| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
In cell differentiation, a group of differentiation-related genes are selectively expressed by various epigenome regulations including transcription factors and histone modifications. In recent years, it has been cleared that histone variants form a chromatin structure at a specific composition ratio and are widely involved in the selective gene expression on the genome to the regulation of transcriptional amount. However, there are still many unclear points about the formation mechanism and function. Therefore, in the present study, novel identified skeletal muscle-specific histone variants from the selection of differentiation genes in the process of reaching various precursor cells and mature muscle tissues in the process from skeletal muscle stem cells to mature muscle tissues. We have elucidated the chromatin composition on the genome and its function when controlling the transcription level, some of which have been published and others have been submitted.
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