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A study on molecular robotics blood glucose level control method with NOD mice

Research Project

Project/Area Number 17H00769
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Life / Health / Medical informatics
Research InstitutionTokyo Institute of Technology

Principal Investigator

KONAGAYA Akihiko  東京工業大学, 情報理工学院, 特任教授 (00301200)

Co-Investigator(Kenkyū-buntansha) 池田 将  岐阜大学, 工学部, 教授 (20432867)
湯川 博  名古屋大学, 未来社会創造機構, 特任准教授 (30634646)
川又 生吹  東北大学, 工学研究科, 助教 (30733977)
野口 洋文  琉球大学, 医学(系)研究科(研究院), 教授 (50378733)
柳澤 実穂  東京大学, 大学院総合文化研究科, 准教授 (50555802)
豊田 太郎  東京大学, 大学院総合文化研究科, 准教授 (80422377)
梅田 民樹  神戸大学, 海事科学研究科, 准教授 (90243336)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000)
Fiscal Year 2019: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2018: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2017: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Keywords分子ロボティクス / DNAコンピュータ / 糖尿病
Outline of Final Research Achievements

In the artificial molecular pancreatic islets project, we have developed: a) phenylboronic acid derivatives capable of showing glucose responsiveness (which are incorporated into liposome membrane of liposome aggregation) b) DNA frame structure coating and supporting liposome, c) glucose response in vitro assay of liposome aggregates with a microchannel simulating blood flow, d) DNA channel structures for emitting peptide hormones, e) mouse in vivo infrared light fluorescence imaging of liposome aggregates with quantum dots in addition to diabetic mice, theory and molecular dynamics simulation of liposome aggregate explosion.
Due to the business trip restriction caused by coronavirus disaster, we could not achieved in vivo assay of liposome aggregate with diabetic mice including transportation of liposome aggregate to the diabetic mice, blood glucose level control experiment with hypodermic glucose solution injection and in vivo infrared light fluorescence imaging, to name a few.

Academic Significance and Societal Importance of the Research Achievements

分子人工膵島細胞の基盤技術を確立し、血流を模したマイクロ流路を用いたin vitro実験でのリポソーム凝集体の滞留およびグルコース応答分子の機能を確認した。また、マウスを用いたin vivo実験においてリポソーム凝集体の近赤外線蛍光イメージングにも成功した。コロナ禍により糖尿病マウスへの移植実験までは到達できなかったが、本研究により分子人工膵島細胞の実現可能性については十分実証できたと考える。
これまでに、情報計算生物(CBI)学会、日本生体医工学会、人工知能学会などにおいて、シンポジウムや研究会を開催し、医薬分野からも革新的な創薬モダリティ技術として注目を集めている。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (152 results)

All 2020 2019 2018 2017 Other

All Journal Article (50 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 46 results,  Open Access: 28 results,  Acknowledgement Compliant: 1 results) Presentation (88 results) (of which Int'l Joint Research: 12 results,  Invited: 11 results) Book (8 results) Remarks (6 results)

  • [Journal Article] Novel cell-permeable p38-MAPK inhibitor efficiently prevents porcine islet apoptosis and improves islet graft function.2020

    • Author(s)
      Noguchi H, Miyagi-Shiohira C, Nakashima Y, Saitoh I, Watanabe M.
    • Journal Title

      Am J Transplant.

      Volume: in press Issue: 5 Pages: 1296-1308

    • DOI

      10.1111/ajt.15740

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Large deformation of a DNA origami nanoarm through the cumulative actuation of tension-adjustable modules2020

    • Author(s)
      Yuki Suzuki, Ibuki Kawamata, Kohei Mizunom Satoshi Murata
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 59 Issue: 15 Pages: 6230-6234

    • DOI

      10.1002/anie.201916233

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DNA Origami “Quick” Refolding inside of a Micron-Sized Compartment2020

    • Author(s)
      Taiki Watanabe, Yusuke Sato, Hayato Otaka, Ibuki Kawamata, Satoshi Murata, Shin-Ichiro M. Nomura
    • Journal Title

      Molecules

      Volume: 25 Issue: 1 Pages: 8-8

    • DOI

      10.3390/molecules25010008

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quantitative Analysis of Membrane Surface and Small Confinement Effects on Molecular Diffusion2020

    • Author(s)
      C. Watanabe, Y. Kobori, J. Yamamoto, M. Kinjo, M. Yanagisawa, (+ equally contributed)
    • Journal Title

      The Journal of Physical Chemistry (J. Phys. Chem.)

      Volume: 124 Issue: 6 Pages: 1090-1098

    • DOI

      10.1021/acs.jpcb.9b10558

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visualization of human iPS cells-derived 3D cartilage tissue by gelatin nanospheres2020

    • Author(s)
      Murata Yuki、Jo Jun-ichiro、Yukawa Hiroshi、Tsumaki Noriyuki、Baba Yoshinobu、Tabata Yasuhiko
    • Journal Title

      Tissue Engineering Part C: Methods

      Volume: - Issue: 5 Pages: 244-252

    • DOI

      10.1089/ten.tec.2020.0029

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tailored Photoluminescence Properties of Ag(In,Ga)Se2 Quantum Dots for Near-Infrared In Vivo Imaging2020

    • Author(s)
      Tatsuya Kameyama, Hiroki Yamauchi, Takahisa Yamamoto, Toshiki Mizumaki, Hiroshi Yukawa, Masahiro Yamamoto, Shigeru Ikeda, Taro Uematsu, Yoshinobu Baba, Susumu Kuwabata, Tsukasa Torimoto
    • Journal Title

      ACS Applied Nano Materials

      Volume: 3 Issue: 4 Pages: 3275-3287

    • DOI

      10.1021/acsanm.9b02608

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Near infrared photoimmunotherapy targeting DLL3 for small cell lung cancer2020

    • Author(s)
      Yoshitaka Isobe, Kazuhide Sato, Yuko Nishinaga, Kazuomi Takahashi, Shunichi Taki, Hirotoshi Yasui, Misae Shimizu, Rena Endo, Chiaki Koike, Noriko Kuramoto, Hiroshi Yukawa, Shota Nakamura, Takayuki Fukui, Koji Kawaguchi, Toyofumi F. Chen-Yoshikawa, Yoshinobu Baba, Yoshinori Hasegawa
    • Journal Title

      EBioMedicine

      Volume: 52 Pages: 102632-102632

    • DOI

      10.1016/j.ebiom.2020.102632

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Novel Treatment with Stem Cells from Human Exfoliated Deciduous Teeth for Hypoxic-Ischemic Encephalopathy in Neonatal Rats2020

    • Author(s)
      Kitase Yuma、Sato Yoshiaki、Ueda Kazuto、Suzuki Toshihiko、Mikrogeorgiou Alkisti、Sugiyama Yuichiro、Matsubara Kohki、Tsukagoshi Okabe Yuka、Shimizu Shinobu、Hirata Hitoshi、Yukawa Hiroshi、Baba Yoshinobu、Tsuji Masahiro、Takahashi Yoshiyuki、Yamamoto Akihito、Hayakawa Masahiro
    • Journal Title

      Stem Cells and Development

      Volume: 29 Issue: 2 Pages: 63-74

    • DOI

      10.1089/scd.2019.0221

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeted Phototherapy for Malignant Pleural2020

    • Author(s)
      Yuko Nishinaga, Kazuhide Sato, Hirotoshi Yasui, Shunichi Taki,
    • Journal Title

      Cells

      Volume: 9(4) Issue: 4 Pages: 1019-1019

    • DOI

      10.3390/cells9041019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chemical stimulus-responsive supramolecular hydrogel formation and shrinkage of a hydrazone-containing short peptide derivative2020

    • Author(s)
      Sugiura Takumi、Kanada Takurou、Mori Daisuke、Sakai Hiroyuki、Shibata Aya、Kitamura Yoshiaki、Ikeda Masato
    • Journal Title

      Soft Matter

      Volume: 16 Issue: 4 Pages: 899-906

    • DOI

      10.1039/c9sm01969c

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydrodynamic condensation of small molecules and ions into cell-sized liposomes2020

    • Author(s)
      H. Sugiyama, T. Osaki, S. Takeuchi, T. Toyota
    • Journal Title

      Communications Chemistry

      Volume: 3 Issue: 1 Pages: 32-32

    • DOI

      10.1038/s42004-020-0277-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 分子ロボット倫理:分子ロボット研究開発におけるELSIの実践と課題2020

    • Author(s)
      小長谷 明彦
    • Journal Title

      CBI学会誌

      Volume: 8 Pages: 3-20

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Lipid Membrane Effect on the Elasticity of Gelatin Microgel Prepared inside Lipid Microdroplets2019

    • Author(s)
      A. Sakai, N. Hiro-oka, S. Sasaki, S. Kidoaki, M. YANAGISAWA
    • Journal Title

      Nihon Reoroji Gakkaishi

      Volume: 47 Issue: 2 Pages: 55-59

    • DOI

      10.1678/rheology.47.55

    • NAID

      130007650358

    • ISSN
      0387-1533, 2186-4586
    • Year and Date
      2019-04-15
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Excellent Islet Yields after 18-h Porcine Pancreas Preservation by Ductal Injection, Pancreas Preservation with MK Solution, Bottle Purification, and Islet Purification Using Iodixanol with UW Solution and Iodixanol with MK Solution.2019

    • Author(s)
      Kuwae K, Miyagi-Shiohira C, Hamada E, Tamaki Y, Nishime K, Sakai M, Yonaha T, Makishi E, Saitoh I, Watanabe M, Noguchi H.
    • Journal Title

      J Clin Med.

      Volume: 8(10). Issue: 10 Pages: 1561-1561

    • DOI

      10.3390/jcm8101561

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of c-Jun NH(2)-Terminal Kinase for Islet Transplantation.2019

    • Author(s)
      Noguchi H.
    • Journal Title

      J Clin Med.

      Volume: 8(11). Issue: 11 Pages: 1763-1763

    • DOI

      10.3390/jcm8111763

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isothermal amplification of specific DNA molecules inside giant unilamellar vesicles2019

    • Author(s)
      Yusuke Sato, Ken Komiya, Ibuki Kawamata, Satoshi Murata, Shin-ichiro M. Nomura
    • Journal Title

      Chemical Communications

      Volume: 印刷中 Issue: 62 Pages: 9084-9087

    • DOI

      10.1039/c9cc03277k

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sol-Gel Coexisting Phase of Polymer Microgels Triggers Spontaneous Buckling2019

    • Author(s)
      Koyanagi Keisuke、Kudo Kazue、Yanagisawa Miho
    • Journal Title

      Langmuir

      Volume: 35 Issue: 6 Pages: 2283-2288

    • DOI

      10.1021/acs.langmuir.8b03751

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高分子混雑とミクロな閉じ込めが導く分子拡散2019

    • Author(s)
      渡邊千穂,柳澤実穂
    • Journal Title

      Colloid and Interface Communication (C&I Commun.)

      Volume: 44 Pages: 1-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell-sized confinement controls generation and stability of a protein wave for spatiotemporal regulation in cells2019

    • Author(s)
      Kohyama Shunshi、Yoshinaga Natsuhiko、Yanagisawa Miho、Fujiwara Kei、Doi Nobuhide
    • Journal Title

      eLife

      Volume: 8

    • DOI

      10.7554/elife.44591

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] リポソームの応用における基本課題と対策:膜構造と閉じ込め2019

    • Author(s)
      渡邊千穂, 柳澤実穂
    • Journal Title

      膜誌

      Volume: 44 Pages: 234-238

    • NAID

      130007724561

    • Related Report
      2019 Annual Research Report
  • [Journal Article] DNA Origami Nanoplate‐Based Emulsion with Nanopore Function2019

    • Author(s)
      Ishikawa Daisuke、Suzuki Yuki、Kurokawa Chikako、Ohara Masayuki、Tsuchiya Misato、Morita Masamune、Yanagisawa Miho、Endo Masayuki、Kawano Ryuji、Takinoue Masahiro
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 58 Issue: 43 Pages: 15299-15303

    • DOI

      10.1002/anie.201908392

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single cell imaging of transplanted stem cells in the whole cleared tissue by quantum dots2019

    • Author(s)
      水巻登志樹, 湯川博, 洲崎悦生, 上田泰己
    • Journal Title

      Organ Biology

      Volume: 26 Issue: 2 Pages: 199-204

    • DOI

      10.11378/organbio.26.199

    • NAID

      130007716006

    • ISSN
      1340-5152, 2188-0204
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 分子夾雑生命化学に基づく新規計測技術のがん診断への展開 ナノバイオ夾雑環境デバイスによる肝がん細胞由来エクソソームの血管新生評価2019

    • Author(s)
      湯川博, 馬場嘉信
    • Journal Title

      化学と工業

      Volume: 72(5) Pages: 410-412

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 量子ナノ材料による移植幹細胞 in vivo 蛍光イメージングと再生医療2019

    • Author(s)
      湯川博, 馬場嘉信
    • Journal Title

      化學工業

      Volume: 70(5) Pages: 234-240

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-cell microscopic raman spectroscopy for rapid microbial detection2019

    • Author(s)
      Daisuke Onoshima, Kentaro Uchida, Hiroshi Yukawa, Kenji Ishikawa, Masaru Hori, and Yoshinobu Baba
    • Journal Title

      Micro Total Analysis Systems 2019

      Volume: - Pages: 1374-1375

    • Related Report
      2019 Annual Research Report
  • [Journal Article] In Vivo Fluorescence Visualization of Anterior Chamber Injected Human Corneal Endothelial Cells Labeled With Quantum Dots2019

    • Author(s)
      Toda Munetoyo、Yukawa Hiroshi、Yamada Jun、Ueno Morio、Kinoshita Shigeru、Baba Yoshinobu、Hamuro Junji
    • Journal Title

      Investigative Opthalmology & Visual Science

      Volume: 60 Issue: 12 Pages: 4008-4020

    • DOI

      10.1167/iovs.19-27788

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ultrasensitive detection of disease biomarkers using an immuno-wall device with enzymatic amplification2019

    • Author(s)
      Keine Nishiyama, Toshihiro Kasama, Seiya Nakamata, Koya Ishikawa, Daisuke Onoshima, Hiroshi Yukawa, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Yoshinobu Baba, Manabu Tokeshi
    • Journal Title

      Analyst

      Volume: 144(15) Issue: 15 Pages: 4589-4595

    • DOI

      10.1039/c9an00480g

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monitoring spin coherence of single nitrogen-vacancy centers in nanodiamonds during pH changes in aqueous buffer solutions2019

    • Author(s)
      Masazumi Fujiwara, Ryuta Tsukahara, Yoshihiko Sera, Hiroshi Yukawa, Yoshinobu Baba, Shinichi Shikata, and Hideki Hashimoto
    • Journal Title

      RSC Advances

      Volume: 9 Issue: 22 Pages: 12606-12614

    • DOI

      10.1039/c9ra02282a

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Temperature-Dependent Dynamics of Giant Vesicles Composed of Hydrolysable Lipids Having an Amide Linkage2019

    • Author(s)
      Tameyuki Maito、Hiranaka Hisato、Toyota Taro、Asakura Kouichi、Banno Taisuke
    • Journal Title

      Langmuir

      Volume: 35 Issue: 52 Pages: 17075-17081

    • DOI

      10.1021/acs.langmuir.9b02707

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA Length-dependent Division of a Giant Vesicle-based Model Protocell2019

    • Author(s)
      Muneyuki Matsuo、Yumi Kan、Kensuke Kurihara、Takehiro Jimbo、Masayuki Imai、Taro Toyota、Yuiko Hirata、Kentaro Suzuki、Tadashi Sugawara
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 6916-6916

    • DOI

      10.1038/s41598-019-43367-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A sustainable self-reproducing liposome consisting of a synthetic phospholipid2019

    • Author(s)
      Matsuo Muneyuki、Ohyama Shota、Sakurai Kotoba、Toyota Taro、Suzuki Kentaro、Sugawara Tadashi
    • Journal Title

      Chemistry and Physics of Lipids

      Volume: 222 Pages: 1-7

    • DOI

      10.1016/j.chemphyslip.2019.04.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hybrid soft nanomaterials composed of DNA microspheres and supermolecular nanostructures of semi-artificial glycopeptides.2019

    • Author(s)
      Sayuri L. Higashi, Aya Shibata, Yoshiaki Kitamura, Koichiro M. Hirosawa, Kenichi G. N. Suzuki, Kazunori Matsuda, Masato Ikeda.
    • Journal Title

      Chemistry

      Volume: 25 Issue: 51 Pages: 11955-11962

    • DOI

      10.1002/chem.201902421

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 分子ロボティクスを用いた分子人工膵島細胞の実現を目指して2019

    • Author(s)
      小長谷 明彦
    • Journal Title

      Precision Medicine

      Volume: 2 Pages: 69-73

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Programmable reactions and diffusion using DNA for pattern formation in hydrogel medium2019

    • Author(s)
      Keita Abe, Ibuki Kawamata, Shin-ichiro M. Nomura, Satoshi Murata
    • Journal Title

      Molecular Systems Design & Engineering

      Volume: accepted Issue: 3 Pages: 639-643

    • DOI

      10.1039/c9me00004f

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pattern Formation on Discrete Gel Matrix based on DNA Computing2019

    • Author(s)
      Takuto Hosoya, Ibuki Kawamata, Shin-ichiro M. Nomura, Satoshi Murata
    • Journal Title

      New Generation Computing

      Volume: 37 Issue: 1 Pages: 97-111

    • DOI

      10.1007/s00354-018-0047-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stimuli-responsive supramolecular systems guided by chemical reaction2019

    • Author(s)
      Masato Ikeda
    • Journal Title

      Polymer Journal

      Volume: 51 Issue: 4 Pages: 371-380

    • DOI

      10.1038/s41428-018-0132-9

    • NAID

      40021935758

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stimuli-responsive DNAzyme displaying Boolean logic-gate responses2019

    • Author(s)
      Ayaka Banno, Sayuri Higashi, Aya Shibata, Masato Ikeda
    • Journal Title

      Chemical Communications

      Volume: 55 Issue: 13 Pages: 1959-1962

    • DOI

      10.1039/c8cc09345h

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel preservation solution containing a JNK inhibitory peptide efficiently improves islet yield for porcine islet isolation.2019

    • Author(s)
      Noguchi H, Miyagi-Shiohira C, Nakashima Y, Ebi N, Hamada E, Tamaki Y, Kuwae K, Kitamura S, Kobayashi N, Saitoh I, Watanabe M
    • Journal Title

      Transplantation.

      Volume: 103 Issue: 2 Pages: 344-352

    • DOI

      10.1097/tp.0000000000002555

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] <b>All-atom molecular dynamics of film supported flat-shaped DNA origami in water</b>2018

    • Author(s)
      Ryuzo Azuma, Sae Kishi, Greg Gutmann, Akihiko Konagaya
    • Journal Title

      Chem-Bio Informatics Journal

      Volume: 18 Issue: 0 Pages: 96-118

    • DOI

      10.1273/cbij.18.96

    • NAID

      130007484978

    • ISSN
      1347-0442, 1347-6297
    • Year and Date
      2018-09-19
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diffusion modulation of DNA by toehold exchange2018

    • Author(s)
      Thanapop Rodjanapanyakul, Fumi Takabatake, Keita Abe, Ibuki Kawamata, Shin-ichiro M. Nomura, Satoshi Murata
    • Journal Title

      Physical Review E

      Volume: 97 Issue: 5 Pages: 052617-052617

    • DOI

      10.1103/physreve.97.052617

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduction-Responsive DNA Duplex Containing O6-Nitrobenzyl-Guanine2018

    • Author(s)
      Yukiko Hayakawa, Ayaka Banno, Hiroaki Kitagawa, Sayuri Higashi, Yukio Kitade, Aya Shibata, Masato Ikeda
    • Journal Title

      ACS Omega

      Volume: 3 Issue: 8 Pages: 9267-9275

    • DOI

      10.1021/acsomega.8b01177

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modified cell-permeable JNK inhibitors efficiently prevents islet apoptosis and improves the outcome of islet transplantation.2018

    • Author(s)
      Noguchi H, Miyagi-Shiohira C, Nakashima Y, Ebi N, Hamada E, Tamaki Y, Kuwae K, Kobayashi N, Saitoh I, Watanabe M.
    • Journal Title

      Sci Rep.

      Volume: 8(1) Issue: 1 Pages: 11082-11082

    • DOI

      10.1038/s41598-018-29481-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison Between Modified Extracellular-Type Trehalose-Containing Kyoto Solution and University of Wisconsin Solution in 18-Hour Pancreas Preservation for Islet Transplantation.2018

    • Author(s)
      Hamada E, Ebi N, Miyagi-Shiohira C, Tamaki Y, Nakashima Y, Kobayashi N, Saitoh I, Watanabe M, Kinjo T, Noguchi H.
    • Journal Title

      Pancreas.

      Volume: 47(7) Issue: 7 Pages: e46-e47

    • DOI

      10.1097/mpa.0000000000001104

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induced Tissue-Specific Stem Cells and Epigenetic Memory in Induced Pluripotent Stem Cells.2018

    • Author(s)
      Noguchi H, Miyagi-Shiohira C, Nakashima Y.
    • Journal Title

      Int J Mol Sci.

      Volume: 21;19(4) Issue: 4 Pages: 930-930

    • DOI

      10.3390/ijms19040930

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increasing Elasticity through Changes in the Secondary Structure of Gelatin by Gelation in a Microsized Lipid Space2018

    • Author(s)
      Sakai Atsushi、Murayama Yoshihiro、Fujiwara Kei、Fujisawa Takahiro、Sasaki Saori、Kidoaki Satoru、Yanagisawa Miho
    • Journal Title

      ACS Central Science

      Volume: 印刷中 Issue: 4 Pages: 477-483

    • DOI

      10.1021/acscentsci.7b00625

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exogenous DKK-3/REIC inhibits Wnt/β-catenin signaling and cell proliferation in human kidney cancer KPK12017

    • Author(s)
      Xu Jiaqi、Sadahira Takuya、Kinoshita Rie、Li ShunAi、Huang Peng、Wada Koichiro、Araki Motoo、Ochiai Kazuhiko、Noguchi Hirofumi、Sakaguchi Masakiyo、Nasu Yasutomo、Watanabe Masami
    • Journal Title

      Oncology Letters

      Volume: 14 Pages: 5638-5642

    • DOI

      10.3892/ol.2017.6833

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A proteome analysis of pig pancreatic islets and exocrine tissue by liquid chromatography with tandem mass spectrometry.2017

    • Author(s)
      Nakashima Y, Miyagi-Shiohira C, Kobayashi N, Saitoh I, Watanabe M, Noguchi H.
    • Journal Title

      Islets.

      Volume: 9(6) Issue: 6 Pages: 159-176

    • DOI

      10.1080/19382014.2017.1389826

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of carbohydrate structures on the hydrogelation ability and morphology of self-assembled structures of peptide-carbohydrate conjugates in water2017

    • Author(s)
      Tomoya Tsuzuki, Marina Kabumoto, Hanae Arakawa, Masato Ikeda
    • Journal Title

      Org. Biomol. Chem.

      Volume: 15 Issue: 21 Pages: 4595-4600

    • DOI

      10.1039/c7ob00816c

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RCAN-11R peptide provides immunosuppression for fully mismatched islet allografts in mice.2017

    • Author(s)
      Noguchi H, Sugimoto K, Miyagi-Shiohira C, Nakashima Y, Kobayashi N, Saitoh I, Watanabe M, Noguchi Y.
    • Journal Title

      Scientific Reprots.

      Volume: - Issue: 1 Pages: 3043-3043

    • DOI

      10.1038/s41598-017-02934-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isolation and characterization of lymphoid enhancer factor-1-positive deciduous dental pulp stem-like cells after transfection with a piggyBac vector containing LEF1 promoter-driven selection markers.2017

    • Author(s)
      Murakami T, Saitoh I, Sato M, Inada E, Soda M, Oda M, Domon H, Iwase Y, Sawami T, Matsueda K, Terao Y, Ohshima H, Noguchi H, Hayasaki H
    • Journal Title

      Archives of Oral Biology

      Volume: 81 Pages: 110-120

    • DOI

      10.1016/j.archoralbio.2017.04.033

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 蛍光ナノ材料と組織透明化技術の融合による移植エクソソームの診断技術確立に向けて2020

    • Author(s)
      浦野大智,湯川博,小野島大介, 洲﨑悦生, 上田泰己,馬場嘉信
    • Organizer
      日本化学会第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 超早期がん治療に向けた量子ナノ光免疫治療法(QPIT)の開発2020

    • Author(s)
      服部亮佑, 湯川博, 佐藤和秀, 磯部好考, 金谷準一, 小野島大介, 馬場嘉信
    • Organizer
      日本化学会第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 量子ナノセンサーによる幹細胞再生機能温度センシング2020

    • Author(s)
      宮地冬, 湯川博, 小野島大介, 藤原正澄, 西村勇姿, 馬場嘉信
    • Organizer
      日本化学会第100春季年会2020
    • Related Report
      2019 Annual Research Report
  • [Presentation] SIG-MBIを振り返って2020

    • Author(s)
      小長谷 明彦
    • Organizer
      人工知能学会分子生物情報研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 分子ロボティクスを用いた分子人工膵島細胞開発の現状と倫理的課2020

    • Author(s)
      小長谷 明彦, 河原 直人, 野口 洋文, 豊田 太郎, 池田 将, 湯川 博, 川又 生吹, 柳澤 実穂, 梅田 民樹, 小野 喜志雄
    • Organizer
      日本臨床試験学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 分子ロボットの創製に向けた超分子ナノ構造体の多成分化2019

    • Author(s)
      池田将
    • Organizer
      第69回分子生物情報(SIG-MBI)研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マルチコンポーネント型超分子ヒドロゲルの創製2019

    • Author(s)
      池田将
    • Organizer
      第50回 中部化学関係学協会支部連合秋季大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 化学反応性人工分子と生体分子を組み合わせてつくる刺激答性超分子システム2019

    • Author(s)
      池田将
    • Organizer
      有機合成化学協会中国四国支部パネル討論会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Membrane adhesion of liposomes increases membrane tension and regulates in-membrane molecular diffusion2019

    • Author(s)
      小田淳士,渡邊千穂,柳澤実穂
    • Organizer
      The 5th International Soft Matter Conference (ISMC2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 膜外多糖溶液によるリポソームの相転移温度の上昇2019

    • Author(s)
      冨田和甫,渡邊千穂,柳澤実穂
    • Organizer
      第18回関東ソフトマター研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] リポソームの変形に伴う膜タンパク質の濃度変化2019

    • Author(s)
      小林瑞輝, 藤原慶,柳澤実穂
    • Organizer
      第18回関東ソフトマター研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高分子混雑がもたらすリポソームの相転移温度上昇2019

    • Author(s)
      冨田和甫,渡邊千穂,柳澤実穂
    • Organizer
      定量生物学会 北海道キャラバン
    • Related Report
      2019 Annual Research Report
  • [Presentation] 相分離したリポソーム膜内て?の膜タンパク質の濃縮2019

    • Author(s)
      小林瑞輝, 藤原慶,柳澤実穂
    • Organizer
      定量生物学会 北海道キャラバン
    • Related Report
      2019 Annual Research Report
  • [Presentation] リポソームの膜組成と再構築された膜タンパク質量の相関2019

    • Author(s)
      小林瑞輝, 藤原慶,柳澤実穂
    • Organizer
      第9回ソフトマター研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] リポソームの形状変化の数値シミュレーションによる解析2019

    • Author(s)
      梅田民樹
    • Organizer
      第58回日本生体医工学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] リポソーム凝集体の形状と力学的性質の解析2019

    • Author(s)
      梅田民樹
    • Organizer
      人工知能学会合同研究会2019 分子生物情報研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 筒状DNAオリガミ構造によるリポソーム内外の分子拡散にむけて2019

    • Author(s)
      生吹, 岩渕祥璽, 野村 M. 慎一郎, 村田智
    • Organizer
      SIG-MBI
    • Related Report
      2019 Annual Research Report
  • [Presentation] Current and Future Trends of DNA Molecule Computation2019

    • Author(s)
      Ibuki Kawamata
    • Organizer
      SIG-NAC
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] A database to store design information of DNA nanostructure2019

    • Author(s)
      Ibuki Kawamata, Sho Aradachi, Satoshi Murata
    • Organizer
      Molecular Robotics Session, Chem-Bio Informatics Society (CBI) Annual Meeting 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] oward molecular diffusion through liposome membrane using DNA origami structure2019

    • Author(s)
      Ibuki Kawamata, Shoji Iwabuchi, Shin-ichiro M. Nomura, Satoshi Murata
    • Organizer
      Japanese Society for Cell Synthesis Research 12.0
    • Related Report
      2019 Annual Research Report
  • [Presentation] A database of cadnano file to store design information of DNA nanostructure2019

    • Author(s)
      Ibuki Kawamata, Sho Aradachi, Satoshi Murata
    • Organizer
      the 25th International Conference on DNA Computing and Molecular Programming (DNA25)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Toward making a database of design information of DNA nanostructure2019

    • Author(s)
      Ibuki Kawamata, Sho Aradachi, Satoshi Murata
    • Organizer
      Nucleic Acid Nanotechnology: from algorithmic design to biochemical applications (NANTECH2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 量子ナノ材料による移植幹細胞in vivo蛍光イメージングと再生医療への貢献2019

    • Author(s)
      湯川博
    • Organizer
      2019年度神戸再生医療勉強会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 量子ナノ材料による急性肝不全マウスに対する移植幹細胞intra-vital 蛍光イメージング2019

    • Author(s)
      湯川博, 馬場嘉信
    • Organizer
      日本分子イメージング学会第14回学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 量子ナノ材料によるiPS細胞イメージングと再生医療への貢献2019

    • Author(s)
      湯川博
    • Organizer
      2019年度中部談話会 見学講演会 -日本の粉体産業を支える研究・技術
    • Related Report
      2019 Annual Research Report
  • [Presentation] 量子ナノ光学に基づく最先端イメージング診断技術の医学応用2019

    • Author(s)
      湯川博
    • Organizer
      in vivoイメージングフォーラム2019~第14回IVISユーザー会~
    • Related Report
      2019 Annual Research Report
  • [Presentation] 量子ナノ光学が導くiPS細胞イメージングと再生医療への貢献2019

    • Author(s)
      湯川博
    • Organizer
      第4回最先端イメージングセミナー
    • Related Report
      2019 Annual Research Report
  • [Presentation] 量子ナノ材料による移植幹細胞in vivo蛍光イメージングと再生医療への貢献2019

    • Author(s)
      湯川博
    • Organizer
      日本薬物動態学会 第34回年会 つくば
    • Related Report
      2019 Annual Research Report
  • [Presentation] 量子ナノ材料による急性肝不全マウスに対する完全透明化組織・臓器内移植幹細胞イメージング2019

    • Author(s)
      湯川博, 水巻登志樹, 洲崎悦夫, 上田泰己, 馬場嘉信
    • Organizer
      第40回日本炎症‐再生医療学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ナノダイヤモンド量子温度センシングとその汎用計測システムの開発2019

    • Author(s)
      藤原正澄, 湯川博, 小林香央里, 梅原有美, 公文優花, 宮地冬, 岩崎孝之, 波多野睦子, 橋本秀樹, 馬場嘉信
    • Organizer
      量子生命科学会第1回大会,
    • Related Report
      2019 Annual Research Report
  • [Presentation] 蛍光ナノダイヤモンドによる幹細胞再生機能温度センシング2019

    • Author(s)
      宮地冬, 湯川博, 小野島大介, 藤原正澄, 西村勇姿, 馬場嘉信
    • Organizer
      量子生命科学会第1回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 量子ドット・磁性ナノ粒子含有ゼラチンナノ粒子を用いたヒトiPS 細胞由来3 次元軟骨組織の可視化2019

    • Author(s)
      城潤一郎, 村田勇樹, 湯川 博, 馬場嘉信, 田畑泰彦
    • Organizer
      日本分子イメージング学会第14回学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 量子ドットによる完全透明化組織内移植幹細胞イメージング2019

    • Author(s)
      水巻登志樹, 湯川博, 小野島大介, 洲崎悦生, 上田泰己, 馬場嘉信
    • Organizer
      日本分子イメージング学会第14回学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 近赤外蛍光色素による幹細胞由来エクソソームin vivo イメージング2019

    • Author(s)
      公文優花, 湯川博, 小野島大介, 馬場嘉信
    • Organizer
      日本分子イメージング学会第14回学会総会・学術集会,
    • Related Report
      2019 Annual Research Report
  • [Presentation] フタロシアニン色素を用いた近赤外蛍光標識材料の開発2019

    • Author(s)
      早川純平, 横倉梨乃, 皆嶋英範, 湯川博, 馬場嘉信
    • Organizer
      日本分子イメージング学会第14回学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 量子ドットを用いた透明化組織内移植幹細胞イメージング技術の開発2019

    • Author(s)
      水巻登志樹, 湯川博, 小野島大介, 洲崎悦生, 上田泰己, 馬場嘉信
    • Organizer
      第58回日本生体医工学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 量子ドットによる幹細胞由来エクソソームイメージングと再生医療への応用2019

    • Author(s)
      公文優花, 湯川博, 小野島大介, 馬場嘉信
    • Organizer
      第58回日本生体医工学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 量子ドットを用いた透明化組織内移植幹細胞イメージング診断技術の開発2019

    • Author(s)
      水巻登志樹, 湯川博, 小野島大介, 洲崎悦生, 上田泰己, 馬場嘉信
    • Organizer
      第35回日本DDS学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 量子ドットによる幹細胞由来エクソソームラベリング技術の構築2019

    • Author(s)
      公文優花, 湯川博, 小野島大介, 馬場嘉信
    • Organizer
      第35回日本DDS学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] in vivo応用に向けた量子ナノ材料による幹細胞再生機能温度センシング2019

    • Author(s)
      宮地 冬, 湯川 博, 小野島大介, 藤原正澄, 西村勇姿, 小林香央里, 馬場嘉信
    • Organizer
      In Vivoイメージングフォーラム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 超早期がん診断・治療に向けた量子ナノがん光免疫治療法(QPIT)の開発2019

    • Author(s)
      服部亮佑, 湯川博, 小野島大介, 佐藤和秀, 磯部好考, 金谷準一, 馬場嘉信
    • Organizer
      In Vivoイメージングフォーラム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 量子ナノ光学に基づく幹細胞由来エクソソームイメージング技術の構築2019

    • Author(s)
      公文優花, 湯川博, 小野島大介, 馬場嘉信
    • Organizer
      In Vivoイメージングフォーラム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 量子ドットを用いた透明化組織内移植幹細胞イメージング診断技術の開発2019

    • Author(s)
      水巻登志樹, 湯川博, 小野島大介, 洲崎悦生, 上田泰己, 馬場嘉信
    • Organizer
      In Vivoイメージングフォーラム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 微小な薄膜球核構造を有する3次元再生肺胞の開発2019

    • Author(s)
      服部亮佑,湯川博 小野島大介, 土谷智史,馬場嘉信
    • Organizer
      第46回日本臓器保存生物医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 蛍光ナノダイヤモンドによる幹細胞再生機能温度センシング2019

    • Author(s)
      宮地冬, 湯川博, 小野島大介, 藤原正澄, 西村勇姿, 小林香央里, 馬場嘉信
    • Organizer
      第46回日本臓器保存生物医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 量子ナノ光学に基づく幹細胞由来エクソソームイメージング技術の 創製と再生医療への展開2019

    • Author(s)
      公文優花, 湯川博, 小野島大介, 馬場嘉信
    • Organizer
      第46回日本臓器保存生物医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 量子ナノ材料による移植幹細胞・免疫細胞間インタラクションの intra-vital 蛍光イメージングと組織透明化技術CUBIC の応用2019

    • Author(s)
      水巻登志樹, 湯川博, 北村晃大,小野島大介, 洲崎悦生, 上田泰己,
    • Organizer
      第46回日本臓器保存生物医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Intra-vital fluorescence imaging of interaction between transplanted stem cells and immune cells by quantum nano-materials and tissue clearing (CUBIC) technology2019

    • Author(s)
      Mizumaki T, Yukawa H, Kitamura K, Onoshima D, Susaki E, Ueda H, Baba Y
    • Organizer
      The 3rd QST International Symposium
    • Related Report
      2019 Annual Research Report
  • [Presentation] In vivo imaging of exosomes derived from stem cells by using quantum dots for regenerative medicine2019

    • Author(s)
      Kumon Y, Yukawa H, Onoshima D, Baba Y.
    • Organizer
      The 3rd QST International Symposium
    • Related Report
      2019 Annual Research Report
  • [Presentation] Intra-vital fluorescence imaging of interaction between transplanted stem cells and immune cells by quantum nano-materials and tissue clearing (CUBIC) technology2019

    • Author(s)
      Mizumaki T, Yukawa H, Kitamura K, Onoshima D, Susaki E, Ueda H, Baba Y.
    • Organizer
      The 6th International Symposium on Bioimaging
    • Related Report
      2019 Annual Research Report
  • [Presentation] In vivo imaging of exosomes derived from stem cells by using quantum nano-optics for regenerative medicine2019

    • Author(s)
      Kumon Y, Yukawa H, Onoshima D, Baba Y.
    • Organizer
      The 6th International Symposium on Bioimaging
    • Related Report
      2019 Annual Research Report
  • [Presentation] In vivo real-time NIR Imaging of transplanted stem cells using quantum dots2019

    • Author(s)
      Yukawa H.
    • Organizer
      TERMIS-AP + ABMC7 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Microfluidic trapping and observation of size-sorted liposomes prepared by water-in-oil emulsion transfer method2019

    • Author(s)
      Hironori Sugiyama, Toshihisa Osaki, Shoji Takeuchi, Taro Toyota
    • Organizer
      ACS Fall 2019 National Meeting & Exposition
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Automated Observation of Cell-sized Liposome with Feedback Control of the Outer Environment2019

    • Author(s)
      Hironori Sugiyama, Toshihisa Osaki, Shoji Takeuchi, Taro Toyota
    • Organizer
      The 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (?TAS 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Growth of giant vesicles linking to hydrophobic chain extention of phospholipids by Suzuki-Miyaura cross-coupling reaction2019

    • Author(s)
      Atsufumi Ohtani, Hironori Sugiyama, Taro Toyota
    • Organizer
      OKINAWA COLLOIDS 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ジャイアントベシクルの医工学的応用:人工細胞型センサーからマルチモーダルイメージングプローブまで2019

    • Author(s)
      豊田太郎
    • Organizer
      第58回日本生体医工学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 水に分散した両親媒性分子による細胞模倣分子システム2019

    • Author(s)
      豊田太郎
    • Organizer
      第29回日本MRS年次大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ELSI in University and Research Institution projects:A Case Study of Molecular Robotics2019

    • Author(s)
      KONAGAYA Akihiko
    • Organizer
      日本化学会第100春季年会2020
    • Related Report
      2019 Annual Research Report
  • [Presentation] 分子ロボットの環境応用と倫理的課題2019

    • Author(s)
      小長谷 明彦
    • Organizer
      循環共生圏農工業・帯広ワークショップ
    • Related Report
      2019 Annual Research Report
  • [Presentation] 分子ロボティクス:今後の展望と課題2019

    • Author(s)
      小長谷 明彦
    • Organizer
      人工知能学会分子生物情報研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ELSI and RRI of molecular robotics ? from a scientist’s perspective2019

    • Author(s)
      KONAGAYA Akihiko
    • Organizer
      OsloMet Workshop on the Ethics of Molecular Robotics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Knowledge Creation in the Life Science2019

    • Author(s)
      KONAGAYA Akihiko
    • Organizer
      International Conference on Creating Value for the Future of AI and Society
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 分子ロボットの過去・現在・未来:循環共生圏農工業への展開2019

    • Author(s)
      小長谷 明彦
    • Organizer
      東京工業大学「循環共生圏農工業研究推進体」キックオフシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 分子人工膵島細胞開発の現状と倫理的課題2019

    • Author(s)
      小長谷 明彦
    • Organizer
      SICE分子ロボティクス研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 仮想現実と全原子MDシミュレーションを用いた 超分子設計支援システムの構築2019

    • Author(s)
      小長谷 明彦
    • Organizer
      日本生体医工学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Programming DNA reaction-diffusion system for pattern formation in hydrogel medium2019

    • Author(s)
      Ibuki Kawamata
    • Organizer
      Shaping Self-Assembled Mesoscale (Bio)Materials with Microengineering
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 分子ロボット創薬への道2019

    • Author(s)
      小長谷明彦
    • Organizer
      人工知能学会第68回分子生物情報研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 膜接着リポソームにおける膜張力と分子拡散の相関2018

    • Author(s)
      小田敦士, 柳澤実穂
    • Organizer
      第17回関東ソフトマター研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] DNAナノテクを用いた細胞モデルの力学的制御2018

    • Author(s)
      柳澤実穂
    • Organizer
      第67回人工知能学会分子生物情報研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] DNA骨格による細胞モデルの自在な力学的特性の制御2018

    • Author(s)
      篠原千加子、酒井淳、 柳澤実穂
    • Organizer
      第5回サイボウニクス研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 基礎から学ぶ DNAナノ構造体の設計2018

    • Author(s)
      川又生吹
    • Organizer
      分子ロボ若手会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Modulating diffusion speed of DNA by toehold exchange2018

    • Author(s)
      Ibuki Kawamata, Thanapop Rodjanapanyakul, Fumi Takabatake, Keita Abe, Shin-ichiro M. Nomura, Satoshi Murata
    • Organizer
      The 45th International Symposium on Nucleic Acids Chemistry (ISNAC 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DNAオリガミを用いて膜に穴を開ける:Φ12 nm人工チャネルの設計と機能評価2018

    • Author(s)
      岩渕 祥璽,片山 航一郎, 川又 生吹, 鈴木 勇輝, 村田 智, 野村 M.慎一郎
    • Organizer
      第85回形のシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Design and evaluation of φ12 nm artificial channel2018

    • Author(s)
      Shoji Iwabuchi,Koichiro Katayama, Ibuki Kawamata, Yuki Suzuki, Satoshi Murata, Shin-ichiro M. Nomura, “Making pores on biomembrane using DNA origami
    • Organizer
      CBI学会2018年大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Design and construction of DNA origami with large pore structure for transmembrane transportation2018

    • Author(s)
      Shoji Iwabuchi,Koichiro Katayama, Ibuki Kawamata, Yuki Suzuki, Satoshi Murata, Shin-ichiro M. Nomura
    • Organizer
      「細胞を創る」研究会11.0
    • Related Report
      2018 Annual Research Report
  • [Presentation] サイズ選択を可能にするポア構造を有するDNAオリガミの設計と構築2018

    • Author(s)
      岩渕 祥璽,片山 航一郎, 川又 生吹, 鈴木 勇輝, 村田 智, 野村 M.慎一郎
    • Organizer
      第2回分子ロボティクス年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 自律性をもった超分子ナノ構造体の創製2018

    • Author(s)
      池田将
    • Organizer
      第65回SIGMBI: 分子ロボティクスの今後の展望について
    • Related Report
      2018 Annual Research Report
  • [Presentation] 化学反応を起点に刺激に応答する超分子システム2018

    • Author(s)
      池田将
    • Organizer
      第67回高分子学会年次大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Bioinspired supramolecular nanofiber2018

    • Author(s)
      Masato Ikeda
    • Organizer
      N.I.C.E Conference 2018 (4th International Conference on Bioinspired and Biobased Chemistry and Materials)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ベクシル凝集体の形状の数理モデルによる解析2018

    • Author(s)
      梅田民樹
    • Organizer
      人工知能学会合同研究会2018 分子生物情報研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 分子ロボティクス:これまでの成果と将来構想2018

    • Author(s)
      小長谷明彦
    • Organizer
      CBI学会第394回CBI学会講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 分子ロボットを”Beyond the Pill”の視点から考える2018

    • Author(s)
      小長谷明彦
    • Organizer
      人工知能学会合同研究会2018 分子生物情報研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脂質膜ミクロ閉じ込めが誘起するゼラチンゲルの弾性及び構造変化2018

    • Author(s)
      酒井淳、村山能宏、藤原慶、木戸秋悟、柳澤実穂
    • Organizer
      日本物理学会第73回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 粘弾性溶液を内包した細胞膜モデルの膜変形や拡散挙動2017

    • Author(s)
      柳澤 実穂
    • Organizer
      日本物理学会2017年秋季大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Micrometric Confinement Induces Anomalous Diffusion in Semi-dilute Polymer Solution2017

    • Author(s)
      Chiho Watanabe, Miho Yanagisawa
    • Organizer
      International Symposium on Fluctuation and Structure out of Equilibrium 2017 (SFS2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of lipid membrane on elasticity of microgel prepared inside the lipid droplet2017

    • Author(s)
      Atsushi Sakai, Yoshihiro Murayama, Saori Sasaki, Takahiro Fujisawa, Satoru Kidoaki, Miho Yanagisawa
    • Organizer
      International Symposium on Fluctuation and Structure out of Equilibrium 2017 (SFS2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] タンパク質によるリポソームの変形の数値シミュレーション2017

    • Author(s)
      梅田民樹
    • Organizer
      人工知能学会合同研究会2017 分子生物情報研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 環境を感知して形を変える分子系2017

    • Author(s)
      池田 将
    • Organizer
      第64回SIGMBI
    • Related Report
      2017 Annual Research Report
  • [Book] 分子ロボティクス概論 分子のデザインでシステムを創る2019

    • Author(s)
      川又生吹, 他 (分子ロボティクス研究会著), 村田智編
    • Total Pages
      312
    • Publisher
      eBook Series No.3 情報計算化学生物学会 (CBI学会)出版
    • ISBN
      9784990907648
    • Related Report
      2019 Annual Research Report
  • [Book] Yano E plus・次世代先端デバイス動向(4)量子ドットデバイス2019

    • Author(s)
      湯川博
    • Total Pages
      29
    • Publisher
      株式会社矢野経済研究所
    • Related Report
      2019 Annual Research Report
  • [Book] Bioanalysis: Applications of Microfluidic Systems in Biology and Medicine2019

    • Author(s)
      Tokeshi Manabu (Ed.) , Daisuke Onoshima, Hiroshi Yukawa, Yoshinobu Baba
    • Total Pages
      26
    • Publisher
      Springer
    • ISBN
      9789811362293
    • Related Report
      2019 Annual Research Report
  • [Book] 化学と工業:分子夾雑生命化学に基づく新規計測技術のがん診断への展開 ナノバイオ夾雑環境デバイスによる肝がん細胞由来エクソソームの血管新生評価2019

    • Author(s)
      湯川博, 馬場嘉信
    • Total Pages
      3
    • Publisher
      公益社団法人日本化学会
    • Related Report
      2019 Annual Research Report
  • [Book] 化學工業:量子ナノ材料による移植幹細胞in vivo蛍光イメージングと再生医療 (特集 バイオイメージングの展望)2019

    • Author(s)
      湯川博, 馬場嘉信
    • Total Pages
      7
    • Publisher
      小峰工業出版
    • Related Report
      2019 Annual Research Report
  • [Book] 分子ロボティクス概論 (村田 智 編集)2019

    • Author(s)
      豊田太郎,池田将,本多智
    • Total Pages
      312
    • Publisher
      CBI学会出版
    • ISBN
      9784990907648
    • Related Report
      2019 Annual Research Report
  • [Book] MDB技術予測レポート2019

    • Author(s)
      小長谷 明彦
    • Total Pages
      12
    • Publisher
      株式会社日本能率協会総合研究所
    • Related Report
      2019 Annual Research Report
  • [Book] 分子ロボティクス概論2019

    • Author(s)
      分子ロボティクス研究会
    • Total Pages
      302
    • Publisher
      CBI学会出版
    • ISBN
      9784990907648
    • Related Report
      2018 Annual Research Report
  • [Remarks] 小長谷研究室ホームページ

    • URL

      http://konagaya-lab.com/jp/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 柳澤実穂研究室ホームページ

    • URL

      https://sites.google.com/g.ecc.u-tokyo.ac.jp/yanagisawa-lab/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 馬場研究室ホームページ

    • URL

      https://www.chembio.nagoya-u.ac.jp/labhp/bioanal1/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 東京大学大学院 総合文化研究科先進科学研究機構 / 広域科学専攻 相関基礎科学系柳澤研究室

    • URL

      https://sites.google.com/g.ecc.u-tokyo.ac.jp/yanagisawa-lab/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 岐阜大学工学部化学・生命工学科 池田研究室

    • URL

      http://www1.gifu-u.ac.jp/~mb_chem1/IkedaGroup/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 小長谷研究室 分子ロボット創薬

    • URL

      http://konagaya-lab.com/jp/?page_id=1010

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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