|Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
|Outline of Final Research Achievements
We analyzed the effects of accelerated catabolism of branched chain amino acids (BCAA: Leu, Ile, Val) on endurance capacity, obesity and insulin resistance, and protein synthesis and degradation. First, we discovered a novel activator for BCAA catabolism, and clarified its mechanism of activation in vitro and its effect on plasma BCAA concentrations in vivo. In addition, we revealed that BCAA catabolism was promoted by vitamin B1 in vivo and the effects of vitamin B1 intake or genetically promoted BCAA catabolism on running endurance, obesity and insulin resistance. Furthermore, we also found that the response of mTORC1 to BCAA was influenced by accelerated BCAA metabolism and dietary protein content.