Non-invasive medical technology using novel glioma-homing peptide
| Project/Area Number |
17H03590
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor diagnostics
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| Research Institution | Niigata University |
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Principal Investigator |
Eisaku Kondo 新潟大学, 医歯学系, 教授 (30252951)
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| Co-Investigator(Kenkyū-buntansha) |
小根山 千歳 愛知県がんセンター(研究所), 感染腫瘍学部, 部長 (90373208)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | ペプチド / グリオーマ / 低侵襲性 / 治療 / 診断 / グリオブラストーマ / ホーミングペプチド / イメージング / 腫瘍診断 / 腫瘍治療 / 脳腫瘍 / 標的化 / 腫瘍診断学 / がんの個性診断 |
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| Outline of Final Research Achievements |
We have idenfied the glioma-homing peptide which shows highly-shifted incorporation to the target, glioblastoma cells, with minimized absorption to the various linegage of normal(non-neoplastic) cells. By additional technical trials, its hydrophobicity and protease-resistance were much improved with practical utility as in vivo imaging and a therapeutic tool. We also succeeded to develope tumor suppressor peptide which restore the lost p14ARF function in glioblastoma cells. Based on these results, we finally developed the homing peptide-p14 tumor suppressor peptide fusion peptide which is expected to serve as a anti-glioblastoma peptide, and its specific action point could be clarified by molecular study to explain its antitumor effect against human glioblastoma cells.
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| Academic Significance and Societal Importance of the Research Achievements |
高悪性度脳腫瘍グリオブラストーマは、現行医療においてなお難治悪性腫瘍として危急の解決を求められている疾患の一つであり、特に同腫瘍の急速な脳内進展という性質や進行段階にある同腫瘍に対する医療的制御技術は未だ十分とは言えない状況である。本研究を通じてわれわれは生体内で増殖・進展する高悪性度グリオーマ細胞特異的・選択的に吸収・集積を起こし、抗腫瘍効果を発揮できるポテンシャルを有するペプチド性抗腫瘍剤のプロトタイプの開発に成功した。この知見は発展的に、難治悪性脳腫瘍の新規かつ生体低尾侵襲性治療技術の基盤構築に資するものと考えられる。
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness.2019
Author(s)
Chen Y, Sumardika IW, Tomonobu N, Kinoshita R, Inoue Y, Iioka H, Mitsui Y, Saito K, Ruma IMW, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Kubo M, Putranto EW, Murakami T, Liu M, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M.
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Journal Title
Neoplasia
Volume: 21
Pages: 627-640
DOI
Related Report
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[Journal Article] Neuroplastin-β mediates S100A8/A9-induced lung cancer disseminative progression.2019
Author(s)
Sumardika IW, Chen Y, Tomonobu N, Kinoshita R, Ruma IMW, Sato H, Kondo E, Inoue Y, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Putranto EW, Hibino T, Nishibori M, Toyooka S, Sakaguchi M.
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Journal Title
Mol Carcinog.
Volume: 58
Pages: 980-995
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion.2019
Author(s)
Chen Y, Sumardika IW, Tomonobu N, Winarsa Ruma IM, Kinoshita R, Kondo E, Inoue Y, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Liu M, Futami J, Sasai K, Katayama H, Kubo M, Putranto EW, Hibino T, Sun B, Nishibori M, Toyooka S, Sakaguchi M.
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Journal Title
Cancer Lett.
Volume: 452
Pages: 178-190
DOI
Related Report
Peer Reviewed
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[Journal Article] Extracellular S100A11 plays a critical role in spread of the fibroblast population in pancreatic Cancers.2019
Author(s)
Takamatsu H, Yamamoto KI, Tomonobu N, Murata H, Inoue Y, Yamauchi A, Sumardika IW, Youyi C, Kinoshita R, Yamamura M, Fujiwara H, Mitsui Y, Araki K, Futami J, Saito K, Iioka H, Ruma IMW, Putranto EW, Nishibori M, Kondo E, Yamamoto Y, Toyooka S, Sakaguchi M.
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Journal Title
Oncol Res.
Volume: 印刷中
Pages: 印刷中
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of TRA-1-60-positive cells as a potent refractory population in follicular lymphomas.2019
Author(s)
Takata K, Saito K, Maruyama S, Miyata-Takata T, Iioka H, Okuda S, Ling Y, Karube K, Miki Y, Maeda Y, Yoshino T, Steidl C, Kondo E.
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Journal Title
Cancer Sci.
Volume: 110
Pages: 443-457
DOI
Related Report
Peer Reviewed
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[Journal Article] Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis.2018
Author(s)
Kinoshita R, Sato H, Yamauchi A, Takahashi Y, Inoue Y, Sumardika IW, Chen Y, Tomonobu N, Araki K, Shien K, Tomida S, Torigoe H, Namba K, Kurihara E, Ogoshi Y, Murata H, Yamamoto KI, Futami J, Putranto EW, Ruma IMW, Yamamoto H, Soh J, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M.
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Journal Title
Int J Cancer.
Volume: 印刷中
Pages: 印刷中
DOI
Related Report
Peer Reviewed
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[Journal Article] exSSSRs (extracellular S100 soil sensor receptors)-Fc fusion proteins work as prominent decoys to S100A8/A9-induced lung tropic cancer metastasis.2018
Author(s)
Kinoshita R, Sato H, Yamauchi A, Takahashi Y, Inoue Y, Sumardika IW, Chen Y, Tomonobu N, Araki K, Shien K, Tomida S, Torigoe H, Namba K, Kurihara E, Ogoshi Y, Murata H, Yamamoto KI, Futami J, Putranto EW, Ruma IMW, Yamamoto H, Soh J, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M.M.
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Journal Title
Int J Cancer.
Volume: 144
Pages: 3138-3145
DOI
Related Report
Peer Reviewed
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[Journal Article] Visualizing the Rapid and Dynamic Elimination of Allogeneic T Cells in Secondary Lymphoid Organs.2018
Author(s)
Kanda Y, Takeuchi A, Ozawa M, Kurosawa Y, Kawamura T, Bogdanova D, Iioka H, Kondo E, Kitazawa Y, Ueta H, Matsuno K, Kinashi T, Katakai T.
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Journal Title
J Immunol
Volume: 201
Pages: 1062-1072
DOI
Related Report
Peer Reviewed
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[Journal Article] ß-1,3-galactosyl-O-glycosyl-glycoprotein ß-1,6-N-acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.2017
Author(s)
Sumardika IW, Youyi C, Kondo E, Inoue Y, Ruma IMW, Murata H, Kinoshita R, Yamamoto KI, Tomida S, Shien K, Satoh H, Yamauchi A, Futami J, Putranto EW, Hibino T, Toyooka S, Nishibori M, Sakaguchi M
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Journal Title
Oncol. Res.
Volume: -
Pages: -
DOI
Related Report
Peer Reviewed
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[Book] 新潟医学雑誌2017
Author(s)
齋藤憲, 近藤英作
Total Pages
63
Publisher
新潟医学会
ISBN
0029-0440
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