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Examination of high-resolution MRI and MR spectroscopy evaluating therapieutic effect of radiation therapy and chemotherapy in animal model.

Research Project

Project/Area Number 17591297
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKanazawa Medical University

Principal Investigator

MATOBA Munetaka  Kanazawa Medical University, Department of medicine, assistant professor, 医学部, 助教授 (90288308)

Co-Investigator(Kenkyū-buntansha) YOKOTA Hajime  Kanazawa Medical University, Department of medicine, instructor, 医学部, 講師 (30182695)
OOGUCH Manabu  Kanazawa Medical University, Department of medicine, instructor, 医学部, 講師 (10176852)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Keywordsirradiation / animal study / VX2 carcinoma / MRI / MR spectroscopy / 動物実験 / 腫瘍 / 放射線治療 / 化学療法
Research Abstract

We assessed the role of the high-resolution MRI and ^1H-MRS evaluating the therapieutic effect of chemotherapy and radiation therapy for VX2 carcinoma in rabbits. The rabbits with VX2 carcinoma in the thigh were underwent MRI and ^1H-MRS at before, 3 days, 1 week, and 2 weeks after 30Gy irradiation and one shot chemotherapy. After taking postirradiation MRI and ^1H-MRS, rabbits were killed for histopathologic examination at each time interval.
The high-resolution MRI findings were correlated with the histopathological findings, however, the early stage of necrosis of tumor was not able to evaluate using the high-resolution MRI. On ^1H-MRS, the ratio of lactate / creatine was elevated in the early stage of necrosis of tumor.
It was suggested that ^1H-MRS was superior to high-resolution MRI evaluating the early stage of necrosis of VX2 carcinoma post chemotherapy and radiation therapy.
The ^1H-MRS might be superior evaluating the therapieutic effects earlier.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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