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Development of next generation continuous separation processes based on fluid behaviour in microchannel

Research Project

Project/Area Number 17H01339
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Properties in chemical engineering process/Transfer operation/Unit operation
Research InstitutionKyoto University (2019)
The University of Tokushima (2017-2018)

Principal Investigator

Ken-Ichiro Sotowa  京都大学, 工学研究科, 教授 (00336009)

Co-Investigator(Kenkyū-buntansha) 滝山 博志  東京農工大学, 工学(系)研究科(研究院), 教授 (40251582)
工藤 翔慈  群馬工業高等専門学校, 物質工学科, 助教 (50735008)
ALCANTARA J.RAFAEL  京都大学, 工学研究科, 講師 (50709219)
堀河 俊英  徳島大学, 大学院社会産業理工学研究部(理工学域), 准教授 (90380112)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000)
Fiscal Year 2019: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2018: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2017: ¥27,560,000 (Direct Cost: ¥21,200,000、Indirect Cost: ¥6,360,000)
Keywords蒸留 / 晶析 / 単位操作 / マイクロ流路 / 移動現象 / 連続操作 / 化学工学 / 流体力学 / 物質移動
Outline of Final Research Achievements

This study focused on intensification of distillation and crystallization technologies through exploitation of novel fluid flow systems. For distillation, a horizontal apparatus with agitator was developed and the effect of shape of rotating elements on the separation performance was investigated experimentally. A cascade crystallization system, which involves a Taylor Couette flow apparatus, was developed. The crystal size can be easily controlled by varying a fraction of flow rates, which is one of the important operating parameters in this system. A CFD simulation was conducted to examine the mass transfer rate around a particle under shear dominated conditions, and the results showed fine crystals grow faster in Taylor Couette flow than in a stirred tank. Clogging prevention is important in segmented flow crystallization in microchannels. An experimental study was conducted to clarify the condition which promotes initiation of crystal deposition on the wall.

Academic Significance and Societal Importance of the Research Achievements

フロー合成技術は近い未来の医薬品製造技術として注目されている。このような製造プロセスで利用できる反応技術の開発が進められている一方で、分離精製技術の進展が遅れている。本研究では特に重要となる晶析技術、さらにはより一般の化学産業でも広く使われる蒸留を取り上げた検討を行った。研究の結果、テイラークエット流を利用した晶析システムの提案や、せん断流における物質移動の解析など学術的にも新規な知見を得ることができた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report

Research Products

(28 results)

All 2020 2019 2018 2017

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (24 results) (of which Int'l Joint Research: 13 results,  Invited: 2 results)

  • [Journal Article] Control of Reaction Crystallization of Organic Compounds Using the Supersaturation Profile2019

    • Author(s)
      Sato Eriko、Seki Yuichiro、Takiyama Hiroshi
    • Journal Title

      J. Chem. Eng. Japan

      Volume: 52 Issue: 7 Pages: 599-604

    • DOI

      10.1252/jcej.19we017

    • NAID

      130007681656

    • ISSN
      0021-9592, 1881-1299
    • Related Report
      2019 Annual Research Report
  • [Journal Article] Effect of Two Kinds of Supersaturation on Crystal Qualities during Cocrystallization2019

    • Author(s)
      Nishimaru Momoko、Kudo Shoji、Takiyama Hiroshi
    • Journal Title

      J. Chem. Eng. Japan

      Volume: 52 Issue: 6 Pages: 579-585

    • DOI

      10.1252/jcej.18we281

    • NAID

      130007665276

    • ISSN
      0021-9592, 1881-1299
    • Related Report
      2019 Annual Research Report
  • [Journal Article] Production of crystalline particles with high homogeneity in reaction crystallization by using pH-solubility-profile2019

    • Author(s)
      Ohyama Mitsuki、Kudo Shoji、Amari Shuntaro、Takiyama Hiroshi
    • Journal Title

      Journal of Industrial and Engineering Chemistry

      Volume: 75 Pages: 38-43

    • DOI

      10.1016/j.jiec.2019.03.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Operation condition for continuous anti-solvent crystallization of CBZ-SAC cocrystal considering deposition risk of undesired crystals2017

    • Author(s)
      Nishimaru Momoko、Nakasa Miku、Kudo Shoji、Takiyama Hiroshi
    • Journal Title

      Journal of Crystal Growth

      Volume: 470 Pages: 89-93

    • DOI

      10.1016/j.jcrysgro.2017.04.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 非球形粒子の攪拌槽内構造物への衝突現象の解析2020

    • Author(s)
      千明知広、工藤翔慈
    • Organizer
      化学工学会 第85年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 新規カスケード型連続フロー晶析を用いた結晶粒子群の品質制御2020

    • Author(s)
      小山 真奈、甘利 俊太朗、滝山 博志
    • Organizer
      化学工学会第85年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] バニリンの非溶媒添加晶析での結晶粒子群品質2020

    • Author(s)
      木村一輝、工藤翔慈
    • Organizer
      化学工学会 第85年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 溶液からの共結晶粒子群晶創製のための多成分相図を利用した操作設計2019

    • Author(s)
      工藤翔慈、滝山博志
    • Organizer
      分離技術会年会2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of Continuous Flow Production Process with High Shear Field for Reaction Crystallization2019

    • Author(s)
      Shuntaro AMARI, Chinami SUGAWARA, Hiroshi TAKIYAMA
    • Organizer
      18th Asian Pacific Confederation of Chemical Engineering Congress (APCChE 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of the size of rotating elements on the performance of horizontal distillation column2019

    • Author(s)
      Yumi Uno, Ken-Ichiro Sotowa, Yusuke Shimada and Toshihide Horikawa
    • Organizer
      The 32nd International Symposium on Chemical Engineering
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 反応晶析にpH-溶解度プロファイルを用いた結晶粒子群の凝集制御2018

    • Author(s)
      大山満希、工藤翔慈、滝山博志
    • Organizer
      分離技術会年会2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effect of gas-liquid slug length on the mass transfer rate in microchannel2018

    • Author(s)
      Junya Matsushita, Ken-Ichiro Sotowa, Toshihide Horikawa and Jesus Rafael Alcantara Avila
    • Organizer
      The 31st International Symposium on Chemical Engineering
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of shear flow on mass transfer rate around a crystal2018

    • Author(s)
      Natsuki Kitagawa, Ken-Ichiro Sotowa, Toshihide Horikawa and Jesus Rafael Alcantara Avila
    • Organizer
      The 31st International Symposium on Chemical Engineering
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Numerical Investigation of the effect of bend on the gas absorption rate in microchannels2018

    • Author(s)
      Takumi Nishimoto, Ken-Ichiro Sotowa, Toshihide Horikawa and Jesus Rafael Alcantara Avila
    • Organizer
      2018 AIChE Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of rotating elements on HEPT of a horizontal distillation column2018

    • Author(s)
      Shimada Yuusuke, Yumi Uno, Ken-Ichiro Sotowa, Jesus Rafael Alcantara Avila and Toshihide Horikawa
    • Organizer
      2018 AIChE Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Numerical Analysis of Interfacial Mass Transfer Rate of Deforming Fluid Slugs in Microchannels2018

    • Author(s)
      Ken-Ichiro Sotowa, Takumi Nishimoto, Shunsuke Miyai, Toshihide Horikawa and Jesus Rafael Alcantara Avila
    • Organizer
      International Conference on Micro Reaction Technology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of interfacial mass transfer rate in microchannels2018

    • Author(s)
      Ken-Ichiro Sotowa
    • Organizer
      International symposium on the fluidized beds and multi-phase flow reactor
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 晶析装置内における単一結晶周りの流動状態と物質 移動速度2018

    • Author(s)
      北川 菜月, 外輪 健一郎, 堀河 俊英, アルカンタラ アビラ ヘスース ラファエル
    • Organizer
      化学工学会第50回秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マイクロ・フロー合成における化学プロセス技術の考察と展望2018

    • Author(s)
      外輪 健一郎
    • Organizer
      マイクロプロセス最前線シリーズ -来たるべき変革に向けた始動-
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Anti-solvent添加晶析を併用した共結晶製造での結晶品質制御2018

    • Author(s)
      西丸萌々子,工藤翔慈,滝山博志
    • Organizer
      化学工学会第83年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Anti-solvent添加を併用した共結晶粒子群製造での品質制御手法の検討2017

    • Author(s)
      西丸萌々子,工藤翔慈,滝山博志
    • Organizer
      分離技術会年会2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] スラグ流を活用した貧溶媒晶析技術の検討2017

    • Author(s)
      岡﨑 大周, 外輪 健一郎, 堀河 俊英, アルカンタラ アビラ ヘスース ラファエル
    • Organizer
      日本海水学会第68年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Quality Control during Cocrystallization by Using Two Kinds of Supersaturation Operation2017

    • Author(s)
      Momoko NISHIMARU, Shoji KUDO, Hiroshi TAKIYAMA
    • Organizer
      The 11th International Conference on Separation Science and Technology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Separation performance of a horizontal type distillation system2017

    • Author(s)
      Yusuke Shimada, Ken-Ichiro Sotowa, Jesus Rafael Alcantara Avila and Toshihide Horikawa
    • Organizer
      The 11th International Conference on Separation Science and Technology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Continuous anti-solvent crystallization of glycine using slug flow2017

    • Author(s)
      Taishu Okazaki, Ken-Ichiro Sotowa, Toshihide Horikawa and Jesus Rafael Alcantara Avila
    • Organizer
      The 11th International Conference on Separation Science and Technology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Flow around a single crystal and the mass transfer rate2017

    • Author(s)
      Natsuki Kitagawa, Ken-Ichiro Sotowa, Toshihide Horikawa and Jesus Rafael Alcantara Avila
    • Organizer
      The 30th International Symposium on Chemical Engineering
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Continuous anti-solvent crystallization using gas-liquid slug flow generated in microchannel2017

    • Author(s)
      Taishu Okazaki, Ken-Ichiro Sotowa, Toshihide Horikawa and Jesus Rafael Alcantara Avila
    • Organizer
      The 30th International Symposium on Chemical Engineering
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] スラグ流を用いた貧溶媒晶析における結晶品質制御2017

    • Author(s)
      岡﨑 大周, 外輪 健一郎, 堀河 俊英, アルカンタラ アビラ ヘスース ラファエル
    • Organizer
      化学工学会 第49回秋季大会
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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