| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2020: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Outline of Final Research Achievements |
The aim of this study is to follow the intracellular dynamics of drug delivery systems (DDS) by optical microscopy and to understand the drug properties using nanowire-enhanced Raman microscopy (NW-SERS) developed by this researcher. In this project, we synthesized "active DDS particles" modified with hyaluronic acid, which is a ligand for glycoproteins expressed on the surface of lung cancer cells (A549), and delivered the anticancer drug into the cells with the ligand-modified DDS particles. In addition to this, we found that the anticancer drug molecules interacted with DNA much more quickly than when delivered alone. Furthermore, differences in the subcellular localization of the anticancer drug molecules were also observed, which may affect the drug efficacy characteristics.
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