| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
Mucosal associated invariant T (MAIT) cell is a novel innate like T cell which play a role in bacterial infection. Although MAIT cells are very abundant in humans, there is no suitable animal model for studying MAIT cells due to a very low frequency in laboratory mice. We have established induced pluripotent stem cells derived from mouse MAIT cells in lungs (MAIT-iPSCs) and redifferentiated MAIT cells (m-reMAIT cells). m-reMAIT cells were activated by a vitamin B2 metabolite and bacterial bodies and released various cytokines and chemokines. Further, we have created novel mouse models: m-reMAIT cell adoptive transfer model and MAIT mice established through the intermediary chimeric mice derived from MAIT-iPSCs. Vα19 mice, one of strains of MAIT mice, possessed thousands of times more MAIT cells than wild-type mice, and protected early growth of Mycobacterium bovis BCG in liver.
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