|Budget Amount *help
¥41,730,000 (Direct Cost: ¥32,100,000、Indirect Cost: ¥9,630,000)
Fiscal Year 2020: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2019: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2018: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2017: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
|Outline of Final Research Achievements
We have developed an on-demand genome editing system that enables arbitrary genetic modification by combining CRISPR/Cas9 genome editing technology with lentiviral vectors and ES cells, which are the applicant's specialties. In addition, using the developed genome editing technology and animals, we conducted functional analysis of testis-specific expressed genes to clarify the mechanisms of spermatogenesis and acquisition of sperm function.