New developments of the asymmetric reactions mediated by chiral phosphoric acid and derivatives
| Project/Area Number |
17H03060
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Gakushuin University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 不斉合成 / 有機分子触媒 / インドール / キラルブレンステッド酸 / 選択的合成 / 還元反応 / 反応開発 / 不斉触媒反応 / 触媒 / BINOL / トリフルオロメチル / キラルリン酸 / 有機合成化学 / トリフルオロメチル基 / 不斉合成反応 / 触媒化学 / 不斉触媒 / 光学活性 |
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| Outline of Final Research Achievements |
We have developed catalyzed enantioselective reactions by means of chiral phosphoric acid, such as 1) Friedel-Crafts alkylation reactions of pyrrole with N-H CF3 ketimines, 2) Friedel-Crafts alkylation reaction of indole with nitroalkene, 3) dehydrohydrogenation of 2-indolylalcohols, 4) reduction of nitroarenes by use of benzothiazoline and its application to enantioselective synthesis of 2-aryltetrahydroquinoline, 5) [3+2] cycloaddition reaction, and 5) internal redox reaction.
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| Academic Significance and Societal Importance of the Research Achievements |
新たな不斉触媒反応の開発は，新たな医薬品の合成さらには製造段階において用いられる可能性もあり重要な研究課題の一つである。本研究の成果も，遷移金属を用いることなく，有用な化合物の合成につながり，有意義であると考えられる。
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Report
(4 results)
Research Products
(27 results)
