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Study on the multi-functionalization and control of micron-scale bubbles

Research Project

Project/Area Number 17H03171
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Fluid engineering
Research InstitutionThe University of Tokyo

Principal Investigator

Takagi Shu  東京大学, 大学院工学系研究科(工学部), 教授 (30272371)

Co-Investigator(Kenkyū-buntansha) 杵淵 郁也  東京大学, 大学院工学系研究科(工学部), 准教授 (30456165)
杉山 和靖  大阪大学, 基礎工学研究科, 教授 (50466786)
田川 義之  東京農工大学, 工学(系)研究科(研究院), 准教授 (70700011)
東 隆  東京大学, 大学院医学系研究科(医学部), 教授 (90421932)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Keywordsマイクロバブル / 超音波 / 医療応用 / ドラッグデリバリーシステム / ベシクル / バブルクラスター / マイクロチャネル / マイクロフルイディクス / 混相流
Outline of Final Research Achievements

In the present study, as one of the medical applications using microbubbles, we have developed a method to generate microbubble-encapsulated vesicles containing microbubbles which can be available for the drug delivery system and a method to control these vesicles using ultrasound field. First, we developed the method using oil-water interface passage method and succeeded in generating microbubble-encapsulated vesicles more stably than conventional methods. We also succeeded in capturing the generated microbubble-containing vesicles in a standing sound field. In addition, we have developed a basic technology for generating microbubble-encapsulated vesicles using a flow-focus type microchannel as a method for stably generating equally-sized vesicles.

Academic Significance and Societal Importance of the Research Achievements

本研究で対象としている薬物搬送担体は,通常用いられる数十ナノメートルの小さな粒子ではなく,その100倍程度大きいミクロンスケールのマイクロバブル内包ベシクルである,内包されたマイクロバブルを体外から照射させた超音波で制御し,ベシクルの膜を破壊することにより,薬物放出を局所で可能にすれば,従来のものに比べ,一度に大量の薬剤を局所的に送りこむことが可能となる.そのための基礎技術として,マイクロバブル内包ベシクルを安定に作り出す技術の開発は重要な学術的及び社会的意義を持つ.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (10 results)

All 2019 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (9 results) (of which Int'l Joint Research: 6 results,  Invited: 1 results)

  • [Journal Article] 集束超音波を利用したマイクロバブルの二次元マニピュレーション2018

    • Author(s)
      松崎玄伸,尾崎太一,井上和仁,東 隆,一柳 満久,松本洋一郎,高木 周
    • Journal Title

      混相流

      Volume: 32

    • NAID

      130006731321

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Numerical study on the interaction of two bubbles rising in a power-law fluid2019

    • Author(s)
      Shu Takagi, Varun Jadon, Kazuyasu Sugiyama
    • Organizer
      72nd Annual Meeting of the American Physical Society, Division of Fluid Dynamics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Interaction between two bubbles rising side by side in Newtonian and Non-Newtonian fluid2019

    • Author(s)
      Jadon Varun, Kazuyasu Sugiyama, Shu Takagi
    • Organizer
      10th International Conference on Multiphase Flow
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳神経系培養細胞の超音波刺激に関する力学的作用機序の検討2019

    • Author(s)
      笹岡憲也, 高橋毅, 榛葉健太, 石島歩, 佐久間一郎, 東隆, 神保泰彦, 高木周
    • Organizer
      第18回日本超音波治療研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] On the microbubble generation process using thin T-junction Microchannel2018

    • Author(s)
      Shu Takagi
    • Organizer
      The 32nd International Congress on High-Speed Imaging and Photonics
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Behaviors of microbubble clusters trapped in focused ultrasound filed2018

    • Author(s)
      Hironobu Matsuzaki
    • Organizer
      The 32nd International Congress on High-Speed Imaging and Photonics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of single bubble-cluster in upward bubbly flow on large-scale vortex structure2018

    • Author(s)
      Masahiro Eguchi
    • Organizer
      71st Annual Meeting of the American Physical Society Division of Fluid Dynamics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation on interaction between ultrasound and living tissue2018

    • Author(s)
      Satoshi Sobue
    • Organizer
      IEEE International Ultrasonics Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Numerical Simulations of Rising Bubbles in Non-Newtonian Fluid2018

    • Author(s)
      Shu Takagi
    • Organizer
      8th European-Japanese Two-phase Flow Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 集束超音波を用いたマイクロバブルクラウドの制御に関する研究2017

    • Author(s)
      松崎玄伸(東大)、尾崎太一(東大)、川口京(東大)、一柳満久(上智大)、東隆(東大)、高木周(東大)
    • Organizer
      混相流シンポジウム
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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