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Elucidation of the regulatory mechanism of amino acid metabolism in response to stress

Research Project

Project/Area Number 17H01503
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Animal production science
Research InstitutionKyushu University

Principal Investigator

Furuse Mitsuhiro  九州大学, 農学研究院, 教授 (30209176)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000)
Fiscal Year 2019: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2018: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2017: ¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
Keywordsストレス / アミノ酸 / ニューロペプチドY / 乳汁 / ヒナ / 体温 / 脳 / 代謝 / アルギニン / シトルリン / オルニチン / 催眠作用 / 神経ペプチド / 消化管 / 筋肉 / 暑熱ストレス / ゴナドトロピン抑制ホルモン / 酸化ストレス / ポリフェノール / ストレッサー / 行動 / 拘束ストレス / D-アルギニン / L-ロイシン / タウリン / アンセリン / ミルク / 脳・神経 / 栄養学 / 畜産学 / 生体機能利用
Outline of Final Research Achievements

The effect of suppressing the increase in body temperature was confirmed by oral administration of the live bacterial culture medium containing L-citrulline or the watermelon rind rich in L-citrulline. Central administration of neuropeptide Y increased plasma taurine and anserine concentrations under high environmental temperature. In ovo injection of L-leucine into broiler eggs imparted heat resistance to male chicks after hatching, and attenuated elevation of arginine in diencephalon and liver due to high environmental temperature.
Restraint stress on lactating mother mice promoted the transfer of taurine into milk. Dietary L-serine increased free L-serine levels in milk. Oral administration of D-arginine rapidly transferred to the cerebral cortex, hypothalamus, and milk. L-Ornithine was rapidly metabolized to L-citrulline, increasing the levels of L-proline and glycine, which are important components of collagen, in the skin.

Academic Significance and Societal Importance of the Research Achievements

優秀な遺伝子を選抜し、栄養的に優れた飼料を与えたとしても家畜・家禽は十分にその能力を発揮できないことがある。その一因がストレスであり、軽減のために飼育環境の改善が求められている。特に幼い動物はストレス負荷の影響を受けやすく、施設などの改善に留まらず、動物の内面からのストレス軽減方法を見出すことは学術的に意義がある。そこでアミノ酸を用いて検討した。
社会に及ぼす影響としては、暑熱ストレスによる負荷が増大する中、化石燃料を用いて施設の環境温度を下げるのではなくアミノ酸を用いることにより体温上昇を軽減できることを示した。また、乳汁の遊離アミノ酸の濃度の制御が可能であることも認めた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (45 results)

All 2020 2019 2018 2017 Other

All Journal Article (18 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 18 results,  Open Access: 11 results) Presentation (25 results) (of which Int'l Joint Research: 2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Oral Administration of Watermelon Rind Extract to Induce Hypothermia in Chicks2020

    • Author(s)
      Nguyen Linh T.N.、Eltahan Hatem M.、Pham Cuong V.、Han Guofeng、Chowdhury Vishwajit S.、Furuse Mitsuhiro
    • Journal Title

      The Journal of Poultry Science

      Volume: 57 Issue: 1 Pages: 37-44

    • DOI

      10.2141/jpsa.0190054

    • NAID

      130007792223

    • ISSN
      1346-7395, 1349-0486
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intracerebroventricular Injection of L-Pipecolic Acid Exerts Hypnotic Effects Without Activating NMDA Receptors in Neonatal Chicks under Social Isolation-induced Stress2020

    • Author(s)
      Shigemura, A., Chowdhury, V.S. and Furuse, M.
    • Journal Title

      The Journal of Poultry Science

      Volume: 57 Issue: 1 Pages: 84-87

    • DOI

      10.2141/jpsa.0190067

    • NAID

      130007792193

    • ISSN
      1346-7395, 1349-0486
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Orally administrated D-arginine exhibits higher enrichment in the brain and milk than L-arginine in ICR mice2020

    • Author(s)
      Aso, K., Nishigawa, T., Nagamachi, S., Takakura, M. and Furuse, M.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 82 Issue: 3 Pages: 307-313

    • DOI

      10.1292/jvms.19-0630

    • NAID

      130007805850

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nutritional Characteristics and Functions of D-Amino Acids in the Chicken2020

    • Author(s)
      Tomonaga, S. and Furuse, M.
    • Journal Title

      The Journal of Poultry Science

      Volume: 57 Issue: 1 Pages: 18-27

    • DOI

      10.2141/jpsa.0190062

    • NAID

      130007792232

    • ISSN
      1346-7395, 1349-0486
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of oral administration of yoghurt whey on free amino acid concentration in rat brains2019

    • Author(s)
      Kawase, T. and Furuse, M.
    • Journal Title

      Journal of Pet Animal Nutrition

      Volume: 22 Issue: 2 Pages: 84-94

    • DOI

      10.11266/jpan.22.2_84

    • NAID

      130007739736

    • ISSN
      1344-3763, 2185-7601
    • Year and Date
      2019-10-10
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral administration of L-ornithine increases the content of both collagen constituting amino acids and polyamines in mouse skin2019

    • Author(s)
      Harada, D., Nagamachi, S., Aso, K., Ikeda, K., Takahasi, Y. and Furuse, M.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 81 Issue: 4 Pages: 1-11

    • DOI

      10.1016/j.bbrc.2019.03.147

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased stress-induced depression-like behavior in lactating rats is associated with changes in the hypothalamic-pituitary-adrenal axis, brain monoamines, and brain amino acid metabolism2019

    • Author(s)
      Hamada, M., Nishigawa, T., Maesono, S., Aso, K., Ikeda, H. and Furuse, M.
    • Journal Title

      Stress

      Volume: 22 Issue: 4 Pages: 482-491

    • DOI

      10.1080/10253890.2019.1584179

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in free amino acid concentrations in milk between Wistar and Wistar Kyoto rats2019

    • Author(s)
      Hamada, M., Ihara, T. and Furuse, M.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 81 Issue: 6 Pages: 838-845

    • DOI

      10.1292/jvms.19-0064

    • NAID

      130007660449

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral Administration of a Medium Containing L-Citrulline-producing Live Bacteria Reduces Body Temperature in Chicks2019

    • Author(s)
      Tran Phuong V.、Do Phong H.、Han Guofeng、Bahry Mohammad A.、Yang Hui、Chowdhury Vishwajit S.、Furuse Mitsuhiro
    • Journal Title

      The Journal of Poultry Science

      Volume: 56 Issue: 4 Pages: 285-289

    • DOI

      10.2141/jpsa.0180136

    • NAID

      130007733393

    • ISSN
      1346-7395, 1349-0486
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Central regulation of feeding behavior through neuropeptides and amino acids in neonatal chicks2019

    • Author(s)
      Tran, P.V., Chowdhury, V.S. and Furuse, M.
    • Journal Title

      Amino Acids

      Volume: 51 Issue: 8 Pages: 1129-1152

    • DOI

      10.1007/s00726-019-02762-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of in ovo feeding of L-leucine on amino acids metabolism and heat-shock protein-70, and -90 mRNA expression in heat-exposed chicks.2019

    • Author(s)
      Han, G., Yang, H., Ikeda, H., Wang, Y., Zhang, R., Tashiro, K., Bungo, T., Furuse, M. and Chowdhury, V.S.
    • Journal Title

      Poultry Science,

      Volume: 98 Issue: 3 Pages: 1243-1253

    • DOI

      10.3382/ps/pey444

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Flavangenol regulates gene expression of HSPs, anti-apoptotic and anti-oxidative factors to protect primary chick brain cells exposed to high temperature2019

    • Author(s)
      Yang H, Chowdhury VS, Han G, Zhang R, Furuse M.
    • Journal Title

      Journal of Thermal Biology

      Volume: 81 Pages: 1-11

    • DOI

      10.1016/j.jtherbio.2019.02.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reduction in voluntary food intake, but not fasting, stimulates hypothalamic gonadotropin-inhibitory hormone precursor mRNA expression in chicks under heat stress2018

    • Author(s)
      Bahry MA, Yang H, Tran PV, Do PH, Han G, Eltahan HM, Chowdhury VS, Furuse M.
    • Journal Title

      Neuropeptides

      Volume: 71 Pages: 90-96

    • DOI

      10.1016/j.npep.2018.09.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Taurine and β-alanine intraperitoneal injection in lactating mice modifies the growth and behavior of offspring2018

    • Author(s)
      Nishigawa Takuma、Nagamachi Satsuki、Chowdhury Vishwajit S.、Yasuo Shinobu、Furuse Mitsuhiro
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 495 Issue: 2 Pages: 2024-2029

    • DOI

      10.1016/j.bbrc.2017.12.063

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In ovo L -leucine administration stimulates lipid metabolisms in heat-exposed male, but not female, chicks to afford thermotolerance2018

    • Author(s)
      Han Guofeng、Yang Hui、Bungo Takashi、Ikeda Hiromi、Wang Yunhao、Nguyen Linh T.N.、Eltahan Hatem M.、Furuse Mitsuhiro、Chowdhury Vishwajit S.
    • Journal Title

      Journal of Thermal Biology

      Volume: 71 Pages: 74-82

    • DOI

      10.1016/j.jtherbio.2017.10.020

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dietary L-serine modifies free amino acid composition of maternal milk and lowers the body weight of the offspring in mice2018

    • Author(s)
      NAGAMACHI Satsuki、NISHIGAWA Takuma、TAKAKURA Mayumi、IKEDA Hiromi、KODAIRA Momoko、YAMAGUCHI Takeshi、CHOWDHURY Vishwajit Sur、YASUO Shinobu、FURUSE Mitsuhiro
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 2 Pages: 235-241

    • DOI

      10.1292/jvms.17-0577

    • NAID

      130006339622

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Restraint stress in lactating mice alters the levels of sulfur-containing amino acids in milk2018

    • Author(s)
      NISHIGAWA Takuma、NAGAMACHI Satsuki、IKEDA Hiromi、CHOWDHURY Vishwajit S.、FURUSE Mitsuhiro
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 3 Pages: 503-509

    • DOI

      10.1292/jvms.17-0661

    • NAID

      130006588561

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Central NPY-Y5 sub-receptor partially functions as a mediator of NPY-induced hypothermia and affords thermotolerance in heat-exposed fasted chicks2017

    • Author(s)
      Eltahan Hatem M.、Bahry Mohammad A.、Yang Hui、Han Guofeng、Nguyen Linh T. N.、Ikeda Hiromi、Ali Mohamed N.、Amber Khairy A.、Furuse Mitsuhiro、Chowdhury Vishwajit S.
    • Journal Title

      Physiological Reports

      Volume: 5 Issue: 23

    • DOI

      10.14814/phy2.13511

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 母マウスへの D-アルギニンまたは D-セリン投与が仔マウスの成長および行動に及ぼす影響2019

    • Author(s)
      麻生 賢太,池田 和輝,原田 大暉,古瀬 充宏
    • Organizer
      日本アミノ酸学会第13回学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 急性ストレスが皮膚のアミノ酸代謝に及ぼす影響2019

    • Author(s)
      早川 佳歩,麻生 賢太,池田 和輝,原田 大暉,古瀬 充宏
    • Organizer
      日本アミノ酸学会第13回学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 骨格筋のアミノ酸代謝に及ぼす β-ヒドロキシβ-メチルブチレート(HMB)の影響2019

    • Author(s)
      池田 和輝,原田 大暉,早川 佳歩,古瀬 充宏
    • Organizer
      日本アミノ酸学会第13回学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 輸送ストレスが黒毛和牛の血漿遊離アミノ酸濃度に及ぼす影響について2019

    • Author(s)
      尾川寅太,稲田淳,深水大,渡邉美佐江,池田和輝,原田大暉,浜田瑞貴,古瀬充宏
    • Organizer
      第126回日本畜産学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] L-Leucine stimulates growth in heat-exposed broilers2019

    • Author(s)
      Chowdhury VS, Han G, Bungo T, Tashiro K, Furuse M,
    • Organizer
      第125回日本畜産学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Neuropeptide Y plays an anti-stress role in heat-exposed chicks2018

    • Author(s)
      Chowdhury VS, Cockrem JF, Furuse M.
    • Organizer
      8th Intercongress Symposium of the Asia and Oceania Society for Comparative Endcrinology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Oral administration of L-citrulline affords thermotolerance in heat-exposed broilers2018

    • Author(s)
      Chowdhury VS, Han G, Shiraishi J, Sugino T, Furuse M, Bungo, T.
    • Organizer
      18th AAAP Animal Science Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] スイカ外皮抽出物の経口投与はヒナに低体温症をもたらす2018

    • Author(s)
      リン T. N. グェン・ハテム M. エルタハン・クオン V. ファム・韓 国鋒・ スルチードリ ビシュワジット・古瀬 充宏
    • Organizer
      日本家禽学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] タウリンの中枢投与はヒナに低体温を引き起こすが、経口投与では逆に体温上昇を誘発する2018

    • Author(s)
      ハテム M. エルタハン・韓 国鋒・楊 輝・リン T. N. グェン・ クオン・ヴァン・ファム・古瀬 充宏・スルチードリ ビシュワジット
    • Organizer
      日本家禽学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 卵内へのロイシン投与はブロイラーのアミノ酸代謝及び熱ショックタンパク質遺伝子発現量に影響する2018

    • Author(s)
      韓 国鋒・楊 輝・田代 康介・豊後 貴嗣・古瀬 充宏・スルチードリ ビシュワジット
    • Organizer
      日本家禽学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] In ovo administration of L-leucine, but not oral or central, improves thermotolerance in chicks2018

    • Author(s)
      Han G, Yang H, Tashiro K, Bungo T, Furuse M, Chowdhury VS
    • Organizer
      日本家禽学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effects of pine bark extract (flavangenol) on the expression of heat-shock proteins and related other genes in heat-exposed chick brain cells2018

    • Author(s)
      Yang H, Han G, Zhang R, Chowdhury VS, Furuse M
    • Organizer
      日本家禽学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マウスの肝臓と皮膚におけるL-オルニチンの単回経口投与による遊離アミノ酸およびポリアミンの変化2018

    • Author(s)
      原田 大暉・長町 さつ・麻生 健太・池田 和輝・高橋 芳弘・安尾 しのぶ・古瀬 充宏
    • Organizer
      日本アミノ酸学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 2系統ラット間の妊娠前後の行動および授乳期の血漿・母乳中遊離アミノ酸濃度2018

    • Author(s)
      浜田 瑞貴・井原 翼・安尾 しのぶ・古瀬 充宏
    • Organizer
      日本アミノ酸学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] L-ロイシンの卵内投与は暑熱ストレスによる雄ブロイラー雛のアミノ酸代謝を変化させる2018

    • Author(s)
      韓 国鋒・楊 輝・田代 康介・豊後 貴司・古瀬 充宏・スルチョードリビシュワジット
    • Organizer
      日本アミノ酸学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] D-およびL-アルギニンの経口投与が母マウスの乳汁遊離アミノ酸組成に及ぼす影響2018

    • Author(s)
      麻生 賢太・長町 さつき・ 安尾 しのぶ・古瀬 充宏
    • Organizer
      日本アミノ酸学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 卵内へのロイシン投与は出荷日齢ブロイラーの脂質代謝に影響を与えず熱耐性を誘導する2018

    • Author(s)
      韓 国鋒・楊 輝・豊後 貴嗣・古瀬 充宏・スルチードリ ビシュワジット
    • Organizer
      日本家禽学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Different modes of L-leucine in ovo feeding on embryonic growth and rectal temperature in chicks2018

    • Author(s)
      韓国鋒・楊輝・池田裕美・豊後貴嗣・古瀬充宏・Sur Chowdhury Vishwajit
    • Organizer
      第124回日本畜産学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 授乳期間中の母マウスへのタウリン及びβ‐アラニン投与が仔マウスの初期成長と行動に及ぼす影響2017

    • Author(s)
      西川琢磨・長町さつき・浜田瑞貴・池田裕美・スルチョードリ ビシュワジット・安尾 しのぶ・古瀬充宏
    • Organizer
      日本アミノ酸学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 妊娠・出産およびストレスが母体の行動やアミノ酸代謝に及ぼす影響2017

    • Author(s)
      浜田瑞貴・西川琢磨・前園沙織・麻生賢太・池田裕美・スルチョードリ ビシュワジット・安尾 しのぶ・古瀬 充宏
    • Organizer
      日本アミノ酸学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 経口投与によるL-アルギニンおよびD-アルギニンの脳への取り込みについて2017

    • Author(s)
      麻生賢太・池田裕美・西川琢磨・黒木優美・山本恵理・浅見幸夫・安尾 しのぶ・古瀬 充宏
    • Organizer
      日本アミノ酸学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] L-ロイシンの卵内投与はブロイラー雛の脂質代謝および耐熱性を変化させる2017

    • Author(s)
      韓 国鋒・楊 輝・豊後 貴嗣・池田裕美・古瀬 充宏・スルチードリ ビシュワジット
    • Organizer
      日本アミノ酸学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] L-Leucine in ovo injection stimulates lipid metabolisms and affords thermotolerance in male broiler chicks2017

    • Author(s)
      Han, G., Yang, H., Ikeda, H., Bungo, T., Furuse, M., Chowdhury, V.S.
    • Organizer
      第123回日本畜産学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Chronic administration of pine bark extract (flavangenol) attenuates brain HSPs mRNA expressions in in vivo and in vitro2017

    • Author(s)
      Yang, H., Chowdhury, V.S., Han, G., Furuse, M.
    • Organizer
      第123回日本畜産学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Maternal stress influences the sulfur amino acid levels in milk and the growth of offspring2017

    • Author(s)
      Nishigawa, T., Nagamachi, S., Ikeda, H., Hamada, M., Chowdhury, V.S., Shinobu Yasuo, Furuse, M.
    • Organizer
      第123回日本畜産学会
    • Related Report
      2017 Annual Research Report
  • [Book] The Neuroscience of Aging2020

    • Author(s)
      Furuse, M.
    • Publisher
      Elsevier
    • Related Report
      2019 Annual Research Report
  • [Remarks] 研究者情報

    • URL

      https://hyoka.ofc.kyushu-u.ac.jp/search/details/K000452/

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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