|Budget Amount *help
¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2019: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2018: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2017: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
|Outline of Final Research Achievements
We found that there are many protein aggregates in lysosomes during senescence induction. These aggregates triggers activation of CaMKII-p38MAPK-IL-1 alpha-NF-kB axis, leading to the induction of SASP. Survival of senescent cells depends on activation of glutaminolysis and its inhibition induces mortality specifically in senescent cells. We develop mouse model in which senescent cells are visualized and can be analyzed at a single cell level. We also develop mouse model in which senescence induction can be regulated. Interestingly, aging process appears to be accelerated in these mouse after induction of senescence.