| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
Reorganization of myelin in the peripheral nervous system is essential for maintaining homeostasis of the nervous tissue as a whole; however, the concept that myelin in the peripheral nervous system is a strong structure has been established. Until now, few studies have been directed to the myelin reorganization. The purpose of this study has been to clarify the mechanism of this myelin reorganization. We tried to elucidate the major molecules that control myelin reorganization and maintenance. As a result, we have identified new molecules such as BIG1 and Arf1 that control myelin reorganization and maintenance. By identifying the molecules involved in myelin reorganization and maintenance, it would be expected that the mechanism "inherent in the body" can be induced and the molecular basis for a new therapeutic strategy for demyelinating diseases can be provided.
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