|Budget Amount *help
¥41,860,000 (Direct Cost: ¥32,200,000、Indirect Cost: ¥9,660,000)
Fiscal Year 2020: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2019: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2018: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2017: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
|Outline of Final Research Achievements
New neurons are continuously generated from neural stem cells in the postnatal brain. These new neurons migrate toward their destinations, where they are differentiated into mature neurons. After brain injuries, new neurons migrate toward the injured area for regeneration. Neuronal migration is restricted by the meshwork of activated astrocytes. Radial glial fibers in the injured neonatal mouse brain provide a scaffold on which new neurons migrate toward the injured cerebral cortex. New neuron migration toward the lesion can be promoted by clearing the path of astrocytic processes, and by inserting artificial scaffolds that mimic the endogenous scaffolds. These treatments facilitate neuronal regeneration and neurological recovery. These findings suggest that strategies designed to help migrating neurons reach the lesion may improve stem/progenitor cell-based therapies for brain injury.