がん臨床研究における多変量生存時間データの解析

• Project/Area Number: 17700275
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Statistical science
• Research Institution: The University of Tokyo
• Principal Investigator: 山口 拓洋 The University of Tokyo, 医学部・附属病院, 容員准教授 (50313101)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,600,000 (Direct Cost: ¥3,600,000); Fiscal Year 2007: ¥500,000 (Direct Cost: ¥500,000); Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000); Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: 生物統計学 / 生存時間解析 / がん

Research Abstract

平成17,18年度に引き続き、がん臨床試験における多変量生存時間データの解析方法について、実データへの適用を考慮いつつ検討した。
・クラスターデータの解析
昨年度の胃がんの手術療法に関する多施設臨床試験データの解析に加えて、同じく胃がんの化学療法に関する多施設臨床試験データを用いて、施設間差の検討を行った。Frailtyモデルのパラメータ推定にはWinBUGSを用いた。ペナルティー付き尤度に基づく方法などと比して、ベイズ流のアプローチを用いることで安定した結果が得られ、推定の性能も良好であった。
・多段階遷移データ及び競合危険データの解析
血液がんにおける移植療法のデータを中心に検討した。多段階遷移データに関して、GVL効果を検討するために提案されている複数の統計モデルについて比較を行った。通常用いられている、GVHDの発症を時間依存性変数として考慮したCox回帰モデルの適用には限界があると考えられたが、一方で、他の因果モデルの適用についても既存のデータを生状況が直感的に理解できるようなグラフ表示方法について検討した。また、Cumulative Incidence及び対応する回帰手法である競合危険回帰について、どのような状況において用いることが適当であるか実データに基づき検討した。競合危険回帰については、利用可能な統計パッケージについて調査した。

Research Products

• [Journal Article] Regional differences exist in allogeneic stem cell transplantation rates for acute leukemia. (2008)
  • Author(s): Miura Y, Yamaguchi T, Azuma T, Hamaki T, Kodama Y, Kusumi E, Matsumura T, Nakamura T, Kami M, Komatsu T.
  • Journal Title: International Journal of Hematology 87 Pages: 236-238
  • NAID: 10021255875
  • Peer Reviewed
• [Journal Article] Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem cell trans plantation from related donors in adult patients with hematological malignancies after myeloablative conditioning regimen. (2007)
  • Author(s): Takahashi S, Ooi J, Tomonari A, Konuma T, Tsukada N, Oiwa-Monna M, Fukuno K, Uchiyama M, Takasugi K, Iseki T, Tojo A, Yamaguchi T, Asano S.
  • Journal Title: Blood 109 Pages: 1332-1330
  • Peer Reviewed
• [Journal Article] Tacrolimus as prophylaxis for acute graft-versus-host disease in reduced intensity cord blood transplantation for adult patients with advanced hematologic diseases. (2007)
  • Author(s): Miyakoshi S, Kami M, Tanimoto T, Yamaguchi T, Narimatsu H, Kusumi E, Matsumura T, Takagi S, Kato D, Kishi Y, Murashige N, Yuji K, Uchida N, Masuoka K, Wake A, Taniguchi S.
  • Journal Title: Transplantation 84 Pages: 316-322
  • Peer Reviewed
• [Journal Article] Impact of cytomegalovirus serostatus on outcome of unrelated cord blood transplantation for adults: a single-institute experience in Japan. (2007)
  • Author(s): Tomonari A, Takahashi S, Ooi J, Tsukada N, Konuma T, Kato S, Kasahara S, Iseki T, Yamaguchi T, Tojo A, Asano S.
  • Journal Title: European Journal of Haematology 80 Pages: 251-257
  • Peer Reviewed
• [Journal Article] The prognostic value of E-Cadherin, a-, b-, and g-Catenin in urothelial cancer of the upper urinary tract. (2006)
  • Author(s): Kashibuchi K, Tomita K, Schalken JA, Kume H, Yamaguchi T, Muto S, Horie S, Kitamura T
  • Journal Title: European Urology 49 Pages: 839-845
• [Journal Article] Phase I and pharmacokinetic study of halofuginone, an oral quinazolinone derivative in patients with advanced solid tumours. (2006)
  • Author(s): de Jonge MJ, Dumez H, Verweij J, Yarkoni S, Snyder D, Lacombe D, Marreaud S, Yamaguchi T, Punt CJ, van Oosterom A; on behalf of the EORTC New Drug Development Group (NDDG).
  • Journal Title: European Journal of Cancer 42(12) Pages: 1768-1774
• [Journal Article] Predictors of seminal vesicle invasion before radical prostatectomy. (2006)
  • Author(s): Tsurumaki Y, Tomita K, Kume H, Yamaguchi T, Morikawa T, Takahashi S, Takeuchi T, Kitamura T
  • Journal Title: International Journal of Urology 13(12) Pages: 1501-1508
  • NAID: 10018440593
• [Journal Article] Posttransplantation engraftment and safety of cord blood transplantation with grafts containing relatively low cell doses in adults. (2006)
  • Author(s): Takahashi S, Ooi J, Tomonari A, Konuma T, Tsukada N, Tojo A, Yamaguchi T, Asano S
  • Journal Title: International Journal of Hematology 84(4) Pages: 359-362
  • NAID: 10019259789
• [Journal Article] 看護系教育課程を持つ大学における疫学・生物統計学教育の実態調査 (2005)
  • Author(s): 田中司朗, 山口拓洋, 大橋靖雄
  • Journal Title: 日本公衆衛生雑誌 52(1) Pages: 66-75
  • NAID: 130004684367
• [Journal Article] The overlap coefficient for assessing the similarity of pharmacokinetic data between ethnically different populations (2005)
  • Author(s): Mizuno S, Yamagucni T, Fukushima A, Matsuyama Y, Ohashi Y.
  • Journal Title: Clinical Trials 2 Pages: 174-181
• [Journal Article] 再発事象データの解析 (2005)
  • Author(s): 山口拓洋
  • Journal Title: 計量生物学 26(2) Pages: 81-117
  • NAID: 10017123417
• [Journal Article] Estimation of the marginal survival time in the presence of dependent competing risks using inverse probability of censoring weighted (IPCW) methods. (.)
  • Author(s): Matsuyama Y, Yamaguchi T
  • Journal Title: Pharmaceutical Statistics (In press)(掲載確定)
• [Presentation] Equivalent disease-free survival results after CBT ahd BMT from unrelated donor using TBI containing myeloablative regimen and calsinulin inhibitors plus MTX methods in patients with MDS in Japan: multivariate analysis by competing risk regression models. (2008)
  • Author(s): Takahashi S, Yamaguchi T, Monna-Ooiwa M, Taniguchi S, Akiyama H, Morii T, Nagari Y, Takaue Y, Okamoto S, Miyamura K, Sao H, Nagamura T, Kato S, Kawase T, Morishima Y, Asano Son behalf of the Japan Marrow Donor Program and the Japan Cord Blood Bank.
  • Organizer: 34th Annual Meeting of the European Group for Blood and Marrow Transplantation
  • Place of Presentation: Florence
• [Presentation] Quantitative evaluation of heterogeneities in treatment effects and baseline risks among hospitals: from a phase III surgicaltrial of gastric cancer. (2007)
  • Author(s): Kurokawa Y, Yamaguchi T, Yoshimura K, Yamamoto S, Nakamura N, Sasako M, Fukuda H.
  • Organizer: 43rd ASCO 2007 Annual Meeting
  • Place of Presentation: Chicago
• [Presentation] The Comparative Analysis of Bone Marrow Transplantation and Cord Blood Transplantation from Unrelated Donors in Patients with Myelodysplastic Syndrome in Japan. (2007)
  • Author(s): Takahashi S, Yamaguchi T, Ooi J, Tomonari A, Tsukada N, Konuma T, Nagamura T, Kato S, Kawase T, Morishima Y, Asano S.
  • Organizer: ASH Annual Meeting
  • Place of Presentation: Atlanta
• [Presentation] Unrelated Cord Blood Transplantation Using Myeloablative Regimen for Acute Leukemia Patients Aged between 50 and 55 Years: Single Institutional Retrospective Comparison with Patients Less Than 50 Years of Age. (2007)
  • Author(s): Konuma T, Takahashi S, Ooi J, Tomonari A, Tsukada N, Kato A, Oiwa-Monna M, Uchimaru K, Tojo A, Yamaguchi T, Asano S.
  • Organizer: ASH Annual Meeting
  • Place of Presentation: Atlanta
• [Presentation] Unrelated Cord Blood Transplanation for Malignant Lymphoma: A Retro spective Study from the Japan Cord Blood Bank Network (JCBNW). (2007)
  • Author(s): Takita M, Yuji K, Yamaguchi T, Matsumura T, Kami M, Sakamaki H, Kouzai Y, Okada M, Osugi Y, Kobayashi R, Inoue M, Takahashi S, Murata M, Kai S, Kato K, Nagamura T, Taniguchi S, Kato S.
  • Organizer: ASH Annual Meeting
  • Place of Presentation: Atlanta
• [Presentation] Acute Graft-Versus-Host Disease Following Umbilical Cord Blood Transplantation: Retrospective Survey Involving 2015 Japanese Patients. (2007)
  • Author(s): Miyakoshi S, Yamaguchi T, Kami M, Matsumura T, Yuji K, Narimatsu H, Kusumi E, Sakamaki H, Kouzai H, Okada M, Osugi Y, Kobayashi R, Inoue M, Takahashi S, Murata M, Kai S, Kato K, Nagamura T, Taniguchi S, Kato S.
  • Organizer: ASH Annual Meeting
  • Place of Presentation: Atlanta
• [Book] Bladder Cancer Clinical Trial Design, in Textbook of Bladder Cancer (2005)
  • Author(s): Sylvester R, Yamaguchi T
  • Total Pages: 10
  • Publisher: Taylor & Francis Medical Books