Functional analysis of novel membrane complexes involved in collagen secretion and ERES formation
| Project/Area Number |
17H03651
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Akita University |
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Principal Investigator |
Saito Kota 秋田大学, 医学系研究科, 教授 (60549632)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | 分泌 / ER exit site / Sec16 / TANGO1 / コラーゲン / 小胞体 / キナーゼ / 細胞生物学 |
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| Outline of Final Research Achievements |
How ER exit sites disassemble during mitosis was not well understood. We revealed that TANGO1, a cargo receptor originally identified for collagens, acts as a core for ER exit site disassembly. We revealed that TANGO1 is phosphorylated by Casein Kinase 1 and dephosphorylated by Protein Phosphatase 1.
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| Academic Significance and Societal Importance of the Research Achievements |
我々は、細胞分裂期においてもERESが崩壊しない状態を作り出すことに成功した。これによって細胞分裂を停止することができれば、新たな抗がん剤の標的となりうる。
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Report
(4 results)
Research Products
(29 results)
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[Presentation] cTAGE5 acts as a Sar1 GTPase regulator for collagen export2019
Author(s)
Maeda, M.,Sasaki,N., Shiraiwa, M., Yorimitsu, T., Sato, K., Katada, T., Saito, K.
Organizer
Gordon Research Conferences, Molecular Membrane Biology
Related Report
Int'l Joint Research
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