The physical fitness study on the crosstalk between skeletal muscle and gut with a focus on metabolism, myokine, and intestine barrier
Project/Area Number |
17H02176
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied health science
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Research Institution | Kyoto Prefectural University |
Principal Investigator |
Aoi Wataru 京都府立大学, 生命環境科学研究科, 准教授 (60405272)
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Co-Investigator(Kenkyū-buntansha) |
内藤 裕二 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (00305575)
佐久間 邦弘 東京工業大学, リベラルアーツ研究教育院, 教授 (60291176)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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Keywords | 骨格筋 / 運動 / 腸内環境 / マイオカイン / 代謝 / エネルギー代謝 / 腸バリア / 腸内細菌 |
Outline of Final Research Achievements |
This study examined the interactions between intestine barrier function, microbiota and metabolic/secretory function of skeletal muscle. We found that impairment of intestine barrier function caused glucose intolerance with muscle metabolic dysfunction in experimental mouse models. In addition, in the mice transplanted with microbiota from trained mice, metabolic/secretory factors in skeletal muscle were enhanced. On the other hand, in the mice with impaired muscle metabolism, myokine secretory- and intestinal barrier- functions were suppressed. These results support the concept of organ communication between skeletal muscle and gut.
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Academic Significance and Societal Importance of the Research Achievements |
本研究により,腸バリア機能,腸内細菌の変化は骨格筋の代謝を調整すること,逆に骨格筋の代謝・分泌機能は腸管免疫機能に影響を与えることが示され,腸内環境と骨格筋は血液を介して互いに協調しあっていることが明らかになった。体力向上,健康づくりにおいて,腸と骨格筋がともに良好な機能を保持することが重要であり,このことを考慮した運動習慣,食習慣を検討することが有意義と考えられる。
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Combined intake of astaxanthin, β-carotene, and resveratrol elevates protein synthesis during muscle hypertrophy in mice2020
Author(s)
Kawamura, A., Aoi, W., Abe, R, Kobayashi, Y., Wada, S., Kuwahata, M., Higashi, A.
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Journal Title
Nutrition
Volume: 69
Pages: 110561-110561
DOI
Related Report
Peer Reviewed
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[Journal Article] Lower birth weight is associated with higher sprint performance in female university students2019
Author(s)
Abe, R., Aoi, W., Harada, K., Iwasa, M., Saruwatari, A., Odani, K., Yoshii, K., Ito, C., Ohmi, N., Takayama, Y., Nishikawa, K., Wada, S., Higashi, A.
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Journal Title
The Journal of Physical Fitness and Sports Medicine
Volume: 8
Issue: 3
Pages: 117-125
DOI
NAID
ISSN
2186-8123, 2186-8131
Year and Date
2019-05-25
Related Report
Peer Reviewed / Open Access
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[Journal Article] Secreted Protein Acidic and Rich in Cysteine (SPARC) improves glucose tolerance via AMP-activated protein kinase activation2019
Author(s)
Aoi, W., Hirano, N., Lassiter, D.G., Björnholm, M., Chibalin, A.V., Sakuma, K., Tanimura, Y., Mizushima, K., Takagi, T., Naito, Y., Zierath, J.R., Krook, A.
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Journal Title
FASEB J.
Volume: 33
Issue: 9
Pages: 10551-10652
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] .Effect of downhill walking on next-day muscle damage and glucose metabolism in healthy young subjects2019
Author(s)
Nakayama, A., Aoi, W., Takami, M., Hirano, N., Ogaya, Y., Wada, S., Higashi, A.
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Journal Title
J. Physiol. Sci.
Volume: 69
Issue: 1
Pages: 31-38
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Effect of dietary antioxidant-rich foods combined with aerobic training on energy metabolism in healthy young men2019
Author(s)
Takami, M., Aoi W., Terajima, H., Tanimura, Y., Wada, S., Higashi, A.
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Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 64
Issue: 1
Pages: 79-85
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
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[Journal Article] IL6 and LIF mRNA expression in skeletal muscle is regulated by AMPK and the transcription factors NFYC, ZBTB14 and SP12018
Author(s)
Nylén, C., Aoi, W., Abdelmoez, A.M., Lassiter, D.G., Lundell, L.S., Wallberg-Henriksson, H., Näslund, E., Pillon, N.J., and Krook, A.
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Journal Title
Am. J. Physiol. Endcrinol. Metab.
Volume: 315
Issue: 5
Pages: E995-E1004
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Secreted protein acidic and rich in cysteine functions in colitis via IL17A regulation in mucosal CD4(+) T cells.2018
Author(s)
Tanaka M, Takagi T, Naito Y, Uchiyama K, Hotta Y, Toyokawa Y, Ushiroda C, Hirai Y, Aoi W, Higashimura Y, Mizushima K, Okayama T, Katada K, Kamada K, Ishikawa T, Handa O, Itoh Y.
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Journal Title
J Gastroenterol Hepatol.
Volume: 33
Issue: 3
Pages: 671-680
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comparison of the effect of non-esterified and esterified astaxanthins on endurance performance in mice2018
Author(s)
Aoi, W., Maoka, T., Abe, R., Fujishita, M., Tominaga, K.
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Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 62
Issue: 2
Pages: 161-166
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
Peer Reviewed
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