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Safe and quality sterilization of protein rich liquid foods

Research Project

Project/Area Number 17H03220
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Power engineering/Power conversion/Electric machinery
Research InstitutionKumamoto University

Principal Investigator

KATSUKI Sunao  熊本大学, 産業ナノマテリアル研究所, 教授 (80233758)

Co-Investigator(Kenkyū-buntansha) 上野 崇寿  大分工業高等専門学校, 電気電子工学科, 准教授 (30508867)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywords液状食品の低温殺菌 / 高電界パルス / PEF / パルスパワー電源 / 液状食品 / 低温殺菌 / 高エネルギー効率 / パルス電界 / 温熱との併用 / 非加熱殺菌 / 液体食品 / パルス電源 / 超高電界パルス / 液体殺菌 / タンパク性液体食品 / エネルギー効率 / 温熱併用 / 高繰り返しパルスパワー / SiCパワーデバイス / タンパク性食品 / パルスと温熱の併用 / 高流量液送システム
Outline of Final Research Achievements

Pulsed electric field (PEF) is one of the non-thermal physical bactericidal agents that are unlikely to denature ingredients in fresh liquid foods. We have achieved in this project the following: (1) clarifying the roles of PEF and the subsequent thermal energy in killing bacteria, (2) figuring out the characteristics of the PEF sterilization in liquid whole egg, (3) optimizing the operation parameters to maximize the killing effect, (4) developing the highly repetitive pulsed power generator to deliver electrical pulses to a large mass flow treatment chamber, and (5) figuring out the local heating in the vicinity of electrode, which is concerned about degrading protein-rich foods.

Academic Significance and Societal Importance of the Research Achievements

パルス高電界(PEF)は、液状食品の非加熱殺菌法として、現行の高タンパク食品の品質を劇的に向上させうる技術であるが、殺菌の強さ、処理速度ともに実用レベルには程遠い。液卵や牛乳等の高タンパク液状食品を機能を損なわせずに長期間保存できるようになる。他の食品にも転用できることから、食品業界への波及効果と社会へのインパクトは大きい。本課題では、殺菌におけるPEFと温熱の役割を明らかにし、これに基づいて殺菌プロセスを総合的に最適化することによって、殺菌性能を実用可能レベルに引き上げ、さらに、産業利用可能な処理速度を達成するための技術課題を明らかにした。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (45 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (14 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 14 results,  Open Access: 1 results) Presentation (24 results) (of which Int'l Joint Research: 14 results,  Invited: 7 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Int'l Joint Research] Karlsruhe Institute of Technology(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Eindhoven University of Technology(オランダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Old Dominion University(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Intense Pulsed Electric Fields Denature Urease Protein2020

    • Author(s)
      Urabe Gen、Katagiri Toshiaki、Katsuki Sunao
    • Journal Title

      Bioelectricity

      Volume: 2 Issue: 1 Pages: 33-39

    • DOI

      10.1089/bioe.2019.0021

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高電界パルス殺菌におけるパルス波形に関する考察2020

    • Author(s)
      宮﨑大貴, 豊満陽希, 片野景一郎, 主計俊哉, 勝木淳
    • Journal Title

      静電気学会誌

      Volume: 44 Pages: 8-13

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Post-breakdown dielectric recovery characteristics of water for high-repetition-rate switch2020

    • Author(s)
      Yang Z.、Cao H.、Hao J.、Hosano H.、Katsuki S.、Akiyama H.、Zhang C.
    • Journal Title

      IEEE Transactions on Dielectrics and Electrical Insulation

      Volume: 27 Issue: 3 Pages: 909-914

    • DOI

      10.1109/tdei.2020.008507

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study of SiC device for pulsed power switching circuit2019

    • Author(s)
      T. Tagawa, T. Yamashita, T. Sakugawa, S. Katsuki, K. Hukuda, and K. Sakamoto
    • Journal Title

      Electrical Engineering in Japan

      Volume: 209 Issue: 1-2 Pages: 3-9

    • DOI

      10.1002/eej.23242

    • NAID

      210000162144

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fast SiC Switching Limits for Pulsed Power Applications2019

    • Author(s)
      Collier Landon、Kajiwara Taiga、Dickens James、Mankowski John、Neuber Andreas
    • Journal Title

      IEEE Transactions on Plasma Science

      Volume: 47 Issue: 12 Pages: 5306-5313

    • DOI

      10.1109/tps.2019.2928535

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variations of Intracellular Ca2 Mobilization Initiated by Nanosecond and Microsecond Electrical Pulses in HeLa Cells2018

    • Author(s)
      Ohnishi Nobuaki、Fujiwara Yusuke、Kamezaki Taichi、Katsuki Sunao
    • Journal Title

      IEEE Transactions on Biomedical Engineering

      Volume: in print Issue: 8 Pages: 1-1

    • DOI

      10.1109/tbme.2018.2886602

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] がん治療を目的とした 高周波バーストパルスががん細胞へ与える影響の調査2018

    • Author(s)
      佐藤浩美, 安啓太, 南谷靖史, 大西伸明, 藤原裕介, 松林恭平, 宮川大輝, 勝木淳
    • Journal Title

      静電気学会誌

      Volume: 42 Pages: 90-95

    • NAID

      40021619005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low-Temperature Pasteurization of Liquid Whole Egg using Intense Pulsed Electric Fields2018

    • Author(s)
      K. Baba, T. Kajiwara, S. Watanabe, S. Katsuki, R. Sasahara, K. Inoue
    • Journal Title

      Electronics and Communications in Japan

      Volume: 101 Issue: 2 Pages: 87-94

    • DOI

      10.1002/ecj.12053

    • NAID

      210000170078

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell Death induced by Nanosecond Pulsed Electric Fields and its Dependence on Pulse Duration2018

    • Author(s)
      R. Adachi, S. Hatayama, N. Ohnishi, S. Katsuki, T. Wada, K. Abe
    • Journal Title

      Electronics and Communications in Japan

      Volume: 101 Issue: 3 Pages: 38-48

    • DOI

      10.1002/ecj.12032

    • NAID

      210000168642

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-Voltage, Multiphasic, Nanosecond Pulses to Modulate Cellular Responses2018

    • Author(s)
      H.A. Ryan, S. Hirakawa, E. Yang, C. Zhou, S Xiao
    • Journal Title

      IEEE Transactions on Biomedical Circuit and Systems

      Volume: 12 Issue: 2 Pages: 338-350

    • DOI

      10.1109/tbcas.2017.2786586

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Study on Inactivation of Vibrio fischeri by Pulsed Electric Field2017

    • Author(s)
      T. Ueno, J. Ninomiya, N. Takamura, T. Sakugawa, S. Katsuki
    • Journal Title

      Proceedings of Global Conference on Engineering and Applied Science

      Volume: GCEAS-0096-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship Between Responsiveness of Switching and Rise Time of Applied Voltage in Electrospray2017

    • Author(s)
      D. Obata, S. Katsuki
    • Journal Title

      Proceedings of 19th International Conference on Dielectric Liquids

      Volume: - Pages: 1-3

    • DOI

      10.1109/icdl.2017.8124683

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Response of Mammalian Cells to Non-thermal Intense Narrowband Pulsed Electric Fields2017

    • Author(s)
      S. Katsuki, Y. Li, D. Miyakawa, R. Yamada, N. Onishi, S. Lim
    • Journal Title

      Proceedings of The 11th European Conference on Antennas and Propagation

      Volume: - Pages: 1358-1361

    • DOI

      10.23919/eucap.2017.7928345

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trends of Advanced Research and Development of Pulsed Power Technology2017

    • Author(s)
      勝木淳, 江衛華, 堀岡一彦, 菊池崇志, 橋本好幸, 南谷靖史, 高木浩一
    • Journal Title

      IEEJ Transactions on Fundamentals and Materials

      Volume: 137 Issue: 1 Pages: 10-14

    • DOI

      10.1541/ieejfms.137.10

    • NAID

      130005188805

    • ISSN
      0385-4205, 1347-5533
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Rapid recovery of injured bacteria subjected to pulsed electric fields2019

    • Author(s)
      K. Katano, D. Miyazaki, S. Katsuki
    • Organizer
      APSPT11 The 11th Asia-Pacific Symposium on Plasma Technology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Visualization of ion flow in cells with pulsed electric field2019

    • Author(s)
      M. Shimada, T. Ogata, G. Urabe, S. Katsuki
    • Organizer
      APSPT11 The 11th Asia-Pacific Symposium on Plasma Technology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Thermal hydraulics of tubular liquid flow exposed to repetitive high power electrical pulses for large-scale PEF pasteurization system2019

    • Author(s)
      S. Kazue, H. Toyomitsu, S. Katsuki
    • Organizer
      APSPT11 The 11th Asia-Pacific Symposium on Plasma Technology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Extraction of yeast intracellular molecules using pulsed electric fields2019

    • Author(s)
      T. Kamezaki, S. Okamoto, G. Urabe, S. Katsuki
    • Organizer
      APSPT11 The 11th Asia-Pacific Symposium on Plasma Technology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pulsed power generators for bioelectrics2019

    • Author(s)
      S. Katsuki, G. Urabe, G. Nakamura, A. Tokuchi
    • Organizer
      3 World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rapid recovery of injured bacteria subjected to pulsed electric fields2019

    • Author(s)
      K. Katano, D. Miyazaki, S. Katsuki
    • Organizer
      3 World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Protein Response under 1 MV/cm Pulsed Electric Fields2019

    • Author(s)
      G. Urabe, G. Nakamura, S. Katsuki
    • Organizer
      3 World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 強電界パルスの生体作用と医療・食品プロセスへの革新応用2019

    • Author(s)
      勝木淳
    • Organizer
      プラズマ・核融合学会第36回年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Novel Non-thermal Food Processing using Pulsed Electric Fields2019

    • Author(s)
      S. Katsuki
    • Organizer
      Scandinova User's Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effects of Intense Pulsed Electric Field to Biological Cells2018

    • Author(s)
      S. Katsuki, N. Ohnishi, G. Urabe
    • Organizer
      19th International Congress on Plasma Physics, Vancouver
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Structural change of multimer proteins exposed to 300 kV/cm electrical pulses2018

    • Author(s)
      N. Ohnishi, Y. Fujiwara, T. Kamezaki, S. Okamoto, S. Katsuki
    • Organizer
      15th International Bioelectrics Symposium, Prague
    • Related Report
      2018 Annual Research Report
  • [Presentation] Structural change of multimer proteins exposed to 300 kV/cm electrical pulses2018

    • Author(s)
      G. Urabe, T. Katagiri, N. Ohnishi, S. Katsuki
    • Organizer
      15th International Bioelectrics Symposium, Prague
    • Related Report
      2018 Annual Research Report
  • [Presentation] Efficient liquid pasteurization using PEF combined with mild thermal energy2018

    • Author(s)
      S. Watanabe, T. Kajiwara, K. Katano, S. Katsuki
    • Organizer
      15th International Bioelectrics Symposium, Prague
    • Related Report
      2018 Annual Research Report
  • [Presentation] Structural change of multimer proteins exposed to 300 kV/cm electrical pulses2018

    • Author(s)
      G. Urabe, T. Katagiri, N. Ohnishi, S. Katsuki
    • Organizer
      40th International Symposium on Dry Process, Nagoya
    • Related Report
      2018 Annual Research Report
  • [Presentation] Extraction of yeast ingredient using intense pulsed electric fields2018

    • Author(s)
      T. Kamezaki, Y. Fujiwara, N. Ohnishi, S. Okamoto, S. Katsuki
    • Organizer
      The 13th International Student Conference on Advanced Science and Technology, Manila
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cellular response of mammalian cells exposed to high power microwave2018

    • Author(s)
      S. Kazue, K. Kishimoto, H. Toyomitsu, G. Urabe, S. Katsuki
    • Organizer
      The 13th International Student Conference on Advanced Science and Technology, Manila
    • Related Report
      2018 Annual Research Report
  • [Presentation] パルスパワーを用いた革新的食品加工技術2018

    • Author(s)
      勝木淳
    • Organizer
      化学工学会第50回秋季大会, 鹿児島
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] パルスパワーを用いる革新的食品低温プロセス ~殺菌、抽出を中心に~2018

    • Author(s)
      勝木淳
    • Organizer
      第334回RISTフォーラム, 熊本
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Inactivation of Gram-negative bacteria in liquid whole egg using intense pulsed lectric field combined with mild thermal energy2017

    • Author(s)
      S. Katsuki, T. Kajiwara, S. Hirakawa, S. Watanabe
    • Organizer
      10th Asia-Pasific Symposium on Plasma Technology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characteristics of Saccharomyces cerevisiae Exposed to Nanosecond Pulsed Electric Fields2017

    • Author(s)
      K. Matsubayashi, Y. Fujiwara, S. Katsuki
    • Organizer
      10th Asia-Pasific Symposium on Plasma Technology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 1 MV/cm sub-nanosecond pulse exposure system for a study of PEF effect on proteins2017

    • Author(s)
      S. Katsuki
    • Organizer
      2nd World Congress on Electroporation
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Efficient PEF Sterilization of Liquid Whole Egg2017

    • Author(s)
      T. Kajiwara, S. Hirakawa, S. Watanabe, S. Katsuki
    • Organizer
      2nd World Congress on Electroporation
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DSC measurement of Gram-negative bacteria for understanding the dependence of the PEF sterilization effect on the treatment temperature2017

    • Author(s)
      S. Hirakawa, T. Kajiwara, S. Watanabe, S. Katsuki
    • Organizer
      2nd World Congress on Electroporation
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of Intense Electrical Pulses on Proteins2017

    • Author(s)
      S. Katsuki, S. Lim, N. Ohnishi, T. Terahira, T. Katagiri
    • Organizer
      13th Pacific Symposium on Pulsed Power and its applications
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Remarks] 熊本大学 応用バイオエレクトリクス研究室(勝木研究室)

    • URL

      http://www.cs.kumamoto-u.ac.jp/~katsuki/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 熊本大学パルスパワー科学研究所応用バイオエレクトリクス研究室

    • URL

      http://www.cs.kumamoto-u.ac.jp/~katsuki/

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 抽出物の製造方法、細胞内成分の抽出方法、及び抽出装置2019

    • Inventor(s)
      勝木淳、亀崎太一、岡本修治
    • Industrial Property Rights Holder
      勝木淳、亀崎太一、岡本修治
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-169632
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] パルス電界を用いた液状食品の殺菌方法2017

    • Inventor(s)
      勝木淳、梶原大河、大橋重夫、井上和幸、笹原亮
    • Industrial Property Rights Holder
      勝木淳、梶原大河、大橋重夫、井上和幸、笹原亮
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-094021
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2022-05-23  

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