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Single cell interrogation for drug delivery system

Research Project

Project/Area Number 17H03003
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical chemistry
Research InstitutionHokkaido University

Principal Investigator

Uji-i Hiroshi  北海道大学, 電子科学研究所, 教授 (40519352)

Co-Investigator(Kenkyū-buntansha) 猪瀬 朋子  京都大学, 高等研究院, 特定助教 (10772296)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2020: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywords単一細胞解析 / プラズモン / バイオセンシング / ラマン分光 / 薬輸送システム / ラマン散乱 / 表面増強ラマン散乱 / エンドスコピー / 単一細胞分光 / 増強ラマン散乱 / 単一細胞内視鏡 / DDS / Drug Delivery System / ラマン顕微鏡 / ナノワイヤー / 化学物理 / ナノ材料
Outline of Final Research Achievements

The aim of this study is to follow the intracellular dynamics of drug delivery systems (DDS) by optical microscopy and to understand the drug properties using nanowire-enhanced Raman microscopy (NW-SERS) developed by this researcher. In this project, we synthesized "active DDS particles" modified with hyaluronic acid, which is a ligand for glycoproteins expressed on the surface of lung cancer cells (A549), and delivered the anticancer drug into the cells with the ligand-modified DDS particles. In addition to this, we found that the anticancer drug molecules interacted with DNA much more quickly than when delivered alone. Furthermore, differences in the subcellular localization of the anticancer drug molecules were also observed, which may affect the drug efficacy characteristics.

Academic Significance and Societal Importance of the Research Achievements

次世代の化学治療法として期待される薬輸送システムの細胞内・組織内挙動は、いまだ不明点が多い。そのことが実用化を妨げる一つの要因となっている。本研究で開発した技術を用いることで、これまで議論することが困難であった薬と生体分子の相互作用を時系列で解析することが可能となり、今後の創薬設計、スクリーニングに大きく貢献することが期待される。また本研究で見いだされた抗がん剤分子の細胞内局在化が抗がん特性に関与している可能性も示唆された。このように、細胞内部における抗がん特性を評価する新たな解析技術を提供することにより、医学・創薬の分野への貢献は計り知れないと考える。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (68 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (6 results) Journal Article (25 results) (of which Int'l Joint Research: 25 results,  Peer Reviewed: 25 results,  Open Access: 6 results) Presentation (36 results) (of which Int'l Joint Research: 12 results,  Invited: 18 results) Remarks (1 results)

  • [Int'l Joint Research] ルーバン大学(ベルギー)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] メルボルン大学(オーストラリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] KU Leuven(ベルギー)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] KU Leuven(ベルギー)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Universidad del Pais Vasco(スペイン)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] MultiModel Molecular Imaging institut(オランダ)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Gold-etched Silver Nanowire Endoscopy: Towards a Widely Accessible Platform for SERS-based Analysis in Living Cells2021

    • Author(s)
      Ricci Monica, Fortuni Beatrice, Vitale Raffaele, Zhang Qiang, Fujita Yasuhiko, Toyouchi Shuichi, Lu Gang, Rocha Susana, Inose Tomoko, Uji-i Hiroshi
    • Journal Title

      Analytical Chemistry

      Volume: 93 Issue: 12 Pages: 5037-5045

    • DOI

      10.1021/acs.analchem.0c04120

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Two-Photon-Induced [2 + 2] Cycloaddition of Bis-thymines: A Biocompatible and Reversible Approach2020

    • Author(s)
      Ricci Monica、Rutten Martin G.T.A.、Toyouchi Shuichi、Nanayakkara Sepa、Fortuni Beatrice、Vitale Raffaele、Rocha Susana、Wilson Daniela A.、Hofkens Johan、Saito Kei、Uji-i Hiroshi
    • Journal Title

      ACS Omega

      Volume: 5 Issue: 20 Pages: 11547-11552

    • DOI

      10.1021/acsomega.0c00770

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Simple Production of Highly Luminescent Organometal Halide Perovskite Nanocrystals Using Ultrasound-Assisted Bead Milling2020

    • Author(s)
      Umemoto Kazuki、Ebe Hinako、Sato Ryota、Enomoto Junya、Oshita Naoaki、Kimura Taisei、Inose Tomoko、Nakamura Takahiro、Chiba Takayuki、Asakura Satoshi、Uji-i Hiroshi、Masuhara Akito
    • Journal Title

      ACS Sustainable Chemistry & Engineering

      Volume: 8 Issue: 44 Pages: 16469-16476

    • DOI

      10.1021/acssuschemeng.0c05171

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pseudo‐Membrane Jackets: Two‐Dimensional Coordination Polymers Achieving Visible Phase Separation in Cell Membrane2020

    • Author(s)
      Ohtani Ryo、Kawano Kenichi、Kinoshita Masanao、Yanaka Saeko、Watanabe Hikaru、Hirai Kenji、Futaki Shiroh、Matsumori Nobuaki、Uji‐i Hiroshi、Ohba Masaaki、Kato Koichi、Hayami Shinya
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 59 Issue: 41 Pages: 17931-17937

    • DOI

      10.1002/anie.202006600

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Label-free visualization of heterogeneities and defects in metal organic frameworks using nonlinear optics2020

    • Author(s)
      Wolf Mathias、Hirai Kenji、Toyouchi Shuichi、Fron Eduard、Peeters Wannes、De Feyter Steven、Uji-i Hiroshi
    • Journal Title

      Chemical Communications

      Volume: 56 Issue: 87 Pages: 13331-13334

    • DOI

      10.1039/d0cc05470d

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] FRET-based intracellular investigation of nanoprodrugs toward highly efficient anticancer drug delivery2020

    • Author(s)
      Taemaitree Farsai、Fortuni Beatrice、Koseki Yoshitaka、Fron Eduard、Rocha Susana、Hofkens Johan、Uji-i Hiroshi、Inose Tomoko、Kasai Hitoshi
    • Journal Title

      Nanoscale

      Volume: 12 Issue: 32 Pages: 16710-16715

    • DOI

      10.1039/d0nr04910g

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Controlled Fabrication of Optical Signal Input/Output Sites on Plasmonic Nanowires2020

    • Author(s)
      Shuichi Toyouchi, Mathias Wolf, Yusuke Nakao, Yasuhiko Fujita, Tomoko Inose, Beatrice Fortuni, Kenji Hirai, Johan Hofkens, Steven De Feyter, James Hutchison, Hiroshi Uji-i
    • Journal Title

      Nano Letters

      Volume: 20 Issue: 4 Pages: 2460-2467

    • DOI

      10.1021/acs.nanolett.9b05199

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Photo-induced electrodeposition of metallic nanostructures on graphene2020

    • Author(s)
      Xia Kangwei、Chiang Wei-Yi、Lockhart de la Rosa Cesar Javier、Fujita Yasuhiko、Toyouchi Shuichi、Yuan Haifeng、Su Jia、Masuhara Hiroshi、De Gendt Stefan、De Feyter Steven、Hofkens Johan、Uji-i Hiroshi
    • Journal Title

      Nanoscale

      Volume: 12 Issue: 20 Pages: 11063-11069

    • DOI

      10.1039/d0nr00934b

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Low-Cytotoxic Gold-Coated Silver Nanoflowers for Intracellular pH Sensing2020

    • Author(s)
      Zhang Qiang、Wen Han、Watanabe Kiri、Kotani Ibuki、Ricci Monica、Fortuni Beatrice、Dao Anh Thi Ngoc、Masuhara Akito、Hirai Kenji、Kasai Hitoshi、Inose Tomoko、Uji-i Hiroshi
    • Journal Title

      ACS Applied Nano Materials

      Volume: 3 Issue: 8 Pages: 7643-7650

    • DOI

      10.1021/acsanm.0c01278

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Adaptive Optical Two-Photon Microscopy for Surface-Profiled Living Biological Specimens2020

    • Author(s)
      Yamaguchi Kazushi、Otomo Kohei、Kozawa Yuichi、Tsutsumi Motosuke、Inose Tomoko、Hirai Kenji、Sato Shunichi、Nemoto Tomomi、Uji-i Hiroshi
    • Journal Title

      ACS Omega

      Volume: 6 Issue: 1 Pages: 438-447

    • DOI

      10.1021/acsomega.0c04888

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multicolour photochromic fluorescence of a fluorophore encapsulated in a metal?organic framework2020

    • Author(s)
      Hirai Kenji、Kitagawa Taisei、Fujiwara Hideki、Pirillo Jenny、Hijikata Yuh、Inose Tomoko、Uji-i Hiroshi
    • Journal Title

      Chemical Communications

      Volume: 56 Issue: 67 Pages: 9651-9654

    • DOI

      10.1039/d0cc03624b

    • NAID

      120007145359

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Water-mediated polyol synthesis of pencil-like sharp silver nanowires suitable for nonlinear plasmonics2019

    • Author(s)
      Inose Tomoko、Toyouchi Shuichi、Lu Gang、Umemoto Kazuki、Tezuka Yuki、Lyu Bozhang、Masuhara Akito、Fron Eduard、Fujita Yasuhiko、Hirai Kenji、Uji-i Hiroshi
    • Journal Title

      Chemical Communications

      Volume: 55 Issue: 77 Pages: 11630-11633

    • DOI

      10.1039/c9cc04743c

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Polymeric Engineering of Nanoparticles for Highly Efficient Multifunctional Drug Delivery Systems2019

    • Author(s)
      Fortuni Beatrice、Inose Tomoko、Ricci Monica、Fujita Yasuhiko、Van Zundert Indra、Masuhara Akito、Fron Eduard、Mizuno Hideaki、Latterini Loredana、Rocha Susana、Uji-i Hiroshi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 2666-2666

    • DOI

      10.1038/s41598-019-39107-3

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PSF Distortion in Dye-Plasmonic Nanomaterial Interactions: Friend or Foe?2019

    • Author(s)
      Baiyasi Rashad、Jebeli Seyyed Ali Hosseini、Zhang Qingfeng、Su Liang、Hofkens Johan、Uji-i Hiroshi、Link Stephan、Landes Christy F.
    • Journal Title

      ACS Photonics

      Volume: 6 Issue: 3 Pages: 699-708

    • DOI

      10.1021/acsphotonics.8b01576

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Organoids from pituitary as a novel research model toward pituitary stem cell exploration2019

    • Author(s)
      Cox Benoit、Laporte Emma、Vennekens Annelies、Kobayashi Hiroto、Nys Charlotte、Van Zundert Indra、Uji-i Hiroshi、Vercauteren Drubbel Alizee、Beck Benjamin、Roose Heleen、Boretto Matteo、Vankelecom Hugo
    • Journal Title

      Journal of Endocrinology

      Volume: 240 Issue: 2 Pages: 287-308

    • DOI

      10.1530/joe-18-0462

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synthesis of 42-faceted bismuth vanadate microcrystals for enhanced photocatalytic activity2019

    • Author(s)
      Zhai Xueting、Li Zhuoyao、Lu Zichen、Wang Guilin、Li Ping、Gao Yongqian、Huang Xiao、Huang Wei、Uji-i Hiroshi、Lu Gang
    • Journal Title

      Journal of Colloid and Interface Science

      Volume: 542 Pages: 207-212

    • DOI

      10.1016/j.jcis.2019.02.008

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Silver nanowires for highly reproducible cantilever based AFM-TERS microscopy: towards a universal TERS probe2018

    • Author(s)
      Walke Peter、Fujita Yasuhiko、Peeters Wannes、Toyouchi Shuichi、Frederickx Wout、De Feyter Steven、Uji-i Hiroshi
    • Journal Title

      Nanoscale

      Volume: 10 Issue: 16 Pages: 7556-7565

    • DOI

      10.1039/c8nr02225a

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mapping Transient Protein Interactions at the Nanoscale in Living Mammalian Cells2018

    • Author(s)
      De Keersmaecker Herlinde、Camacho Rafael、Rantasa David Manuel、Fron Eduard、Uji-i Hiroshi、Mizuno Hideaki、Rocha Susana
    • Journal Title

      ACS Nano

      Volume: 12 Issue: 10 Pages: 9842-9854

    • DOI

      10.1021/acsnano.8b01227

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Facilitating Tip-Enhanced Raman Scattering on Dielectric Substrates via Electrical Cutting of Silver Nanowire Probes2018

    • Author(s)
      Walke Peter、Toyouchi Shuichi、Wolf Mathias、Peeters Wannes、Prabhu Sugosh R.、Inose Tomoko、De Feyter Steven、Fujita Yasuhiko、Uji-i Hiroshi
    • Journal Title

      The Journal of Physical Chemistry Letters

      Volume: 9 Issue: 24 Pages: 7117-7122

    • DOI

      10.1021/acs.jpclett.8b03189

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Separation of mono-dispersed CH3NH3PbBr3 perovskite quantum dots via dissolution of nanocrystals2018

    • Author(s)
      Umemoto Kazuki、Takeda Masaki、Tezuka Yuki、Chiba Takayuki、White Matthew Schuette、Inose Tomoko、Yoshida Tsukasa、Asakura Satoshi、Toyouchi Shuichi、Uji-i Hiroshi、Masuhara Akito
    • Journal Title

      CrystEngComm

      Volume: 20 Issue: 44 Pages: 7053-7057

    • DOI

      10.1039/c8ce01239c

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] One-Directional Antenna Systems: Energy Transfer from Monomers to J-Aggregates within 1D Nanoporous Aluminophosphates2017

    • Author(s)
      Sola-Llano Rebeca、Fujita Yasuhiko、Gomez-Hortiguela Luis、Alfayate Almudena、Uji-i Hiroshi、Fron Eduard、Toyouchi Shuichi、Perez-Pariente Joaquin、Lopez-Arbeloa Inigo、Martinez-Martinez Virginia
    • Journal Title

      ACS PHOTONICS

      Volume: 5 Issue: 1 Pages: 151-157

    • DOI

      10.1021/acsphotonics.7b00553

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In situ synthesis of Au-shelled Ag nanoparticles on PDMS for flexible, long-life, and broad spectrum-sensitive SERS substrates2017

    • Author(s)
      Fortuni B.、Inose T.、Uezono S.、Toyouchi S.、Umemoto K.、Sekine S.、Fujita Y.、Ricci M.、Lu G.、Masuhara A.、Hutchison J. A.、Latterini L.、Uji-i H.
    • Journal Title

      CHEMICAL COMMUNICATIONS

      Volume: 53 Issue: 82 Pages: 11298-11301

    • DOI

      10.1039/c7cc05420c

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Surface Density-of-States Engineering of Anatase TiO2 by Small Polyols for Enhanced Visible-Light Photocurrent Generation2017

    • Author(s)
      Aubert Remko、Kenens Bart、Chamtouri Maha、Fujita Yasuhiko、Fortuni Beatrice、Lu Gang、Hutchison James A.、Inose Tomoko、Uji-i Hiroshi
    • Journal Title

      ACS OMEGA

      Volume: 2 Issue: 10 Pages: 6309-6313

    • DOI

      10.1021/acsomega.7b00853

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Highly controllable direct femtosecond laser writing of gold nanostructures on titanium dioxide surfaces2017

    • Author(s)
      Fujita Y.、Aubert R.、Walke P.、Yuan H.、Kenens B.、Inose T.、Steuwe C.、Toyouchi S.、Fortuni B.、Chamtouri M.、Janssen K. P. F.、De Feyter S.、Roeffaers M. B. J.、Uji-i H.
    • Journal Title

      NANOSCALE

      Volume: 9 Issue: 35 Pages: 13025-13033

    • DOI

      10.1039/c7nr04299j

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Plasmon-Mediated Surface Engineering of Silver Nanowires for Surface-Enhanced Raman Scattering2017

    • Author(s)
      Gang Lu, Haifeng Yuan, Liang Su, Bart Kenens, Yasuhiko Fujita, Maha Chamtouri, Maria Pszona, Eduard Fron, Jacek Waluk, Johan Hofkens, Hiroshi Uji-i
    • Journal Title

      JOURNAL OF PHYSICAL CHEMISTRY LETTERS

      Volume: 8 Issue: 13 Pages: 2774-2779

    • DOI

      10.1021/acs.jpclett.7b00958

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Gold-deposited Silver Nanowires for the Cellular pH Sensing2021

    • Author(s)
      Qiang Zhang, Monica Ricci, Jiangtao Li, Takuto Ishida, Han Wen, Haruka Kojima, Tomoko Inose, Shuichi Toyouchi, Yasuhiko Fujita, Kenji Hirai, Beatrice Fortuni, Hiroshi Uji-i
    • Organizer
      The 101st CSJ Annual Meeting
    • Related Report
      2020 Annual Research Report
  • [Presentation] Nanoscale characterisation of carbon nanomaterials using tip-enhanced Raman spectroscopy2021

    • Author(s)
      Han Wen, Syoji Sugioka, Naoyuki Kanda, Jiangtao Li, Tomoko Inose, Yasumitsu Miyata, Yusuke Nakanishi, Kenji Hirai, Yasuhiko Fujita, Hiroshi Uji-i
    • Organizer
      第68回応用物理学会春季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Length controlled AFM-AgNW probes for TERS2021

    • Author(s)
      Hiroya Saito, Han Wen, Tomoko Inose, Kenji Hirai, Hiroshi Uji-i
    • Organizer
      第68回応用物理学会春季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 低侵襲ナノワイヤー遺伝子導入の開発2020

    • Author(s)
      石田 拓都、猪瀬 朋子、平井 健二、雲林院 宏
    • Organizer
      第81回応用物理学会秋季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 銀ナノワイヤへの金ナノ粒子析出とナノ熱源としての利用2020

    • Author(s)
      中尾 佑輔, 豊内 修一, 平井 健二, 猪瀬 朋子, 雲林院宏
    • Organizer
      第81回応用物理学会秋季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 探針増強ラマン分光法によるグラフェンナノリボンの評価2020

    • Author(s)
      杉岡 祥治、豊内 秀一、原 慎之介、猪瀬 朋子、平井 健二、藤田 康彦、田中 啓文、雲林院 宏
    • Organizer
      第81回応用物理学会秋季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Silver nanowire tip-enhanced Raman scattering probe2019

    • Author(s)
      hiroshi Uji-i
    • Organizer
      14th International Conference on Atomically Controlled Surfaces, Interfaces and Nanostructures (ACSIN-14)and 26th International Colloquium on Scanning Probe Microscopy (ICSPM26)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Plasmonic Waveguiding Spectroscopy and Microscopy2019

    • Author(s)
      hiroshi Uji-i
    • Organizer
      CLEO2019 Laser Science to Photonic Applications
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Single cell endoscopy for single cell interrogation2019

    • Author(s)
      Hiroshi Uji-i
    • Organizer
      Symposium of Nikon Imaging Center directors' meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] プラズモニック単一細胞内視鏡法2019

    • Author(s)
      雲林院宏
    • Organizer
      第71回日本生物工学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 生きた細胞内の分子間相互作用を光で観測2019

    • Author(s)
      猪瀬朋子、B. Fortuni, M. Ricci, 平井健二、S. Rocha, 雲林院宏
    • Organizer
      第80回応用物理学会秋季学術講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Nanoparticle engineering towards highly efficient drug delivery systems and SERS-based bio-sensing2019

    • Author(s)
      猪瀬朋子
    • Organizer
      The SPIRITS International Symposium -Shaping Self-Assembled Mesoscale (Bio)Materials with Microengineering-
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Plasmonic waveguiding tip-enhanced Raman microscopy2018

    • Author(s)
      雲林院宏
    • Organizer
      RamanFest 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ナノスケールで見るポリマーダイナミクス2018

    • Author(s)
      雲林院宏
    • Organizer
      第67回高分子討論会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Silver nanowire tip-enhanced Raman scattering probe2018

    • Author(s)
      雲林院宏
    • Organizer
      14th International Conference on Atomically Controlled Surfaces, Interfaces and Nanostructures (ACSIN-14)and 26th International Colloquium on Scanning Probe Microscopy (ICSPM26)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Layer by layer surface coating of silver nanoparticles for active SERS detection inside live cells2018

    • Author(s)
      INOSE Tomoko, ISHIDA Takuto, WATANABE Kiri, FARSAI Taemaitree, FORTUNI Beatrice, KOSEKI Yoshitaka, KASAI Hitoshi, UJI-I Hiroshi
    • Organizer
      2018年光化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Novel and facile fabrication method of Au coated AgNPs flexible SERS substrate2018

    • Author(s)
      猪瀬朋子
    • Organizer
      ナノ構造・物性-ナノ機能・応用部会合同シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 広域pH応答性を示すPDMS上新規金被覆銀ナノ粒子SERS基板の作製法 Novel and facile fabrication method of AgNPs@Au-shell SERS substrate on PDMS film with pH response over wide pH range2018

    • Author(s)
      猪瀬朋子
    • Organizer
      金沢大学NanoLSI公開セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 広域pH応答性金被覆銀ナノ粒子フレキシブルSERS基板の作製2018

    • Author(s)
      猪瀬 朋子、上園 周平、Beatrice Fortuni、豊内 秀一、藤田 康彦、雲林院 宏
    • Organizer
      第16回医用分光学研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Layer by layer 法を利用した抗がん剤含有ナノ粒子のコーティングと細胞への取込み観察2018

    • Author(s)
      猪瀬朋子
    • Organizer
      「ナノマテリアルの実用展開」inナノマテリアルコロキウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Novel and facile fabrication method of AgNPs@Au-shelled flexible SERS substrate with a wide range of pH response2018

    • Author(s)
      Inose Tomoko, Uezono Shuhei, Fortuni Beatrice, Toyouchi Shuichi, Fujita Yasuhiko, Umemoto Kazuki, Masuhara Akito, Uji-i Hiroshi
    • Organizer
      日本化学会 第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] シルバーナノワイヤー探針増強ラマン散乱顕微鏡2018

    • Author(s)
      藤田康彦、猪瀬朋子、雲林院宏
    • Organizer
      第65回応用物理学会春季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Functionalization of Mesoporous Silica Nanoparticles with efficient Endosomal Escape for Cancer Targeted Drug Delivery2018

    • Author(s)
      Fortuni Beatrice, Ricci Monica, Susana Rocha, Masuhara Akito, Inose Tomoko, Uji-i Hiroshi
    • Organizer
      日本化学会 第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Layer by layer surface modification of mesoporous silica nanoparticles for taergeting drug delivery system2017

    • Author(s)
      Tomoko Inose, Beatrice Fortuni, Kiri Watanabe, Natsuki Hori, Yasuhiko Fujita, Yoshitaka Koseki, Hitoshi Kasai, Hiroshi Uji-i
    • Organizer
      ナノ学会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nano-sponge for active-targeting anti-cancer drug delivery2017

    • Author(s)
      Tomoko Inose, Beatrice Fortuni, Yasuhiko Fujita, Yositaka Koseki, Hitoshi Kasai, Hiroshi Uji-i
    • Organizer
      RACI National Centenary Conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Noble fabrication of flexible Ag@Au NPs SERS substrate on PDMS2017

    • Author(s)
      猪瀬朋子、上園周平、Fortuni Beatrice、豊内秀一、藤田康彦、雲林院宏
    • Organizer
      光化学協会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Noble And Facile Fabrication Of Chemically Insert SERS_Active Au Nanostars And AgNPs@Au-Shell On PDMS Films2017

    • Author(s)
      Tomoko Inose, Beatrice Fortuni, Syuhei Uezono, Yasuhiko Fujita, Hiroshi Uji-i
    • Organizer
      15th Conference on Methods and Applications in Fluorescence
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Noble, simple fabrication of flexible SERS substrates on PDMS2017

    • Author(s)
      Tomoko Inose, Beatrice Fortuni, Syuhei Uezono, Yasuhiko Fujita, Hiroshi Uji-i
    • Organizer
      錯体化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Plasmonic waveguiding Remote Excitation of Tip-enhanced Raman Scattering2017

    • Author(s)
      Yasuhiko Fujita, Tomoko Inose, Hiroshi Uji-i
    • Organizer
      ナノ学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] プラズモン導波路リモート励起探針増強ラマン顕微鏡2017

    • Author(s)
      藤田康彦、猪瀬朋子、雲林院宏
    • Organizer
      第73回日本顕微鏡学会学術講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Plasmonic endoscopy toward single cell interrogation2017

    • Author(s)
      Hiroshi Uji-i
    • Organizer
      RACI National Centenary Conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Study of anti-cancer drug administration in single cancer cells using remote excitation of SERS (RE-SERS)2017

    • Author(s)
      雲林院宏、Ricci Monica、Fortuni Beatrice、Rocha Susana、豊内秀一、藤田康彦、猪瀬朋子
    • Organizer
      光化学協会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Plasmonic Waveguiding Remote Excitation Spectroscopy toward Single-cell Interrogation2017

    • Author(s)
      Hiroshi Uji-i
    • Organizer
      The 15th Conference on Methods and Applications in Fluorescence
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Surface density-of-states engineering of TiO2 by adsorption of small polyols for enhanced visible photo-catalytic activity2017

    • Author(s)
      Remko Aubert, Bart Kenens, Maha Chamtouri, Yasuhiko Fujita, Tomoko Inose, Akito Masuhara, Hiroshi Uji-i
    • Organizer
      錯体化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Plasmonic endoscopy at single cell level2017

    • Author(s)
      Hiroshi Uji-i
    • Organizer
      日本物理学会 2017年秋季大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Remote Spectroscopy Using Plasmonic Waveguide toward Single-Cell Interrogation2017

    • Author(s)
      Hiroshi Uji-i
    • Organizer
      2017 RIIES-CIS Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Remarks] 北海道大学電子科学研究所光科学研究部門ナノ材料光計測研究分野

    • URL

      http://www.es.hokudai.ac.jp/labo/lnn/Top.html

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

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