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Material design for microscale load sensor having bio-degradability

Research Project

Project/Area Number 17H01327
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Structural/Functional materials
Research InstitutionKobe University

Principal Investigator

Mukai Toshiji  神戸大学, 未来医工学研究開発センター, 教授 (40254429)

Co-Investigator(Kenkyū-buntansha) 磯野 吉正  神戸大学, 工学研究科, 教授 (20257819)
福本 巧  神戸大学, 医学研究科, 教授 (70379402)
池尾 直子  神戸大学, 工学研究科, 助教 (80647644)
上杉 晃生  神戸大学, 工学研究科, 助教 (90821710)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2020: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2018: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2017: ¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000)
Keywords生体材料 / 生体内分解性金属 / 検力センサー / マイクロワイヤ / 粒界偏析 / 細線 / 高靱性材料設計
Outline of Final Research Achievements

Biodegradable implants are gaining attention as devices that do not require removal surgery because they degrade in the body over time. This study aims to construct a force testing system capable of real-time monitoring of the mechanical strength associated with degradability, and to establish the elemental technology for such a system. First-principles calculations were used to design the composition of biodegradable magnesium and zinc alloys to optimize their strength and degradability. Toughened wires were fabricated by forming heterogeneous microstructures through plastic working. Finally, a method to form biodegradable microforce sensors was established and implemented on the implant surface.

Academic Significance and Societal Importance of the Research Achievements

生体内分解性インプラントは経時に伴い体内で分解されるため、抜去手術を必要としない利点を有しているが、治癒部を維持する力学的性能を検証するためにはX線CTなど体外からの観察以外に取り得る手段がない。本研究ではインプラントに作用する力を計測するための生体内分解性を有する検力センサーおよびマイクロワイヤの創製研究を実施した。強靱化および分解性制御に有効な構成元素を計算により選定し、生体内分解性を有する高強度マイクロワイヤの創製を試みた。本研究で得られた成果は、体内で分解するマイクロ検力センサーの開発につながるだけではなく、細線を活用したステントや縫合糸など各種の医療デバイス開発にも応用が期待される。

Report

(5 results)
  • 2022 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (92 results)

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article (25 results) (of which Int'l Joint Research: 2 results,  Open Access: 9 results,  Peer Reviewed: 21 results) Presentation (67 results) (of which Int'l Joint Research: 12 results,  Invited: 8 results)

  • [Journal Article] Bioabsorbable zinc alloys for use in urological surgery2023

    • Author(s)
      Takanori Sano、Hinata Nobuyuki、Kobayashi Ryoya、Nakatsuji Tatsuya、Okamura Yasuyoshi、Furukawa Junya、Nakano Yuzo、Mukai Toshiji、Fujisawa Masato
    • Journal Title

      World Journal of Urology

      Volume: 41 Issue: 4 Pages: 1181-1186

    • DOI

      10.1007/s00345-023-04342-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tension bending deformability of Mg-Ca and Mg-Zn alloy wires by coiling and evaluation of degradability <i>in vitro</i>2022

    • Author(s)
      Sannomiya Hiroki、Nakatsuji Tatsuya、Nakamura Kunimitsu、Mukai Toshiji
    • Journal Title

      Journal of Japan Institute of Light Metals

      Volume: 72 Issue: 12 Pages: 708-710

    • DOI

      10.2464/jilm.72.708

    • ISSN
      0451-5994, 1880-8018
    • Year and Date
      2022-12-15
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Grain Refinement on Fatigue Properties of Mg–0.3 at%Ca Alloy in Air and Simulated Body Fluid2022

    • Author(s)
      Naoko Ikeo, Naoya Kawamura, Toshiji Mukai
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 63 Issue: 1 Pages: 69-72

    • DOI

      10.2320/matertrans.MT-M2021186

    • NAID

      130008134286

    • ISSN
      1345-9678, 1347-5320
    • Year and Date
      2022-01-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biodegradation behaviors of magnesium(Mg)-based alloy nails in autologous bone grafts: In vivo study in rabbit skulls2022

    • Author(s)
      Yanagisawa Yuta、Shimizu Yoshinaka、Mukai Toshiji、Sano Yuya、Odashima Kenji、Ikeo Naoko、Saito Haruka、Yamauchi Kensuke、Takahashi Tetsu、Kumamoto Hiroyuki
    • Journal Title

      Journal of Applied Biomaterials &amp; Functional Materials

      Volume: 20 Pages: 1-14

    • DOI

      10.1177/22808000221095230

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Different Effects of Calcium and Zinc as a Solute Element on the Fatigue Properties in Simulated Body Fluids of Magnesium Alloys2021

    • Author(s)
      Ikeo Naoko、Uemura Taichi、Taguma Akihito、Mukai Toshiji
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 62 Issue: 12 Pages: 1806-1809

    • DOI

      10.2320/matertrans.MT-M2021180

    • NAID

      130008120259

    • ISSN
      1345-9678, 1347-5320
    • Year and Date
      2021-12-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microstructural Evolution in Magnesium after Hyper-Velocity Impact of Alumina Projectile2021

    • Author(s)
      Fujita Naoki、Nakatsuji Tatsuya、Hasegawa Sunao、Ikeo Naoko、Sato Eiichi、Mukai Toshiji
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 62 Issue: 9 Pages: 1401-1406

    • DOI

      10.2320/matertrans.MT-L2021003

    • NAID

      130008077583

    • ISSN
      1345-9678, 1347-5320
    • Year and Date
      2021-09-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Osteogenic response under the periosteum by magnesium implantation in rat tibia2021

    • Author(s)
      Kenji odashima
    • Journal Title

      Dental Materials Journal

      Volume: 40 Issue: 2 Pages: 498-507

    • DOI

      10.4012/dmj.2020-011

    • NAID

      130008009417

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2021-03-25
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of cold-working on phase formation during heat treatment in CrMnFeCoNi system high-entropy alloys with Al addition2021

    • Author(s)
      Watanabe Hiroyuki、Murata Toru、Nakamura Shunsuke、Ikeo Naoko、Mukai Toshiji、Tsuchiya Koichi
    • Journal Title

      Journal of Alloys and Compounds

      Volume: 872 Pages: 159668-159668

    • DOI

      10.1016/j.jallcom.2021.159668

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of initial microstructure on grain refinement under hot compression in CrMnFeCoNi high-entropy alloy with Al addition2021

    • Author(s)
      Watanabe Hiroyuki、Murata Toru、Ikeo Naoko、Mukai Toshiji、Han Kwangsik、Tsuchiya Koichi
    • Journal Title

      Materialia

      Volume: 18 Pages: 101172-101172

    • DOI

      10.1016/j.mtla.2021.101172

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase transformation and morphological features in a cold-worked CrMnFeCoNi high entropy alloy with Al addition2021

    • Author(s)
      Singh Alok、Hiroto Takanobu、Watanabe Hiroyuki、Ikeo Naoko、Mukai Toshiji、Tsuchiya Koichi
    • Journal Title

      Materials Characterization

      Volume: 182 Pages: 111556-111556

    • DOI

      10.1016/j.matchar.2021.111556

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PO-1587: Novel biocompatible artifact-robust and highly visible fiducial marker for image-guided radiotherapy2020

    • Author(s)
      Wang T.、Ikeo N.、Okumura K.、Akasaka H.、Yada R.、Yoshida K.、Miyawaki D.、Ishihara T.、Mukumoto N.、Shimizu Y.、Mukai T.、Nakaoka A.、Sasaki R.
    • Journal Title

      Radiotherapy and Oncology

      Volume: 152 Pages: S862-S862

    • DOI

      10.1016/s0167-8140(21)01605-4

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] Influence of Manganese on Deformation Behavior of Magnesium Under Dynamic Loading2020

    • Author(s)
      Goeda Ryutaro、Yamaguchi Masatake、Nakatsuji Tatsuya、Ikeo Naoko、Mukai Toshiji
    • Journal Title

      Magnesium Technology 2020

      Volume: 1 Pages: 381-385

    • DOI

      10.1007/978-3-030-36647-6_56

    • ISBN
      9783030366469, 9783030366476
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel artifact‐robust and highly visible zinc solid fiducial marker for kilovoltage x‐ray image‐guided radiation therapy2020

    • Author(s)
      Wang Tianyuan、Inubushi Sachiko、Ikeo Naoko、Mukai Toshiji、Okumura Keisuke、Akasaka Hiroaki、Yada Ryuichi、Yoshida Kenji、Miyawaki Daisuke、Ishihara Takeaki、Nakaoka Ai、Sasaki Ryohei
    • Journal Title

      Medical Physics

      Volume: 47 Issue: 10 Pages: 4703-4710

    • DOI

      10.1002/mp.14412

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Domain structure and lattice effects in a severely plastically deformed CoCrFeMnNi high entropy alloy2020

    • Author(s)
      Singh Alok、Basha D.A.、Matsushita Yoshitaka、Tsuchiya Koichi、Lu Zhaoping、Nieh Tai-Gang、Mukai Toshiji
    • Journal Title

      Journal of Alloys and Compounds

      Volume: 812 Pages: 152028-152028

    • DOI

      10.1016/j.jallcom.2019.152028

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 生体内で「とける」医療用金属材料2020

    • Author(s)
      池尾直子、向井敏司
    • Journal Title

      バイオマテリアル

      Volume: 38 Pages: 224-229

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Development of bioabsorbable zinc?magnesium alloy wire and validation of its application to urinary tract surgeries2020

    • Author(s)
      Okamura Yasuyoshi、Hinata Nobuyuki、Hoshiba Taichi、Nakatsuji Tatsuya、Ikeo Naoko、Furukawa Junya、Harada Kenichi、Nakano Yuzo、Fukumoto Takumi、Mukai Toshiji、Fujisawa Masato
    • Journal Title

      World Journal of Urology

      Volume: 39 Issue: 1 Pages: 201-208

    • DOI

      10.1007/s00345-020-03138-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] <i>In vitro</i> and <i>in vivo</i> analysis of the biodegradable behavior of a magnesium alloy for biomedical applications2019

    • Author(s)
      SATO Takumi、SHIMIZU Yoshinaka、ODASHIMA Kenji、SANO Yuya、YAMAMOTO Akiko、MUKAI Toshiji、IKEO Naoko、TAKAHASHI Tetsu、KUMAMOTO Hiroyuki
    • Journal Title

      Dental Materials Journal

      Volume: 38 Issue: 1 Pages: 11-21

    • DOI

      10.4012/dmj.2017-324

    • NAID

      130007593296

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2019-01-28
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Processing and Mechanical Properties of a Tricalcium Phosphate-Dispersed Magnesium-Based Composite2019

    • Author(s)
      Watanabe Hiroyuki、Ikeo Naoko、Mukai Toshiji
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 60 Issue: 1 Pages: 105-110

    • DOI

      10.2320/matertrans.M2018304

    • NAID

      130007549934

    • ISSN
      1345-9678, 1347-5320
    • Year and Date
      2019-01-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel biodegradable magnesium alloy clips compared with titanium clips for hepatectomy in a rat model2019

    • Author(s)
      Urade Takeshi、Yoshida Toshihiko、Ikeo Naoko、Naka Kosuke、Kido Masahiro、Toyama Hirochika、Ueno Kimihiko、Tanaka Motofumi、Mukai Toshiji、Fukumoto Takumi
    • Journal Title

      BMC Surgery

      Volume: 19 Issue: 1

    • DOI

      10.1186/s12893-019-0600-y

    • NAID

      120007002614

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] マグネシウム合金他2019

    • Author(s)
      向井敏司
    • Journal Title

      特殊鋼

      Volume: 68 Pages: 34-36

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] Fabrication and characterization of Mg?0.2?at% Ca/α-tricalcium phosphate composites2019

    • Author(s)
      Ikeo Naoko、Kawasaki Hiroki、Watanabe Hiroyuki、Mukai Toshiji
    • Journal Title

      Materials Letters

      Volume: 241 Pages: 96-99

    • DOI

      10.1016/j.matlet.2019.01.042

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of yttrium addition on the hot deformation behaviors and microstructure development of magnesium alloy2019

    • Author(s)
      W. Huang, X. Yang, Y. Yang, T. Mukai, T. Sakai
    • Journal Title

      Journal of Alloys and Compounds

      Volume: 786 Pages: 118-125

    • DOI

      10.1016/j.jallcom.2019.01.269

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of Calcium Solute on Mechanical Properties and Bio-degradability of Magnesium2018

    • Author(s)
      T. Hoshiba, M. Yamaguchi, N. Ikeo, T. Mukai
    • Journal Title

      Proceedings of the 11th International Conference on Magnesium Alloys and Their Applications

      Volume: 1 Pages: 409-413

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] マグネシウム合金の衝撃変形特性2018

    • Author(s)
      前田智也,向井敏司
    • Journal Title

      日本塑性加工学会会報誌

      Volume: 1 Pages: 253-257

    • NAID

      130007817452

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Fabrication of biodegradable materials with high strength by grain refinement of Mg-0.3 at.% Ca alloys2018

    • Author(s)
      Naoko Ikeo, Masayuki Nishioka, Toshiji Mukai
    • Journal Title

      Materials Letters

      Volume: 223 Pages: 65-68

    • DOI

      10.1016/j.matlet.2018.03.188

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 医療用亜鉛ワイヤの引抜加工およびマグネシウム添加による組織変化2022

    • Author(s)
      野田幸伸, 中辻竜也, 向井敏司
    • Organizer
      第170回 超塑性研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Mg-Ca二元合金の疲労特性に与えるカルシウム添加濃度の影響2022

    • Author(s)
      野口大, 池尾直子, 向井敏司
    • Organizer
      第170回 超塑性研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 亜鉛系コンポジットによる生体内分解性ネイルの貫入特性評価2022

    • Author(s)
      竹内友哉, 中辻竜也, 向井敏司
    • Organizer
      第170回 超塑性研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 有限要素解析による骨固定プレートの材質および形状の検討2022

    • Author(s)
      勝井陽介, 中辻竜也, 向井敏司
    • Organizer
      第170回 超塑性研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 亜鉛系コンポジットを用いた生体内分解性ネイルの貫入特性評価2022

    • Author(s)
      竹内友哉, 中辻竜也, 向井敏司
    • Organizer
      日本金属学会2022年秋期大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 温間引抜加工によるZn-Mg合金ワイヤの結晶粒微細化2022

    • Author(s)
      野田幸伸, 中辻竜也, 向井敏司
    • Organizer
      日本金属学会2022年秋期大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 生体内分解性亜鉛クリップ創成に向けたマグネシウム添加による亜鉛の機械的性質および生体内分解性向上2022

    • Author(s)
      小林遼也, 中辻竜也, 池尾直子, 向井敏司
    • Organizer
      日本金属学会2022年秋期大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 生体内分解性Mg-Ca合金のin vitro疲労寿命に与えるカルシウム添加の効果2022

    • Author(s)
      野口大, 池尾直子, 中辻竜也, 向井敏司
    • Organizer
      軽金属学会 第143回秋期大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] マグネシウムの加工硬化挙動に及ぼすスカンジウムの影響2022

    • Author(s)
      長谷川開渡, 中辻竜也, 池尾直子, 向井敏司
    • Organizer
      軽金属学会 第143回秋期大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 亜鉛系コンポジットによる生体内分解性ネイルの貫入特性評価2022

    • Author(s)
      竹内友哉, 中辻竜也, 向井敏司
    • Organizer
      第5回 日本金属学会第7分野講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Mg-Zn合金細線の組織変化に及ぼす減面率の影響2021

    • Author(s)
      沢口信介, 三宮大喜, 中辻竜也, 池尾直子, 向井敏司
    • Organizer
      軽金属学会第140回春期大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Effects of Adding Zinc and Calcium Solute on Mechanical Properties in Magnesium Fine Wires2021

    • Author(s)
      Hiroki Sannomiya, Shinsuke Sawaguchi, Tatsuya Nakatsuji, Naoko Ikeo, Kunimitsu Nakamura, Toshiji Mukai
    • Organizer
      The 12th International Conference on Magnesium Alloys and their Applications (Mg 2021)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Effect of Adding Third Element on Deformability of Mg-Al Alloy2021

    • Author(s)
      Kazuki Senoo, Tatsuya Nakatsuji, Naoko Ikeo, Masatake Yamaguchi, Toshiji Mukai
    • Organizer
      The 12th International Conference on Magnesium Alloys and their Applications (Mg 2021)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Influence of reduction rate on microstructure evolution in Mg alloy wire2021

    • Author(s)
      Shinsuke Sawaguchi, Hiroki Sannomiya, Tatsuya Nakatsuji, Naoko Ikeo, Toshiji Mukai
    • Organizer
      13th Symposium on Biodegradable Metals for Biomedical Applications
    • Related Report
      2020 Annual Research Report
  • [Presentation] マグネシウム添加による亜鉛の生体内分解性および機械的性質改善2021

    • Author(s)
      小林遼也, 漆谷建治, 中辻竜也, 池尾直子, 向井敏司
    • Organizer
      日本金属学会2021年秋期大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Mg-Ca合金のin vitro疲労寿命に与えるカルシウム濃度の影響2021

    • Author(s)
      野口大, 中辻竜也, 池尾直子, 向井敏司
    • Organizer
      日本金属学会2021年秋期大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Mg-Al合金の塑性異方性に及ぼすジルコニウム添加効果2021

    • Author(s)
      妹尾和樹, 中辻竜也, 池尾直子, 山口正剛, 向井敏司
    • Organizer
      日本金属学会2021年秋期大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 高強度マグネシウム合金プレートによる下顎骨固定の応力分布解析2021

    • Author(s)
      勝井陽介, 中辻竜也, 池尾直子, 向井敏司
    • Organizer
      日本金属学会2021年秋期大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 六方晶金属の室温インデンテーションクリープに及ぼす結晶方位の影響2021

    • Author(s)
      鈴木直尭, 池尾直子, 中辻竜也, 向井敏司
    • Organizer
      日本金属学会2021年秋期大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] マグネシウムの延性に及ぼすスカンジウムの添加効果2021

    • Author(s)
      長谷川開渡, 中辻竜也, 山口正剛, 池尾直子, 向井敏司
    • Organizer
      軽金属学会第141回秋期大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 軽金属プレートによる下顎骨固定時の応力遮蔽効果に対する材質の影響2021

    • Author(s)
      勝井陽介, 中辻竜也, 池尾直子, 向井敏司
    • Organizer
      軽金属学会第141回秋期大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Mg-Mn合金の室温変形機構に及ぼすひずみ速度の影響2021

    • Author(s)
      伊藤祐介, 中辻竜也, 池尾直子, 向井敏司
    • Organizer
      軽金属学会第141回秋期大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 高強度マグネシウム合金プレートによる骨固定の応力分布解析2021

    • Author(s)
      勝井陽介, 池尾直子, 中辻竜也, 向井敏司
    • Organizer
      第4回日本金属学会第7分野講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] マグネシウムの塑性異方性緩和に対するアルミニウムおよび第三元素添加効果2020

    • Author(s)
      妹尾和樹, 長尾昌樹, 中辻竜也, 山口正剛, 池尾直子, 向井敏司
    • Organizer
      日本金属学会2020年春期大会
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Presentation] ジルコニウムの粒界偏析によるマグネシウムの衝撃靭性の向上2020

    • Author(s)
      井上裕理, 馬場鷹人, 中辻竜也, 山口正剛, 池尾直子, 向井敏司
    • Organizer
      日本金属学会2020年春期大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] マグネシウムの塑性異方性改善に向けたアルミニウムおよびジルコニウムの共添加効果2020

    • Author(s)
      妹尾和樹, 長尾昌樹, 中辻竜也, 山口正剛, 池尾直子, 向井敏司
    • Organizer
      軽金属学会第139回秋期大会
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Presentation] 純Mgのインデンテーションクリープに対する方位依存性2020

    • Author(s)
      鈴木直堯, 池尾直子, 中辻竜也, 向井敏司
    • Organizer
      第3回日本金属学会第7分野講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] マグネシウム細線の機械的性質に及ぼす亜鉛およびカルシウム添加の影響2020

    • Author(s)
      三宮大喜, 沢口信介, 中辻竜也, 池尾直子, 中村国光, 向井敏司
    • Organizer
      第3回日本金属学会第7分野講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 生体内分解性クリップの開発に向けたマグネシウム添加による亜鉛の機械的性質改善2020

    • Author(s)
      小林遼也, 中辻竜也, 池尾直子, 向井敏司
    • Organizer
      日本金属学会2021年春期大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] マグネシウムの衝撃靭性改善に向けたアルミニウムおよび第三元素添加の効果2020

    • Author(s)
      妹尾和樹, 中辻竜也, 山口正剛, 池尾直子, 向井敏司
    • Organizer
      軽金属学会第138回春期大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Mg-Ca合金の高速変形挙動に及ぼす温度及びひずみ速度の影響2020

    • Author(s)
      佐藤涼太, 中辻竜也, 池尾直子, 向井敏司
    • Organizer
      第13回材料の衝撃問題シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Mechanical response of high-strength Mg-Ca alloy nail penetrating bone tissue2019

    • Author(s)
      N. Ikeo, J. Shimizu, Y. Sano, Y. Shimizu, T. Mukai
    • Organizer
      11th Symposium on Biodegradable Metals
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体内分解性インプラントに向けたマグネシウムのマテリアルデザイン2019

    • Author(s)
      向井敏司
    • Organizer
      第28回日本形成外科学会基礎学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Microstructure Evolution in CoCrFeMnNi High-entropy Alloy by Localized Shear Deformation2019

    • Author(s)
      R. Serada, A. Singh, I. Gutierrez-Urrutia, K. Tsuchiya, T. Mukai
    • Organizer
      World Congress on High Entropy Alloys 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マグネシウムの対応粒界における粒界エネルギーと粒界凝集エネルギーの相関2019

    • Author(s)
      馬場鷹人, 山口正剛, 池尾直子, 向井敏司
    • Organizer
      日本金属学会2019年秋期大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マグネシウムの高速変形特性に及ぼすマンガンの影響2019

    • Author(s)
      五枝龍太郎, 山口正剛, 中辻竜也, 池尾直子, 向井敏司
    • Organizer
      軽金属学会第136回春期大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 衝撃荷重下におけるMg-Ca二元合金の高温圧縮変形応答2019

    • Author(s)
      佐藤涼太, 中辻竜也, 池尾直子, 向井敏司
    • Organizer
      軽金属学会第137回秋期大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 第一原理計算によるマグネシウムの衝撃靭性向上に向けた亜鉛添加効果の解明2019

    • Author(s)
      馬場鷹人, 山口正剛, 池尾直子, 向井敏司
    • Organizer
      軽金属学会第137回秋期大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 生体内分解性Mg合金のin vitro疲労寿命に対する内部組織の影響2019

    • Author(s)
      川村尚也, 池尾直子, 向井敏司
    • Organizer
      第41回日本バイオマテリアル学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 亜鉛合金の機械的性質及び生体内分解性に対するストロンチウム添加の影響2019

    • Author(s)
      成田道洋, 中辻竜也, 池尾直子, 向井敏司
    • Organizer
      第41回日本バイオマテリアル学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 骨構造への貫入時における生体内分解性Mg-Ca合金ネイルの変形挙動2019

    • Author(s)
      大岡亮太, 中辻竜也, 池尾直子, 向井敏司
    • Organizer
      第41回日本バイオマテリアル学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 構造制御によるマグネシウム基コンポジットの高機能化に関する基礎研究2019

    • Author(s)
      中野加菜, 池尾直子, 渡辺博行, 向井敏司
    • Organizer
      日本金属学会2019年春期大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effect of solute on grain boundary plasticity in fine-grained Mg alloys2018

    • Author(s)
      T. Mukai, T. Hoshiba, M. Yamaguchi, N. Ikeo
    • Organizer
      13th International Conference on Superplasticity in Advanced Materials (ICSAM 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of calcium and zinc on deformation behaviour of magnesium under dynamic loading2018

    • Author(s)
      T. Mukai, T. Maeda, Y. Chikanari, N. Ikeo, T. Baba
    • Organizer
      11th International Conference on Magnesium Alloys and Their Applications (Mg2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of Calcium Solute on Mechanical Properties and Bio-degradability of Magnesium2018

    • Author(s)
      T. Hoshiba, M. Yamaguchi, N. Ikeo, T. Mukai
    • Organizer
      11th International Conference on Magnesium Alloys and Their Applications
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of in vitro fatigue of the biodegradable Mg alloy Bearing essential elements in simulated body fluid2018

    • Author(s)
      N. Ikeo, N. Kawamura, T. Uemura, T. Mukai
    • Organizer
      11th International Conference on Magnesium Alloys and Their Applications
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体用インプラントに向けたマグネシウム合金の開発2018

    • Author(s)
      向井敏司
    • Organizer
      日本塑性加工学会 東京・南関東支部 第14回技術フォーラム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] マグネシウムの生体内分解性に与える溶質カルシウム元素の影響2018

    • Author(s)
      干場太一, 山口正剛, 池尾直子, 向井敏司
    • Organizer
      軽金属学会第134回春期大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マグネシウムの衝撃変形挙動に及ぼす亜鉛濃度の影響2018

    • Author(s)
      馬場鷹人, 前田智哉, 山口正剛, 池尾直子, 向井敏司
    • Organizer
      軽金属学会第134回春期大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 純マグネシウムの生体内分解性に及ぼす圧縮ひずみの影響2018

    • Author(s)
      依藤駿, 池尾直子, 向井敏司
    • Organizer
      日本金属学会2018年秋期大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 生体内分解性Mg-Zn-Ca合金のin vitro疲労寿命に及ぼす結晶粒微細化の効果2018

    • Author(s)
      川村尚也, 植村太一, 池尾直子, 向井敏司
    • Organizer
      日本金属学会2018年秋期大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マグネシウムの粒界強度および塑性異方性に対するマンガンの添加効2018

    • Author(s)
      五枝龍太郎, 山口正剛, 池尾直子, 向井敏司
    • Organizer
      日本金属学会2018年秋期大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effect of solute elements on bio-degradability in magnesium2018

    • Author(s)
      T. Hoshiba, M. Yamaguchi, N. Ikeo, T. Mukai
    • Organizer
      軽金属学会第135回秋期大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マグネシウム合金における変形応力のひずみ速度依存性に及ぼすCaの影響2018

    • Author(s)
      近成勇太, 中辻竜也, 池尾直子, 向井敏司
    • Organizer
      軽金属学会第135回秋期大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Material Design f or Enhancing Toughness of Mg Alloy and Application for Biodegradable Devices2018

    • Author(s)
      Toshiji MUKAI
    • Organizer
      Magnesium Technology 2018, TMS 2018 Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of a New Biodegradable Surgical Clip Made of a Magnesium Alloy: Evaluation of its Safety and Tolerability for Canine Cholecystectomy2018

    • Author(s)
      Takumi Fukumoto, Toshihiko Yoshida, Takeshi Urade, Naoko Ikeo, Toshiji Mukai
    • Organizer
      Biodegradable Materials for Medical Applications, TMS 2018 Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of Additive Zinc on Mechanical Properties and Degradation Behavior of Magnesium2018

    • Author(s)
      Naoko Ikeo, Kengo Fujiwara, YooJin Kim, Toshiji Mukai
    • Organizer
      Biodegradable Materials for Medical Applications, TMS 2018 Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Enhancing Impact Toughness of Mg-3%Al-1%Zn Alloy by Grain Structure Modification2018

    • Author(s)
      Tomoya Maeda, Naoko Ikeo, Yoshiaki Osawa, Toshiji Mukai
    • Organizer
      Magnesium Technology 2018, TMS 2018 Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マグネシウム合金の粒界強度および塑性異方性に対する溶質元素添加の効果2018

    • Author(s)
      五枝龍太郎, 干場太一, 山口正剛, 池尾直子, 向井敏司
    • Organizer
      日本金属学会2018年春期(第162回)講演大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Material Design of Magnesium Alloy for Biodegradable Implant Devices2017

    • Author(s)
      Toshiji MUKAI
    • Organizer
      Bridging Nature and Technology 8th Annual Symposium by Indian Scientists Association in Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Deformation behavior of severe plastically rolled Al-Mg alloy under dynamic loading2017

    • Author(s)
      Toshiji MUKAI, Yuki NINOMIYA, Naoko IKEO, Ivan G.-Urrutia, Alok Singh, Yoshiaki Osawa, Koichi Tsuchiya
    • Organizer
      7th International Conference on Nanomaterials by Severe Plastic Deformation
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マグネシウムの衝撃破壊特性に及ぼすカルシウムおよび亜鉛の添加効果2017

    • Author(s)
      前田智哉, 長谷貴之, 池尾直子, 向井敏司
    • Organizer
      日本金属学会2017年秋期(第161回)講演大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マグネシウム-亜鉛合金の分解性に及ぼす集合組織の影響2017

    • Author(s)
      加藤あおい, 藤原健吾, 池尾直子, 向井敏司
    • Organizer
      日本金属学会2017年秋期(第161回)講演大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生体内分解性 Zn の分解性評価および元素添加効果の解明2017

    • Author(s)
      漆谷建治, 山口正剛, 池尾直子, 向井敏司
    • Organizer
      日本金属学会2017年秋期(第161回)講演大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マグネシウム基アパタイト複合材料の機械的性質評価2017

    • Author(s)
      川崎浩輝, 渡辺博行, 池尾直子, 向井敏司
    • Organizer
      軽金属学会第133回秋期大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 強ひずみ加工によるMg-3A-1Zn合金の高靱性化2017

    • Author(s)
      前田智哉, 大澤嘉昭, 池尾直子, 向井敏司
    • Organizer
      第12回材料の衝撃問題シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 衝撃圧縮荷重下におけるMg -Ca 合金の変形応答に及ぼすCa 濃度2017

    • Author(s)
      近成勇太, 前田智哉, 池尾直子, 向井敏司
    • Organizer
      第12回材料の衝撃問題シンポジウム
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2024-01-30  

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