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Development of exercise and diet therapies for the improvement of risk of cardiovascular disease targeting novel myokine

Research Project

Project/Area Number 17H02182
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionRitsumeikan University

Principal Investigator

家光 素行  立命館大学, スポーツ健康科学部, 教授 (90375460)

Co-Investigator(Kenkyū-buntansha) 真田 樹義  立命館大学, スポーツ健康科学部, 教授 (50421227)
橋本 健志  立命館大学, スポーツ健康科学部, 教授 (70511608)
金森 雅夫  立命館大学, スポーツ健康科学部, 教授 (90127019)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Granted (Fiscal Year 2019)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2017: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords動脈硬化 / マイオカイン / 運動 / 栄養
Outline of Annual Research Achievements

最近,骨格筋から分泌される内分泌因子:マイオカインが複数同定されており,自己作用だけでなく,脂肪細胞や骨細胞とクロストーク(相互作用)することが報告されている。しかしながら,運動や食品摂取によって誘発されるマイオカインが動脈硬化改善に関与するか否かの検討は国内外を見ても皆無である。本研究は,動脈硬化に対する運動・食品摂取効果のメカニズムに関与するマイオカインを同定し,マイオカイン作用の貢献度や分子機序の解明から効率的な運動・食事プログラムの構築を目指すことを目的とする。平成30年度では,老齢マウスを用いて,運動による動脈硬化度の改善効果に関わる候補マイオカインXの分泌部位およびマイオカイン変動が動脈硬化度の低下に対して関与しているかについて検討した。38週齢の老齢促進SAMP1マウスを老齢対照群および老齢有酸素運動群の2群に分け,12週間後に脳,肺,心臓,肝臓,腎臓,腹腔マクロファージ,骨格筋(前脛骨筋)を摘出した。Xマイオカイン遺伝子発現はreal-time PCR法にて測定した結果,他の組織よりも骨格筋で顕著に高い発現が認められた(P < 0.01)。また,有酸素性運動により骨格筋のXマイオカイン遺伝子発現は有意に変化し(P < 0.05),動脈血管の内皮機能(アセチルコリンによる血管拡張応答)の変化に対応していた。さらに,38週齢の老齢促進SAMP1マウスを用いて12週間のマルチサプリメントによる栄養摂取によっても骨格筋のXマイオカインの遺伝子発現が変化することも明らかにした。これらの結果から,候補マイオカインXは骨格筋にて発現が高く,運動や栄養摂取により変動することが明らかとなった。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

ヒト試験において有酸素性運動や栄養摂取により動脈硬化度の改善効果に関わる候補Xマイオカインは動物実験においても同様の結果が得られた。今後,異なる運動様式(レジスタンストレーニング)による変化および栄養摂取との併用効果についても検討する必要性がある。

Strategy for Future Research Activity

運動や栄養摂取によるマイオカイン分泌の変化は有酸素性運動による変化は異なる運動様式(レジスタンストレーニング)によっても同様の変化を示すのか,また,栄養摂取との併用効果について検討し,運動や栄養摂取による動脈硬化に及ぼす影響にマイオカインが関与するのかについて検討する。

Report

(2 results)
  • 2018 Annual Research Report
  • 2017 Annual Research Report

Research Products

(64 results)

All 2019 2018 2017 Other

All Int'l Joint Research Journal Article Presentation

  • [Int'l Joint Research] University of Missouri(米国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Effect of combination of chlorella intake and aerobic exercise training on glycemic control in type 2 diabetic rats.2019

    • Author(s)
      Horii Naoki、Hasegawa Natsuki、Fujie Shumpei、Uchida Masataka、Iemitsu Keiko、Inoue Kenichiro、Iemitsu Motoyuki
    • Journal Title

      Nutrition

      Volume: 63-64 Pages: 45-50

    • DOI

      10.1016/j.nut.2019.01.008

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Short‐term cycling restores endothelial dysfunction after resistance exercise2019

    • Author(s)
      Morishima Takuma、Iemitsu Motoyuki、Ochi Eisuke
    • Journal Title

      Scandinavian Journal of Medicine & Science in Sports

      Volume: -

    • DOI

      10.1111/sms.13434

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-intensity resistance exercise with low repetitions maintains endothelial function2018

    • Author(s)
      Morishima Takuma、Tsuchiya Yosuke、Iemitsu Motoyuki、Ochi Eisuke
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology

      Volume: 315

    • DOI

      10.1152/ajpheart.00281.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profile of muscle adaptation to high-intensity intermittent exercise training in young men.2018

    • Author(s)
      Miyamoto-Mikami E, Tsuji K, Horii N, Hasegawa N, Fujie S, Homma T, Uchida M, Hamaoka T, Kanehisa H, Tabata I, Iemitsu M
    • Journal Title

      Sci Rep.

      Volume: 8 Pages: 16811-16811

    • DOI

      10.1038/s41598-018-35115-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 閉経後サルコペニア女性を対象とした骨密度に対する軽負荷パワートレーニング効果の個体差に関連する要因の検討2018

    • Author(s)
      浜口佳奈子, 栗原俊之, 藤本雅大, 家光素行, 佐藤幸治, 浜岡隆文, 真田樹義.
    • Journal Title

      トレーニング科学

      Volume: 30 Pages: 45-54

    • NAID

      40021758952

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 日本人中高齢女性を対象とした内臓脂肪の分布とメタボリックシンドロームリスク因子との関係2018

    • Author(s)
      中山侑紀, 井門あゆみ, 石井好二郎, 家光素行, 佐藤幸治, 藤本雅大, 栗原俊之, 浅原哲子, 真田樹義.
    • Journal Title

      京都滋賀体育学研究

      Volume: 34 Pages: 10-18

    • NAID

      40021680070

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肥満ラットの有酸素性トレーニングによる動脈血管のapelin産生の増加は内皮型一酸化窒素合成酵素の活性に影響する2018

    • Author(s)
      井上健一郎, 藤江隼平, 長谷川夏輝, 堀居直希, 内田昌孝, 佐藤幸治, 家光素行.
    • Journal Title

      京都滋賀体育学研究

      Volume: 34 Pages: 20-28

    • NAID

      40021680076

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肥満者を対象とした低強度レジスタンストレーニングの効果:腹部サルコペニアの有無による比較2018

    • Author(s)
      4.村上泰一, 中村由紀, 古嶋大詩, 家光素行, 栗原俊之, 藤本雅大, 有光琢磨, 石井好二郎, 浅原哲子, 真田樹義.
    • Journal Title

      肥満研究

      Volume: 24 Pages: 30-40

    • NAID

      40021632760

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Role of Dehydroepiandrosterone (DHEA) in Skeletal Muscle2018

    • Author(s)
      Sato Koji、Iemitsu Motoyuki
    • Journal Title

      Vitamins and Hormones

      Volume: 108 Pages: 205-221

    • DOI

      10.1016/bs.vh.2018.03.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of different exercise modes on arterial stiffness and nitric oxide synthesis2018

    • Author(s)
      Hasegawa N, Fujie S, Horii N, Miyamoto-Mikami E, Tsuji K, Uchida M, Hamaoka T, Tabata I, Iemitsu M.
    • Journal Title

      Medicine and Science in Sports and Exercise

      Volume: - Pages: 1177-1185

    • DOI

      10.1249/mss.0000000000001567

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resistance training prevents muscle fibrosis and atrophy via down-regulation of C1q-induced Wnt signaling in senescent mice2018

    • Author(s)
      Horii N, Uchida M, Hasegawa N, Fujie S, Oyanagi E, Yano H, Hashimoto T, Iemitsu M.
    • Journal Title

      FASEB J.

      Volume: - Pages: 3547-3559

    • DOI

      10.1096/fj.201700772rrr

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aerobic exercise training-induced changes in serum C1q/TNF-related protein levels are associated with reduced arterial stiffness in middle-aged and older adults.2018

    • Author(s)
      Hasegawa N, Fujie S, Horii N, Uchida M, Kurihara T, Sanada K, Hamaoka T, Iemitsu M.
    • Journal Title

      American Journal of Physiology, Regulatory Integrative and Comparative Physiology

      Volume: 314 Pages: 94-101

    • DOI

      10.1152/ajpregu.00212.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of prediction equations for estimating appendicular skeletal muscle mass in Japanese men and women.2017

    • Author(s)
      Furushima T, Miyachi M, Iemitsu M, Murakami H, Kawano H, Gando Y, Kawakami R, Sanada K.
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 36 Pages: 34-34

    • DOI

      10.1186/s40101-017-0150-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The effects of low-repetition and light-load power training on bone mineral density in postmenopausal women with sarcopenia: a pilot study2017

    • Author(s)
      Kanako Hamaguchi; Toshiyuki Kurihara; Masahiro Fujimoto; Motoyuki Iemitsu; Koji Sato; Takafumi Hamaoka; Kiyoshi Sanada
    • Journal Title

      BMC Geriatr

      Volume: 17 Pages: 102-102

    • DOI

      10.1186/s12877-017-0490-8

    • NAID

      120006352264

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Mechanism Underlying Preventive Effect of High-Intensity Training on Colon Cancer2017

    • Author(s)
      Matsuo K, Sato K, Suemoto K, Miyamoto-Mikami E, Fuku N, Higashida K, Tsuji K, Xu Y, Liu X, Iemitsu M, Hamaoka T, Tabata I.
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: 印刷中 Pages: 1805-1816

    • DOI

      10.1249/mss.0000000000001312

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Acute effect of stretching one leg on regional arterial stiffness in young men.2017

    • Author(s)
      Yamato Y, Hasegawa N, Fujie S, Ogoh S, Iemitsu M
    • Journal Title

      European Journal of Applied Physiology

      Volume: 117 Pages: 1227-1232

    • DOI

      10.1007/s00421-017-3609-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-intensity intermittent exercise training with chlorella intake accelerates exercise performance and muscle glycolytic and oxidative capacity in rats2017

    • Author(s)
      Horii N, Hasegawa N, Fujie S, Uchida M, Miyamoto-Mikami E, Hashimoto T, Tabata I, Iemitsu M.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 印刷中 Pages: 520-528

    • DOI

      10.1152/ajpregu.00383.2016

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Habitual aerobic exercise-induced decrease in circulating C1q level is associated with reduction of cardiovascular diseases risks in the elderly.2019

    • Author(s)
      Hasegawa N, Horii N, Fujie S, Uchida M, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      Epidemiology and Prevention and Lifestyle and Cardiometabolic Health 2019 Scientific Sessions
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Salusin-α is a novel biomarker of cardiovascular disease risk in aging and exercise lifestyle: Cross-Sectional and Intervention Study.2019

    • Author(s)
      Fujie S, Hasegawa N, Sanada K, Hamaoka T, Maeda S, Padilla J, Martinez-Lemus LA, Iemitsu M.
    • Organizer
      Epidemiology and Prevention and Lifestyle and Cardiometabolic Health 2019 Scientific Sessions
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of regular lower limb stretching exercise on arterial stiffness in middle-aged and older women.2018

    • Author(s)
      Yamato Y, Hasegawa N, Horii N, Uchida M, Iemitsu M.
    • Organizer
      Singapore-International Physiotherapy Congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Increased serum irisin level by aerobic training is involved in NO production in obese rats.2018

    • Author(s)
      Inoue K, Fujie S, Hasegawa N, Horii N, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      American College of Sports Medicine 65th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Different responses of arterial stiffness and nitric oxide bioavailability to different exercise training programs.2018

    • Author(s)
      Hasegawa N, Fujie S, Horii N, Miyamoto-Mikami E, Tsuji K, Uchida M, Hamaoka T, Tabata I, Iemitsu M.
    • Organizer
      American College of Sports Medicine 65th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chlorella intake further enhances anaerobic and aerobic capacities increased by high intensity intermittent training.2018

    • Author(s)
      Fujie S, Hasegawa N, Horii N, Oshiden M, Tsuji K, Xu Y, Mizoguchi T, Okumura E, Tabata I, Iemitsu M.
    • Organizer
      American College of Sports Medicine 65th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Resistance training-induced decrease in circulating C1q is associated with attenuated muscle degradation in senescent mice.2018

    • Author(s)
      Horii N, Uchida M, Hasegawa N, Fujie S, Oyanagi E, Yano H, Hashimoto T, Iemitsu M.
    • Organizer
      American College of Sports Medicine 65th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of aerobic training-induced acceleration of adiponectin secretion from local fat cells on arterial stiffness in elderly.2018

    • Author(s)
      Hasegawa N, Fujie S, Horii N, Uchida M, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      23rd annual congress of the European College of Sport Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activation of protein synthesis signaling via increase in muscle 5α-dihydrotestosterone by acute resistance exercise affects muscle hypertrophy in type 2 diabetic rats.2018

    • Author(s)
      Horii N, Hasegawa N, Fujie S, Uchida M, Inoue K, Iemitsu M.
    • Organizer
      23rd annual congress of the European College of Sport Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] G-protein coupled estrogen receptor (GPER) rs3808350 polymorphism is associated with central arterial stiffness in healthy japanese people.2018

    • Author(s)
      Hayashi K, Iemitsu M, Murakami H, Sanada K, Kawano H, Gando Y, Tanaka N, Kawakami R, Miyachi M.
    • Organizer
      23rd annual congress of the European College of Sport Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sparassis crispa intake is attenuated the reduction of LPS-induced TNF-α production by exhaustive exercise in mice.2018

    • Author(s)
      Uchida M, Horii N, Iemitsu M.
    • Organizer
      23rd annual congress of the European College of Sport Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gut microflora diversity is induced by resistance training in aged mice, but its acquired diversity might not be contributed with the high physical performance.2018

    • Author(s)
      Yano H, Horii N, Kremenik MJ, Aoki T, Uchida M, Iemitsu M, Oyanagi E.
    • Organizer
      23rd annual congress of the European College of Sport Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Attenuation of NPR-C binding with muscle-derived musclin is related to reduced cardiovascular disease risks by aerobic exercise training in type 2 diabetic rats.2018

    • Author(s)
      Toyama Y, Hasegawa N, Horii N, Inoue K, Iemitsu K, Fujie S, Uchida M, Iemitsu M.
    • Organizer
      American Heart Association scientific sessions 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aerobic exercise training-induced changes in anti-inflammatory adipokines secretion from local source are related to reduction of arterial stiffness in elderly.2018

    • Author(s)
      Hasegawa N, Fujie S, Horii N, Uchida M, Iemitsu K, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      American Heart Association scientific sessions 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elevation of arterial adropin secretion by aerobic exercise training is related to vasodilation via increase in nitric oxide production in aged mice.2018

    • Author(s)
      Fujie S, Hasegawa N, Horii N, Uchida M, Maeda S, Iemitsu M.
    • Organizer
      American Heart Association scientific sessions 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aerobic exercise training-induced increase in muscle-derived Follistatin-like 1 (FSTL1) secretion is associated with nitric oxide production in type 2 diabetic rats.2018

    • Author(s)
      Inoue K, Hasegawa N, Fujie S, Horii N, Uchida M, Iemitsu M.
    • Organizer
      American Heart Association scientific sessions 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serum C1q level is a novel biomarker of cardiovascular diseases risk.2018

    • Author(s)
      Hasegawa N, Horii N, Fujie S, Uchida M, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      11th international SCWD conference on cachexia, sarcopenia and muscle wasting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chlorella intake prevents aging-induced muscle atrophy and fibrosis in senescent mice.2018

    • Author(s)
      Horii N, Uchida M, Hasegawa N, Fujie S, Mizoguchi T, Okumura E, Sanada K, Iemitsu M.
    • Organizer
      11th international SCWD conference on cachexia, sarcopenia and muscle wasting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 運動による骨格筋由来生理活性因子(マイオカイン)の分泌と抗加齢効果.2018

    • Author(s)
      家光素行.
    • Organizer
      第18回日本抗加齢医学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] サルコペニアに関わる新規マイオカイン.2018

    • Author(s)
      家光素行.
    • Organizer
      日本スポーツ栄養学会第5回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 運動と栄養による動脈硬化の改善効果と分子機序.2018

    • Author(s)
      家光素行.
    • Organizer
      第9回ILSI Japanライフサイエンスシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 2型糖尿病ラットにおけるクロレラ摂取と有酸素性トレーニングとの併用効果2017

    • Author(s)
      堀居直希,長谷川夏輝,藤江隼平,内田昌孝,溝口亨,大西真人,家光素行.
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] クロレラ摂取と短時間間欠的高強度運動の併用が無酸素性および有酸素性運動能力に及ぼす影響.2017

    • Author(s)
      王子田萌,藤江隼平,長谷川夏輝,堀居直希,街勝憲,徐宇中,溝口亨,大西真人,田畑泉,家光素行.
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 若年者におけるトゲドコロの長期摂取が心血管疾患リスクに及ぼす影響.2017

    • Author(s)
      長谷川夏輝,藤江隼平,堀居直希,王子田萌,家光素行.
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 2型糖尿病ラットの長期クロレラ摂取は血管内皮由来拡張物質の産生増大を介して動脈硬化度を低下させる.2017

    • Author(s)
      藤江隼平,長谷川夏輝,堀居直希,溝口亨,大西真人,内田昌孝,家光素行.
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 習慣的なレジスタンス運動による血中C1q濃度の低下は筋損傷後の再生能力の回復に関与する.2017

    • Author(s)
      堀居直希,内田昌孝,長谷川夏輝,家光素行.
    • Organizer
      第25回日本運動生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アスリートのトゲドコロ摂取がレジスタンストレーニングによる筋量・筋力に及ぼす影響.2017

    • Author(s)
      堀居直希,長谷川夏輝,藤江隼平,佐藤幸治,浜岡隆文,家光素行.
    • Organizer
      日本スポーツ栄養学会第4回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 異なる運動様式のトレーニングが動脈血管拡張因子に及ぼす影響.2017

    • Author(s)
      長谷川夏輝,藤江隼平,堀居直希,内田昌孝,田畑泉,家光素行.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肥満者の有酸素性トレーニングによる血中irisin濃度の増大は動脈硬化度の低下に関与する.2017

    • Author(s)
      井上健一郎,藤江隼平,長谷川夏輝,堀居直希,真田樹義,浜岡隆文,家光素行.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 降圧ペプチドホルモンsalusin-αの分泌変化は中高齢者の習慣的な有酸素性運動による血圧低下に関与する.2017

    • Author(s)
      藤江隼平,長谷川夏輝,真田樹義,浜岡隆文,家光素行.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 陸上競技400m走のレース展開と無酸素性・有酸素性運動能力の貢献度.2017

    • Author(s)
      王子田萌,長谷川夏輝,藤江隼平,堀居直希,家光素行.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 2型糖尿病ラットの異なる運動様式に対する筋内のFstl1発現の変動.2017

    • Author(s)
      家原蒼一朗,堀居直希,藤江隼平,長谷川夏輝,内田昌孝,家光素行.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 習慣的なレジスタンス運動は血中C1q濃度の低下を介して加齢に伴う筋の線維化を抑制する.2017

    • Author(s)
      堀居直希,内田昌孝,長谷川夏輝,藤江隼平,橋本健志,小柳えり,矢野博己,家光素行.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 陸上競技女子長距離選手における貧血状態と血中アミノ酸濃度の関連.2017

    • Author(s)
      門馬怜子,熊谷仁,王子田萌,家光素行,前田清司.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 加齢による臓器内の炎症性サイトカイン動態と運動効果.2017

    • Author(s)
      内田昌孝,堀居直希,長谷川夏輝,藤江隼平,橋本健志,小柳えり,矢野博己,家光素行.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] RANK gene polymorphism is associated with incidence of stress fractures in Japanese female endurance athletes.2017

    • Author(s)
      Numa A, Fujie S, Hasegawa N, Horii N, Oshiden M, Uchida M, Tabata I, Iemitsu M.
    • Organizer
      64nd American College of Sports Medicine Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serum salusin-α level is associated with exercise training-induced reduction of arterial stiffness in the elderly.2017

    • Author(s)
      Fujie S, Hasegawa N, Uchida M, Horii N, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      64nd American College of Sports Medicine Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serum CTRPs levels are associated with exercise training-induced reduction of arterial stiffness in the elderly.2017

    • Author(s)
      Hasegawa N, Fujie S, Uchida M, Horii N, Kurihara T, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      64nd American College of Sports Medicine Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High intensity intermittent training and chlorella intake enhance muscle glycolytic and oxidative metabolism in rats.2017

    • Author(s)
      Horii N, Hasegawa N, Fujie S, Uchida M, Miyamoto-Mikami E, Hashimoto T, Tabata I, Iemitsu M.
    • Organizer
      64nd American College of Sports Medicine Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acute effect of passive one-legged stretching on peripheral blood flow in young men.2017

    • Author(s)
      Yamato Y, Hasegawa N, Fujie S, Uchida M, Ogoh S, Iemitsu M.
    • Organizer
      WCPT-AWP & PTAT Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chronic responses of inflammation and macrophage function to exercise training in various tissues of senescence mice.2017

    • Author(s)
      Uchida M, Horii N, Hasegawa N, Fujie S, Oyanagi E, Yano H, Hashimoto T, Iemitsu M.
    • Organizer
      13th International Society for Exercise and Immunology Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reduced serum C1q by resistance training is related to the prevention of sarcopenia.2017

    • Author(s)
      Horii N, Uchida M, Hasegawa N, Fujie S, Oyanagi E, Yano H, Hashimoto T, Iemitsu M.
    • Organizer
      ACFS 2017 3rd Asian Conference for Frailty and Sarcopenia
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aerobic and resistance training-induced attenuation of chronic inflammation involves functional change of macrophages in various tissues of senescent mice.2017

    • Author(s)
      Uchida M, Horii N, Hasegawa N, Fujie S, Oyanagi E, Yano H, Hashimoto T, Iemitsu M.
    • Organizer
      ACFS 2017 3rd Asian Conference for Frailty and Sarcopenia
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Short lasting exhaustive high-intensity intermittent exercise reduces arterial stiffness through enhancement of aortic NO bioavailability.2017

    • Author(s)
      Hasegawa N, Fujie S, Horii N, Miyamoto-Mikami E, Tsuji K, Uchida M, Hamaoka T, Tabata I, Iemitsu M.
    • Organizer
      American Heart Association scientific sessions 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Change in salusin-α is related to aerobic exercise training-induced blood pressure reduction in middle-aged and older adults.2017

    • Author(s)
      Fujie S, Hasegawa N, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      American Heart Association scientific sessions 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aerobic exercise training-induced increase in circulating irisin level is associated with reduced arterial stiffness in obesity.2017

    • Author(s)
      Inoue K, Fujie S, Hasegawa N, Horii N, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      American Heart Association scientific sessions 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2019-12-27  

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