| Project/Area Number |
17591744
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
IRAHARA Minoru The University of Tokushima Graduate School, Institute of Health Biosciences, Professor, 大学院ヘルスバイオサイエンス研究部, 教授 (20160070)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUZAKI Toshiya The University of Tokushima Graduate School, Institute of Health Biosciences, Assistant Professor, 大学院ヘルスバイオサイエンス研究部, 講師 (70294692)
KUWAHARA Akira The University of Tokushima, Tokushima University Hospital, Assistant Professor, 医学部・歯学部附属病院, 講師 (20325278)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | ovulation induction / low-dose FSH therapy / FSH-pulsatile GnRH therapy / self injection / metformin / polycystic ovary syndrome / safety / convenience |
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| Research Abstract |
Ovulation induction using gonadotropin for infertile women requires daily attendance to hospital for injection, and is highly associated with multiple pregnancies. We developed and evaluated new method to induce ovulation: FSH-pulsatile GnRH(F-G), chronic low-dose FSH self-injection(LD-F) and clomiphene-metformine(Cl-Met). Study designs were prospective randomized and cross over in all investigations.
1. F-G
We compared efficacy and safety between F-G and LD-F in 10 PCOS patients. Schedule of LD-F: Daily injection of FSH was started with a dose of 75 IU and increased after 14 days treatment in case no follicle developed.
Schedule of F-G: Daily injection of FSH was started with a dose of 150 IU and switched to pulsatile GnRH administration when follicle reached 11mm. Both treatments were equally effective. Total day of attendance to hospital per cycle was significantly shorter in F-G(8.8± 1.3 days, mean±SE) than in LD-F(17.7± 6.6) (P<0.01).
2. LD-F by self-injection
LD-F was performed by self-injection(SI) or by attendance to hospital(AH) to 3 anovulatory patients. All cycles of both treatment achieved single ovulation, and no side effect was observed. Total days of attendance to follicular maturation were 6.0 ±1.0 clays in SI and 17.7± 8.0 days in AH (p=0.067).
3. Cl-Met
We compared efficacy and safety between Cl and Cl-Met in 5 clomiphene (100mg)-resistant women with PCOS. Dose of clomiphene was 150 mg/day and dose of metformin was 750 mg/day(day5 to follicular maturation). One out of 4 in Cl, and 4 out of 5 in Cl-Met showed ovulation. All cycles achieved single ovulations. Pregnancies were achieved in 2 of Cl-Met(singletons).
In conclusion, all of new methods were safe and comprehensive methods for infertile patients.
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