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Non-invasive medical technology using novel glioma-homing peptide

Research Project

Project/Area Number 17H03590
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Tumor diagnostics
Research InstitutionNiigata University

Principal Investigator

Eisaku Kondo  新潟大学, 医歯学系, 教授 (30252951)

Co-Investigator(Kenkyū-buntansha) 小根山 千歳  愛知県がんセンター(研究所), 感染腫瘍学部, 部長 (90373208)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywordsペプチド / グリオーマ / 低侵襲性 / 治療 / 診断 / グリオブラストーマ / ホーミングペプチド / イメージング / 腫瘍診断 / 腫瘍治療 / 脳腫瘍 / 標的化 / 腫瘍診断学 / がんの個性診断
Outline of Final Research Achievements

We have idenfied the glioma-homing peptide which shows highly-shifted incorporation to the target, glioblastoma cells, with minimized absorption to the various linegage of normal(non-neoplastic) cells. By additional technical trials, its hydrophobicity and protease-resistance were much improved with practical utility as in vivo imaging and a therapeutic tool. We also succeeded to develope tumor suppressor peptide which restore the lost p14ARF function in glioblastoma cells. Based on these results, we finally developed the homing peptide-p14 tumor suppressor peptide fusion peptide which is expected to serve as a anti-glioblastoma peptide, and its specific action point could be clarified by molecular study to explain its antitumor effect against human glioblastoma cells.

Academic Significance and Societal Importance of the Research Achievements

高悪性度脳腫瘍グリオブラストーマは、現行医療においてなお難治悪性腫瘍として危急の解決を求められている疾患の一つであり、特に同腫瘍の急速な脳内進展という性質や進行段階にある同腫瘍に対する医療的制御技術は未だ十分とは言えない状況である。本研究を通じてわれわれは生体内で増殖・進展する高悪性度グリオーマ細胞特異的・選択的に吸収・集積を起こし、抗腫瘍効果を発揮できるポテンシャルを有するペプチド性抗腫瘍剤のプロトタイプの開発に成功した。この知見は発展的に、難治悪性脳腫瘍の新規かつ生体低尾侵襲性治療技術の基盤構築に資するものと考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (56 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (16 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 16 results,  Open Access: 12 results) Presentation (31 results) (of which Int'l Joint Research: 12 results,  Invited: 7 results) Book (3 results) Remarks (3 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] Institute of Pathology/Wuerzburg University(Germany)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] PLOD2 Is Essential to Functional Activation of Integrin β1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas.2020

    • Author(s)
      Ueki Y, Saito K, Iioka H, Sakamoto I, Kanda Y, Sakaguchi M, Horii A, Kondo E.
    • Journal Title

      iScience

      Volume: 23 Issue: 2 Pages: 100850-100850

    • DOI

      10.1016/j.isci.2020.100850

    • NAID

      120006840775

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PODXL1 promotes metastasis of the pancreatic ductal adenocarcinoma by activating the C5aR/C5a axis from the tumor microenvironment.2019

    • Author(s)
      Saito K, Iioka H, Maruyama S, Sumardika IW, Sakaguchi M and Kondo E.
    • Journal Title

      Neoplasia

      Volume: 21(12) Issue: 12 Pages: 1121-1132

    • DOI

      10.1016/j.neo.2019.09.003

    • NAID

      120006842043

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crumbs3 regulates the expression of glycosphingolipids on the plasma membrane to promote colon cancer cell migration.2019

    • Author(s)
      Iioka H, Saito K, Kondo E.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 519 Issue: 2 Pages: 287-293

    • DOI

      10.1016/j.bbrc.2019.08.161

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crumbs3 is a critical factor that regulates invasion and metastasis of colon adenocarcinoma via the specific interaction with FGFR1.2019

    • Author(s)
      Iioka H, Saito K, Sakaguchi M, Tachibana T, Homma K, Kondo E.
    • Journal Title

      Int J Cancer

      Volume: 145 Issue: 10 Pages: 2740-2753

    • DOI

      10.1002/ijc.32336

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness.2019

    • Author(s)
      Chen Y, Sumardika IW, Tomonobu N, Kinoshita R, Inoue Y, Iioka H, Mitsui Y, Saito K, Ruma IMW, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Kubo M, Putranto EW, Murakami T, Liu M, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M.
    • Journal Title

      Neoplasia.

      Volume: 21(7) Issue: 7 Pages: 627-640

    • DOI

      10.1016/j.neo.2019.04.006

    • NAID

      120006948963

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neuroplastin-β mediates S100A8/A9-induced lung cancer disseminative progression.2019

    • Author(s)
      Sumardika IW, Chen Y, Tomonobu N, Kinoshita R, Ruma IMW, Sato H, Kondo E, Inoue Y, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Putranto EW, Hibino T, Nishibori M, Toyooka S, Sakaguchi M
    • Journal Title

      Mol Carcinog.

      Volume: - Issue: 6 Pages: 980-995

    • DOI

      10.1002/mc.22987

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion.2019

    • Author(s)
      Chen Y, Sumardika IW, Tomonobu N, Winarsa Ruma IM, Kinoshita R, Kondo E, Inoue Y, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Liu M, Futami J, Sasai K, Katayama H, Kubo M, Putranto EW, Hibino T, Sun B, Nishibori M, Toyooka S, Sakaguchi M
    • Journal Title

      Cancer Lett.

      Volume: - Pages: 178-190

    • DOI

      10.1016/j.canlet.2019.03.023

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Extracellular S100A11 plays a critical role in spread of the fibroblast population in pancreatic cancers2019

    • Author(s)
      Takamatsu H, Yamamoto K, Tomonobu N, Murata H, Inoue Y, Yamauchi A, Sumardika W, Youyi C, Kinoshita R, Yamamura M, Fujiwara H, Mitsui Y, Araki K, Futami J, Saito K, Iioka H, Ruma MW, Putranto EW, Nishibori M, Kondo E, Yamamoto Y, Toyooka S, Sakaguchi M
    • Journal Title

      Oncol Res

      Volume: - Issue: 6 Pages: 713-727

    • DOI

      10.3727/096504018x15433161908259

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of TRA-1-60-positive cells as a potent refractory population in follicular lymphomas.2019

    • Author(s)
      Takata K, Saito K, Maruyama S, Miyata-Takata T, Iioka H, Okuda S, Ling Y, Karube K, Miki Y, Maeda Y, Yoshino T, Steidl C, Kondo E.
    • Journal Title

      Cancer Sci.

      Volume: 110(1) Issue: 1 Pages: 443-457

    • DOI

      10.1111/cas.13870

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis.2018

    • Author(s)
      Kinoshita R, Sato H, Yamauchi A, Takahashi Y, Inoue Y, Sumardika IW, Chen Y, Tomonobu N, Araki K, Shien K, Tomida S, Torigoe H, Namba K, Kurihara E, Ogoshi Y, Murata H, Yamamoto KI, Futami J, Putranto EW, Ruma IMW, Yamamoto H, Soh J, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M.
    • Journal Title

      Int J Cancer.

      Volume: 印刷中 Issue: 2 Pages: 569-575

    • DOI

      10.1002/ijc.31982

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] exSSSRs (extracellular S100 soil sensor receptors)-Fc fusion proteins work as prominent decoys to S100A8/A9-induced lung tropic cancer metastasis.2018

    • Author(s)
      Kinoshita R, Sato H, Yamauchi A, Takahashi Y, Inoue Y, Sumardika IW, Chen Y, Tomonobu N, Araki K, Shien K, Tomida S, Torigoe H, Namba K, Kurihara E, Ogoshi Y, Murata H, Yamamoto KI, Futami J, Putranto EW, Ruma IMW, Yamamoto H, Soh J, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M
    • Journal Title

      Int J Cancer.

      Volume: - Issue: 12 Pages: 3138-3145

    • DOI

      10.1002/ijc.31945

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Visualizing the Rapid and Dynamic Elimination of Allogeneic T Cells in Secondary Lymphoid Organs2018

    • Author(s)
      Kanda Yasuhiro、Takeuchi Arata、Ozawa Madoka、Kurosawa Yoichi、Kawamura Toshihiko、Bogdanova Dana、Iioka Hidekazu、Kondo Eisaku、Kitazawa Yusuke、Ueta Hisashi、Matsuno Kenjiro、Kinashi Tatsuo、Katakai Tomoya
    • Journal Title

      The Journal of Immunology

      Volume: 201 Issue: 3 Pages: 1062-1072

    • DOI

      10.4049/jimmunol.1700219

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stromal mesenchymal stem cells facilitate pancreatic cancer progression by regulating specific secretory molecules through mutual cellular interaction.2018

    • Author(s)
      Saito K, Sakaguchi M, Maruyama S, Iioka H, Putranto EW, Sumardika IW, Tomonobu N, Kawasaki T, Homma K, Kondo E.
    • Journal Title

      J Cancer.

      Volume: 9(16) Issue: 16 Pages: 2916-2929

    • DOI

      10.7150/jca.24415

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induction of Short NFATc1/αA Isoform Interferes with Peripheral B Cell Differentiation.2018

    • Author(s)
      Muhammad K, Rudolf R, Pham DAT, Klein-Hessling S, Takata K, Matsushita N, Ellenrieder V, Kondo E, Serfling E.
    • Journal Title

      Front. Immunol.

      Volume: 9

    • DOI

      10.3389/fimmu.2018.00032

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] b-1,3-galactosyl-O-glycosyl-glycoprotein b-1,6-N-acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.2017

    • Author(s)
      Sumardika I Wayan、Youyi Chen、Kondo Eisaku、Inoue Yusuke、Ruma I Made Winarsa、Murata Hitoshi、Kinoshita Rie、Yamamoto Ken-Ichi、Tomida Shuta、Shien Kazuhiko、Satoh Hiroki、Yamauchi Akira、Futami Junichiro、Putranto Endy Widya、Hibino Toshihiko、Toyooka Shinichi、Nishibori Masahiro、Sakaguchi Masakiyo
    • Journal Title

      Oncology Reserch

      Volume: in press Issue: 3 Pages: 431-444

    • DOI

      10.3727/096504017x15031557924123

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of a novel component leading to anti-tumor activity besides the major ingredient cordycepin in Cordyceps militaris extract.2017

    • Author(s)
      Wada T, Sumardika IW, Saito S, Ruma IMW, Kondo E, Shibukawa M, Sakaguchi M
    • Journal Title

      J Chromatogr B Analyt Technol Biomed Life Sci.

      Volume: - Pages: 209-219

    • DOI

      10.1016/j.jchromb.2017.07.022

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] ゲノム編集技術~CRISPR/Cas9を用いた研究材料の作成と病理学研究への利用2019

    • Author(s)
      近藤英作
    • Organizer
      第108回日本病理学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] TRA-ポドカリキシン発言細胞の腫瘍組織における生物学的特徴2019

    • Author(s)
      近藤英作,飯岡英和,齋藤憲
    • Organizer
      第108回日本病理学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 胎児消化管類似胃癌におけるTRA1-60の発現2019

    • Author(s)
      Ivanov Vaniamin,Eisaku Kondo
    • Organizer
      第108回日本病理学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 浸潤・転移のkey分子インテグリンの機能的活性化制御のPLOD2を介する新規メカニズム2019

    • Author(s)
      齋藤憲、近藤英作
    • Organizer
      第23回日本がん分子標的治療学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 分子腫瘍病理学研究の基盤となる組織・細胞イメージング技術2019

    • Author(s)
      近藤英作
    • Organizer
      第51回日本臨床分子形態学会総会・学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 膵がんの転移を制御するポドカリキシンとケモカイン受容体の相互反応2019

    • Author(s)
      近藤英作、飯岡英和、齋藤憲
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] PLOD2 is essential functional activation of integrin beta1 for invasion/metastasis of cancer.2019

    • Author(s)
      Eisaku Kondo, Ken Saito
    • Organizer
      AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tumor-Homing Peptides for Tumor-Targeting Medicine2018

    • Author(s)
      Kondo E
    • Organizer
      10th International Peptide Symposium(10th IPS)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 浸潤性膵管がんの転移におけるPODXL1の生物学的役割2018

    • Author(s)
      近藤英作,阪口政清,齋藤憲,飯岡英和
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] がん間質を紐解く ~がん進展の重要な鍵は普段診ている間質にある!?2018

    • Author(s)
      近藤英作,齋藤憲
    • Organizer
      第107回日本病理学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 幹細胞マーカーTRA-PODXL1と悪性腫瘍との関り~tumor development or tumor progression?2018

    • Author(s)
      近藤英作
    • Organizer
      第15回日本病理学会カンファレンス
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] PODXL1 as acritical accelerator for pancreatic cancer metastasis2018

    • Author(s)
      Kondo E
    • Organizer
      AACR Annual meeting 2018 Chicago, Illinois
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Peptide-based tumor tecnology using tumorhoming CPPs.2017

    • Author(s)
      Eisaku Kondo
    • Organizer
      The 4th RIKEN/Karolonska Insitutet/SciLifeLab Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 濾胞性リンパ腫難治性を規定する特殊細胞集団の発見2017

    • Author(s)
      近藤英作,高田尚良,齋藤憲
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] S100A8/A9とその受容体との結合遮断を目指した転移抑制タンパク質製剤の開発2017

    • Author(s)
      木下理恵,山内明,枝園和彦,富田秀太,豊岡伸一,近藤英作,坂口政清
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Crumbs3は焦点接着構成因子を制御することで大腸癌の転移を促進する2017

    • Author(s)
      飯岡英和,齋藤憲,坂口政清,森井英一,近藤英作
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] R-loop 蓄積と関連するTREX2複合体の機能不全は乳がん細胞において化学療法感受性を増大させる2017

    • Author(s)
      桑原一彦,近藤英作
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 口腔扁平上皮癌におけるPLOD2の発現と細胞移動能との関連2017

    • Author(s)
      植木雄志,齋藤憲,近藤英作
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PLOD2は口腔がん細胞の移動能を制御する2017

    • Author(s)
      齋藤憲,植木雄志,近藤英作
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体内腫瘍におけるR-loop 形成亢進の特徴と意義2017

    • Author(s)
      栗田彩花,桑原一彦,近藤英作
    • Organizer
      第14回日本病理学会カンファレンス
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔がん細胞相互作用におけるPLOD2の役割2017

    • Author(s)
      斎藤憲,植木雄志,近藤英作
    • Organizer
      第21回日本がん分子標的治療学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 乳癌細胞においてTREX2複合体構成分子は薬剤感受性誘導の標的となる2017

    • Author(s)
      桑原一彦,近藤英作
    • Organizer
      第21回日本がん分子標的治療学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] R-loop発現の病理学的意義2017

    • Author(s)
      田中萌恵,桑原一彦,近藤英作
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 多様な系統の癌における薬物代謝酵素CYP3A5の発現とその意義2017

    • Author(s)
      田坂杏美,田中萌恵,桑原一彦,植木雄志,齋藤憲,近藤英作
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 濾胞性リンパ腫難治性を規定する特殊細胞集団の発見2017

    • Author(s)
      近藤英作,高田尚良,齋藤憲
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Crumbs3は大腸癌細胞の接着性制御を介し腫瘍形成を促進する2017

    • Author(s)
      飯岡英和,齋藤憲,森井栄一,近藤英作
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 病理学のアドバンテージを活かした腫瘍医学研究へのアプローチ2017

    • Author(s)
      近藤英作
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 抗がん治療増強の標的としてのTREX2複合体2017

    • Author(s)
      桑原一彦,近藤英作
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肺がん選択的透過ペプチドの開発2017

    • Author(s)
      斎藤憲,飯岡英和,近藤英作
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Forced reduction of DSS1, a member of TREX2 complex, highly sensitizes chemotherapy to breast cancer cells in a BRCA2-independent manner.2017

    • Author(s)
      Kazuhiko Kuwahara, Eisaku Kondo
    • Organizer
      AACR Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cellular interaction between pancreatic cancer cells and MSC as tumor microenvironment.2017

    • Author(s)
      Eisaku Kondo, Ken Saito
    • Organizer
      AACR Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Book] ペプチド医薬品の スクリーニング・安定化・製剤化技術2017

    • Author(s)
      近藤英作
    • Total Pages
      557
    • Publisher
      技術情報協会
    • Related Report
      2017 Annual Research Report
  • [Book] 医療・診断を支えるペプチド科学2017

    • Author(s)
      齋藤憲、近藤英作
    • Total Pages
      315
    • Publisher
      シーエムシー出版
    • ISBN
      9784781312675
    • Related Report
      2017 Annual Research Report
  • [Book] 新潟医学雑誌2017

    • Author(s)
      齋藤憲, 近藤英作
    • Total Pages
      63
    • Publisher
      新潟医学会
    • Related Report
      2017 Annual Research Report
  • [Remarks] 新潟大学医学部医学科実験病理学講座ホームページ

    • URL

      https://www.med.niigata-u.ac.jp/pa2/index.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 新潟大学大学院医歯学総合研究科分子細胞病理学分野

    • URL

      https://www.med.niigata-u.ac.jp/pa2/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 新潟大学大学院医歯学総合研究科分子細胞病理学

    • URL

      http://www.med.niigata-u.ac.jp/pa2/index.html

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] ペプチドおよびその使用2018

    • Inventor(s)
      近藤英作、斎藤憲
    • Industrial Property Rights Holder
      近藤英作、斎藤憲
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] Peptide having accumulation specific to pancreatic cancer, and use of said peptide.2018

    • Inventor(s)
      Kondo E, Saito K
    • Industrial Property Rights Holder
      Kondo E, Saito K
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
    • Overseas

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Published: 2017-04-28   Modified: 2021-02-19  

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