Study on the mechanism of CAPS-dependent secretory vesicle exocytosis and its deficits in the nervous system and behavior
Project/Area Number |
17H03563
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Tokyo University of Science |
Principal Investigator |
Furuichi Teiichi 東京理科大学, 理工学部応用生物科学科, 教授 (50219094)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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Keywords | CAPS / シナプス小胞 / 有芯小胞 / 開口放出 / 学習記憶行動 / 社会行動 / プロオピオメラノコルチン / オキシトシン / CAPS2 / POMC / 食欲制御 / ペプチド分泌 / 分子神経科学 / 脳・神経 / 神経科学 / 脳神経疾患 |
Outline of Final Research Achievements |
Classical and peptidic neurotransmitters are taken up by small synaptic vesicles (SVs) and large dense-core vesicles (DCVs) that are produced in different ways, and then released by a similar exocytosis phenomenon. The purpose of this study was to clarify the functional role of CAPS proteins involved in both exocytosis and their significance in physiology and behavior. It was suggested that CAPS1 is involved in exocytosis of glutamatergic SVs in the hippocampus, has an important role in synaptic transmission and plasticity, and is essential for learning memory. It was suggested that CAPS2 is involved in exocytosis of proopiomelanocortinergic and oxytocinergic DCVs, and plays an important role in the control of feeding and the expression of social behavior, respectively.
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Academic Significance and Societal Importance of the Research Achievements |
CAPS1は,興奮性グルタミン酸シナプス小胞の開口放出機構に関与し,海馬シナプス伝達,シナプス可塑性の回路機能から,学習記憶行動まで重要な役割をもつ。CAPS2は,神経ペプチドを含む有芯小胞の開口放出機構に関与し,CAPS2依存的なプロオピオメラノコルチン分泌は摂食行動に,CAPS2依存的なオキシトシン分泌は社会行動に,それぞれ関連することが示された。これらの研究成果から,中枢神経系の古典的とペプチド性の神経伝達物質をそれぞれ含有するシナプス小胞と有芯小胞の開口放出機構が,CAPSという共通のタンパク質によって制御されており,この欠損が多様な神経機能異常を引き起こすことが解明された。
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] LAMP5 in presynaptic inhibitory terminals in the hindbrain and spinal cord: a role in startle response and auditory processing2019
Author(s)
.Koebis, M., Urata, S., Shinoda, Y., Okabe, S., Yamasoba, T., Nakao, K., Aiba, A., and T. Furuichi,
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Journal Title
Molecular Brain
Volume: 12
Issue: 1
Pages: 20-20
DOI
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Peer Reviewed / Open Access
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[Journal Article] Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments.2019
Author(s)
Hosoi N, Shibasaki K, Hosono M, Konno A, Shinoda Y, Kiyonari H, Inoue K, Muramatsu SI, Ishizaki Y, Hirai H, Furuichi T, Sadakata T
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Journal Title
J Neurosci
Volume: 39(32)
Issue: 32
Pages: 6339-6353
DOI
Related Report
Peer Reviewed
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[Journal Article] ViBrism DB: an interactive search and viewer platform for 2D/3D anatomical images of gene expression and co-expression networks.2018
Author(s)
M. Morita, K. Shimokawa,M. Nishimura, S.Nakamura, Y. Tsujimura, S. Takemoto, T. Tawara, H. Yokota, S. Wemier, D. Miyamoto, H. Ikeno, A. Sato, T. Furuichi, N. Kobayashi, Y. Okumura, Y. Yamaguchi, Y. O-Oho
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Journal Title
Nucleic acids research
Volume: 47
Issue: D1
Pages: D859-D866
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation.2017
Author(s)
Nakayama K., Ohashi R., Shinoda Y., Yamazaki M., Abe M., Fujikawa A., Shigenobu S., Futatsugi A., Noda M., Mikoshiba K., Furuichi T., Sakimura K., and Shiina N.
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Journal Title
Related Report
Peer Reviewed / Open Access
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[Journal Article] The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination2017
Author(s)
Hayashi K, Furuya A, Sakamaki Y, Akagi T, Shinoda Y, Sadakata T, Hashikawa T, Shimizu K, Minami H, Sano Y, Nakayama M, and Furuichi T.
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Journal Title
PLoS ONE
Volume: 12
Issue: 3
Pages: e0173175-e0173175
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Significant role of CAPS1, a regulator of synaptic exocytosis, in trisynaptic circuit and hippocampal learning.2019
Author(s)
T. Arima, C. Ishii, Y. Ishii, N. Shibano, M. Yamazaki, Y. Kato, A. Yamato, Y. Shinoda, T. Sadakata, Y. Sano, T. Furuichi.
Organizer
第42回日本神経科学大会・第62回日本神経化学会大会
Related Report
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[Presentation] 味覚嫌悪学習における脳領域間相互作用2018
Author(s)
Konami Abe, Yosuke Narumi, Shuhei Fujima, Yuki Kobayashi, Shigeyoshi Itohara, Teiichi Furuichi, Yoshitake Sano
Organizer
Neuroscience 2018 第41回日本神経科学大会2018
Related Report
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[Presentation] CAPS1 finely regulates the exocytosis of synaptic vesicles in calcium- and/or synapse type-dependent manners, affecting on learning and memory.2018
Author(s)
C. ISHII , Y. SHINODA , T. SADAKATA , Y. SANO , Y. ISHII , N. SHIBANO , Y. KATO , M. YAMAZAKI , A. YAMATO , T. FURUICHI
Organizer
Neuroscience 2018, Annual Meeting of Society for Neuroscience
Related Report
Int'l Joint Research
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[Presentation] 2D/3D image integration on the BAH viewer.2018
Author(s)
Y. OKAMURA-OHO , D. MIYAMOTO , H. IKENO , M. MORITA , H. YOKOTA , S. WEMLER , A. SATO , T. FURUICHI , Y. OKUMURA , Y. YAMAGUCHI
Organizer
Neuroscience 2018, Annual Meeting of Society for Neuroscience
Related Report
Int'l Joint Research
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[Presentation] CAPS1 stabilizes synaptic vesicles on active zones and ensures basal synaptic transmission at hippocampal CA3-CA1 synapses2017
Author(s)
Ishii, C., Shinoda, Y., Fukazawa, Y., Sadakata, T., Sano, Y., Ishii, Y., Shibano, N., Furuichi, T.
Organizer
Neuroscience 2017, Society for Neuroscience
Related Report
Int'l Joint Research
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[Presentation] Aberrant responses to the biological motion of CAPS2 knockout mice by conspecifics2017
Author(s)
Atsumi, T., Ide, M., Sano, Y., Shinoda, Y., Furuichi, T., Wada, M
Organizer
行動2017 日本動物行動関連学会・研究会合同大会
Related Report
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