s)
      Achanta G, Sasaki R
    • Journal Title

      EMBO J 24(19)

      Pages: 3482-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mitochondrial DNA determines androgen dependence in prostate cancer cell lines.2005

    • Author(s)
      Higuchi M
    • Journal Title

      Oncogene 25(10)

      Pages: 1437-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy.

    • Author(s)
      Ejima Y
    • Journal Title

      Radiotherapy and Oncology 78(1)

      Pages: 6-92006

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi