• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of exercise and diet therapies for the improvement of risk of cardiovascular disease targeting novel myokine

Research Project

Project/Area Number 17H02182
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionRitsumeikan University

Principal Investigator

Iemitsu Motoyuki  立命館大学, スポーツ健康科学部, 教授 (90375460)

Co-Investigator(Kenkyū-buntansha) 真田 樹義  立命館大学, スポーツ健康科学部, 教授 (50421227)
橋本 健志  立命館大学, スポーツ健康科学部, 教授 (70511608)
金森 雅夫  立命館大学, スポーツ健康科学部, 教授 (90127019)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2017: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywordsマイオカイン / 動脈硬化 / 加齢 / 運動 / 栄養
Outline of Final Research Achievements

In this study, regular aerobic exercise reduced carotid-femoral pulse wave velocity (cfPWV) and elevated circulating levels of nitrite/nitrate (NOx) and irisin in middle-aged and older adults with obesity. Furthermore, change in circulating irisin levels by regular exercise was positively correlated with circulating NOx levels and was negatively correlated with cfPWV. As a result of animal study, cfPWV was decreased, and arterial phosphorylation levels of AMPK, Akt, and endothelial NO synthase (eNOS), circulating levels of NOx and irisin, and muscle mRNA expression of fibronectin type III domain containing 5 (Fndc5) were increased in OLETF-EX group compared to OLETF-CON group. Thus, aerobic exercise training-induced increase in irisin secretion may be related to reduction of arterial stiffness achieved by NO production via activated arterial AMPK-Akt-eNOS signaling pathway in middle-aged and older adults with obesity.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、irisinを運動による動脈硬化改善効果の血液バイオマーカーとして用いて、動脈硬化の予防・改善に対する科学的根拠に基づく運動療法の提案が可能となる発展性の高い研究課題である。さらに有酸素性トレーニングによる動脈硬化改善効果のメカニズムを明らかにできれば、効果的な運動様式、運動量(強度・時間)、運動期間を明確化することができるための基礎資料となり、運動生理学・健康科学分野だけでなく、疾患の第2次予防に対しても有益な情報となりうるため、医科学分野に対しても新たな情報を提供するインパクトのある研究であると考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report

Research Products

(86 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (23 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 23 results,  Open Access: 11 results,  Acknowledgement Compliant: 1 results) Presentation (60 results) (of which Int'l Joint Research: 37 results) Book (1 results)

  • [Int'l Joint Research] University of Missouri(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Missouri(米国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Increased serum salusin-alpha by aerobic exercise training correlates with improvements in arterial stiffness in middle-aged and older adults2020

    • Author(s)
      Fujie Shumpei、Hasegawa Natsuki、Sanada Kiyoshi、Hamaoka Takafumi、Maeda Seiji、Padilla Jaume、Martinez-Lemus Luis A.、Iemitsu Motoyuki
    • Journal Title

      Aging.

      Volume: 12 Pages: 1201-1212

    • DOI

      10.18632/aging.102678

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aerobic exercise training-induced irisin secretion is associated with the reduction of arterial stiffness via nitric oxide production in adults with obesity.2020

    • Author(s)
      Inoue K, Fujie S, Hasegawa N, Horii N, Uchida M, Iemitsu K, Sanada K, Hamaoka T, Iemitsu M.
    • Journal Title

      Appl Physiol Nutr Metab.

      Volume: - Pages: 715-722

    • DOI

      10.1139/apnm-2019-0602

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Associations among Bone Mineral Density, Physical Activity and Nutritional Intake in Middle-Aged Women with High Levels of Arterial Stiffness: A Pilot Study2020

    • Author(s)
      Hamaguchi Kanako、Kurihara Toshiyuki、Fujimoto Masahiro、Sato Koji、Iemitsu Motoyuki、Hamaoka Takafumi、Sanada Kiyoshi
    • Journal Title

      Int J Environ Res Public Health

      Volume: 17 Pages: 1-15

    • DOI

      10.3390/ijerph17051620

    • NAID

      120006873068

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of Dioscorea esculenta intake with resistance training on muscle hypertrophy and strength in sprint athletes.2020

    • Author(s)
      Horii N, Hasegawa N, Fujie S, Iemitsu K, Uchida M, Hamaoka T, Iemitsu M.
    • Journal Title

      J Clin Biochem Nutr

      Volume: -

    • NAID

      130007934170

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sparassis crispa Intake Improves the Reduced Lipopolysaccharide-Induced TNF-α Production That Occurs upon Exhaustive Exercise in Mice2019

    • Author(s)
      Uchida Masataka、Horii Naoki、Hasegawa Natsuki、Oyanagi Eri、Yano Hiromi、Iemitsu Motoyuki
    • Journal Title

      Nutrients

      Volume: 11 Pages: 2049-2049

    • DOI

      10.3390/nu11092049

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aging-induced elevation in circulating complement C1q level is associated with arterial stiffness2019

    • Author(s)
      Hasegawa Natsuki、Fujie Shumpei、Horii Naoki、Uchida Masataka、Toyama Yuta、Inoue Kenichiro、Sanada Kiyoshi、Hamaoka Takafumi、Iemitsu Motoyuki
    • Journal Title

      Exp Gerontol

      Volume: 124 Pages: 110650-110650

    • DOI

      10.1016/j.exger.2019.110650

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of combination of chlorella intake and aerobic exercise training on glycemic control in type 2 diabetic rats2019

    • Author(s)
      Horii Naoki、Hasegawa Natsuki、Fujie Shumpei、Uchida Masataka、Iemitsu Keiko、Inoue Kenichiro、Iemitsu Motoyuki
    • Journal Title

      Nutrition.

      Volume: 63-64 Pages: 45-50

    • DOI

      10.1016/j.nut.2019.01.008

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Short‐term cycling restores endothelial dysfunction after resistance exercise2019

    • Author(s)
      Morishima Takuma、Iemitsu Motoyuki、Ochi Eisuke
    • Journal Title

      Scandinavian Journal of Medicine & Science in Sports

      Volume: - Pages: 1115-1120

    • DOI

      10.1111/sms.13434

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-intensity resistance exercise with low repetitions maintains endothelial function2018

    • Author(s)
      Morishima Takuma、Tsuchiya Yosuke、Iemitsu Motoyuki、Ochi Eisuke
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology

      Volume: 315

    • DOI

      10.1152/ajpheart.00281.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profile of muscle adaptation to high-intensity intermittent exercise training in young men2018

    • Author(s)
      Miyamoto-Mikami E, Tsuji K, Horii N, Hasegawa N, Fujie S, Homma T, Uchida M, Hamaoka T, Kanehisa H, Tabata I, Iemitsu M
    • Journal Title

      Sci Rep.

      Volume: 8 Pages: 16811-16811

    • DOI

      10.1038/s41598-018-35115-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 閉経後サルコペニア女性を対象とした骨密度に対する軽負荷パワートレーニング効果の個体差に関連する要因の検討2018

    • Author(s)
      浜口佳奈子, 栗原俊之, 藤本雅大, 家光素行, 佐藤幸治, 浜岡隆文, 真田樹義.
    • Journal Title

      トレーニング科学

      Volume: 30 Pages: 45-54

    • NAID

      40021758952

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 日本人中高齢女性を対象とした内臓脂肪の分布とメタボリックシンドロームリスク因子との関係2018

    • Author(s)
      中山侑紀, 井門あゆみ, 石井好二郎, 家光素行, 佐藤幸治, 藤本雅大, 栗原俊之, 浅原哲子, 真田樹義.
    • Journal Title

      京都滋賀体育学研究

      Volume: 34 Pages: 10-18

    • NAID

      130007970072

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肥満ラットの有酸素性トレーニングによる動脈血管のapelin産生の増加は内皮型一酸化窒素合成酵素の活性に影響する2018

    • Author(s)
      井上健一郎, 藤江隼平, 長谷川夏輝, 堀居直希, 内田昌孝, 佐藤幸治, 家光素行.
    • Journal Title

      京都滋賀体育学研究

      Volume: 34 Pages: 20-28

    • NAID

      130007970074

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肥満者を対象とした低強度レジスタンストレーニングの効果:腹部サルコペニアの有無による比較2018

    • Author(s)
      4.村上泰一, 中村由紀, 古嶋大詩, 家光素行, 栗原俊之, 藤本雅大, 有光琢磨, 石井好二郎, 浅原哲子, 真田樹義.
    • Journal Title

      肥満研究

      Volume: 24 Pages: 30-40

    • NAID

      40021632760

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Role of Dehydroepiandrosterone (DHEA) in Skeletal Muscle2018

    • Author(s)
      Sato Koji、Iemitsu Motoyuki
    • Journal Title

      Vitamins and Hormones

      Volume: 108 Pages: 205-221

    • DOI

      10.1016/bs.vh.2018.03.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of different exercise modes on arterial stiffness and nitric oxide synthesis.2018

    • Author(s)
      Hasegawa N, Fujie S, Horii N, Miyamoto-Mikami E, Tsuji K, Uchida M, Hamaoka T, Tabata I, Iemitsu M.
    • Journal Title

      Medicine and Science in Sports and Exercise

      Volume: - Pages: 1177-1185

    • DOI

      10.1249/mss.0000000000001567

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resistance training prevents muscle fibrosis and atrophy via down-regulation of C1q-induced Wnt signaling in senescent mice.2018

    • Author(s)
      Horii N, Uchida M, Hasegawa N, Fujie S, Oyanagi E, Yano H, Hashimoto T, Iemitsu M.
    • Journal Title

      FASEB J.

      Volume: - Pages: 3547-3559

    • DOI

      10.1096/fj.201700772rrr

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aerobic exercise training-induced changes in serum C1q/TNF-related protein levels are associated with reduced arterial stiffness in middle-aged and older adults2018

    • Author(s)
      Hasegawa N, Fujie S, Horii N, Uchida M, Kurihara T, Sanada K, Hamaoka T, Iemitsu M.
    • Journal Title

      American Journal of Physiology, Regulatory Integrative and Comparative Physiology

      Volume: 314 Pages: 94-101

    • DOI

      10.1152/ajpregu.00212.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of prediction equations for estimating appendicular skeletal muscle mass in Japanese men and women2017

    • Author(s)
      Furushima T, Miyachi M, Iemitsu M, Murakami H, Kawano H, Gando Y, Kawakami R, Sanada K.
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 36 Pages: 34-34

    • DOI

      10.1186/s40101-017-0150-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The effects of low-repetition and light-load power training on bone mineral density in postmenopausal women with sarcopenia: A pilot study2017

    • Author(s)
      Kanako Hamaguchi; Toshiyuki Kurihara; Masahiro Fujimoto; Motoyuki Iemitsu; Koji Sato; Takafumi Hamaoka; Kiyoshi Sanada
    • Journal Title

      BMC Geriatr

      Volume: 17 Pages: 102-102

    • DOI

      10.1186/s12877-017-0490-8

    • NAID

      120006352264

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Mechanism Underlying Preventive Effect of High-Intensity Training on Colon Cancer.2017

    • Author(s)
      Matsuo K, Sato K, Suemoto K, Miyamoto-Mikami E, Fuku N, Higashida K, Tsuji K, Xu Y, Liu X, Iemitsu M, Hamaoka T, Tabata I.
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: 印刷中 Pages: 1805-1816

    • DOI

      10.1249/mss.0000000000001312

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Acute effect of stretching one leg on regional arterial stiffness in young men2017

    • Author(s)
      Yamato Y, Hasegawa N, Fujie S, Ogoh S, Iemitsu M
    • Journal Title

      European Journal of Applied Physiology

      Volume: 117 Pages: 1227-1232

    • DOI

      10.1007/s00421-017-3609-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-intensity intermittent exercise training with chlorella intake accelerates exercise performance and muscle glycolytic and oxidative capacity in rats2017

    • Author(s)
      Horii N, Hasegawa N, Fujie S, Uchida M, Miyamoto-Mikami E, Hashimoto T, Tabata I, Iemitsu M.
    • Journal Title

      American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

      Volume: 312 Pages: 520-528

    • DOI

      10.1152/ajpregu.00383.2016

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Time course of improvement in secretory unbalance of asymmetric dimethylarginine and nitric oxide productions in response to exercise training in middle-aged and older adults.2019

    • Author(s)
      Fujie S, Hasegawa N, Sanada K, Hamaoka T, Maeda S, Iemitsu M.
    • Organizer
      ESC Asia with APSC & AFC 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of carbonated sports drink intake after high-intensity exercise on fatigue recovery in athletic sprinters.2019

    • Author(s)
      Hasegawa N, Fujie S, Horii N, Hamaoka T, Iemitsu M.
    • Organizer
      American College of Sports Medicine 66th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Changes in salivary cortisol and IgA levels are associated with fatigue after acute endurance exercise.2019

    • Author(s)
      Hashizume N, Hasegawa N, Horii N, Yoshikawa M, Tsuji K, Uchida M, Iemitsu K, Hashimoto T, Sanada K, Kanamori M, Watanabe K, Iemitsu M.
    • Organizer
      American College of Sports Medicine 66th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Increased muscle 5α-dihydrotestosterone by acute resistance exercise contributes to muscle GLUT4 signaling in diabetic rats.2019

    • Author(s)
      Horii N, Hasegawa N, Uchida M, Iemitsu M.
    • Organizer
      American College of Sports Medicine 66th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aerobic training-induced increase in follistatin-like 1 secretion is associated with eNOS phosphorylation in diabetic rats.2019

    • Author(s)
      Inoue K, Hasegawa N, Fujie S, Horii N, Uchida M, Iemitsu M.
    • Organizer
      American College of Sports Medicine 66th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of musclin on aerobic training-induced reduction of arterial stiffness in obese rats.2019

    • Author(s)
      Toyama Y, Hasegawa N, Horii N, Inoue K, Iemitsu K, Fujie S, Uchida M, Iemitsu M.
    • Organizer
      American College of Sports Medicine 66th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Short-term cycling restores endothelial dysfunction after resistance exercise.2019

    • Author(s)
      Morishima T, Iemitsu M, Ochi E.
    • Organizer
      American College of Sports Medicine 66th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Voluntary wheel running influences on dynamics of gut microbiota F/B ratio in TLR5 deficient mice.2019

    • Author(s)
      Yano H, Kobiki N, Watanabe C, Kremenik M J, Aoki T, Uchida M, Iemitsu M, Oyanagi E.
    • Organizer
      24th Annual Congress of the European College of Sport Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 短時間のサイクリングはレジスタンス運動後における血管内皮機能の低下を回復させる.2019

    • Author(s)
      森嶋琢真, 家光素行.
    • Organizer
      第27回日本運動生理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Tlr5遺伝子欠損マウスの腸内細菌叢と身体活動性.2019

    • Author(s)
      矢野博己, 内田昌孝, 渡邉知央, 小引菜々子, 三浦鈴夏, 横川由佳, 青木孝文, 家光素行, 小栁えり.
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 有酸素性トレーニングによる局所の脂肪組織からのアディポネクチン分泌の亢進が動脈機能に及ぼす影響.2019

    • Author(s)
      長谷川夏輝, 藤江隼平, 堀居直希, 内田昌孝, 家光恵子, 外山雄大, 井上健一郎, 浜岡隆文, 家光素行.
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 有酸素性トレーニングによる持久性能力亢進に対する腸内細菌叢の影響.2019

    • Author(s)
      内田昌孝, 堀居直希, 長谷川夏輝, 藤江隼平, 小柳えり, 矢野博己, 家光素行.
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 安静時の唾液中のコルチゾール濃度がその後の運動パフォーマンスおよび主観的疲労感と関連する.2019

    • Author(s)
      橋爪夏香, 吉川万紀, 長谷川夏輝, 堀居直希, 街勝憲,内田昌孝, 家光恵子,金森雅夫,渡邊航平,家光素行.
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 骨格筋由来の性ステロイドホルモンの新たな役割2019

    • Author(s)
      家光素行
    • Organizer
      第10回テストステロン研究会/Men’s Health医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Habitual aerobic exercise-induced decrease in circulating C1q level is associated with reduction of cardiovascular diseases risks in the elderly.2019

    • Author(s)
      Hasegawa N, Horii N, Fujie S, Uchida M, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      Epidemiology and Prevention and Lifestyle and Cardiometabolic Health 2019 Scientific Sessions
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Salusin-α is a novel biomarker of cardiovascular disease risk in aging and exercise lifestyle: Cross-Sectional and Intervention Study.2019

    • Author(s)
      Fujie S, Hasegawa N, Sanada K, Hamaoka T, Maeda S, Padilla J, Martinez-Lemus LA, Iemitsu M.
    • Organizer
      Epidemiology and Prevention and Lifestyle and Cardiometabolic Health 2019 Scientific Sessions
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of regular lower limb stretching exercise on arterial stiffness in middle-aged and older women.2018

    • Author(s)
      Yamato Y, Hasegawa N, Horii N, Uchida M, Iemitsu M.
    • Organizer
      Singapore-International Physiotherapy Congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Increased serum irisin level by aerobic training is involved in NO production in obese rats.2018

    • Author(s)
      Inoue K, Fujie S, Hasegawa N, Horii N, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      American College of Sports Medicine 65th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Different responses of arterial stiffness and nitric oxide bioavailability to different exercise training programs.2018

    • Author(s)
      Hasegawa N, Fujie S, Horii N, Miyamoto-Mikami E, Tsuji K, Uchida M, Hamaoka T, Tabata I, Iemitsu M.
    • Organizer
      American College of Sports Medicine 65th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chlorella intake further enhances anaerobic and aerobic capacities increased by high intensity intermittent training.2018

    • Author(s)
      Fujie S, Hasegawa N, Horii N, Oshiden M, Tsuji K, Xu Y, Mizoguchi T, Okumura E, Tabata I, Iemitsu M.
    • Organizer
      American College of Sports Medicine 65th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Resistance training-induced decrease in circulating C1q is associated with attenuated muscle degradation in senescent mice.2018

    • Author(s)
      Horii N, Uchida M, Hasegawa N, Fujie S, Oyanagi E, Yano H, Hashimoto T, Iemitsu M.
    • Organizer
      American College of Sports Medicine 65th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of aerobic training-induced acceleration of adiponectin secretion from local fat cells on arterial stiffness in elderly.2018

    • Author(s)
      Hasegawa N, Fujie S, Horii N, Uchida M, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      23rd annual congress of the European College of Sport Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activation of protein synthesis signaling via increase in muscle 5α-dihydrotestosterone by acute resistance exercise affects muscle hypertrophy in type 2 diabetic rats.2018

    • Author(s)
      Horii N, Hasegawa N, Fujie S, Uchida M, Inoue K, Iemitsu M.
    • Organizer
      23rd annual congress of the European College of Sport Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] G-protein coupled estrogen receptor (GPER) rs3808350 polymorphism is associated with central arterial stiffness in healthy japanese people.2018

    • Author(s)
      Hayashi K, Iemitsu M, Murakami H, Sanada K, Kawano H, Gando Y, Tanaka N, Kawakami R, Miyachi M.
    • Organizer
      23rd annual congress of the European College of Sport Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sparassis crispa intake is attenuated the reduction of LPS-induced TNF-α production by exhaustive exercise in mice.2018

    • Author(s)
      Uchida M, Horii N, Iemitsu M.
    • Organizer
      23rd annual congress of the European College of Sport Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gut microflora diversity is induced by resistance training in aged mice, but its acquired diversity might not be contributed with the high physical performance.2018

    • Author(s)
      Yano H, Horii N, Kremenik MJ, Aoki T, Uchida M, Iemitsu M, Oyanagi E.
    • Organizer
      23rd annual congress of the European College of Sport Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Attenuation of NPR-C binding with muscle-derived musclin is related to reduced cardiovascular disease risks by aerobic exercise training in type 2 diabetic rats.2018

    • Author(s)
      Toyama Y, Hasegawa N, Horii N, Inoue K, Iemitsu K, Fujie S, Uchida M, Iemitsu M.
    • Organizer
      American Heart Association scientific sessions 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aerobic exercise training-induced changes in anti-inflammatory adipokines secretion from local source are related to reduction of arterial stiffness in elderly.2018

    • Author(s)
      Hasegawa N, Fujie S, Horii N, Uchida M, Iemitsu K, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      American Heart Association scientific sessions 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elevation of arterial adropin secretion by aerobic exercise training is related to vasodilation via increase in nitric oxide production in aged mice.2018

    • Author(s)
      Fujie S, Hasegawa N, Horii N, Uchida M, Maeda S, Iemitsu M.
    • Organizer
      American Heart Association scientific sessions 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aerobic exercise training-induced increase in muscle-derived Follistatin-like 1 (FSTL1) secretion is associated with nitric oxide production in type 2 diabetic rats.2018

    • Author(s)
      Inoue K, Hasegawa N, Fujie S, Horii N, Uchida M, Iemitsu M.
    • Organizer
      American Heart Association scientific sessions 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serum C1q level is a novel biomarker of cardiovascular diseases risk.2018

    • Author(s)
      Hasegawa N, Horii N, Fujie S, Uchida M, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      11th international SCWD conference on cachexia, sarcopenia and muscle wasting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chlorella intake prevents aging-induced muscle atrophy and fibrosis in senescent mice.2018

    • Author(s)
      Horii N, Uchida M, Hasegawa N, Fujie S, Mizoguchi T, Okumura E, Sanada K, Iemitsu M.
    • Organizer
      11th international SCWD conference on cachexia, sarcopenia and muscle wasting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 運動による骨格筋由来生理活性因子(マイオカイン)の分泌と抗加齢効果.2018

    • Author(s)
      家光素行.
    • Organizer
      第18回日本抗加齢医学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] サルコペニアに関わる新規マイオカイン.2018

    • Author(s)
      家光素行.
    • Organizer
      日本スポーツ栄養学会第5回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 運動と栄養による動脈硬化の改善効果と分子機序.2018

    • Author(s)
      家光素行.
    • Organizer
      第9回ILSI Japanライフサイエンスシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 2型糖尿病ラットにおけるクロレラ摂取と有酸素性トレーニングとの併用効果2017

    • Author(s)
      堀居直希,長谷川夏輝,藤江隼平,内田昌孝,溝口亨,大西真人,家光素行.
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] クロレラ摂取と短時間間欠的高強度運動の併用が無酸素性および有酸素性運動能力に及ぼす影響.2017

    • Author(s)
      王子田萌,藤江隼平,長谷川夏輝,堀居直希,街勝憲,徐宇中,溝口亨,大西真人,田畑泉,家光素行.
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 若年者におけるトゲドコロの長期摂取が心血管疾患リスクに及ぼす影響.2017

    • Author(s)
      長谷川夏輝,藤江隼平,堀居直希,王子田萌,家光素行.
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 2型糖尿病ラットの長期クロレラ摂取は血管内皮由来拡張物質の産生増大を介して動脈硬化度を低下させる.2017

    • Author(s)
      藤江隼平,長谷川夏輝,堀居直希,溝口亨,大西真人,内田昌孝,家光素行.
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 習慣的なレジスタンス運動による血中C1q濃度の低下は筋損傷後の再生能力の回復に関与する.2017

    • Author(s)
      堀居直希,内田昌孝,長谷川夏輝,家光素行.
    • Organizer
      第25回日本運動生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アスリートのトゲドコロ摂取がレジスタンストレーニングによる筋量・筋力に及ぼす影響.2017

    • Author(s)
      堀居直希,長谷川夏輝,藤江隼平,佐藤幸治,浜岡隆文,家光素行.
    • Organizer
      日本スポーツ栄養学会第4回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 異なる運動様式のトレーニングが動脈血管拡張因子に及ぼす影響.2017

    • Author(s)
      長谷川夏輝,藤江隼平,堀居直希,内田昌孝,田畑泉,家光素行.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肥満者の有酸素性トレーニングによる血中irisin濃度の増大は動脈硬化度の低下に関与する.2017

    • Author(s)
      井上健一郎,藤江隼平,長谷川夏輝,堀居直希,真田樹義,浜岡隆文,家光素行.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 降圧ペプチドホルモンsalusin-αの分泌変化は中高齢者の習慣的な有酸素性運動による血圧低下に関与する.2017

    • Author(s)
      藤江隼平,長谷川夏輝,真田樹義,浜岡隆文,家光素行.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 陸上競技400m走のレース展開と無酸素性・有酸素性運動能力の貢献度.2017

    • Author(s)
      王子田萌,長谷川夏輝,藤江隼平,堀居直希,家光素行.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 2型糖尿病ラットの異なる運動様式に対する筋内のFstl1発現の変動.2017

    • Author(s)
      家原蒼一朗,堀居直希,藤江隼平,長谷川夏輝,内田昌孝,家光素行.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 習慣的なレジスタンス運動は血中C1q濃度の低下を介して加齢に伴う筋の線維化を抑制する.2017

    • Author(s)
      堀居直希,内田昌孝,長谷川夏輝,藤江隼平,橋本健志,小柳えり,矢野博己,家光素行.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 陸上競技女子長距離選手における貧血状態と血中アミノ酸濃度の関連.2017

    • Author(s)
      門馬怜子,熊谷仁,王子田萌,家光素行,前田清司.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 加齢による臓器内の炎症性サイトカイン動態と運動効果.2017

    • Author(s)
      内田昌孝,堀居直希,長谷川夏輝,藤江隼平,橋本健志,小柳えり,矢野博己,家光素行.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] RANK gene polymorphism is associated with incidence of stress fractures in Japanese female endurance athletes.2017

    • Author(s)
      Numa A, Fujie S, Hasegawa N, Horii N, Oshiden M, Uchida M, Tabata I, Iemitsu M.
    • Organizer
      64nd American College of Sports Medicine Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serum salusin-α level is associated with exercise training-induced reduction of arterial stiffness in the elderly.2017

    • Author(s)
      Fujie S, Hasegawa N, Uchida M, Horii N, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      64nd American College of Sports Medicine Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serum CTRPs levels are associated with exercise training-induced reduction of arterial stiffness in the elderly.2017

    • Author(s)
      Hasegawa N, Fujie S, Uchida M, Horii N, Kurihara T, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      64nd American College of Sports Medicine Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High intensity intermittent training and chlorella intake enhance muscle glycolytic and oxidative metabolism in rats.2017

    • Author(s)
      Horii N, Hasegawa N, Fujie S, Uchida M, Miyamoto-Mikami E, Hashimoto T, Tabata I, Iemitsu M.
    • Organizer
      64nd American College of Sports Medicine Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acute effect of passive one-legged stretching on peripheral blood flow in young men.2017

    • Author(s)
      Yamato Y, Hasegawa N, Fujie S, Uchida M, Ogoh S, Iemitsu M.
    • Organizer
      WCPT-AWP & PTAT Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chronic responses of inflammation and macrophage function to exercise training in various tissues of senescence mice.2017

    • Author(s)
      Uchida M, Horii N, Hasegawa N, Fujie S, Oyanagi E, Yano H, Hashimoto T, Iemitsu M.
    • Organizer
      13th International Society for Exercise and Immunology Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reduced serum C1q by resistance training is related to the prevention of sarcopenia.2017

    • Author(s)
      Horii N, Uchida M, Hasegawa N, Fujie S, Oyanagi E, Yano H, Hashimoto T, Iemitsu M.
    • Organizer
      ACFS 2017 3rd Asian Conference for Frailty and Sarcopenia
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aerobic and resistance training-induced attenuation of chronic inflammation involves functional change of macrophages in various tissues of senescent mice.2017

    • Author(s)
      Uchida M, Horii N, Hasegawa N, Fujie S, Oyanagi E, Yano H, Hashimoto T, Iemitsu M.
    • Organizer
      ACFS 2017 3rd Asian Conference for Frailty and Sarcopenia
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Short lasting exhaustive high-intensity intermittent exercise reduces arterial stiffness through enhancement of aortic NO bioavailability.2017

    • Author(s)
      Hasegawa N, Fujie S, Horii N, Miyamoto-Mikami E, Tsuji K, Uchida M, Hamaoka T, Tabata I, Iemitsu M.
    • Organizer
      American Heart Association scientific sessions 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Change in salusin-α is related to aerobic exercise training-induced blood pressure reduction in middle-aged and older adults.2017

    • Author(s)
      Fujie S, Hasegawa N, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      American Heart Association scientific sessions 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aerobic exercise training-induced increase in circulating irisin level is associated with reduced arterial stiffness in obesity.2017

    • Author(s)
      Inoue K, Fujie S, Hasegawa N, Horii N, Sanada K, Hamaoka T, Iemitsu M.
    • Organizer
      American Heart Association scientific sessions 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Book] 認知症plus予防教育 「循環器系疾患の予防と健康運動」2020

    • Author(s)
      家光素行
    • Total Pages
      216
    • Publisher
      日本看護協会出版会
    • ISBN
      9784818022485
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi