| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
In the ciliate Tetrahymena, there are two types of nuclei with different structures and functions, a macronucleus and a micronucleus, in one cell. By utilizing the characteristics of this "binuclear" organism, the role of the nuclear pore complex involved in nuclear functional differentiation has been investigated. In this study, we identified the nucleus-specific nuclear pore complex proteins that are involved in differentiating the macronucleus and micronucleus. We analyzed the dynamic process of nuclear differentiation during sexual reproduction using fluorescence imaging and clarified the role of the nuclear pore complex in nuclear functional differentiation.
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