| Project/Area Number |
17606005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
臨床疫学
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| Research Institution | Louis Pasteur Center for Medical Research |
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Principal Investigator |
UNO Kazuko Louis Pasteur Center for Medical Research, Basic Research, Head Researcher, 基礎研究部, 室長 (50211082)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAKAWA Taro Kyoto University, Graduate School of Public Health, Department of Health Promotion & Human Behavior, 医学研究科・社会医学, 教授 (40196613)
KAKIMI Kazuhiro The University of Tokyo, Graduate School of Medicine, Department of Immunotherapeutics, 医学部附属病院・寄付講座, 客員助教授 (80273358)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | IFN-a production / Hepatitis C virus infection / Hepatocellular carcinoma / Cancer Risk / Plasmacytoid dendritic cell |
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| Research Abstract |
Previously, we published a manuscript entitled "Impairment of IFN-α production capacity in patients with hepatitis C virus and the risk of the development of hepatocellular carcinoma" in World J Gastroenterology, which forms the basis of this project. The project entailed the establishment of a database of IFN-α production and blood tests spanning 17 years by the Louis Pasteur Center for Medical Research. Data for IFN-α production was obtained retrospectively over a 17-year period by examining medical records in a study population of 2,315 individuals, of which 112 healthy controls and 20 HCV-infected patients were selected. Sixty percent of the HCV-infected patients had impaired or declining IFN-α production in comparison to 17% in the healthy control group. Mean IFN-α levels were lower in patients who developed hepatocellular carcinoma than in the HCV-infected patients who remained cancer-free. These results have been published in J IFN ＆ Cytokine Research as "Impaired interferon-a production and the risk of cancer development." Further, we established the methodto detect IFN-α producing cells by Sendai virus stimulation using FACS, and the main IFN-α producing cells were plasmacytoid dendritic cells. This method will be useful to understand the analysis of impaired IFN-α production.
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