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Comprehensive evaluation of residual pharmaceuticals in the aquatic environment and their removal efficiency in wastewater treatment plant

Research Project

Project/Area Number 17H00786
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation and chemicals
Research InstitutionKyoto University

Principal Investigator

Nakada Norihide  京都大学, 工学研究科, 講師 (00391615)

Co-Investigator(Kenkyū-buntansha) 井原 賢  京都大学, 工学研究科, 特定助教 (70450202)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000)
Fiscal Year 2019: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2018: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2017: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Keywords薬理活性 / 環境医薬品 / 予測スクリーニング / バイオアッセイ / 精密質量分析 / 下水処理 / ノンターゲット分析 / 生理活性 / 医薬品汚染 / 下水処理性能評価 / 下水処理性能 / ターゲット分析 / 医薬品による環境汚染 / 四重極飛行時間型質量分析計
Outline of Final Research Achievements

The purpose of this study is to gain a further understanding of residual pharmaceuticals in the aquatic environment and to assess their impact on the aquatic organisms in the future. Targeted instrumental analysis and a bioassay that can detect physiological activity directly from water samples were applied to wastewater samples together with suspect screening based on the approaches to qualify untargeted or unknown active substances. A total of 36 types of G-protein-conjugated receptor antagonists, including 4 metabolites or degradation products were quantified in the wastewater samples from 5 wastewater treatment plants (WWTPs). The results revealed that low removal efficiencies of them and their activities by the conventional wastewater treatment and the occurrence of metabolites or degradation products at a relatively high concentrations and frequency of detection in the effluent of WWTPs.

Academic Significance and Societal Importance of the Research Achievements

水環境中に残留する医薬品の定量は、これまでは分析用標準物質が販売されている比較的古い薬剤に対するターゲット分析が主流であったが、それでは残留医薬品の評価に漏れが生じている可能性がある。また、今後の残留医薬品の評価においては、化学物質としてではなく、薬効成分として評価する必要がある。このような背景から、水試料からの薬理活性の直接の検出と予測スクリーニングを組合せ、残留医薬品を評価した点は革新的であると言える。

Report

(4 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (15 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results) Presentation (9 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results)

  • [Int'l Joint Research] Centre for Ecology and Hydrology/Brunel University London(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] National Environment Monitoring Centre(中国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] N-nitrosodimethylamine formation potential (NDMA-FP) of ranitidine remains after chlorination and/or photo-irradiation: Identification of transformation products in combination with NDMA-FP test2021

    • Author(s)
      Zhao Bo、Zhou Jiajun、Nakada Norihide
    • Journal Title

      Chemosphere

      Volume: 267 Pages: 129200-129200

    • DOI

      10.1016/j.chemosphere.2020.129200

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological Activity-Based Prioritization of Pharmaceuticals in Wastewater for Environmental Monitoring: G Protein-Coupled Receptor Inhibitors2020

    • Author(s)
      Zhang Han、Ihara Mariko O.、Nakada Norihide、Tanaka Hiroaki、Ihara Masaru
    • Journal Title

      Environmental Science & Technology

      Volume: 54 Issue: 3 Pages: 1720-1729

    • DOI

      10.1021/acs.est.9b05768

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Learning from the past and considering the future of chemicals in the environment2020

    • Author(s)
      Johnson Andrew C.、Jin Xiaowei、Nakada Norihide、Sumpter John P.
    • Journal Title

      Science

      Volume: 367 Issue: 6476 Pages: 384-387

    • DOI

      10.1126/science.aay6637

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 水環境中の医薬品の存在状況2020

    • Author(s)
      中田典秀
    • Journal Title

      化学物質と環境

      Volume: 161 Pages: 4-6

    • Related Report
      2019 Annual Research Report
  • [Presentation] Biological activity-based prioritization of pharmaceuticals in wastewater of England and Japan2019

    • Author(s)
      Han Zhang, Norihide Nakada, Masaru Ihara, Hiroaki Tanaka
    • Organizer
      The 5th Asian Symposium on Water Reuse -Technology Renovation and Risk Management
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NDMA Formation from Ranitidine Affected by Chlorination and/or Photo-irradiation2019

    • Author(s)
      Jiajun Zhou, Bo Zhao, Hiroaki Tanaka, Norihide Nakada
    • Organizer
      11th Micropol & Ecohazard Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Screening of Physiological Activity in Wastewater Effluents by Combination of in vitro Bioassay, Target Analysis and Suspect Screening2019

    • Author(s)
      Norihide Nakada, Han Zhang, Masaru Ihara
    • Organizer
      11th Micropol & Ecohazard Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PPCPsの環境中での存在状況2019

    • Author(s)
      中田典秀
    • Organizer
      第33回環境ホルモン学会講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] PPCPsの水生生物への影響:神経系薬を中心に2019

    • Author(s)
      井原賢
    • Organizer
      第33回環境ホルモン学会講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] バイオアッセイ、ターゲット分析、予測スクリーニングによる下水処理水中の各種受容体拮抗作用物質の探索2019

    • Author(s)
      中田典秀、張晗、井原賢
    • Organizer
      日本水環境学会 第53回日本水環境学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 生理活性に基づく下水処理水中のアンジオテンシンII 受容体拮抗作用(薬)のターゲット分析および予測スクリーニング2018

    • Author(s)
      中田典秀、張晗、井原賢
    • Organizer
      日本環境化学会 第27回環境化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アンジオテンシンII受容体拮抗薬の都市水環境における存在実態2018

    • Author(s)
      中田典秀、長谷川英資、井原賢
    • Organizer
      第52回に本水環境学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生理活性に基づく下水処理水中のアンジオテンシンII 受容体拮抗作用(薬)のターゲット分析および予測スクリーニング2018

    • Author(s)
      中田典秀、張晗、井原賢
    • Organizer
      第27回環境化学討論会
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2022-01-27  

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