|Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
|Outline of Final Research Achievements
This study is a cohort study aimed to clarify the prevalence rate of human T-cell lymphotropic virus type-1 (HTLV-1) infection in Japanese community dwellers and to examine the association between HTLV-1 infection and chronic inflammation including atherosclerosis. We conducted a cross-sectional study with enrolled 2,184 participants who attended an annual health check-up during 2014-2017, and found that 406 (18.6%) were positive for anti-HTLV-1 antibody detected by CLEIA, and HTLV-1 infection was positively associated with atherosclerosis assessed by carotid intima-media thickness. Furthermore, we demonstrated that HTLV-1 infection significantly associated with advanced periodontitis and sarcopenia. By results of a series of this research activities, we successfully established the cohort study structure by 4,763 residents in Goto city, Nagasaki prefecture.