Prevention of muscle atrophy by local bioactive androgen through mechanical stretch
| Project/Area Number |
17H02161
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Senshu University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 身体運動 / 骨格筋 / アンドロゲン / サルコペニア / メカニカルストレス / 萎縮 / 転写調節 / 筋萎縮 / 運動 / 性ホルモン |
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| Outline of Final Research Achievements |
Skeletal muscle is constantly exposed to physical force including exercise or mechanical stretch. Testosterone is converted into its bioactive metabolite dihydrotestosterone (DHT) by 5α-reductase (srd5a1). DHT is also involved in exercise-induced skeletal muscular metabolism. However, it remains to be elucidated whether muscular DHT production through srd5a1 is locally involved in skeletal muscular plasticity. Here we found that local DHT production in skeletal muscle inhibited muscular atrophy through the suppression of atrophy-related gene expression. We show that mechanical stretch transactivates an androgenic enzyme, srd5a1 through the binding of early growth response 2 (Egr2) in skeletal muscle. These results suggest that bioactive androgen metabolism through the Egr2-srd5a1 axis could play important roles in maintaining muscle mass in mechanical stretch.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、とくに中高齢期におけるサルコペニアの予防や改善メカニズムの基礎的知見として意義があると考えられる。加齢や不活動による骨格筋萎縮の予防において、身体運動による骨格筋機能の維持・改善に骨格筋局所のアンドロゲン産生が関与している可能性が考えられる。
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Report
(4 results)
Research Products
(12 results)
