| Project/Area Number |
17592121
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
TOKUNAGA Atsushi Hyogo College of Medicine, Faculty of Medicine, part-time teacher, 医学部, 非常勤講師 (70254521)
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Koichi Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (10212127)
DAI Yi Hyogo College of Medicine, Faculty of Medicine, Assistant professor, 医学部, 講師 (20330441)
YAMANAKA Hiroki Hyogo College of Medicine, Faculty of Medicine, Research Associate, 医学部, 助手 (20340995)
FUKUOKA Tetsuo Hyogo College of Medicine, Faculty of Medicine, part-time teacher, 医学部, 非常勤講師 (90399147)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2005: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | trigeminal nerve / pain / neuritis / nerve in jury / nociception |
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| Research Abstract |
Previous papers suggested that inflammatory responses around peripheral nerve may be involved in the path mechanisms of neuropathic pain after peripheral nerve injury. In this research project, we have developed the neuritis model with no apparent neural injury using the close placement of CFA to the nerve. We found the injury responses such as expression of ATF3 were observed in mainly small DRG neurons. However, we found almost no change in the threshold in pain behaviors, suggesting that the damage in myelinated neurons might be important factor for the changes in threshold of pain behaviors. We also examined the mRNA expression of TRPA1, TRPV1 and TRPM8 in trigeminal ganglion neurons. The percentage of TRPA1 mRNA expressing neurons in mandibular nerve region was significantly higher than that in other trigeminal nerve regions, indicating an important role of TRPA1 in the trigeminal nerve innervating mouth region.
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