| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
Many animals have a mechanism to know the direction, but the mechanism has not been clarified yet. The purpose of this study was to approach the mechanism of orientation sensing through the analysis of cryptochromes (CRY), which are the most promising candidates for magnetic receptor molecules in vertebrates. To this end, we first completed a highly efficient expression / purification system for recombinant proteins in order to promote molecular analyses of blue light-sensitive CRY4, which is a candidate for magnetoreceptors in birds. Next, millisecond spectroscopic analysis of chicken CRY4 was performed to investigate how radical species presumed to be involved in magnetic reception are generated and decayed with blue light reception. We also found from the analysis of CRY expression in fish that CRY may be involved in the solar compass function in the fish eyes.
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