| Co-Investigator(Kenkyū-buntansha) |
友清 淳 九州大学, 大学病院, 講師 (20507777)
吉田 晋一郎 九州大学, 大学病院, 助教 (30778866)
濱野 さゆり 九州大学, 歯学研究院, 助教 (40757978)
和田 尚久 九州大学, 大学病院, 教授 (60380466)
杉井 英樹 九州大学, 歯学研究院, 助教 (80802280)
長谷川 大学 九州大学, 大学病院, 助教 (20757992)
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| Budget Amount *help |
¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2021: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2020: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2019: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2018: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2017: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
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| Outline of Final Research Achievements |
We clarified the method to induce periodontal ligament (PDL) stem cell-like cells (iPDLSC) from iPS cells, and identified the transcription factor, PAX9, and Fibrillin 2 as the factors to induce the differentiation of iPS cells to iPDLSC.
We also developed the tube-like structure from the spheroids derived from human PDL stem-like cell line that we produced. This structure exhibited not only the PDL-like properties, but the features of cementum, blood vessels, and bone by inserting a hydroxyapatite (HAp) cylinder into the structure.
Finally, we prepared the tube-like structure made of iPDLSC spheroids, and observed the engraftment of this structure including the HAp cylinder.
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