Development for a new histobiological risk stratification and establishing of genomic medicine for pediatric malignant solid tumors

• Project/Area Number: 17H01592
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: Chiba University (2019-2020); National Center for Child Health and Development (2017-2018)
• Principal Investigator: Hishiki Tomoro 千葉大学, 大学院医学研究院, 教授 (00375776)
• Co-Investigator(Kenkyū-buntansha): 市川 仁 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長 (30201924) ; 上條 岳彦 埼玉県立がんセンター(臨床腫瘍研究所), 臨床腫瘍研究所, 所長 (90262708) ; 瀧本 哲也 国立研究開発法人国立成育医療研究センター, 研究所小児がん疫学臨床研究センター, 室長 (40393178)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000); Fiscal Year 2020: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000); Fiscal Year 2019: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000); Fiscal Year 2018: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000); Fiscal Year 2017: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
• Keywords: がんパネル検査 / 小児がん / 神経芽腫 / 肝芽腫 / 遺伝子異常 / 遺伝子パネル / ゲノム医療 / 小児悪性固形腫瘍 / 網羅的ゲノム解析 / ターゲットシークエンス / オンコパネル / 分子病理学的診断 / パネル解析 / パネル診断

Outline of Final Research Achievements

The characteristics of the genomic changes in childhood cancer are significantly distinct from those seen in adult cancer. We established a novel cancer panel named "NCC oncopanel ver 1". This new panel was able to detect large deletions within the CTNNB1 gene, and also was capable to capture NTRK3 fusion genes, which are both unique features of childhood solid tumors. Rearrangement of the promoter region of the TERT gene was also a target of this new panel, although the results were unsatisfactory due to the GC-rich feature of this region.

Academic Significance and Societal Importance of the Research Achievements

本研究の開始後間もなく２種類のがんパネル診断検査が保険収載されるなど臨床実装が急速に進んだ。本研究を発端にオールジャパン体制で小児におけるがんパネル検査のあり方についての議論が展開された。その結果、小児がんにおいては治療標的の探索だけでなく、診断や治療層別化にも有用ながんパネルの開発が望まれるというコンセンサスが得られた。本パネルの性能検証により、必要な改良が明瞭となり、それを踏まえた次世代パネルの開発研究が加速度的に進められている。小児悪性固形腫瘍を対象とするゲノム医療の基盤構築という本研究課題の目標は十分に達成できたと考えられる。

Research Products

• [Journal Article] Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants (2021)
  • Author(s): Arakawa A, Ichikawa H, Kubo T, Motoi N, Kumamoto T, Nakajima M, Yonemori K, Noguchi E, Sunami K, Shiraishi K, Kakishima H, Yoshida H, Hishiki T, Kawakubo N, Kuroda T, Kiyokawa T, Yamada K, Yanaihara N, et al, and Kohno T, Ogawa C.
  • Journal Title: N Engl J Med Volume: 384 Pages: 42-50
  • DOI: 10.1056/nejmoa2030391
  • Peer Reviewed / Open Access
• [Journal Article] CEP131 Abrogates CHK1 Inhibitor-Induced Replication Defects and Is Associated with Unfavorable Outcome in Neuroblastoma. (2020)
  • Author(s): Ando K, Cazares-Ordonez V, Makishima M, Yokoyama A, Suenaga Y, Nagase H, Kobayashi S, Kamijo T, Koshinaga T, Wada S.
  • Journal Title: J Oncol. Volume: 電子 Pages: 2752417-2752417
  • DOI: 10.1155/2020/2752417
  • Peer Reviewed / Open Access
• [Journal Article] RING1A regulates RING1B expression and the collapse of its expression impairs neuroblastoma cell proliferation (2020)
  • Author(s): Hasegawa M, Satoi S, Kamijo T
  • Journal Title: Dokkyo Journal of Medical Sciences Volume: 47 Pages: 115-123
  • Peer Reviewed
• [Journal Article] A nomogram of clinical and biologic factors to predict survival in children newly diagnosed with high-risk neuroblastoma: An International Neuroblastoma Risk Group project. (2020)
  • Author(s): Moreno L, Guo D, Irwin MS, Berthold F, Hogarty M, Kamijo T, Morgenstern D, Pasqualini C, Ash S, Potschger U, Ladenstein R, Valteau-Couanet D, Cohn SL, Pearson ADJ, London WB.
  • Journal Title: Pediatr Blood Cancer Volume: 電子
  • DOI: 10.1002/pbc.28794
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] BRAF V600E mutation is a potential therapeutic target for a small subset of synovial sarcoma. (2020)
  • Author(s): Watanabe S, Shimomura A, Kubo T, Sekimizu M, Seo T, Watanabe SI, Kawai A, Yamamoto N, Tamura K, Kohno T, Ichikawa H, Yoshida A.
  • Journal Title: Modern Pathology Volume: - Pages: 1660-1668
  • DOI: 10.1038/s41379-020-0530-3
  • Peer Reviewed
• [Journal Article] Sindbis viral structural protein cytotoxicity on human neuroblastoma cells. (2020)
  • Author(s): Saito EY, Saito K, Hishiki T, Takenouchi A, Saito T, Sato Y, Terui K, Matsunaga T, Shirasawa H, Yoshida H.
  • Journal Title: Pediatr Surg Int Volume: 36 Pages: 1173-1180
  • DOI: 10.1007/s00383-020-04719-8
  • Peer Reviewed / Open Access
• [Journal Article] Outcome and Late Complications of Hepatoblastomas Treated Using the Japanese Study Group for Pediatric Liver Tumor 2 Protocol. (2020)
  • Author(s): Hiyama E, Hishiki T, Watanabe K, Ida K, Ueda Y, Kurihara S, Yano M, Hoshino K, Yokoi A, Takama Y, Nogami Y, Taguchi T, Mori M, Kihira K, Miyazaki O, Fuji H, Honda S, Iehara T, Kazama T, Fujimura J, Tanaka Y, Inoue T, Tajiri T, Kondo S, Oue T, Yoshimura K.
  • Journal Title: Journal of Clinical Oncology Volume: 38 Pages: 2488-2498
  • DOI: 10.1200/jco.19.01067
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The importance of age as prognostic factor for the outcome of patients with hepatoblastoma: Analysis from the Children's Hepatic tumors International Collaboration (CHIC) database (2020)
  • Author(s): Haeberle B, Rangaswami A, Krailo M, Czauderna P, Hiyama E, Maibach R, Lopez-Terrada D, Aronson DC, Alaggio R, Ansari M, Malogolowkin MH, Perilongo G, O'Neill AF, Trobaugh-Lotrario AD, Watanabe K, Schmid I, von Schweinitz D, Ranganathan S, Yoshimura K, Hishiki T, et al
  • Journal Title: Pediatric Blood Cancer Volume: 67
  • DOI: 10.1002/pbc.28350
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High prevalence of SMARCB1 constitutional abnormalities including mosaicism in malignant rhabdoid tumors (2020)
  • Author(s): Shirai Ryota、Osumi Tomoo、Terashima Keita、et al
  • Journal Title: Eur J Hum Genet. Volume: 未刊 Pages: 1124-1128
  • DOI: 10.1038/s41431-020-0614-z
  • Peer Reviewed / Open Access
• [Journal Article] Definitive Tumor Resection after Myeloablative High Dose Chemotherapy Is a Feasible and Effective Option in the Multimodal Treatment of High-Risk Neuroblastoma: A Single Institution Experience (2020)
  • Author(s): Hishiki Tomoro、Fujino Akihiro、Watanabe Toshihiko、Tahara Kazunori、Ohno Michinobu、Yamada Yohei、Tomonaga Kotaro、Kutsukake Mai、Fujita Takuro、Kawakubo Naonori、Matsumoto Kimikazu、Kiyotani Chikako、Shioda Yoko、Miyazaki Osamu、Fuji Hiroshi、Yoshioka Takako、Kanamori Yutaka
  • Journal Title: J Pediatr Surg. Volume: 未刊 Pages: 1655-1659
  • DOI: 10.1016/j.jpedsurg.2019.08.050
  • Peer Reviewed
• [Journal Article] Prospective Study of Allogeneic Hematopoietic Stem Cell Transplantation with Post-Transplantation Cyclophosphamide and Antithymocyte Globulin from HLA-Mismatched Related Donors for Nonmalignant Diseases (2020)
  • Author(s): Osumi T、Yoshimura S、Sako M、Uchiyama T、Ishikawa T、Kawai T、Inoue E、Takimoto T、Takeuchi I、Yamada M、Sakamoto K、Yoshida K、Kimura Y、Matsukawa Y、Matsumoto K、Imadome K、Arai K、Deguchi T、Imai K、Yuza Y、Matsumoto K、Onodera M、Kanegane H、Tomizawa D、Kato M
  • Journal Title: Biol Blood Marrow Transplant. Volume: 26
  • DOI: 10.1016/j.bbmt.2020.08.008
  • Peer Reviewed
• [Journal Article] A phase II JN-I-10 efficacy study of IDRF-based surgical decisions and stepwise treatment intensification for patients with intermediate-risk neuroblastoma: a study protocol. (2020)
  • Author(s): Iehara T, Yoneda A, Kikuta A, Muraji T, Tokiwa K, Takahashi H, Teramukai S, Takimoto T, Yagyu S, Hosoi H, Tajiri T
  • Journal Title: BMC Pediatrics Volume: 20 Pages: 212-212
  • DOI: 10.1186/s12887-020-02061-5
  • Peer Reviewed / Open Access
• [Journal Article] Recycling endosomal CD133 functions as an inhibitor of autophagy at the pericentrosomal region (2019)
  • Author(s): Hideki Izumi, Yuanyuan Li, Masami Shibaki, Daisuke Mori, Michio Yasunami, Seiji Sato, Hisashi Matsunaga, Takao Mae, Kenji Kodama, Takehiko Kamijo, Yasuhiko Kaneko & Akira Nakagawara
  • Journal Title: Sci Rep. Volume: 9 Pages: 1-17
  • DOI: 10.1038/s41598-019-39229-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Polymorphic Variant in p19Arf Confers Resistance to Chemically Induced Skin Tumors by Activating the p53 Pathway (2019)
  • Author(s): Saito M, Okumura K, Isogai E, Araki K, Tanikawa C, Matsuda K, Kamijo T, Kominami R, Wakabayashi Y.
  • Journal Title: Journal of Investigative Dermatology Volume: in press Issue: 7 Pages: 1459-1469
  • DOI: 10.1016/j.jid.2018.12.027
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Combined Genetic and Chromosomal Characterization of Wilms Tumors Identifies Chromosome 12 Gain as a Potential New Marker Predicting a Favorable Outcome (2019)
  • Author(s): Haruta Masayuki、Arai Yasuhito、Okita Hajime、Tanaka Yukichi、Takimoto Tetsuya、Sugino Ryuichi P.、Yamada Yasuhiro、Kamijo Takehiko、Oue Takaharu、Fukuzawa Masahiro、Koshinaga Tsugumichi、Kaneko Yasuhiko
  • Journal Title: Neoplasia. Volume: 21 Pages: 117-131
  • DOI: 10.1016/j.neo.2018.10.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Results of a prospective clinical trial JN-L-10 using image-defined risk factors to inform surgical decisions for children with low-risk neuroblastoma disease: A report from the Japan Children’s Cancer Group Neuroblastoma Committee (2019)
  • Author(s): Iehara T, Yoneda A, Yokota I, Takahashi H, Teramukai S, Kamijyo T, Nakazawa A, Takimoto T, Kikuta A, Yagyu S, Ikeda H, Nakagawara A, Tajiri T
  • Journal Title: Pediatric Blood & Cancer Volume: 66 Pages: 1-7
  • DOI: 10.1002/pbc.27914
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Feasibility and utility of a panel testing for 114 cancer‐associated genes in a clinical setting: A hospital‐based study (2019)
  • Author(s): Sunami Kuniko、Ichikawa Hitoshi、Kubo Takashi、Kato Mamoru、Fujiwara Yutaka、Shimomura Akihiko、Koyama Takafumi、Kakishima Hiroki、Kitami Mayuko、Matsushita Hiromichi、Furukawa Eisaku、Narushima Daichi、Nagai Momoko、Taniguchi Hirokazu、Motoi Noriko、、Kohno Takashi et al.
  • Journal Title: Cancer Sci Volume: 110 Pages: 1480-1490
  • DOI: 10.1111/cas.13969
  • Peer Reviewed / Open Access
• [Journal Article] Novel NTRK3 Fusions in Fibrosarcomas of Adults. (2019)
  • Author(s): Yamazaki F, Nakatani F, Asano N, Wakai S, Sekimizu M, Mitani S, Kubo T, Kawai A, Ichikawa H, Yoshida A.
  • Journal Title: The American Journal of Surgical Pathology Volume: 43 Pages: 523-530
  • DOI: 10.1097/pas.0000000000001194
  • Peer Reviewed
• [Journal Article] Fluorescence-Guided Surgery for Hepatoblastoma with Indocyanine Green (2019)
  • Author(s): Yamada Yohei、Ohno Michinobu、Fujino Akihiro、Kanamori Yutaka、Irie Rie、Yoshioka Takako、Miyazaki Osamu、Uchida Hajime、Fukuda Akinari、Sakamoto Seisuke、Kasahara Mureo、Matsumoto Kimikazu、Fuchimoto Yasushi、Hoshino Ken、Kuroda Tatsuo、Hishiki Tomoro
  • Journal Title: Cancers (Basel) Volume: 11 Pages: 1215-1215
  • DOI: 10.3390/cancers11081215
  • Peer Reviewed
• [Journal Article] Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation (2019)
  • Author(s): Harada, K., Ihara, F., Takami, M., Kamata, T., Mise, N., Yoshizawa, H., Hishiki, T., Saito, T., Terui, K., Nakata, M., Komatsu, S., Ikeuchi, T., Nakayama, T., Yoshida, H., Motohashi, S.
  • Journal Title: Cancer Science Volume: 110 Pages: 888-902
  • DOI: 10.1111/cas.13933
  • Peer Reviewed / Open Access
• [Journal Article] EZH2 regulates neuroblastoma cell differentiation via NTRK1 promoter epigenetic modifications (2018)
  • Author(s): Li Zhenghao、Takenobu Hisanori、Setyawati Amallia Nuggetsiana、Akita Nobuhiro、Haruta Masayuki、Satoh Shunpei、Shinno Yoshitaka、Chikaraishi Koji、Mukae Kyosuke、Akter Jesmin、Sugino Ryuichi P.、Nakazawa Atsuko、Nakagawara Akira、Aburatani Hiroyuki、Ohira Miki、Kamijo Takehiko
  • Journal Title: ONCOGENE Volume: 37 Pages: 2714-2727
  • DOI: 10.1038/s41388-018-0133-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Results of a phase II trial for high-risk neuroblastoma treatment protocol JN-H-07: a report from the Japan Childhood Cancer Group Neuroblastoma Committee (JNBSG) (2018)
  • Author(s): Hishiki T、For the Japan Childhood Cancer Group Neuroblastoma Committee (JNBSG)、Matsumoto K、Ohira M、Kamijo T、Shichino H、Kuroda T、Yoneda A、Soejima T、Nakazawa A、Takimoto T、Yokota I、Teramukai S、Takahashi H、Fukushima T、Kaneko T、Hara J、Kaneko M、Ikeda H、Tajiri T、Nakagawara A
  • Journal Title: Int J Clin Oncol. Volume: 23 Pages: 965-973
  • DOI: 10.1007/s10147-018-1281-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Invariant natural killer T infiltration in neuroblastoma with favorable outcome. (2018)
  • Author(s): Hishiki T, Mise N, Harada K, Ihara F, Takami M, Saito T, Terui K, Nakata M, Komatsu S, Yoshida H, and Motohashi S
  • Journal Title: Pediatr Surg Int. Volume: 34 Pages: 195-201
  • DOI: 10.1007/s00383-017-4189-x
  • Peer Reviewed
• [Journal Article] Frequency and proliferative response of circulating invariant natural killer T cells in pediatric patients with or without malignant solid tumors. (2018)
  • Author(s): Hishiki T, Mise N, Harada K, Ihara F, Takami M, Saito T, Terui K, Nakata M, Komatsu S, Yoshida H, and Motohashi S
  • Journal Title: Pediatr Surg Int. Volume: 34 Pages: 169-176
  • DOI: 10.1007/s00383-017-4185-1
  • Peer Reviewed
• [Journal Article] Ex vivo reduction of thickness in the left lateral section to tailor the graft size in infantile split deceased donor liver transplantation (2018)
  • Author(s): Sakamoto Seisuke、Sasaki Kengo、Uchida Hajime、Kitajima Toshihiro、Narumoto Soichi、Hirata Yoshihiro、Hishiki Tomoro、Fukuda Akinari、Kasahara Mureo
  • Journal Title: Liver Transplantation Volume: 24 Pages: 428-431
  • DOI: 10.1002/lt.24976
  • Peer Reviewed
• [Journal Article] Modified triangular hepatic vein reconstruction for preventing hepatic venous outflow obstruction in pediatric living donor liver transplantation using left lateral segment grafts (2018)
  • Author(s): Fukuda Akinari、Sakamoto Seisuke、Sasaki Kengo、Narumoto Soichi、Kitajima Toshihiro、Hirata Yoshihiro、Hishiki Tomoro、Kasahara Mureo
  • Journal Title: Pediatric Transplantation Volume: 22
  • DOI: 10.1111/petr.13167
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Surgical treatment strategy for advanced hepatoblastoma: Resection versus transplantation (2018)
  • Author(s): Uchida Hajime、Sakamoto Seisuke、Sasaki Kengo、Takeda Masahiro、Hirata Yoshihiro、Fukuda Akinari、Hishiki Tomoro、Irie Rie、Nakazawa Atsuko、Miyazaki Osamu、Nosaka Shunsuke、Kasahara Mureo
  • Journal Title: Pediatric Blood & Cancer Volume: 65
  • DOI: 10.1002/pbc.27383
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Preoperative diagnosis of clear cell sarcoma of the kidney by detection of BCOR internal tandem duplication in circulating tumor DNA (2018)
  • Author(s): Ueno-Yokohata Hitomi、Okita Hajime、Nakasato Keiko、Hishiki Tomoro、Shirai Ryota、Tsujimoto Shinichi、Osumi Tomoo、Yoshimura Satoshi、Yamada Yuji、Shioda Yoko、Kiyotani Chikako、Terashima Keita、Miyazaki Osamu、Matsumoto Kimikazu、Kiyokawa Nobutaka、Yoshioka Takako、Kato Motohiro
  • Journal Title: Genes, Chromosomes and Cancer Volume: 57 Pages: 525-529
  • DOI: 10.1002/gcc.22648
  • Peer Reviewed
• [Journal Article] Identification of the genetic and clinical characteristics of neuroblastomas using genome-wide analysis (2018)
  • Author(s): Uryu K, Nishimura R, Kataoka K, Sato Y, Nakazawa A, Suzuki H, Yoshida K, Seki M, Hiwatari M, Isobe T, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Koh K, Hanada R, Oka A, Hayashi Y, Ohira M, Kamijo T, Nagase H, Takimoto T, Tajiri T, Nakagawara A, Ogawa S, Takita J
  • Journal Title: Oncotarget. Volume: 8 Pages: 107513-107529
  • DOI: 10.18632/oncotarget.22495
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CFC1 is a cancer stemness-regulating factor in neuroblastoma (2017)
  • Author(s): Chikaraishi Koji、Takenobu Hisanori、Sugino Ryuichi P.、Mukae Kyosuke、Akter Jesmin、Haruta Masayuki、Kurosumi Masafumi、Endo Takaho A.、Koseki Haruhiko、Shimojo Naoki、Ohira Miki、Kamijo Takehiko
  • Journal Title: Oncotarget Volume: 8 Pages: 45046-45059
  • DOI: 10.18632/oncotarget.18464
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genomic analysis–integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway (2017)
  • Author(s): Li Yuanyuan、Ohira Miki、Zhou Yong、Xiong Teng、Luo Wen、Yang Chao、Li Xiangchun、Gao Zhibo、Zhou Rui、Nakamura Yohko、Kamijo Takehiko、Kaneko Yasuhiko、Taketani Takeshi、Ueyama Junichi、Tajiri Tatsuro、Zhang Hongyan、Wang Jian、Yang Huanming、Yin Ye、Nakagawara Akira
  • Journal Title: Oncotarget Volume: 8 Pages: 56684-56697
  • DOI: 10.18632/oncotarget.18079
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cancer-type OATP1B3 mRNA has the potential to become a detection and prognostic biomarker for human colorectal cancer. (2017)
  • Author(s): Sun Y, Harada M, Shimozato O, Souda H, Takiguchi N, Nabeya Y, Kamijo T, Akita H, Anzai N, Chiba K, Furihata T.
  • Journal Title: Biomarkers in Medicine Volume: 印刷中 Pages: 629-639
  • DOI: 10.2217/bmm-2017-0098
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration. (2017)
  • Author(s): Meyers RL, Maibach R, Hiyama E, Harberle B, Krailo M, Rangaswami A, Aronson DC, Malogolowkin MH, Perilongo G, von Schweinitz D, Ansari M, Lopez-Terrada D, Tanaka Y, Alaggio R, Leuschner I, Hishiki T, Schmid I, Watanabe K, Yoshimura K, Feng Y, Rinaldi E, Saraceno D, Derosa M, Czauderna P.
  • Journal Title: The Lancet Oncology Volume: 18 Pages: 122-131
  • DOI: 10.1016/s1470-2045(16)30598-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The role of pulmonary metastasectomy for hepatoblastoma in children with metastasis at diagnosis: Results from the JPLT-2 study (2017)
  • Author(s): Hishiki T, Watanabe K, Ida K, Hoshino K, Iehara T, Aoki Y, Kazama T, Kihira K, Takama Y, Taguchi T, Fujimura J, Honda S, Matsumoto K, Mori M, Yano M, Yokoi A, Tanaka Y, Fuji H, Miyazaki O, Yoshimura K, Takimoto T, Hiyama E
  • Journal Title: J Pediatr Surg Volume: 52 Pages: 2051-2055
  • DOI: 10.1016/j.jpedsurg.2017.08.031
  • Peer Reviewed
• [Journal Article] A female case of pleuropulmonary blastoma type 1 whose pulmonary cystic lesion was followed since neonate. (2017)
  • Author(s): Ohno M, Takezoe T, Watanabe T, Tahara K, Hishiki T, Fujino A, Matsuo M, Higuchi M, Kawasaki K, Shioda Y, Kato M, Kiyotani C, Matsumoto K, Takakuwa E, Irie R, Yoshioka T, Kimura S, Seki M, Takita J, Kanamori Y.
  • Journal Title: J Pediatr Surg Case Reports Volume: 19 Pages: 34-37
  • DOI: 10.1016/j.epsc.2017.02.009
  • Peer Reviewed
• [Presentation] FGFR2はMEK/ERK signalingを介してCHK1阻害剤感受性を低下せしめる (2021)
  • Author(s): 安藤清宏、大平美紀、末永祐介、上條岳彦、永瀬浩喜、小林真一、和田聡
  • Organizer: 第29回日本癌病態治療研究会
• [Presentation] NCC Oncopanel Ped: A novel cancer gene panel test for pediatric solid tumors (2020)
  • Author(s): Fumito Yamazaki, Takashi Kubo, Kuniko Sunami, Takafumi Koyama, Ayumu Arakawa, Sachiyo Mitani, Miki Ohira, Motohiro Kato, Atsuko Nakazawa, Takashi Kohno, Noboru Yamamoto, Takehiko Kamijo, Tomoro Hishiki, Chitose Ogawa, Hitoshi Ichikawa：
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] Mutational profiling and copy number analysis suggest homologous recombination deficiency in osteosarcoma (2020)
  • Author(s): Fumito Yamazaki, Naofumi Asano, Masaya Sekimizu, Sachiyo Mitani, Takashi Kubo, Chitose Ogawa, Akira Kawai, Akihiko Yoshida, Hitoshi Ichikawa
  • Organizer: 第62回日本小児血液・がん学会学術集会
• [Presentation] Polycomb repressive complex 1 controls a tumor suppressor gene BTG2 in neuroblastoma. (2020)
  • Author(s): Shunpei Satoh, Mariko Hasegawa, Miki Ohira, Takehiko Kamijo
  • Organizer: 2020APSN
• [Presentation] Genomic characterization of high-risk neuroblastoma by cancer gene panel test (2020)
  • Author(s): Miki Ohira, Hiroyuki Shichino, Takashi Kubo, Masayuki Haruta, Tetsuya Takimoto, Atsuko Nakazawa, Fumito Yamazaki, Hiroki Nagase, Tatsuro Tajiri, Akira Nakagawara, Hitoshi Ichikawa, Tomoro Hishiki, Takehiko Kamijo
  • Organizer: 2020APSN
• [Presentation] 神経芽腫における分化関連遺伝子のエピジェネティックな発現抑制メカニズムの解明 (2020)
  • Author(s): Hisanori Takenobu, Zhenghao Li, Ryuichi P. Sugino, Kyosuke Mukae, Miki Ohira, Masayuki Haruta, Yuki Endo, Ryu Okada, Dilibaerguli Shaliman, Takehiko Kamijo
  • Organizer: 2020 エピジェネティック研究会
• [Presentation] 神経芽腫におけるＥＺＨ２特異的阻害剤の感受性を制御する分子の探索 (2020)
  • Author(s): 遠藤悠紀、 竹信尚典、仁尾正記、上條岳彦
  • Organizer: 第57回日本小児外科学会学術集会
• [Presentation] Development of artificial tumorigenesis model from iPSC-based neural crest cells (2020)
  • Author(s): Kyosuke Mukae, Hisanori Takenobu, Hiroaki Kanda, Miki Ohira, Yuki Endo, Masayuki Haruta, Junya Toguchida, Kenji Osafune, Tatsutoshi Nakahata, Takehiko Kamijo
  • Organizer: 第 62 回日本小児血液・がん学会学術集会
• [Presentation] Q-PCR C-circle assay may be useful to identify NB patients with poorer prognosis in each High and Low/Intermediate risk. (2020)
  • Author(s): Motoki Sugawara, Masayuki Haruta, Atsuko Nakazawa, Hajime Okita, Tetsuya Takimoto, Tatsuro Tajiri, Shuichiro Uehara, Tsugumichi Koshinaga, Miki Ohira, Takehiko Kamijo,
  • Organizer: 第 62 回日本小児血液・がん学会学術集会
• [Presentation] Genomic characterization of high-risk neuroblastoma by cancer gene panel tests (2020)
  • Author(s): Miki Ohira, Hiroyuki Shichino, Takashi Kubo, Masayuki Haruta, Tetsuya Takimoto, Atsuko Nakazawa, Fumito Yamazaki, Hiroki Nagase, Tatsuro Tajiri, Akira Nakagawara, Hitoshi Ichikawa, Tomoro Hishiki, Takehiko Kamijo
  • Organizer: 第 62 回日本小児血液・がん学会学術集会
• [Presentation] Evaluation of the treatment results according to the status between renal vessels and tumor in the low-risk patients with abdominal neuroblastoma; analysys of the patients who enrolled in the low-risk protocol (JN-L-10) from the japan children’s cancer group neuroblastoma committee (2020)
  • Author(s): Yoneda A , Iehara T, Yokota I , Takahashi H , Teramukai S, Kamijo T, Nakazawa A, Takimoto T, Kikuta A , Ikeda H, Nakagawara A, Tajiri T
  • Organizer: 第 62 回日本小児血液・がん学会学術集会
• [Presentation] A polycomb group protein RING1A preferentially mediates H2AK119 ubiquitination with supporting neuroblastoma cell proliferation. (2020)
  • Author(s): Shunpei Satoh1, Mariko Hasegawa1, 2, Miki Ohira1, Hitoshi Ikeda2, Takehiko Kamijo
  • Organizer: 第 62 回日本小児血液・がん学会学術集会
• [Presentation] Delayed local treatment and Busulfan/Melphalan as a myeloablative chemotherapy for high-risk neuroblastoma (JN-H-15): a report from Neuroblastoma Committee of Japan Children’s Cancer Group (JCCG) Trial (2020)
  • Author(s): Matsumoto, Kimikazu, Shichino, Hiroyuki, Yoneda, Akihiro, Hishiki, Tomoro, et al
  • Organizer: 第 62 回日本小児血液・がん学会学術集会
• [Presentation] Genomic characterization of high-risk neuroblastoma by NCC Oncopanel Ped cancer panel (2020)
  • Author(s): Miki Ohira (1), Hiroyuki Shichino (2), Takashi Kubo (3), Masayuki Haruta (1), Tetsuya Takimoto (4), Atsuko Nakazawa (5), Fumito Yamazaki (3), Hiroki Nagase (6), Tatsuro Tajiri (7), Akira Nakagawara (8), Hitoshi Ichikawa (3), Tomoro Hishiki (4), Takehiko Kamijo (1),
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] p53 deficiency limits ATRX loss induced replication stress and genome instability in neuroblastoma cells (2020)
  • Author(s): Jesmin Akter1, Parvin Sultana1,2, Hisanori Takenobu1, Miki Ohira1, Ryuichi Sugino1, Masayuki Haruta1, and Takehiko Kamijo1
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] Tumor sphere specific gene CDX1 binds to OCT4 and MAX promoters to regulates stemness (2020)
  • Author(s): Hisanori Takenobu, Miki Ohira, Ryuichi Sugino, Koji Chikaraishi, Ryu Okada, Kyosuke Mukae, Tomoko Wada, Yuki Endo, Nobuhiro Akita, Masayuki Haruta, Takehiko Kamijo
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] Recurrent breakpoints in 22q11 segmental duplication regions reveal distinct tumorigenesis in rhabdoid tumor of kidney (2020)
  • Author(s): Kaneko Yasuhiko, Haruta Masayuki, Arai Yasuhito, Sugino Ryuichi, Kamijo Takehiko, Okita Hajime, Oue Takaharu, Koshinaga Tsugumichi
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 神経芽腫細胞における紫外線不活化シンドビスウイルスの抗腫瘍効果 (2020)
  • Author(s): 大野 吉史, 齋藤 謙悟, 李 斉森, 馬 雪, 齋藤 江里子, 室山 良介, 菱木 知郎, 白澤 浩
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] ゲノム医療:小児・AYAがんにおける実装の現状と今後の課題 小児がんゲノム検査の今後の展望 (2020)
  • Author(s): 菱木知郎
  • Organizer: 第62回日本小児血液・がん学会学術集会
• [Presentation] THE EVALUATION OF THE NEW GUIDELINE FOR ASSESSING IMAGE-DEFINED RISK FACTORS IN THE LOW-RISK PROTOCOL (JN-L-10) FROM THE JAPAN CHILDREN’S CANCER GROUP NEUROBLASTOMA COMMITTEE (2019)
  • Author(s): Yoneda A , Iehara T, Yokota I, Takahashi H , Teramukai S, Kamijo T, Nakazawa A Takimoto T, Kikuta A, Ikeda H, Nakagawara A , Tajiri T
  • Organizer: SIOP2019
  • Int'l Joint Research
• [Presentation] Genomic characterization of high-risk neuroblastoma by cancer panels. (2019)
  • Author(s): Ohira, Hiroyuki Shichino, Takashi Kubo, Masayuki Haruta, Tetsuya Takimoto, Atsuko Nakazawa, Hiroki Nagase, Tatsuro Tajiri, Akira Nakagawara, Hitoshi Ichikawa, Tomoro Hishiki, Takehiko Kamijo
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Multiple mechanisms of aromatase inhibitor resistance in resistant model breast cancer cell lines established in vivo. (2019)
  • Author(s): Yuri Yamaguchi, Miki Ohira, Takehiko Kamijo, Shin-ichi Hayashi
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Patterns of the first- and second-hit WT1 mutations may affect the risk of developing Wilms tumor in syndromic patients (2019)
  • Author(s): Kaneko Y, Haruta M, Kamijo T, et al.
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Development of neuroblastoma model from iPSC-based neural crest cell. (2019)
  • Author(s): Mukae, H Takenobu, R Sugino, M Ohira, S Satoh, Y Endo, R Okada, Mi Haruta, J Toguchida, K Osafune, T Nakahata, Takehiko Kamijo
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Toward genome medicine for pediatric cancer: Genomic characterization of high-risk neuroblastoma by cancer gene panel tests. (2019)
  • Author(s): Miki Ohira, Hiroyuki Shichino, Takashi Kubo, Masayuki Haruta, Tetsuya Takimoto, Atsuko Nakazawa, Fumito Yamazaki, Hiroki Nagase, Tatsuro Tajiri, Akira Nakagawara , Hitoshi Ichikawa, Tomoro Hishiki, Takehiko Kamijo, Japan
  • Organizer: 第61回日本小児血液・がん学会
• [Presentation] CDX1 regulates stemness and proliferation of neuroblastoma by MYC pathway modulation. (2019)
  • Author(s): Hisanori Takenobu, Miki Ohira, Ryuichi Sugino, Koji Chikaraishi, Ryu Okada, Kyosuke Mukae, Tomoko Wada,Yuki Endo, Nobuhiro Akita, Masayuki Haruta, Takehiko Kamijo
  • Organizer: 第61回日本小児血液・がん学会
• [Presentation] Oncomine Childhood Cancer Research Assay (OCCRA, ThermoFisher) による小児がんゲノムパネル解析 (2019)
  • Author(s): 上條岳彦
  • Organizer: 第57回日本小児血液・がん学会
  • Invited
• [Presentation] ゲノム解析による思春期・若年成人（adolescents and young adults: AYA）世代肉腫の病因の検討 (2019)
  • Author(s): 山崎文登、浅野尚文、吉田朗彦、岩田慎太郎、関水壮哉、三谷幸代、久保崇、後藤政広、菊田一貴、白石航也、吉田輝彦、河野隆志、嶋田博之、川井章、市川仁
  • Organizer: 第25回日本家族性腫瘍学会学術集会
• [Presentation] 小児がんのゲノム医療の展望 (2019)
  • Author(s): 市川仁
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Genomic analysis of germline and somatic mutations in adolescent and young adult (AYA) sarcoma (2019)
  • Author(s): Fumito Yamazaki, Naofumi Asano, Akihiko Yoshida, Shintaro Iwata, Masaya Sekimizu, Sachiyo Mitani, Takashi Kubo, Masahiro Gotoh, Kazutaka Kikuta, Kouya Shiraishi, Teruhiko Yoshida, Takashi Kohno, Hiroyuki Shimada, Akira Kawai, Hitoshi Ichikawa
  • Organizer: 第61回日本小児血液・がん学会学術集会
• [Presentation] シンポジウム-小児がんの国際共同臨床試験の現状と課題- 小児肝腫瘍の国際共同臨床試験 (2019)
  • Author(s): 2.菱木 知郎, 渡邉 健一郎, 井田 孔明, 森 麻希子, 宮嵜 治, 矢野 道広, 本多 昌平, 田中 祐吉, 瀧本 哲也, 吉村 健一, 横井 暁子, 藤村 純也, 家原 知子, 野上 由貴, 永瀬 浩喜, 北河 徳彦, 鈴木 達也, 松村 梨紗, 山田 洋平, 金田 英秀, 関口 昌央, 花木 良, 高間 勇一, 檜山 英三
  • Organizer: 第61回日本小児血液・がん学会学術集会．
• [Presentation] Surgical Management of Neuroblastoma- Institutional Experience and the Nationwide Clinical Trials in Japan. (2019)
  • Author(s): Tomoro Hishiki, Yohei Yamada, Naonori Kawakubo, Akihiro Yoneda, Tatsuro Tajiri.
  • Organizer: 71st Annual Congress of the Korean Surgical Society
  • Int'l Joint Research
• [Presentation] The “delayed local treatment” strategy is a feasible and effective option for multimodal treatment of high-risk neuroblastoma. (2019)
  • Author(s): Hishiki T, Fujino A, Watanabe T, Tahara K, Ohno M, Yamada Y, Tomonaga K, Kutsukake M, Fujita F, Matsumoto K, Kiyotani C, Shioda Y, Kanamori K.
  • Organizer: 52nd Annual Scientific Meeting of the Pacific Association of Pediatric Surgeons
• [Presentation] The “delayed local treatment” strategy is a feasible and effective option for multimodal treatment of high-risk neuroblastoma. (2019)
  • Author(s): Hishiki T, Fujino A, Watanabe T, Tahara K, Ohno M, Yamada Y, Tomonaga K, Kutsukake M, Fujita F, Matsumoto K, Kiyotani C, Shioda Y, Kanamori K.
  • Organizer: 51th Congress of the International Society of Paediatric Oncology.
  • Int'l Joint Research
• [Presentation] Genome and epigenome profiling of high stage neuroblastoma (2018)
  • Author(s): Miki Ohira, Ryuichi Sugino, Hisanori Takenobu, Zhenghao Li, Masayuki Haruta, Genta Nagae, Claire Renard-Guillet, Akira Nakagawara, Hiroyuki Aburatani, Takehiko Kamijo
  • Organizer: AACR2018
  • Int'l Joint Research
• [Presentation] CDX1 regulates neuroblastoma stemness through MYC pathway modulation and reprogramming gene activation (2018)
  • Author(s): Hisanori Takenobu, Miki Ohira, Ryuichi Sugino, Koji Chikaraishi, Kyosuke Mukae, Nobuhiro Akita, Masayuki Haruta, Akira Nakagawara, Manabu Nakayama, Haruhiko Koseki, Takehiko Kamijo
  • Organizer: ANR2018, San Francisco
  • Int'l Joint Research
• [Presentation] Reevaluation of PDGFRα signal in neuroblastoma: high expression and a new nonsynonymous mutation (2018)
  • Author(s): Shunpei Satoh, Miki Ohira, Hisanori Takenobu, Akira Nakagawara, Takehiko Kamijo
  • Organizer: ANR2018, San Francisco
  • Int'l Joint Research
• [Presentation] Genomic characterization of high-risk/ultra-high-risk neuroblastomas found in 610 patients registered in Japan Children’s Study Group Neuroblastoma Committee (JCCG-JNBSG) (2018)
  • Author(s): Miki Ohira, Takehiko Kamijo, Ryuichi P Sugino, Masayuki Haruta, Hisanori Takenobu Tetsuya Takimoto, Atsuko Nakazawa, Tomoro Hishiki, Kimikazu Matsumoto, Hiroyuki Shichino, Toshikazu Ushijima, Tomoko Iehara, Yohko Nakamura, Hiroki Nagase, Junko Takita, Akihiro Yoneda, Takashi Fukushima, Tatsuro Tajiri, Akira Nakagawara
  • Organizer: ANR2018, San Francisco
  • Int'l Joint Research
• [Presentation] NCCオンコパネル検査の開発と医療実装 (2018)
  • Author(s): 市川 仁
  • Organizer: 第25回日本遺伝子診療学会大会
  • Int'l Joint Research
• [Presentation] All Japan体制での小児がんパネル検査開発の試み (2018)
  • Author(s): 市川 仁
  • Organizer: 第60回日本小児血液・がん学会学術集会
  • Int'l Joint Research
• [Presentation] 小児固形腫瘍NGSパネルによるCTNNB1部分欠失の検出． (2018)
  • Author(s): 山崎文登，中澤温子，中野嘉子，大平美紀，義岡孝子，加藤元博，小川千登世，市村幸一，上條岳彦，菱木知郎，市川 仁
  • Organizer: 第60回日本小児血液・がん学会学術集会
  • Int'l Joint Research
• [Presentation] Genomic and epigenomic profiling of high stage neuroblastoma (2017)
  • Author(s): M Ohira, T Kamijo
  • Organizer: AACR2017
  • Int'l Joint Research
• [Presentation] Sphere specific transcription factor CDX1 has dual functions for regulating stemness of neuroblastoma (2017)
  • Author(s): Takenobu H,Kamijo T
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Effects of development regulators on neuroblastoma biology (2017)
  • Author(s): 上條岳彦
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Is interoperative paracentesis justified for all epithelial ovarian tumors in children? (2017)
  • Author(s): Katsuhiro Ogawa, Tomoro Hishiki, Kotaro Tomonag, Mioko Nomura, Toshiko Takezoe, Michinobu Ohno, Kazunori Tahara, Toshihiko Watanabe, Akihiro Fujino, Rie Irie, Takako Yoshioka, Yutaka Kanamori
  • Organizer: 50th annual meeting of the Pacific Association of Pediatric Surgeons
  • Int'l Joint Research
• [Presentation] The role of pulmonary metastasectomy in children with hepatoblastoma. (2017)
  • Author(s): Hishiki T, Watanabe K, Ida K, Hoshino K, Iehara T, Aoki Y, Kazama T, Kihira K, Takama Y, Taguchi T, Fujimura J, Honda S, Matsumoto K, Mori M, Yano M, Yokoi A, Tanaka Y, Fuji H, Miyazaki O, Yoshimura K, Takimoto T, Hiyama E.
  • Organizer: 50th annual meeting of the Pacific Association of Pediatric Surgeons
  • Int'l Joint Research
• [Presentation] Systemic response evaluated by Curie score is not correlated to the complexity and outcome of primary tumor resection in high-risk neuroblastoma. (2017)
  • Author(s): Hishiki T, Kanamori Y, Fujino A, Watanabe T, Tahara K, Ohno M, Takezoe T, Kiyotani C, Shioda Y, Tomizawa D, Kato M, Terashima K, Osumi T, Miyazaki O, Kitamura M, Matsumoto K.
  • Organizer: 49th Congress of the International Society of Paediatric Oncology.
  • Int'l Joint Research
• [Presentation] Local control for intermediate to high risk neuroblastoma -surgical oncologist’s view. (2017)
  • Author(s): Hishiki T.
  • Organizer: 24th Asia Pacific Cancer Conference (APCC 2017), 2017.6.24. Seoul
  • Int'l Joint Research / Invited
• [Presentation] がん個別化治療のためのNGS遺伝子パネル検査の開発 (2017)
  • Author(s): 市川仁
  • Organizer: 第13回北関東小児がんセミナー
  • Invited
• [Presentation] がん個別化治療のためのNGS（次世代シークエンサー）パネル検査の開発 (2017)
  • Author(s): 市川仁
  • Organizer: 日本人類遺伝学会主催第24回臨床細胞遺伝学セミナー
  • Invited
• [Presentation] FFPE腫瘍検体のRNAシークエンシングと融合遺伝子検出 (2017)
  • Author(s): 三谷幸代、吉田朗彦、関水壮哉、山崎文登、久保崇、元井紀子、川井章、河野隆志、市川仁
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] nCounterアッセイによる肉腫FFPE標本からの融合遺伝子検出 (2017)
  • Author(s): 三谷幸代、吉田朗彦、関水壮哉、山崎文登、久保崇、元井紀子、川井章、河野隆志、市川仁
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] nCounterアッセイによる肉腫FFPE標本からの融合遺伝子検出 (2017)
  • Author(s): 関水壮哉、吉田朗彦、山崎文登、三谷幸代、久保崇、本田隆行、角南久仁子、河野隆志、川井章、市川仁
  • Organizer: 第76回日本癌学会学術総会
• [Book] “はじめて学ぶ小児血液・腫瘍疾患”．腹部に腫瘤が触れる． (2017)
  • Author(s): 菱木知郎
  • Total Pages: 8
  • Publisher: 診断と治療社