|Budget Amount *help
¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000)
Fiscal Year 2020: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2019: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2018: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2017: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
|Outline of Final Research Achievements
Food allergy that often occurs in young children are now a major social problem in Japan. However, basic research on its onset, progression, and remission has not progressed. The development of management and treatment methods for this disease has been delayed. In this study, we found (1) a bioactive lipid called prostaglandin D2 (PGD2) produced by mast cells regulates the absorption of antigen and the production of IgE antibody against antigen. (2) the produced PGD2 inhibit allergic inflammation. (3) PGD2 also affects immune tolerance for food antigen. Based on these observations, we could provide some insight for management of food allergy by pharmacological stimulation/inhibition of PGD2 production and its receptor signaling.