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Three-dimensional investigation of hierarchical chirality in various scales: general dichroism spectroscopic imaging

Research Project

Project/Area Number 17H03014
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical chemistry
Research InstitutionInstitute for Molecular Science

Principal Investigator

Narushima Tetsuya  分子科学研究所, メゾスコピック計測研究センター, 助教 (50447314)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywordsキラリティ / 偏光 / ナノ光学 / 近接場光学 / 円二色性 / 分光分析 / 走査プローブ顕微鏡 / 表面・界面物性 / プローブ顕微鏡
Outline of Final Research Achievements

Various hierarchical chiral structures exist from subnano- to micro-meter scales in biological systems. Observation of fluorescence or optical extinction is routinely made for tracking positions of target molecules. In addition, optical activity signals due to chirality of the molecules/molecular assemblies may provide invaluable information to reveal biological functions and origin of asymmetric morphology. Circular dichroism (CD) microscopy enables direct visualization of the spatial CD signal distribution. However, it has not been commonly employed, because artifacts arising from linear dichroism (LD) of the sample interfere in the CD signal obtained by the conventional CD detection method. Recently, we proposed a new polarization modulation for accurate CD detection, which greatly suppressed the LD interference and achieved reliable CD imaging. Based on this, we demonstrated analysis of individual chiral particles and also show possibility of the reflection CD imaging analysis etc.

Academic Significance and Societal Importance of the Research Achievements

本研究で発展させたキラリティの分光分析イメージングにより,分子単体だけでなく,それらの集合体や複合体がナノからマイクロまでのスケール階層に拡がり形成する,キラルな構造,即ち,分子レベルよりも少し粗視化したキラリティの視点で,物質や生体の本質を見定めることを目指して研究を進めてきた。これまでに,信頼性の高いイメージング分析手法が確立されつつある。本分析手法の高速化を実現し,反射・散乱光による高分解能な分析を可能とするよう深化させることにより,キラリティの動態やキラルな系の過渡的な応答から生体機能や疾患が発症するしくみを探ることも可能になると考えられ,今後もさらに研究を進める意義があると考える。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (45 results)

All 2019 2018 2017 Other

All Int'l Joint Research (4 results) Journal Article (10 results) (of which Peer Reviewed: 7 results,  Open Access: 3 results) Presentation (30 results) (of which Int'l Joint Research: 16 results,  Invited: 16 results) Book (1 results)

  • [Int'l Joint Research] Seoul National University(韓国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Warsaw(ポーランド)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] CIC biomaGUNE, BRTA(スペイン)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Seoul National University(韓国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Synthesis of Chiral Labtb and Visualization of Its Enantiomer Excess by Induced Circular Dichroism Imaging2019

    • Author(s)
      Teppei Yamada, Toshiki Eguchi, Taro Wakiyama, Tetsuya Narushima, Hiromi Okamoto, Nobuo Kimizuka
    • Journal Title

      Chem Pub Soc Europe

      Volume: 25 Issue: 27 Pages: 6698-6702

    • DOI

      10.1002/chem.201900329

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Active Control of Chiral Optical Near Fields on a Single Metal Nanorod2019

    • Author(s)
      Shun Hashiyada, Tetsuya Narushima, Hiromi Okamoto
    • Journal Title

      ACS Photon.

      Volume: 6 Issue: 3 Pages: 677-683

    • DOI

      10.1021/acsphotonics.8b01500

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spectral properties of chiral electromagnetic near fields created by chiral plasmonic nanostructures2019

    • Author(s)
      Hashiyada Shun、Endo Kensaku、Narushima Tetsuya、Togawa Yoshihiko、Okamoto Hiromi
    • Journal Title

      Journal of Physics: Conference Series

      Volume: 1220 Issue: 1 Pages: 012050-012050

    • DOI

      10.1088/1742-6596/1220/1/012050

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circular Dichroism Spectroscopic Imaging for Chiral Materials2019

    • Author(s)
      成島哲也,岡本裕巳
    • Journal Title

      Seibutsu Butsuri

      Volume: 59 Issue: 1 Pages: 035-038

    • DOI

      10.2142/biophys.59.035

    • NAID

      130007557834

    • ISSN
      0582-4052, 1347-4219
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular Technology for Chirality Control: From Structure to Circular Polarization2019

    • Author(s)
      Uchida Yoshiaki、Narushima Tetsuya、Yuasa Junpei
    • Journal Title

      Molecular Technology: Energy Innovation

      Volume: I-6 Pages: 129-154

    • DOI

      10.1002/9783527823987.vol1_c6

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Scanning Near-Field Optical Microscopy/Near-Field Scanning Optical Microscopy2018

    • Author(s)
      Narushima Tetsuya
    • Journal Title

      Compendium of Surface and Interface Analysis

      Volume: 93 Pages: 577-582

    • DOI

      10.1007/978-981-10-6156-1_93

    • ISBN
      9789811061554, 9789811061561
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging Chirality of Optical Fields near Achiral Metal Nanostructures Excited with Linearly Polarized Ligh2018

    • Author(s)
      S. Hashiyada, T. Narushima and H. Okamoto
    • Journal Title

      ACS Photon

      Volume: 5 Issue: 4 Pages: 1486-1492

    • DOI

      10.1021/acsphotonics.7b01511

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of Chiral Optical Near-Fields with Non-Chiral Metallic Nanostructures and Linearly Polarized Light2017

    • Author(s)
      Shun Hashiyada, Tetsuya Narushima, Hiromi Okamoto
    • Journal Title

      Proceedings of SPIE

      Volume: 10252 Pages: 1025214-1025214

    • DOI

      10.1117/12.2274900

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 円二色性顕微鏡による物質の局所的な光学活性の研究2017

    • Author(s)
      成島哲也
    • Journal Title

      機器センターたより2017 /分子科学研究所 機器センター

      Volume: 9 Pages: 84-87

    • Related Report
      2017 Annual Research Report
    • Open Access
  • [Journal Article] 加熱処理による片持ち梁試料の清浄化とそれによる表面応力研究”2017

    • Author(s)
      成島哲也
    • Journal Title

      サーモ理工 熱技術35年史 研究論文集

      Volume: なし Pages: 38-42

    • Related Report
      2017 Annual Research Report
  • [Presentation] A closer look at an optical near-field on interstellar dust nanoparticles as source of homo-chirality2019

    • Author(s)
      T. Narushima
    • Organizer
      Connecting Fundamental Physics, Chemistry, and the Origins of Biomolecular Homochirality
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ホモキラリティの起源としての星間塵ナノ微粒子の可能性2019

    • Author(s)
      成島哲也
    • Organizer
      第1043回 国立天文台談話会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Microscopic Circular Dichroism Imaging to Explore Materials Chirality2019

    • Author(s)
      T. Narushima, and H. Okamoto
    • Organizer
      The International Symposium on Plasmonics and Nano-photonics (iSPN2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 顕微円二色性イメージングによる単一結晶微粒子のキラリティ分析2019

    • Author(s)
      成島哲也, 山田鉄兵,君塚信夫,岡本裕巳
    • Organizer
      第13回分子科学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 物質のキラリティを探る円二色性顕微鏡2018

    • Author(s)
      成島哲也
    • Organizer
      第39回光化学若手の会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 円二色性ナノイメージングによるキラル物質分析2018

    • Author(s)
      成島哲也
    • Organizer
      研究会「光・物質・生命・宇宙におけるキラリティ」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Analysis of Local Chirality with Microscopic Circular Dichroism Imaging2018

    • Author(s)
      T. Narushima, H. Okamoto,
    • Organizer
      The 23rd Hiroshima International Symposium on Synchrotron Radiation -Materials and Biomolecular Science using VUV-SX Synchrotron Radiation-
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Circular Dichroism Microscopy to Explore Local Chiroptical Properties2018

    • Author(s)
      T. Narushima, H. Okamoto,
    • Organizer
      2018 Joint Symposium on Optics (OSJ, OSA, OSK)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Near-field and Far-field Microscopy to Explore Chirality of Materials and Localized Opti-cal fields2018

    • Author(s)
      T. Narushima, S. Hashiyada, H. Okamoto,
    • Organizer
      The 2018 International Conference on Nanoscience + Technology (ICN+T 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Circular Dichroism Microscopic Study to Analyze Chiral Materials2018

    • Author(s)
      T. Narushima, H. Okamoto
    • Organizer
      The 12th International Conference on Excitonic and Photonic Processes in Condensed Matter and Nano Materials (EXCON 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spectral properties of chiral electromagnetic near fields created by chiral plasmonic nanostructures2018

    • Author(s)
      S. Hashiyada, K. Endo, T. Narushima, Y. Togawa and Hiromi Okamoto
    • Organizer
      2018 Joint Symposium on Optics (OSJ, OSA, OSK)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Visualization of chiral optical fields in chiral metal nanostructures2018

    • Author(s)
      S. Hashiyada, K. Endo, T. Narushima, Y. Togawa and Hiromi Okamoto
    • Organizer
      The 12th International Conference on Excitonic and Photonic Processes in Condensed Matter and Nano Materials (EXCON 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 円二色性顕微観察による単一マイクロ微粒子レベルのキラル物質分析2018

    • Author(s)
      成島哲也,岡本裕巳,江口稔季,山田鉄兵,君塚信夫
    • Organizer
      2018年 第79回応用物理学会秋季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] キラル金属ナノ構造体に局在するキラル光電場のスペクトル特性2018

    • Author(s)
      橋谷田俊,遠藤健作,成島哲也,戸川欣彦,岡本裕巳
    • Organizer
      2018年 第79回応用物理学会秋季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 円二色性の顕微観察によるキラル物質の分析と設計2018

    • Author(s)
      成島哲也
    • Organizer
      顕微ナノ・表面科学・SPM合同シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] キラル物質の局所光学活性と分子技術への応用展望2018

    • Author(s)
      成島哲也
    • Organizer
      日本化学会 春季年会中長期テーマシンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 円二色性顕微鏡による階層的なキラル構造変化の可視化の試み2018

    • Author(s)
      成島哲也
    • Organizer
      理研-分子研合同シンポジウム: アト秒から秒にいたるダイナミクス研究の最前線
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Microscopic Study on Optical Activity Localized in Materials to Explore Hierarchical Chirality in Various Scales2017

    • Author(s)
      T. Narushima
    • Organizer
      The 8th International Symposium on Surface Science (ISSS-8)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 強い局所光学活性を利用したキラル光デバイス2017

    • Author(s)
      成島哲也
    • Organizer
      日本化学会秋季事業 第7回CSJ化学フェスタ2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Imaging Chiral Plasmons2017

    • Author(s)
      H. Okamoto, S. Hashiyada, Y. Nishiyama, T. Narushima
    • Organizer
      JSAP-OSA Joint Symposia, The 78th JSAP Autumn Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ナノ構造物質の局所キラリティとその光学的・化学的応用展望2017

    • Author(s)
      成島哲也
    • Organizer
      2017 年度真空・表面科学合同講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 光でナノスケールのキラリティを調べる2017

    • Author(s)
      成島哲也
    • Organizer
      自然科学研究機構 サイトビジット(岡崎地区)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Near-field imaging of chiral optical fields on plasmonic materials2017

    • Author(s)
      H. Okamoto, S. Hashiyada, T. Narushima, Y. Nishiyama
    • Organizer
      The 8th International Conference on Metamaterials, Photonic Crystals and Plasmonics (META2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Imaging of Local Chirality with Near-Field Microscopy2017

    • Author(s)
      H. Okamoto, S. Hashiyada, T. Narushima, Y. Nishiyama
    • Organizer
      The 11th Asia-Pacific Conference on Near-field Optics (APNFO11)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Local Optical Activity Imaging of Metal Nanostructures and Structured Chirality2017

    • Author(s)
      H. Okamoto, S. Hashiyada, T. Narushima, Y. Nishiyama
    • Organizer
      Frontiers in Molecular Science: Structure, Dynamics, & Function of Molecules and Com-plexes
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Generation of chiral optical near-fields with non-chiral metallic nanostructures and linearly polarized light2017

    • Author(s)
      Shun Hashiyada, Tetsuya Narushima, and Hiromi Okamoto
    • Organizer
      The 4th Optical Manipulation Conference 2017 (OMC`17)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microscopic Circular Dichroism Imaging to Explore Materials Chirality2017

    • Author(s)
      T. Narushima, Shun Hashiyada and Hiromi Okamoto
    • Organizer
      The 29th International Symposium on Chirality(Chirality 2017; ISCD-29)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Circular Dichroism Imaging to Analyze Chirality in Materials2017

    • Author(s)
      T. Narushima, Shun Hashiyada and Hiromi Okamoto
    • Organizer
      The 16th International Conference on Chiroptical Spectroscopy (CD2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アミノ酸で誘導したキラルLaBTBの細孔に取り込んだキラルなイオンの運動特性2017

    • Author(s)
      江口稔季,山田鉄兵,成島哲也,君塚信夫
    • Organizer
      錯体化学会第67回討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 金ナノ長方形による近接場光の偏光制御2017

    • Author(s)
      橋谷田俊,成島哲也、岡本裕巳
    • Organizer
      第78回応用物理学会秋季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Book] Compendium of Surface and Interface Analysis/ Scanning Near-Field Optical Microscopy/Near-Field Scanning Optical Microscopy2018

    • Author(s)
      Narushima Tetsuya/ The Surface Science Society of Japan (eds)
    • Publisher
      Springer, Singapore
    • ISBN
      9789811061554
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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