|Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|Outline of Final Research Achievements
We have prepared novel hydrophilic copolymers that can dissolve hydrophobic fullerenes in water. Fullerenes can efficiently convert near-infrared light energy into heat. The hydrophilic copolymers have a thermo-responsive unit. Although the thermo-responsive unit cannot dissolve in water at room temperature, it can dissolve in water at high temperature. Water-soluble complexes were formed with the copolymers and fullerenes. It was confirmed that the complex aqueous solutions generated heat upon irradiation of near-infrared light. Also active oxygen which kills the cancer cells can be generated from fullerenes in the complex upon light irradiation. Furthermore, it was confirmed that drugs such as anticancer drugs encapsulated into the complex at room temperature can be released from the complex upon heating.