| Project/Area Number |
17591622
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
MATSUKAWA Takashi UNIVERSITY OF YAMANASHI, DEPARTMENT OF RESEARCH INTERDISCIPLINARY GRADUATE SCHOOL OF MEDICINE AND ENGINEERING, PROFESSOR, 大学院医学工学総合研究部, 教授 (80209519)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKUYAMA Katsumi UNIVERSITY OF YAMANASHI, DEPARTMENT OF RESEARCH INTERDISCIPLINARY GRADUATE SCHOOL OF MEDICINE AND ENGINEERING, RESEARCH ASSOCIATE, 大学院医学工学総合研究部, 助手 (50242649)
SATO Hiroaki UNIVERSITY OF YAMANASHI, UNIVERSITY OF YAMANASHI HOSPITAL, RESEARCH ASSOCIATE, 医学部附属病院, 助手 (20402026)
|
|---|
| Project Period (FY) |
2005 – 2006
|
| Project Status |
Completed (Fiscal Year 2006)
|
| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
|
|---|
| Keywords | temperature / aging / core / peripheral / pre-warming / premedication / thermoregulation |
|---|
| Research Abstract |
The volunteers' height was 169 ± 7 (162-177) cm, total body mass (TBM) 65 ± 12 (55-85) kg, and age 33 ± 4 (27-36) yr. The lean body mass (LBM) was 52 ± 7 (45-64) kg as determined from height (cm) and TBM (kg) using a formula ; LBM = (1.10TBM)-128(TBM/height)^2. Basal surface area was 1.8±0.2 (1.6-2.1) m2. Sedation scores 30 minutes after administration of midazolam in volunteers with midazolam premedication (0.075 mg kg^<-1>, with or without forced-air warming) were significantly lower than those without intramuscular midazolam administration.
Tympanic membrane temperature (T_<tym>) of the group with forced-air warming + midazolam decreased until 20 min after i.m. midazolam, however afterwards it increased significantly compared with T_<tym> of the group with midazolam i.m. without warming. Forearm minus finger tip and calf minus toe, skin-temperature gradients did not differ significantly among the three groups. Mean skin temperatures of 30 min after midazolam intramuscular administration in the group with i.m. midazolam was significantly lower than those in the other two groups.
In conclusion, we can conclude that forced-air warming after premedication with midazolam is important to prevent anaesthesia-induced redistribution hypothermia.
|
