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Analysis of oncogenesis and heterogenesity in nasopharyngeal carcinoma and development of novel therapy

Research Project

Project/Area Number 17H01590
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKanazawa University

Principal Investigator

Yoshizaki Tomokazu  金沢大学, 医学系, 教授 (70262582)

Co-Investigator(Kenkyū-buntansha) 杉本 寿史  金沢大学, 附属病院, 講師 (20547179)
遠藤 一平  金沢大学, 附属病院, 助教 (30547154)
波多野 都  金沢大学, 附属病院, 助教 (30557484)
近藤 悟  金沢大学, 附属病院, 講師 (70436822)
脇坂 尚宏  金沢大学, 医学系, 准教授 (70377414)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥39,390,000 (Direct Cost: ¥30,300,000、Indirect Cost: ¥9,090,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2018: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2017: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Keywords上咽頭癌 / Epstein-Barr ウイルス / APOBEC / オートファジー / 細胞競合 / LMP1 / 内因性免疫 / 癌 / ウイルス / EBV / 多様性 / ウィルス
Outline of Final Research Achievements

We developed patients derived xenograft of nasopharyngeal carcinoma (NPC) mice model and applied to analysis of heterogeneity in NPC tumor. APOBEC family that induce DNA mutations not only in EBV-DNA but in both host and mitochondria DNA, eventually, produce cancer stem cell and progression of heterogeneity of malignant cells. These results indicate that mutation inducing property of intrinsic immunity factor act double edge of sword for initiation and progression of NPC. Both promotion of cell competition potential in tumor-neighboring normal epithelial cell by modulating NF-kB, and inhibition of autophagy by chloroquine, are novel and promising treatment strategy for NPC.

Academic Significance and Societal Importance of the Research Achievements

本来、細胞内に侵入したウイルスや細菌のDNAに変異を導入して無効化する内因性免疫因子であるAPOBECは体細胞DNAやミトコンドリアDNAにも変異を導入する。EBV関連癌である上咽頭癌では細胞内EBVによる恒常的APOBEC活性化にさらされており、変異の蓄積は継続的に起こることで癌組織における癌細胞の多様性が獲得されることが明らかとなった点は癌生物学的な意義は大きい。また、新規生物学的現象である細胞競合やオートファジーの制御が今後癌治療に応用可能であることを明らかにした点で社会への還元的意義を有する成果が得られた。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (50 results)

All 2021 2020 2019 2018 2017 2016

All Journal Article (30 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 30 results,  Open Access: 20 results) Presentation (20 results) (of which Int'l Joint Research: 9 results,  Invited: 2 results)

  • [Journal Article] Glial cell type-specific gene expression in the mouse cerebrum using the piggyBac system and in utero electroporation2021

    • Author(s)
      Hamabe-Horiike Toshihide、Kawasaki Kanji、Sakashita Masataka、Ishizu Chihiro、Yoshizaki Tomokazu、Harada Shin-ichi、Ogawa-Ochiai Keiko、Shinmyo Yohei、Kawasaki Hiroshi
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 4864-4864

    • DOI

      10.1038/s41598-021-84210-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In scalp incision for cochlear implantation.2021

    • Author(s)
      Sugimoto H, Hatano M, Yoshizaki T
    • Journal Title

      Clinical Otolaryngology

      Volume: 46 Issue: 1 Pages: 101-105

    • DOI

      10.1111/coa.13630

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epstein?Barr Virus LMP1 Induces Soluble PD-L1 in Nasopharyngeal Carcinoma2021

    • Author(s)
      Kase Kina、Kondo Satoru、Wakisaka Naohiro、Dochi Hirotomo、Mizokami Harue、Kobayashi Eiji、Kano Makoto、Komori Takeshi、Hirai Nobuyuki、Ueno Takayoshi、Nakanishi Yosuke、Hatano Miyako、Endo Kazuhira、Moriyama-Kita Makiko、Sugimoto Hisashi、Yoshizaki Tomokazu
    • Journal Title

      Microorganisms

      Volume: 9 Issue: 3 Pages: 603-603

    • DOI

      10.3390/microorganisms9030603

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] EBV-LMP1 induces APOBEC3s and mitochondrial DNA hypermutation in nasopharyngeal cancer2020

    • Author(s)
      Wakae K, Kondo S, Pham HT, Wakisaka N, Que L, Li Y, Zheng X, Fukano K, Kitamura K, Watashi K, Aizaki H, Ueno T, Moriyama-Kita M, Ishikawa K, Nakanishi Y, Endo K, Muramatsu M, Yoshizaki T.
    • Journal Title

      Cancer Med

      Volume: 20 Issue: 20 Pages: 7663-7671

    • DOI

      10.1002/cam4.3357

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influences of Semaphorin 3A Expression on Clinicopathological Features, Human Papillomavirus Status, and Prognosis in Oropharyngeal Carcinoma2020

    • Author(s)
      Pham Hai Thanh、Kondo Satoru、Endo Kazuhira、Wakisaka Naohiro、Aoki Yoshitaka、Nakanishi Yosuke、Kase Kina、Mizokami Harue、Kano Makoto、Ueno Takayoshi、Hatano Miyako、Moriyama-Kita Makiko、Sugimoto Hisashi、Yoshizaki Tomokazu
    • Journal Title

      Microorganisms

      Volume: 8 Issue: 9 Pages: 1286-1286

    • DOI

      10.3390/microorganisms8091286

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deletion of CD38 and supplementation of NAD + attenuate axon degeneration in a mouse facial nerve axotomy model2020

    • Author(s)
      Takaso Y, Noda M, Hattori T, Roboon J, Hatano M, Sugimoto H, Brenner C, Yamamoto Y, Okamoto H, Higashida H, Ito M, Yoshizaki T, Hori O.
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 17795-17795

    • DOI

      10.1038/s41598-020-73984-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Attempting to define sentinel node micrometastasis in oral squamous cell carcinoma2020

    • Author(s)
      Matsuzuka Takashi、Uemura Hirokazu、Yoshimoto Seiichi、Miura Kouki、Shiotani Akihiro、Sugasawa Masashi、Homma Akihiro、Yokoyama Junkichi、Tsukahara Kiyoaki、Yoshizaki Tomokazu、Yatabe Yasushi、Kobari Takehiro、Kosuda Shigeru、Murono Shigeyuki、Hasegawa Yasuhisa
    • Journal Title

      FUKUSHIMA JOURNAL OF MEDICAL SCIENCE

      Volume: 66 Issue: 3 Pages: 143-147

    • DOI

      10.5387/fms.2020-17

    • NAID

      130007952823

    • ISSN
      0016-2590, 2185-4610
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low Skeletal Muscle Mass Is a Risk Factor for Aspiration Pneumonia During Chemoradiotherapy2020

    • Author(s)
      Endo Kazuhira、Ueno Takayoshi、Hirai Nobuyuki、Komori Takeshi、Nakanishi Yosuke、Kondo Satoru、Wakisaka Naohiro、Yoshizaki Tomokazu
    • Journal Title

      The Laryngoscope

      Volume: 131 Issue: 5 Pages: 1524-1529

    • DOI

      10.1002/lary.29165

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modified meatotympanoplasty for external auditory canal stenosis and lateralized tympanic membrane: a preliminary study2020

    • Author(s)
      Kase Kina、Ito Makoto、Hatano Miyako、Sugimoto Hisashi、Shimada Mari、Yoshizaki Tomokazu
    • Journal Title

      Acta Oto-Laryngologica

      Volume: 140 Issue: 4 Pages: 327-332

    • DOI

      10.1080/00016489.2020.1714723

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of Semaphorin 3A is a Marker Associated with Poor Prognosis in Patients with Nasopharyngeal Carcinoma.2019

    • Author(s)
      Imoto T, Kondo S, Wakisaka N, Hai PT, Seishima N, Kano M, Ueno T, Mizokami H, Nakanishi Y, Hatano M, Endo K, Sugimoto H, Moriyama-Kita M, Yoshizaki T.
    • Journal Title

      Microorganisms

      Volume: 17 Issue: 3 Pages: 423-423

    • DOI

      10.3390/microorganisms8030423

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microglial activation in the cochlear nucleus after early hearing loss in rats.2019

    • Author(s)
      Noda M, Hatano M, Hattori T, Takarada-Iemata M, Shinozaki T, Sugimoto H, Ito M, Yoshizaki T, Hori O.
    • Journal Title

      Auris Nasus Larynx.

      Volume: 印刷中 Issue: 5 Pages: 716-723

    • DOI

      10.1016/j.anl.2019.02.006

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of estrogen receptor alpha is associated with pathogenesis and prognosis of human papillomavirus‐positive oropharyngeal cancer2019

    • Author(s)
      Kano Makoto、Kondo Satoru、Wakisaka Naohiro、Wakae Kosho、Aga Mituharu、Moriyama‐Kita Makiko、Ishikawa Kazuya、Ueno Takayoshi、Nakanishi Yosuke、Hatano Miyako、Endo Kazuhira、Sugimoto Hisashi、Kitamura Kouichi、Muramatsu Masamichi、Yoshizaki Tomokazu
    • Journal Title

      International Journal of Cancer

      Volume: 145 Issue: 6 Pages: 1547-1557

    • DOI

      10.1002/ijc.32500

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bone invasion‐targeted chemotherapy with a novel anionic platinum complex (3Pt) for oral squamous cell carcinoma2019

    • Author(s)
      Kasahara Yoshiya、Endo Kazuhira、Ueno Takayoshi、Ueno Haruna、Moriyama‐Kita Makiko、Odani Akira、Yoshizaki Tomokazu
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 10 Pages: 3288-3295

    • DOI

      10.1111/cas.14145

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells2019

    • Author(s)
      Kobayashi Eiji、Hwang Duhyeong、Bheda-Malge Anjali、Whitehurst Christopher B.、Kabanov Alexander V.、Kondo Satoru、Aga Mitsuharu、Yoshizaki Tomokazu、Pagano Joseph S.、Sokolsky Marina、Shakelford Julia
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 15 Pages: 3733-3733

    • DOI

      10.3390/ijms20153733

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Third Epidemiological Analysis of Nasopharyngeal Carcinoma in the Central Region of Japan from 2006 to 20152019

    • Author(s)
      Kanno M, Narita N, Fujimoto Y, Wakisaka N, Yoshizaki T, Kodaira T, Makita C, Sato Y, Yamazaki K, Wakaoka T, Shimode Y, Tsuji H, Kito R, Ishinaga H, Hosokawa S, Takakura H, Nishimura K, Matoba T, Fujieda S.
    • Journal Title

      Cancers

      Volume: 11 Issue: 8 Pages: 1180-1180

    • DOI

      10.3390/cancers11081180

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of l-carnitine administration on health-related quality of life during cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma2019

    • Author(s)
      Endo Kazuhira、Ueno Takayoshi、Ishikawa Kazuya、Nakanishi Yosuke、Kondo Satoru、Wakisaka Naohiro、Yoshizaki Tomokazu
    • Journal Title

      Auris Nasus Larynx

      Volume: 46 Issue: 3 Pages: 431-436

    • DOI

      10.1016/j.anl.2018.10.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study2019

    • Author(s)
      Burtness B, Harrington KJ, Greil R, Soulieres D, Tahara M, de Castro G Jr, Psyrri A, Basté N, Neupane P, Bratland A, Fuereder T, Hughes BGM, Mesia R, Ngamphaiboon N, Rordorf T, Wan Ishak WZ, Hong RL, Gonzalez Mendoza R, Roy A, Zhang Y, Gumuscu B, Cheng JD, Jin F, Rischin D; KEYNOTE-048 Investigators.
    • Journal Title

      The Lancet

      Volume: 394 Issue: 10212 Pages: 1915-1928

    • DOI

      10.1016/s0140-6736(19)32591-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Superior mediastinal lymphadenopathy by silicosis mimicking metastasis of papillary thyroid carcinoma ? Case report and literature review2019

    • Author(s)
      Tsukatani Toshiaki、Niwa Hideki、Komori Takeshi、Yoneyama Tatsuya、Tsuji Hiroyuki、Michigishi Takatoshi、Yokoyama Kunihiko、Yoshizaki Tomokazu
    • Journal Title

      Auris Nasus Larynx

      Volume: - Issue: 6 Pages: 1054-1057

    • DOI

      10.1016/j.anl.2019.12.003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of sentinel lymph node using contrast-enhanced agent, Sonazoid?, and evaluation of its metastasis with superb microvascular imaging in oral and oropharyngeal cancers: a preliminary clinical study2019

    • Author(s)
      Wakisaka Naohiro、Endo Kazuhira、Kitazawa Tomohiro、Shimode Yuzo、Kato Koroku、Moriyama-Kita Makiko、Koda Wataru、Ikeda Hiroko、Ishikawa Kazuya、Ueno Takayoshi、Nakanishi Yosuke、Kondo Satoru、Sugimoto Hisashi、Yoshimura Kenichi、Tsuji Hiroyuki、Kawashiri Shuichi、Omoto Kiyoka、Yoshizaki Tomokazu
    • Journal Title

      Acta Oto-Laryngologica

      Volume: 139 Issue: 1 Pages: 94-99

    • DOI

      10.1080/00016489.2018.1535193

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inhibition of autophagy by chloroquine makes chemotherapy in nasopharyngeal carcinoma more efficient2019

    • Author(s)
      Aga Tomomi、Endo Kazuhira、Tsuji Akira、Aga Mitsuharu、Moriyama-Kita Makiko、Ueno Takayoshi、Nakanishi Yosuke、Hatano Miyako、Kondo Satoru、Sugimoto Hisashi、Wakisaka Naohiro、Yoshizaki Tomokazu
    • Journal Title

      Auris Nasus Larynx

      Volume: 46 Issue: 3 Pages: 443-450

    • DOI

      10.1016/j.anl.2018.10.013

    • NAID

      130007936124

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation2018

    • Author(s)
      Wakae Kousho、Nishiyama Tomoaki、Kondo Satoru、Izuka Takashi、Que Lusheng、Chen Cong、Kase Kina、Kitamura Kouichi、Mohiuddin Md、Wang Zhe、Ahasan Md Monjurul、Nakamura Mitsuhiro、Fujiwara Hiroshi、Yoshizaki Tomokazu、Hosomochi Kazuyoshi、Tajima Atsushi、Nakahara Tomomi、Kiyono Tohru、Muramatsu Masamichi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 9745-9745

    • DOI

      10.1038/s41598-018-27930-z

    • NAID

      120006602143

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] C-Terminal Farnesylation of UCH-L1 Plays a Role in Transport of Epstein-Barr Virus Primary Oncoprotein LMP1 to Exosomes2018

    • Author(s)
      Kobayashi E, Aga M, Kondo S, Whitehurst C, Yoshizaki T, Pagano J. S , Shackelford J
    • Journal Title

      mShpere

      Volume: 3 Issue: 1

    • DOI

      10.1128/msphere.00030-18

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glucocorticoid receptor expression in resident and hematopoietic cells in IgG4-related disease.2018

    • Author(s)
      Iguchi T, Takaori K, Mii A, Sato Y, Suzuki Y, Yoshifuji H, Seno H, Ogawa O, Omori K, Bessho K, Kondo S, Yoshizaki T, Nakashima H, Saito T, Mimori T, Haga H, Kawano M, Yanagita M.
    • Journal Title

      Mod Pathol.

      Volume: - Issue: 6 Pages: 890-899

    • DOI

      10.1038/s41379-018-0036-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reply to the Letter to the Editor concerning "Combined microscopic/endoscopic management of petrous apex lesions"2018

    • Author(s)
      Sugimoto H, Hatano M, Noda M, Hasegawa H, Yoshizaki T
    • Journal Title

      Eur Arch Otorhinolaryngol

      Volume: 275 Issue: 1 Pages: 323-323

    • DOI

      10.1007/s00405-017-4834-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and subcellular localisation of AID and APOBEC3 in adenoid and palatine tonsils2018

    • Author(s)
      Seishima Noriko、Kondo Satoru、Wakae Kousho、Wakisaka Naohiro、Kobayashi Eiji、Kano Makoto、Moriyama-Kita Makiko、Nakanishi Yosuke、Endo Kazuhira、Imoto Tomoko、Ishikawa Kazuya、Sugimoto Hisashi、Hatano Miyako、Ueno Takayoshi、Koura Miki、Kitamura Koichi、Muramatsu Masamichi、Yoshizaki Tomokazu
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 918-918

    • DOI

      10.1038/s41598-017-18732-w

    • NAID

      120006602142

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modulation of Tumor Microenvironment by Epstein-Barr virus Latent Membrane Protein-1 in Nasopharyngeal Carcinoma2018

    • Author(s)
      Yoshizaki T, Kondo S, Endo K, Nakanishi Y, Aga M, Kobayashi E, Hirai N, Sugimoto H, Hatano M, Ueno T, Ishikawa K, Wakisaka N
    • Journal Title

      Cancer Sci

      Volume: 109 Issue: 2 Pages: 272-278

    • DOI

      10.1111/cas.13473

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic management of petrous apex cholesteatoma2017

    • Author(s)
      Sugimoto H, Hatano M, Noda M, Hasegawa H, Yoshizaki T
    • Journal Title

      Eur Arch Otorhinolaryngol

      Volume: 274 Issue: 12 Pages: 4127-4130

    • DOI

      10.1007/s00405-017-4763-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of interferon regulatory factor 7 correlates with the expression of Epstein-Barr Virus latent membrane protein 1 and cervical lymph node metastasis in nasopharyngeal cancer2017

    • Author(s)
      Kondo S, Endo K, Wakisaka N, Aga M, Kano M, Seishima N, Imoto T, Kobayashi E, Moriyama-Kita M, Nakanishi Y, Murono S, Pagano JS, Yoshizaki T
    • Journal Title

      Pathology International

      Volume: 67 Issue: 9 Pages: 461-466

    • DOI

      10.1111/pin.12561

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Progression of understanding for the role of Epstein-Barr virus and management of nasopharyngeal carcinoma2017

    • Author(s)
      Nakanishi Y, Wakisaka N, Kondo S, Endo K, Sugimoto H, Hatano M, Ueno T, Ishikawa K, Yoshizaki T
    • Journal Title

      Cancer and Metastasis Review

      Volume: 36 Issue: 3 Pages: 435-447

    • DOI

      10.1007/s10555-017-9693-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Randomized Controlled Trial of Juzen-taiho-to in Children with Recurrent Acute Otitis Media.2016

    • Author(s)
      Ito M, Maruyama Y, Kitamura K, Kobayashi T, Takahashi H, Yamanaka N, Harabuchi Y, Origasa H, Yoshizaki T
    • Journal Title

      Auris Nusus Larynx

      Volume: 該当なし Issue: 4 Pages: 390-397

    • DOI

      10.1016/j.anl.2016.10.002

    • NAID

      130006449195

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] EB ウイルスが引き起こす多彩な疾患2020

    • Author(s)
      吉崎智一
    • Organizer
      第44回日本頭頸部癌学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Effect of Semaphorin 3A on clinicopathological features and prognosis in oropharyngeal carcinoma2020

    • Author(s)
      Pham Hai
    • Organizer
      第44回日本頭頸部癌学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 上咽頭癌においてEBV-LMP1 が誘導するIRF7 の核内発現は転移を促進するか2020

    • Author(s)
      近藤悟、脇坂尚宏、吉崎智一
    • Organizer
      第79回日本癌学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Inhibition of UCH-L1 DUB Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells2020

    • Author(s)
      小林英士、近藤悟、吉崎智一
    • Organizer
      第79回日本癌学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] EBV 関連上咽頭癌における内因性免疫によるミトコンドリア遺伝子変異誘導とその意義2020

    • Author(s)
      近藤悟
    • Organizer
      第121回日本耳鼻咽喉科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] CONCURRENT SUPERSELECTIVE INTRA-ARTERIAL CHEMORADIOTHERAPY FOR ADVANCED TEMPORAL BONE SQUAMOUS CELL CARCINOMA2019

    • Author(s)
      Yoshizaki Tomokazu, Ishikawa Eriko, Sugimoto Hisashi
    • Organizer
      32nd Politzer Society Meeting & 2nd World Congress of Otology
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effects of L-carnitine administration on health-related quality of life during cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma2019

    • Author(s)
      Endo Kazuhira, Ueno Takayoshi, Ishikawa Kazuya, Nakanishi Yosuke, Kondo Satoru, Wakisaka Naohiro, Yoshizaki Tomokazu
    • Organizer
      5th Congress of European ORL-HNS
    • Related Report
      2019 Annual Research Report
  • [Presentation] ROLE OF EPSTEIN-BARR VIRUS AND ALTERNATING CHEMORADIOTHERAPY IN NASOPHARYNGEAL CARCINOMA2019

    • Author(s)
      Yoshizaki Tomokazu
    • Organizer
      AAO-HNSF Annual Meeting & OTO Experience
    • Related Report
      2019 Annual Research Report
  • [Presentation] THE INFLUENCE OF HUMAN PAPILLOMAVIRUS ON NASOPHARYNGEAL CARCINOMA IN JAPAN.2019

    • Author(s)
      Yoshizaki Tomokazu
    • Organizer
      EUROGIN 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] HPV-status determines the efficacy of an oral fluoropyrimidine, S-1, in oropharyngeal carcinoma.2019

    • Author(s)
      Wakisaka Naohiro, Yoshizaki Tomokazu
    • Organizer
      15th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
    • Related Report
      2019 Annual Research Report
  • [Presentation] Distinct mode of invasion in HPV associate and non-associated oropharyngeal squamous cell carcinoma2018

    • Author(s)
      Tomokazu Yoshizaki
    • Organizer
      17th Japan KoreaJoint Mmeeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of Epstein-Barr virus and Alternating Chemoradiotherapy In Nasopharyngeal Carcinoma.2018

    • Author(s)
      Tomokazu Yoshizaki, Satoru Kondo, Yoshitaka Aoki, Harue Mizokami
    • Organizer
      International conference on EBV & KSHV 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Human papillomavirus genome integration is associated with the expression of ABOBEC3 in oropharyngeal carcinomas.2018

    • Author(s)
      Tomokazu Yoshizaki, Satoru Kondo
    • Organizer
      6th IFNOS
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Protective effects of sodium thiosulfate for cisplatin-mediated ototoxicity in patients with head and neck cancer2018

    • Author(s)
      Tomokazu Yoshizaki, Masao Noda
    • Organizer
      World Audiology Congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 耳鼻咽喉科領域におけるIgG4関連疾患 嗅覚障害との関連も含めて2018

    • Author(s)
      吉崎智一
    • Organizer
      第31回日本口腔咽頭科学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Endoscopy assisted surgery for petrous apex cholesteatoma2017

    • Author(s)
      Sugimoto H, Hatano M, Noda M, Yoshizaki T
    • Organizer
      2nd World Congress on Endoscopic Ear Surgery
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The expression of APOBEC3A associates with human papillomavirus genome integration in oropharyngeal cancers2017

    • Author(s)
      Yoshizaki T, Kondo S, Wakisaka N, Nakanishi Y, Nishiyama T, Wakae K, Muramatsu M
    • Organizer
      The XV World Congress of the International Federation of Oto-Rhino-Laryngological Societies (IFOS)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Expression of APOBEC3A Associates with Human Papilloma Virus Genome Integration in Oropharyngeal Carcinomas2017

    • Author(s)
      Yoshizaki T
    • Organizer
      4th Congress of European ORL-HNS
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lenvatinib therapy for advanced thyroid cancer2017

    • Author(s)
      Nakanishi Y, Yoshizaki T
    • Organizer
      2nd Congress of Asia-Pacific Society of Thyroid Surgery
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expression of interleukin-33 is correlated with poor prognosis in patients with squamous cell carcinoma of the tongue2017

    • Author(s)
      Ishikawa K, Yoshizaki T
    • Organizer
      14th Taiwan Japan Conference on Otolaryngology Head and Neck Surgery
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2022-01-27  

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