| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Outline of Final Research Achievements |
The quality (enzymatic activity) of biomarker molecules in clinical specimens rapidly deteriorate after the collection from patients. In this study, the vacuum drying at room temperature is proposed as a simple feasible method of preserving the enzymatic activity of biomarker molecule. Using the glass transition curve and the dielectric spectrum of the added protective agents, the methods for; 1) designing the amount and preparation of the added protective agents and 2) predicting the deterioration rate of biomarker molecules (shelf time of specimens), are proposed. The enzymatic activity of the sample biomarker molecule is proved to keep its original enzymatic activity for at least two months by preserving the sample with the proposed vacuum-dry preservation method.
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