| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Outline of Final Research Achievements |
Accurate segregation of chromosomes to daughter cells is crucial for the maintenance and inheritance of life. Formation of heterochromatin at the centromere region is essential for accurate chromosome segregation. In fission yeast, non-coding RNAs (ncRNAs) transcribed from centromeres are involved in centromeric heterochromatinization via RNA interference mechanism. In this study, we analyzed the functions of centromeric ncRNAs in chromosome organization and segregation at the molecular level using fission yeast mutants and cultured human cells, and revealed the universal roles of ncRNAs in chromosomal dynamics and their diversity that have evolved in each species. The results of this study are expected to be useful for the development of novel anticancer drugs etc.
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